KEGG   Panthera leo (lion): 122221892
Entry
122221892         CDS       T10741                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
plez  Panthera leo (lion)
Pathway
plez01521  EGFR tyrosine kinase inhibitor resistance
plez01522  Endocrine resistance
plez04010  MAPK signaling pathway
plez04012  ErbB signaling pathway
plez04014  Ras signaling pathway
plez04015  Rap1 signaling pathway
plez04022  cGMP-PKG signaling pathway
plez04024  cAMP signaling pathway
plez04062  Chemokine signaling pathway
plez04066  HIF-1 signaling pathway
plez04068  FoxO signaling pathway
plez04071  Sphingolipid signaling pathway
plez04072  Phospholipase D signaling pathway
plez04114  Oocyte meiosis
plez04140  Autophagy - animal
plez04148  Efferocytosis
plez04150  mTOR signaling pathway
plez04151  PI3K-Akt signaling pathway
plez04210  Apoptosis
plez04218  Cellular senescence
plez04270  Vascular smooth muscle contraction
plez04370  VEGF signaling pathway
plez04371  Apelin signaling pathway
plez04380  Osteoclast differentiation
plez04510  Focal adhesion
plez04517  IgSF CAM signaling
plez04540  Gap junction
plez04550  Signaling pathways regulating pluripotency of stem cells
plez04613  Neutrophil extracellular trap formation
plez04620  Toll-like receptor signaling pathway
plez04650  Natural killer cell mediated cytotoxicity
plez04660  T cell receptor signaling pathway
plez04662  B cell receptor signaling pathway
plez04664  Fc epsilon RI signaling pathway
plez04666  Fc gamma R-mediated phagocytosis
plez04668  TNF signaling pathway
plez04720  Long-term potentiation
plez04722  Neurotrophin signaling pathway
plez04725  Cholinergic synapse
plez04726  Serotonergic synapse
plez04730  Long-term depression
plez04810  Regulation of actin cytoskeleton
plez04910  Insulin signaling pathway
plez04912  GnRH signaling pathway
plez04914  Progesterone-mediated oocyte maturation
plez04915  Estrogen signaling pathway
plez04916  Melanogenesis
plez04917  Prolactin signaling pathway
plez04919  Thyroid hormone signaling pathway
plez04921  Oxytocin signaling pathway
plez04926  Relaxin signaling pathway
plez04928  Parathyroid hormone synthesis, secretion and action
plez04929  GnRH secretion
plez04934  Cushing syndrome
plez04935  Growth hormone synthesis, secretion and action
plez05010  Alzheimer disease
plez05022  Pathways of neurodegeneration - multiple diseases
plez05034  Alcoholism
plez05132  Salmonella infection
plez05135  Yersinia infection
plez05160  Hepatitis C
plez05161  Hepatitis B
plez05163  Human cytomegalovirus infection
plez05164  Influenza A
plez05165  Human papillomavirus infection
plez05166  Human T-cell leukemia virus 1 infection
plez05167  Kaposi sarcoma-associated herpesvirus infection
plez05170  Human immunodeficiency virus 1 infection
plez05200  Pathways in cancer
plez05205  Proteoglycans in cancer
plez05206  MicroRNAs in cancer
plez05207  Chemical carcinogenesis - receptor activation
plez05208  Chemical carcinogenesis - reactive oxygen species
plez05210  Colorectal cancer
plez05211  Renal cell carcinoma
plez05212  Pancreatic cancer
plez05213  Endometrial cancer
plez05214  Glioma
plez05215  Prostate cancer
plez05216  Thyroid cancer
plez05218  Melanoma
plez05219  Bladder cancer
plez05220  Chronic myeloid leukemia
plez05221  Acute myeloid leukemia
plez05223  Non-small cell lung cancer
plez05224  Breast cancer
plez05225  Hepatocellular carcinoma
plez05226  Gastric cancer
plez05230  Central carbon metabolism in cancer
plez05231  Choline metabolism in cancer
plez05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:plez00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122221892 (MAP2K1)
   04012 ErbB signaling pathway
    122221892 (MAP2K1)
   04014 Ras signaling pathway
    122221892 (MAP2K1)
   04015 Rap1 signaling pathway
    122221892 (MAP2K1)
   04370 VEGF signaling pathway
    122221892 (MAP2K1)
   04371 Apelin signaling pathway
    122221892 (MAP2K1)
   04668 TNF signaling pathway
    122221892 (MAP2K1)
   04066 HIF-1 signaling pathway
    122221892 (MAP2K1)
   04068 FoxO signaling pathway
    122221892 (MAP2K1)
   04072 Phospholipase D signaling pathway
    122221892 (MAP2K1)
   04071 Sphingolipid signaling pathway
    122221892 (MAP2K1)
   04024 cAMP signaling pathway
    122221892 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    122221892 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    122221892 (MAP2K1)
   04150 mTOR signaling pathway
    122221892 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    122221892 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122221892 (MAP2K1)
   04148 Efferocytosis
    122221892 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    122221892 (MAP2K1)
   04210 Apoptosis
    122221892 (MAP2K1)
   04218 Cellular senescence
    122221892 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122221892 (MAP2K1)
   04540 Gap junction
    122221892 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    122221892 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122221892 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122221892 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    122221892 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    122221892 (MAP2K1)
   04660 T cell receptor signaling pathway
    122221892 (MAP2K1)
   04662 B cell receptor signaling pathway
    122221892 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    122221892 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    122221892 (MAP2K1)
   04062 Chemokine signaling pathway
    122221892 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122221892 (MAP2K1)
   04929 GnRH secretion
    122221892 (MAP2K1)
   04912 GnRH signaling pathway
    122221892 (MAP2K1)
   04915 Estrogen signaling pathway
    122221892 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    122221892 (MAP2K1)
   04917 Prolactin signaling pathway
    122221892 (MAP2K1)
   04921 Oxytocin signaling pathway
    122221892 (MAP2K1)
   04926 Relaxin signaling pathway
    122221892 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    122221892 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    122221892 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    122221892 (MAP2K1)
   04916 Melanogenesis
    122221892 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    122221892 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    122221892 (MAP2K1)
   04726 Serotonergic synapse
    122221892 (MAP2K1)
   04720 Long-term potentiation
    122221892 (MAP2K1)
   04730 Long-term depression
    122221892 (MAP2K1)
   04722 Neurotrophin signaling pathway
    122221892 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    122221892 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122221892 (MAP2K1)
   05206 MicroRNAs in cancer
    122221892 (MAP2K1)
   05205 Proteoglycans in cancer
    122221892 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    122221892 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    122221892 (MAP2K1)
   05230 Central carbon metabolism in cancer
    122221892 (MAP2K1)
   05231 Choline metabolism in cancer
    122221892 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122221892 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122221892 (MAP2K1)
   05212 Pancreatic cancer
    122221892 (MAP2K1)
   05225 Hepatocellular carcinoma
    122221892 (MAP2K1)
   05226 Gastric cancer
    122221892 (MAP2K1)
   05214 Glioma
    122221892 (MAP2K1)
   05216 Thyroid cancer
    122221892 (MAP2K1)
   05221 Acute myeloid leukemia
    122221892 (MAP2K1)
   05220 Chronic myeloid leukemia
    122221892 (MAP2K1)
   05218 Melanoma
    122221892 (MAP2K1)
   05211 Renal cell carcinoma
    122221892 (MAP2K1)
   05219 Bladder cancer
    122221892 (MAP2K1)
   05215 Prostate cancer
    122221892 (MAP2K1)
   05213 Endometrial cancer
    122221892 (MAP2K1)
   05224 Breast cancer
    122221892 (MAP2K1)
   05223 Non-small cell lung cancer
    122221892 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122221892 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    122221892 (MAP2K1)
   05161 Hepatitis B
    122221892 (MAP2K1)
   05160 Hepatitis C
    122221892 (MAP2K1)
   05164 Influenza A
    122221892 (MAP2K1)
   05163 Human cytomegalovirus infection
    122221892 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122221892 (MAP2K1)
   05165 Human papillomavirus infection
    122221892 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122221892 (MAP2K1)
   05135 Yersinia infection
    122221892 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122221892 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    122221892 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    122221892 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    122221892 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122221892 (MAP2K1)
   01522 Endocrine resistance
    122221892 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:plez01001]
    122221892 (MAP2K1)
Enzymes [BR:plez01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     122221892 (MAP2K1)
Protein kinases [BR:plez01001]
 Serine/threonine kinases: STE group
  STE7 family
   122221892 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 122221892
NCBI-ProteinID: XP_042797586
UniProt: A0A8C8WXC2
LinkDB
Position
B3:complement(38677191..38757136)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgagcagcaacggaagcgcctggaggcctttcttacccagaagcagaaggtc
ggggaattgaaggatgacgactttgagaagatcagcgagctgggcgccggcaacggtggt
gtggtgttcaaggtctcccataagccgtctggcctggtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctgcaggttctacatgag
tgcaactccccatacatcgtgggcttctatggcgcattctacagtgacggcgagatcagt
atctgtatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tccgtgcagtcggacatctggagcatggggctatctctggttgagatggcagtcgggagg
tatcccatccctcctcccgatgccaaggagctggagctgatgtttgggtgccaagtggag
ggagatgcggctgagacgccacccaggccgaggacccctggaaggcccctcagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaagctgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcctcataaaaaacccagcagagagagcagatctgaaacaactcatggttcatgccttt
atcaagagatctgatggtgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagtacaccgacccacgcggccggcgtctaa

DBGET integrated database retrieval system