Panthera leo (lion): 122222398 Help Entry 122222398         CDS       T10741                                  Symbol ADCY4 Name (RefSeq) adenylate cyclase type 4   KO K08044   adenylate cyclase 4 [EC:4.6.1.1] Organism plez  Panthera leo (lion) Pathway plez00230   Purine metabolism plez01100   Metabolic pathways plez01522   Endocrine resistance plez04015   Rap1 signaling pathway plez04020   Calcium signaling pathway plez04022   cGMP-PKG signaling pathway plez04024   cAMP signaling pathway plez04062   Chemokine signaling pathway plez04072   Phospholipase D signaling pathway plez04081   Hormone signaling plez04082   Neuroactive ligand signaling plez04114   Oocyte meiosis plez04211   Longevity regulating pathway plez04213   Longevity regulating pathway - multiple species plez04261   Adrenergic signaling in cardiomyocytes plez04270   Vascular smooth muscle contraction plez04371   Apelin signaling pathway plez04540   Gap junction plez04611   Platelet activation plez04713   Circadian entrainment plez04714   Thermogenesis plez04723   Retrograde endocannabinoid signaling plez04724   Glutamatergic synapse plez04725   Cholinergic synapse plez04727   GABAergic synapse plez04742   Taste transduction plez04750   Inflammatory mediator regulation of TRP channels plez04911   Insulin secretion plez04912   GnRH signaling pathway plez04913   Ovarian steroidogenesis plez04914   Progesterone-mediated oocyte maturation plez04915   Estrogen signaling pathway plez04916   Melanogenesis plez04918   Thyroid hormone synthesis plez04921   Oxytocin signaling pathway plez04923   Regulation of lipolysis in adipocytes plez04925   Aldosterone synthesis and secretion plez04926   Relaxin signaling pathway plez04927   Cortisol synthesis and secretion plez04928   Parathyroid hormone synthesis, secretion and action plez04934   Cushing syndrome plez04935   Growth hormone synthesis, secretion and action plez04970   Salivary secretion plez04971   Gastric acid secretion plez04972   Pancreatic secretion plez04976   Bile secretion plez05032   Morphine addiction plez05163   Human cytomegalovirus infection plez05166   Human T-cell leukemia virus 1 infection plez05200   Pathways in cancer plez05207   Chemical carcinogenesis - receptor activation plez05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:plez00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     122222398 (ADCY4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     122222398 (ADCY4)    04371 Apelin signaling pathway     122222398 (ADCY4)    04020 Calcium signaling pathway     122222398 (ADCY4)    04072 Phospholipase D signaling pathway     122222398 (ADCY4)    04024 cAMP signaling pathway     122222398 (ADCY4)    04022 cGMP-PKG signaling pathway     122222398 (ADCY4)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     122222398 (ADCY4)    04081 Hormone signaling     122222398 (ADCY4)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     122222398 (ADCY4)   09144 Cellular community - eukaryotes    04540 Gap junction     122222398 (ADCY4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     122222398 (ADCY4)    04062 Chemokine signaling pathway     122222398 (ADCY4)   09152 Endocrine system    04911 Insulin secretion     122222398 (ADCY4)    04923 Regulation of lipolysis in adipocytes     122222398 (ADCY4)    04912 GnRH signaling pathway     122222398 (ADCY4)    04913 Ovarian steroidogenesis     122222398 (ADCY4)    04915 Estrogen signaling pathway     122222398 (ADCY4)    04914 Progesterone-mediated oocyte maturation     122222398 (ADCY4)    04921 Oxytocin signaling pathway     122222398 (ADCY4)    04926 Relaxin signaling pathway     122222398 (ADCY4)    04935 Growth hormone synthesis, secretion and action     122222398 (ADCY4)    04918 Thyroid hormone synthesis     122222398 (ADCY4)    04928 Parathyroid hormone synthesis, secretion and action     122222398 (ADCY4)    04916 Melanogenesis     122222398 (ADCY4)    04925 Aldosterone synthesis and secretion     122222398 (ADCY4)    04927 Cortisol synthesis and secretion     122222398 (ADCY4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     122222398 (ADCY4)    04270 Vascular smooth muscle contraction     122222398 (ADCY4)   09154 Digestive system    04970 Salivary secretion     122222398 (ADCY4)    04971 Gastric acid secretion     122222398 (ADCY4)    04972 Pancreatic secretion     122222398 (ADCY4)    04976 Bile secretion     122222398 (ADCY4)   09156 Nervous system    04724 Glutamatergic synapse     122222398 (ADCY4)    04727 GABAergic synapse     122222398 (ADCY4)    04725 Cholinergic synapse     122222398 (ADCY4)    04723 Retrograde endocannabinoid signaling     122222398 (ADCY4)   09157 Sensory system    04742 Taste transduction     122222398 (ADCY4)    04750 Inflammatory mediator regulation of TRP channels     122222398 (ADCY4)   09149 Aging    04211 Longevity regulating pathway     122222398 (ADCY4)    04213 Longevity regulating pathway - multiple species     122222398 (ADCY4)   09159 Environmental adaptation    04713 Circadian entrainment     122222398 (ADCY4)    04714 Thermogenesis     122222398 (ADCY4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     122222398 (ADCY4)    05207 Chemical carcinogenesis - receptor activation     122222398 (ADCY4)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     122222398 (ADCY4)    05163 Human cytomegalovirus infection     122222398 (ADCY4)   09165 Substance dependence    05032 Morphine addiction     122222398 (ADCY4)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     122222398 (ADCY4)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     122222398 (ADCY4)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     122222398 (ADCY4) Enzymes [BR:plez01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      122222398 (ADCY4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N CD52 Motif Other DBs NCBI-GeneID:  122222398 NCBI-ProteinID:  XP_042798788 LinkDB All DBs Position B3:complement(74274574..74292147) Genome browser AA seq 1082 aa AA seqDB search MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLVIVLCALLALLAVASASGRELASDPG FLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWAALLGLGHGFLFTGGLVSAWDQV SFFLFVIFTVYTMLPLGMRDAAAAGLASSLSHLLVLGLYLGPQPDSKPALLPQLAANAVL FLCGNVAGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG AYAVEDAAMEHRDPYLRELGEPTYLVIDPGPPMPQAEEEDEKGTAGGLLSSLEGPKMRPS LLMTRYLESWGAAKPFAHLSHLESPVSTSTPLPEKALASFGPQWSLDRSRTPRGLDDDLD TGDAKFFQVIEQLNSQKQWRQSKDFNPLTLYFRKKELEKEYRLSALPAFKYYAACTFLVF LSNFIIQMLVTNRPPALAITYSITFLLFLLLLFVCFSEHLTRCVLKGPKMLHWLPALSGL VATRPGLRVALGTATILLVFVMAIPSLFFLPAASNCPFGALNVSSMAFNISWELPGSLPL ISIPYSMHCCVLGFLSCSLFLHMSFELKLLLLLLWLGASCSLFLHSHAWLSDCLIARLYP DPSDSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEQEETETME NLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEG LECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSH LGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVAS RMESTGVLGKIQVTEETARVLQSLGYTCYSRGIIKVKGKGQLCTYFLNTDLARTGPPSAT LG NT seq 3249 nt NT seq  +upstreamnt  +downstreamnt atggcccgcctcttcagcccccggccgccccccagcgaagacctcttctacgaaacctac tacagcctgagccagcagtacccgctgctgctactgctgctggtgatcgtgctctgcgcg ctcctggcgctgctggctgtcgcctccgccagcggccgggagctagcttcagacccaggc ttcctgaccactgtgctgtgcgcgctgggtggcttctcgctgctcctgggcctggcttcc cgggagcaacgactgcagcgctggacacgtcccctgtcgggcctcgtatgggcagcgcta ctcgggctaggccacggcttcctgttcactgggggcctggtgagcgcctgggaccaggtg tcctttttcctctttgtcatcttcaccgtgtacaccatgttgcccttgggcatgcgggat gccgctgctgcgggccttgcctcatcgctctcccacttgctggtcctggggctgtacctt gggcctcagccggactcaaagcctgcgctgctgccacagctggcagcgaacgcggtgttg ttcctgtgcgggaacgtggcgggagcgtatcacaaggcgctgatggagcgcgcgctgcgc gccacgttccgcgaggcacttagctccctgcactcgcgccggcggctggacaccgagaag aagcaccaggaacaccttctcttgtccatccttcctgcctacttggcccgagagatgaag gcagagatcatggcacgactgcaggctggacaggggtcacggccagaaagcaccaacaac ttccacagcctctatgtcaagaggcaccagggagtcagtgtgctgtatgctgacatcgtg ggcttcacccggctggccagtgagtgctctcctaaggagttggtgctcatgctcaacgag ctctttggcaagttcgaccagatcgccaaggagcatgaatgcatgcggatcaagatcctg ggagactgttactactgtgtctctgggctaccgctctccctgccagaccacgccatcaac tgcgtgcgcatggggctggacatgtgccgggccatcaggaagctccgggcagccactggc gtggacatcaacatgcgtgtgggcgtgcattcgggcagtgtgctctgcggagtcattggg ctgcagaagtggcagtatgatgtctggtcccatgatgtcacactggccaaccacatggag gcgggtggcgtgccaggacgagtacatattacaggggctaccctggccctgctggcaggg gcttatgctgtggaggatgcagccatggaacaccgggacccataccttcgggagctaggg gagcctacctacctagtcatcgatcccggccctcctatgccccaggctgaggaagaggat gagaagggcactgcaggagggttgctgtcctctcttgagggccccaagatgcgtccgtca ctgctgatgacccgctacctggagtcctggggcgccgccaagccttttgcccatctgagc cacctagagagccctgtgtccacttctacccctctcccggagaaggccctggcttccttt ggcccccagtggagcctggaccggagccgtaccccccgggggctagatgatgacctggac actggggacgccaagttcttccaggtcatcgaacagctcaactctcagaaacagtggagg cagtcaaaggacttcaacccactgacactgtacttcagaaagaaggaactggagaaagag taccgactctctgcactccccgccttcaaatactacgcagcctgcaccttcctggttttc ctttccaatttcatcatccagatgctggtgacaaacaggcccccagctctggccatcacc tatagcatcaccttcctcctcttcctcctcctcctcttcgtctgcttctcagagcacctg acgaggtgtgtcttgaaaggccccaagatgctgcactggctgccggcactgtctggcttg gtggccacacggcccggactgcgagttgcccttggcacagctaccatcctcctggttttt gtgatggccattcccagcctgttcttcttaccagcagcatcaaactgcccttttggggct ctcaatgtgtcctccatggctttcaacatctcctgggagctccctgggtccctgcctctc atcagcatcccttactctatgcactgctgcgtgctggggttcctgtcctgctccctcttt ttgcacatgagcttcgagctgaagttgctgctgctcctgctatggctgggggcctcctgc tccctcttcctgcactcccacgcctggctgtccgactgcctcatcgcccgcctctatccg gatccctcggactccaggccaggggtgctgaaggagcccaaactgatgggagctatctcc ttcttcatcttcttcttcaccctccttgtcctggctcggcagaatgagtattactgccgg ctggacttcctgtggaagaagaagctgcggcaggagcaggaggagacagagaccatggag aacctgactcggctgctgttggagaatgtgctccctgcacatgtggccccccagttcatt ggccagaaccggcgcaacgaggacctctaccaccagtcctatgagtgtgtctgtgtcctg ttcgcctcagttccagacttcaaggagttttactctgagtccaacataaaccacgagggt ctagagtgtctgcggctgctcaatgagataattgctgattttgatgagctgctctcaaag cccaagtttagcggggtggagaagatcaaaaccatcggtagcacctacatggcagctaca ggcttaaatgccacctccggacaggacgcacagcaggatgctgagcgcagctgcagccac cttggcaccatggtggagtttgcggtggctcttggatcaaagctggacgtcatcaataag cactctttcaacaacttccgcttgcgtgtggggttgaaccacggacctgtagtggctgga gtgatcggggcccagaagccgcagtatgacatctggggcaacacagtgaacgtggccagc cgcatggagagtacaggagtcctgggcaagatccaggtgactgaagagacagcccgggtg ctgcagtccttaggctacacctgctacagccggggtatcatcaaggtcaaaggcaaaggg caactctgcacctactttctgaacacagatttggcacgaactggacctccctcggccact ctaggctga

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