KEGG   Panthera leo (lion): 122225002
Entry
122225002         CDS       T10741                                 
Symbol
IGF1
Name
(RefSeq) insulin-like growth factor I isoform X1
  KO
K05459  insulin-like growth factor 1
Organism
plez  Panthera leo (lion)
Pathway
plez01521  EGFR tyrosine kinase inhibitor resistance
plez01522  Endocrine resistance
plez04010  MAPK signaling pathway
plez04014  Ras signaling pathway
plez04015  Rap1 signaling pathway
plez04066  HIF-1 signaling pathway
plez04068  FoxO signaling pathway
plez04081  Hormone signaling
plez04114  Oocyte meiosis
plez04115  p53 signaling pathway
plez04150  mTOR signaling pathway
plez04151  PI3K-Akt signaling pathway
plez04152  AMPK signaling pathway
plez04211  Longevity regulating pathway
plez04213  Longevity regulating pathway - multiple species
plez04510  Focal adhesion
plez04550  Signaling pathways regulating pluripotency of stem cells
plez04730  Long-term depression
plez04750  Inflammatory mediator regulation of TRP channels
plez04913  Ovarian steroidogenesis
plez04914  Progesterone-mediated oocyte maturation
plez04935  Growth hormone synthesis, secretion and action
plez04960  Aldosterone-regulated sodium reabsorption
plez05200  Pathways in cancer
plez05202  Transcriptional misregulation in cancer
plez05205  Proteoglycans in cancer
plez05214  Glioma
plez05215  Prostate cancer
plez05218  Melanoma
plez05224  Breast cancer
plez05410  Hypertrophic cardiomyopathy
plez05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:plez00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122225002 (IGF1)
   04014 Ras signaling pathway
    122225002 (IGF1)
   04015 Rap1 signaling pathway
    122225002 (IGF1)
   04066 HIF-1 signaling pathway
    122225002 (IGF1)
   04068 FoxO signaling pathway
    122225002 (IGF1)
   04151 PI3K-Akt signaling pathway
    122225002 (IGF1)
   04152 AMPK signaling pathway
    122225002 (IGF1)
   04150 mTOR signaling pathway
    122225002 (IGF1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    122225002 (IGF1)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    122225002 (IGF1)
   04115 p53 signaling pathway
    122225002 (IGF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122225002 (IGF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    122225002 (IGF1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    122225002 (IGF1)
   04914 Progesterone-mediated oocyte maturation
    122225002 (IGF1)
   04935 Growth hormone synthesis, secretion and action
    122225002 (IGF1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    122225002 (IGF1)
  09156 Nervous system
   04730 Long-term depression
    122225002 (IGF1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122225002 (IGF1)
  09149 Aging
   04211 Longevity regulating pathway
    122225002 (IGF1)
   04213 Longevity regulating pathway - multiple species
    122225002 (IGF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122225002 (IGF1)
   05202 Transcriptional misregulation in cancer
    122225002 (IGF1)
   05205 Proteoglycans in cancer
    122225002 (IGF1)
  09162 Cancer: specific types
   05214 Glioma
    122225002 (IGF1)
   05218 Melanoma
    122225002 (IGF1)
   05215 Prostate cancer
    122225002 (IGF1)
   05224 Breast cancer
    122225002 (IGF1)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    122225002 (IGF1)
   05414 Dilated cardiomyopathy
    122225002 (IGF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122225002 (IGF1)
   01522 Endocrine resistance
    122225002 (IGF1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:plez04052]
    122225002 (IGF1)
Cytokines and neuropeptides [BR:plez04052]
 Cytokines
  Growth factors (RTK binding)
   122225002 (IGF1)
SSDB
Motif
Pfam: Insulin DUF2865
Other DBs
NCBI-GeneID: 122225002
NCBI-ProteinID: XP_042803482
LinkDB
Position
B4:complement(122148570..122221319)
AA seq 187 aa
MGKISSLPTQLFKCCFCDFLKVKMHIMSPSHLFYLGLCLLTFTSSATAGPETLCGAELVD
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
VRAQRHTDMPKAQKYHPPSTTKKTKSQRRRKGGPKKHPGGEQKVGTEASQQMKGKKKEQR
RETGARN
NT seq 564 nt   +upstreamnt  +downstreamnt
atgggaaaaatcagcagtcttccaacccaattatttaagtgctgcttttgtgatttcttg
aaggtaaagatgcacatcatgtccccctctcatctcttctatctgggcctgtgcttgctc
accttcaccagctctgccacagctggaccagagacgctctgtggggctgagttggtggac
gctcttcagttcgtgtgtggagacaggggtttttatttcaacaagcccacggggtatggc
tccagcagtcggagggcacctcagacaggcatcgtggatgagtgctgcttccggagctgt
gatctgaggcggctagagatgtactgtgcacccctcaagcctgccaagtctgcccgctca
gtccgtgctcagcgccacactgacatgcccaaggctcagaagtatcatcccccatctacc
accaagaaaacgaagtctcagaggagaaggaaaggtgggccaaagaaacacccaggaggg
gagcagaaggtggggacggaagcaagtcagcagatgaaaggaaagaagaaagagcagaga
agggagactggagctagaaactga

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