Panthera leo (lion): 122226327 Help Entry 122226327         CDS       T10741                                  Symbol ITGA4 Name (RefSeq) integrin alpha-4 isoform X1   KO K06483   integrin alpha 4 Organism plez  Panthera leo (lion) Pathway plez04151   PI3K-Akt signaling pathway plez04510   Focal adhesion plez04512   ECM-receptor interaction plez04514   Cell adhesion molecule (CAM) interaction plez04517   IgSF CAM signaling plez04518   Integrin signaling plez04640   Hematopoietic cell lineage plez04670   Leukocyte transendothelial migration plez04672   Intestinal immune network for IgA production plez04810   Regulation of actin cytoskeleton plez04820   Cytoskeleton in muscle cells plez05135   Yersinia infection plez05140   Leishmaniasis plez05165   Human papillomavirus infection plez05410   Hypertrophic cardiomyopathy plez05412   Arrhythmogenic right ventricular cardiomyopathy plez05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:plez00001]  09130 Environmental Information Processing   09132 Signal transduction    04151 PI3K-Akt signaling pathway     122226327 (ITGA4)   09133 Signaling molecules and interaction    04512 ECM-receptor interaction     122226327 (ITGA4)    04514 Cell adhesion molecule (CAM) interaction     122226327 (ITGA4)    04517 IgSF CAM signaling     122226327 (ITGA4)    04518 Integrin signaling     122226327 (ITGA4)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     122226327 (ITGA4)   09142 Cell motility    04820 Cytoskeleton in muscle cells     122226327 (ITGA4)    04810 Regulation of actin cytoskeleton     122226327 (ITGA4)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     122226327 (ITGA4)    04670 Leukocyte transendothelial migration     122226327 (ITGA4)    04672 Intestinal immune network for IgA production     122226327 (ITGA4)  09160 Human Diseases   09172 Infectious disease: viral    05165 Human papillomavirus infection     122226327 (ITGA4)   09171 Infectious disease: bacterial    05135 Yersinia infection     122226327 (ITGA4)   09174 Infectious disease: parasitic    05140 Leishmaniasis     122226327 (ITGA4)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     122226327 (ITGA4)    05412 Arrhythmogenic right ventricular cardiomyopathy     122226327 (ITGA4)    05414 Dilated cardiomyopathy     122226327 (ITGA4)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:plez04147]     122226327 (ITGA4)    04515 Cell adhesion molecules [BR:plez04515]     122226327 (ITGA4)    04090 CD molecules [BR:plez04090]     122226327 (ITGA4) Exosome [BR:plez04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    122226327 (ITGA4)   Exosomal proteins of other cancer cells    122226327 (ITGA4) Cell adhesion molecules [BR:plez04515]  Integrins   Integrin alpha subunits    122226327 (ITGA4) CD molecules [BR:plez04090]  Proteins   122226327 (ITGA4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Integrin_A_Ig_1 Integrin_A_Ig_2 Integrin_A_Ig_3 FG-GAP FG-GAP_3 Integrin_alpha DUF11 Motif Other DBs NCBI-GeneID:  122226327 NCBI-ProteinID:  XP_042805243 UniProt:  A0A8C8YBR0 LinkDB All DBs Position C1:168300043..168390559 Genome browser AA seq 1035 aa AA seqDB search MAGEARCWPGPRGAAVREAVLLPLLLLCLGVPTGRPYNVDTESALLYQGPPNTLFGYSVV LHSHGANRWLVVGAPTASWLANASVVNPGAIYRCKIGENPDLTCEQLQLGSPTGEPCGKT CLEERDNQWLGVTLSRQPGENGSIVACGHRWKNIFYIKNENKLPTGVCYGMPPDLRTELS KRIAPCYQDYVRKFGENFASCQAGISSFYTEDLIVMGAPGSSYWTGSLFVYNITTNKYKA FLDKDNEVKFGSYLGYSVGAGHFRSPHTTEVVGGAPQHEQIGKAYIFSIEARELNILHEM KGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSIIREEGRVFVYINSGSGAVMNEMETE LLGSDKYAARFGESIVNLGDLDNDGFEDVAIGAPQEDGLRGAIYIYNGRADGVSPTFSQR IEGLQISQSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVEASLKHPE SVNRTNFDCVENGLPSVCMDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKIESPSRFYFSS NGTSDVITSSIKVSSKVANCRTHQAFMRKDVRDILTPIQIEAAYHLGHHVISKRSTEEFP PLQPILQQKKEKDRIEKTINFARFCAHQNCSADLQVSGRIGFFKPHENKTYLAVGSMKTL MLNVSLFNAGDDAYETTLHIRLPSGLYFVKILDLEEKQINCEVTDSAGLVKLDCSVGYIY VDHLSRIDISFLLDGSSLSRAEEDLNITVHATCANEGEMDNLKRNKVTLAIPLKYEVMLS VHGFVNPTSFVYGPKEENEPETCMSEKMNFTFHVINTGHSMAPNVSVEIMVPNSFAPQTD QLFNLLDVQTTAGDCHFKSYQRKCALEQDKGPLETLKDIFRFLSKTDKKLLFCIKADPYC LSLLCNFGNMESGKEASVHMQLEGRPSLSEMDETSALTFEIRATAFPEPNPKVIELNKDE NVAHVFLEGLHHQRPKRHFTIAIISSSLLLGLILLLLISYVMWKVGFFKRQYKSILQEEN RRDSWSYVNSKSNDD NT seq 3108 nt NT seq  +upstreamnt  +downstreamnt atggctggggaagcgaggtgctggccgggtccccgaggggccgccgtccgggaggcggtg ttgctgccgctgctgctgctgtgcctgggcgtcccgaccgggcgcccctacaacgtggac accgagagcgcgctgctctaccagggcccccccaacacccttttcggttattcggtggtg ctgcacagccacggggcgaaccgatggctcgtagtgggggcgcccaccgccagctggctc gccaacgcttcagtggtcaatcctggcgcgatttacagatgcaagatcggagagaatcca gacctgacgtgcgaacagctccagctgggtagccctactggagaaccttgtggaaagact tgtctggaagaaagagacaatcagtggttgggggtcacactttccagacagccaggagaa aatggctccatcgtggcttgtgggcatagatggaaaaacatattttatataaagaatgaa aataagctccctacgggtgtttgctatggaatgccccctgatttacgaacagaactgagc aaaagaatagctccatgttatcaagattatgtgagaaaatttggagaaaattttgcatcc tgtcaagctggaatatctagtttttacactgaggatttaattgtgatgggagccccagga tcatcttattggactggctctctttttgtctacaatataactacaaataagtacaaggct tttttagacaaagataatgaagtaaaatttggaagttatttaggctactcagttggagct ggtcattttcggagtccgcatactaccgaagtagttggaggagcccctcaacatgaacag attggtaaagcatacatattcagcatcgaggccagagaactaaacatcttacatgaaatg aaaggtaaaaagcttggctcctattttggagcttctgtctgtgccgtggacctcaacgca gatggcttctcagacctcctcgtgggagctcccatgcagagcatcatcagggaggaaggc agagtgtttgtgtatatcaactctggctcaggagcagtaatgaacgaaatggaaacagag ctccttggaagtgacaaatatgctgcaagatttggggaatctattgttaatcttggagac cttgataatgatggctttgaagatgttgcaattggagctccacaggaagatggcttgaga ggtgctatttatatttacaacggccgagcagatggggtctcaccaacgttctcacagaga attgaaggacttcaaatcagccaatcattaagtatgtttggacagtctatatctggacaa attgatgcagataataatggatatgtagatgtggcagttggtgcttttcggtctgattct gctgtgttgctgaggacaagacccgtagtgattgttgaagcttctttaaaacatcctgag tcagtaaatagaacaaattttgactgtgttgaaaatggattgccttctgtttgcatggat ctaacactctgtttctcatacaagggcaaagaggttccaggttatattgttttgttctat aacatgagtctggatgtgaaccggaagatagaatctccatcaagattttacttttcttct aatggaacatctgatgtgattacaagcagcataaaagtgtcaagcaaagtagctaactgc agaacacatcaagcatttatgcggaaagatgtgcgggacatcctcaccccaattcagatt gaagctgcttaccaccttgggcatcacgtcatcagtaaacgaagtacagaggaattcccc ccacttcaaccaattcttcagcaaaagaaagaaaaagacagaattgaaaaaacgataaat tttgcaagattttgtgcccaccaaaattgctctgctgacttacaggtttctgggagaatt ggattttttaagccacatgaaaataagacctatcttgctgttggaagtatgaagaccttg atgttgaacgtgtccttgtttaatgctggagatgatgcgtacgaaacaactctgcacatc agactcccctctggtctttacttcgttaagattttagatctggaagagaaacaaataaac tgtgaagtaacagacagtgctggcttagtaaaactcgactgcagtgttggatatatatat gtagatcacctatcaaggatagatattagctttctcctggatgggagctcactcagcaga gcggaagaggatctcaacatcacagtgcatgccacctgtgcaaatgaaggagaaatggac aatctgaagcgtaacaaagtgactttagcaatacctctcaagtatgaagtcatgctatct gttcatgggtttgtaaacccaacttcatttgtgtatggaccaaaggaagaaaatgagcct gaaacatgcatgtcagagaaaatgaacttcacttttcatgttatcaacactggccatagc atggctccaaatgttagtgtggaaataatggtaccaaattcttttgccccccaaactgat cagctgttcaaccttttggatgtccagactactgctggagattgccattttaaaagttat caaagaaagtgtgcattagagcaggataaaggtcccctggagaccctgaaagacatcttc agattcttgtcaaagactgataagaagctattgttctgcataaaagctgatccatactgt ttaagtcttttatgtaattttgggaatatggaaagtggaaaagaagccagtgttcacatg cagttggaaggccgcccatctctttcagaaatggatgagacttcagcgctcacatttgag ataagagcaacggcttttccagagcctaatccaaaagttattgaactaaacaaggatgaa aatgttgcacatgttttccttgaaggactacatcatcaaagacccaaacgtcatttcaca atagcaattatttcaagtagcttgctacttggccttattttacttttattgatttcgtat gttatgtggaaggttggtttctttaaaagacagtacaaatctatcctacaagaagaaaac agaagagacagttggagttacgttaacagcaaaagcaatgatgattga

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