Panthera leo (lion): 122226538
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Entry
122226538 CDS
T10741
Symbol
NDUFS1
Name
(RefSeq) NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1
KO
K03934
NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:
7.1.1.2
]
Organism
plez Panthera leo (lion)
Pathway
plez00190
Oxidative phosphorylation
plez01100
Metabolic pathways
plez04714
Thermogenesis
plez04723
Retrograde endocannabinoid signaling
plez04932
Non-alcoholic fatty liver disease
plez05010
Alzheimer disease
plez05012
Parkinson disease
plez05014
Amyotrophic lateral sclerosis
plez05016
Huntington disease
plez05020
Prion disease
plez05022
Pathways of neurodegeneration - multiple diseases
plez05208
Chemical carcinogenesis - reactive oxygen species
plez05415
Diabetic cardiomyopathy
Module
plez_M00143
NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09100 Metabolism
09102 Energy metabolism
00190 Oxidative phosphorylation
122226538 (NDUFS1)
09150 Organismal Systems
09156 Nervous system
04723 Retrograde endocannabinoid signaling
122226538 (NDUFS1)
09159 Environmental adaptation
04714 Thermogenesis
122226538 (NDUFS1)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
122226538 (NDUFS1)
09164 Neurodegenerative disease
05010 Alzheimer disease
122226538 (NDUFS1)
05012 Parkinson disease
122226538 (NDUFS1)
05014 Amyotrophic lateral sclerosis
122226538 (NDUFS1)
05016 Huntington disease
122226538 (NDUFS1)
05020 Prion disease
122226538 (NDUFS1)
05022 Pathways of neurodegeneration - multiple diseases
122226538 (NDUFS1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
122226538 (NDUFS1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
122226538 (NDUFS1)
Enzymes [BR:
plez01000
]
7. Translocases
7.1 Catalysing the translocation of protons
7.1.1 Linked to oxidoreductase reactions
7.1.1.2 NADH:ubiquinone reductase (H+-translocating)
122226538 (NDUFS1)
BRITE hierarchy
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Molybdopterin
Fer4_Nqo3
Fer4_NDSU1
Fer2_4
NADH-G_4Fe-4S_3
NADH_dhqG_C
Fer2
Motif
Other DBs
NCBI-GeneID:
122226538
NCBI-ProteinID:
XP_042805813
LinkDB
All DBs
Position
C1:complement(190650885..190680303)
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AA seq
733 aa
AA seq
DB search
MQAICNMLRIPLKRALVGLSKSHKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACE
KVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKARE
GVMEFLLANHPLDCPICDQGGECDLQDQSMMFGNDRSRFLDGKRAVEDKNIGPLVKTIMT
RCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSK
PYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAY
DGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSVQGKDVAAIAGGLVDAEALVAL
KDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVLLLVGTNPRFEAPLF
NARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQEIALGNHPFSQVLHEAKKPMV
VLGSSALQRNDGAAILAAVSNIAQKIRMSSGVTSDWKVMNILHRIASQVAALDLGYKPGV
EAIRKSPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSA
TYVNTEGRAQQTRVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLV
RYDDVEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAV
TEGAQAVEEPSIC
NT seq
2202 nt
NT seq
+upstream
nt +downstream
nt
atgcaggctatatgcaatatgttaaggatacctctaaaaagggccttagtaggcctttct
aagtctcataaaggatgtgttcgaacaactgccacagcagcaagcaacttaattgaagta
tttgtcgatggtcagtctgtcatggtggaaccaggaactaccgtactccaagcttgtgag
aaggttggcatgcagatccctcgattctgttatcatgaaagattgtctgttgctggaaac
tgtaggatgtgccttgttgaaattgagaaagctcctaaggttgtggcagcttgtgccatg
ccagtaatgaaaggttggaatatcctgacaaactcagagaaatctaagaaagcaagagaa
ggtgtgatggagttcttgttagcaaatcacccactggactgtcctatttgtgaccaggga
ggtgaatgtgatctgcaggaccagtccatgatgtttggaaatgataggagcagattttta
gatgggaaacgtgctgtggaggacaagaatattgggccattggtaaagactatcatgact
agatgtatacagtgtactcgctgcatcaggtttgcaagtgagattgcaggagtagatgat
ttgggaacaacaggcagaggaaatgatatgcaagttggcacgtacattgaaaagatgttc
atgtctgaactgtctggaaatatcattgatatctgccctgtaggtgccctgacttcgaag
ccctatgcttttactgcccgcccttgggaaacaagaaagacggaatccattgatgtaatg
gatgcagttggaagtaatattgtggtaagcacaagaactggagaggtgatgcggattttg
ccaaggatgcatgaggacatcaatgaagagtggatctctgataaaaccagatttgcctat
gatgggctaaaacgtcaaagactaaccgagccaatggtcagaaatgaaaaggggctttta
acctacacttcctgggaagatgcactctctcgtgtagctggaatgttgcagagtgttcaa
ggcaaggatgtggcagcaattgcaggtggcttggtggatgctgaagccctggtagctctc
aaagatttgcttaatagagtggactctgacaccttgtgcactgaagaggtcttccccact
gcaggagctggcacagatttgcgttctaattatcttcttaatactacaattgctggtgtg
gaagaggcagatgttctccttctggttggtacaaatccgcgttttgaggcgccactgttt
aatgctagaattcgaaagagctggcttcataatgacttaaaagtggcccttattggcagc
ccagtggatctcacttacagatatgaccatctgggagattcccccaaaattcttcaggag
attgctttgggtaaccatccgttcagccaggtattacatgaagctaaaaaaccaatggtg
gttttaggcagttctgcactccaaagaaatgatggggcagcaattcttgcagctgtttcc
aacattgctcaaaagattcggatgagtagtggtgttaccagtgattggaaagttatgaat
atccttcataggattgcaagccaagtagctgctttggaccttggctataaacctggggtg
gaagcaattcgtaagagccctcccaaagtgctatttctcctgggagcagatggaggttgt
atcactcgacaggatttgccaaaggattgtttcattatttatcaaggacatcatggagac
gttggagctccaatagctgatgttattctcccaggcgctgcttacacagaaaagtcagcc
acttatgtcaatactgaaggccgagctcagcagacaagagtagcagtgacacctcctggc
ttggcaagagaagactggaaaattataagagccctctctgagattgcaggtatgactctt
ccatatgatactctggatcaagtaaggaacagattggaggaagtctctcctaatcttgtc
cgatatgatgatgtcgaaggagccaattatttccagcaagcaaatgagctctccaagcta
gtgaaccagcaacttcttgctgatccgcttgttccacctcagctaacaataaaagacttc
tacatgacagactcaattagcagagcctcacagacaatggccaaatgtgtcaaagctgtc
acagaaggtgcccaagcagtagaggagccatccatttgctga
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