Panthera leo (lion): 122228565
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Entry
122228565 CDS
T10741
Symbol
NOTCH2
Name
(RefSeq) neurogenic locus notch homolog protein 2 isoform X1
KO
K20994
Notch 2
Organism
plez Panthera leo (lion)
Pathway
plez01522
Endocrine resistance
plez04330
Notch signaling pathway
plez04658
Th1 and Th2 cell differentiation
plez04919
Thyroid hormone signaling pathway
plez05165
Human papillomavirus infection
plez05200
Pathways in cancer
plez05206
MicroRNAs in cancer
plez05207
Chemical carcinogenesis - receptor activation
plez05224
Breast cancer
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
122228565 (NOTCH2)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
122228565 (NOTCH2)
09152 Endocrine system
04919 Thyroid hormone signaling pathway
122228565 (NOTCH2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
122228565 (NOTCH2)
05206 MicroRNAs in cancer
122228565 (NOTCH2)
05207 Chemical carcinogenesis - receptor activation
122228565 (NOTCH2)
09162 Cancer: specific types
05224 Breast cancer
122228565 (NOTCH2)
09172 Infectious disease: viral
05165 Human papillomavirus infection
122228565 (NOTCH2)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
122228565 (NOTCH2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
EGF
hEGF
EGF_TEN
EGF_CA
EGF_2
Ank_2
Ank
Notch
NOD
NODP
Ank_5
Ank_3
Ank_4
EGF_3
EGF_Teneurin
JAG1-like_EGF2
Motif
Other DBs
NCBI-GeneID:
122228565
NCBI-ProteinID:
XP_042809604
LinkDB
All DBs
Position
C1:complement(101949408..102113001)
Genome browser
AA seq
2476 aa
AA seq
DB search
MILQVKKLKHKVDTETDSKWWSQNPSSDAALQCRDSYEPCVNEGICVTYHNGTGYCKCLE
GFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCALGFTGDDCQYSTAHPCFVSHPC
LNGGTCHVRSRDDYECTCQVGFTGKLCQWTDACLSHPCANGSTCTTVANQFSCRCLAGFT
GQKCETDVNECDIPGQCQHGGTCLNLLGSYQCQCPQGFTGQHCDSPYVPCAPSPCVNGGT
CRQTGDFTFECNCLPGFEGITCERNIDDCPNHKCQNGGVCVDGVNTYNCRCPPQWTGQFC
TEDVDECLLQPNACQNGGTCTNRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCID
RVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTED
VDECAMANSNPCEHAGKCVNTDGAFHCECLRGYTGPRCELDINECHSDPCQNDATCLDKI
GGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDD
CSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCIC
NPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCV
HGVCMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINDVNGFRCLCPEGPHHP
SCYSQVNECLSSPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNL
VNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLA
PCSPNPCENAAVCKEAPNFESYTCLCAPGWQGQRCTVDIDECVSKPCMNHGLCHNTQGSY
MCECPPGFSGMDCEEDIDDCLANPCQNGGSCVDGVNTFSCLCHAGFIGDKCQTDMNECLS
EPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNIDECTESSCFNGGTCVDGINSFSCLCPV
GFTGPFCLHEINECNSHPCLNEGVCVDGLGTYRCTCPLGYTGKNCQTLVNLCSRSPCKNK
GTCVQEKAESRCLCPSGWAGAYCDVPNVSCEVAAFHRGVSIDHLCQHSGICINAGNSHHC
QCPLGYTGSYCEEQLDECSSNPCQHGATCRDFIGGYRCECVPGYQGVNCEYEVDECQNQP
CQNGGTCVDLVNHFKCSCPPGTRGLLCEENVDDCAGGPHCLNGGQCVDRIGGYSCRCLPG
FAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPHMPCLN
GGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRRGEQCVHTASGPRCFCPNPQDCE
SGCASSPCQHGGSCYPQRQPPYYFCQCSPPFWGSHCELYTAPTSTPPATCLSQYCADKAR
DGVCDEACNSHACQWDGGDCSLTMKNPWANCSSPLPCWDYINNQCDELCNTAECLFDNFE
CQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADRPENLAEGTLVIVVLMPP
EQLLQDARSFLRALGTLLRTNLQIKRDSQGAFMVYPYYGEKSAAMKKQRMIRRSLPGDQE
QEVVGSKVFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLAPKG
TQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDSSNHKRREPVGQDAV
GLKNLSVQVSEANLIGSGTSEHWVDDEGPQPKKAKAEDEALLSEEDDAIDRRPWTQQHLE
AADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDMSDEDEDGEDSS
ANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLH
AAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDD
HGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFAN
RDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLK
HTPMGKKPRRPNTKSAMPTSLPNLAKEAKDAKGNRRKKSLSDKGQLSESSVTLSPVDSLE
SPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGAN
PVLPSVSQLLSHHHIVPPGSSSTGSLGRLHPVTVPADWMNRMEMNETQYNEMFSMVLAPA
EGTHPGIAPQSRPPEGKHITTPREPLPPIVTFQLIPKGSISQPAGTPQPQSNCPPPVTGP
VPTMYQIPEMARLPNMAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASS
NAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGP
GTHMSEPPRSNMQVYA
NT seq
7431 nt
NT seq
+upstream
nt +downstream
nt
atgattttacaggtgaagaaactgaagcacaaagtggatacagagacagatagtaaatgg
tggagccagaatccaagctcagatgctgcattgcagtgtcgggacagctatgagccctgt
gtaaatgaaggaatatgtgttacctaccacaatggtacaggatactgcaaatgtctggag
ggcttcttgggagaatattgtcaacatcgagacccctgtgagaagaaccgctgccagaat
ggggggacgtgtgtggcccaggccatgttggggaaagccacatgccgatgtgccctgggg
ttcacaggtgatgactgtcagtactcaactgctcacccctgctttgtgtctcacccctgc
ctgaatggaggcacctgccatgtgcgtagccgggacgactatgagtgtacctgccaagtt
ggttttacaggtaagctgtgccaatggaccgatgcctgcctatctcatccctgtgcaaat
ggaagtacctgcaccactgtagccaaccagttctcctgcagatgcctcgcaggcttcaca
ggacagaagtgtgagactgatgtcaatgagtgtgacatcccaggacagtgtcagcatggt
ggcacctgcctcaatctactgggttcctatcagtgccaatgcccccagggcttcacaggc
cagcactgtgacagcccctatgtgccctgtgcaccctccccctgtgttaatggaggcacc
tgccggcagactggtgacttcacatttgaatgcaactgccttccaggttttgaagggatc
acctgtgagcggaatattgatgactgccctaaccacaagtgtcagaatggaggagtttgt
gtggacggggttaatacttacaactgccgctgcccccctcagtggacaggacagttctgc
acagaggatgtagacgagtgtctgctgcaacctaacgcttgtcagaacggaggcacctgc
accaaccgcaacggcggctatggctgcgtgtgtgtcaatggctggagtggagacgactgc
agtgagaacatcgatgactgcgccttcgcctcctgcactcccggctccacgtgcattgac
cgcgtggcctccttctcttgcatgtgccctgaaggaaaggcaggtctcttgtgtcatttg
gatgatgcatgcatcagcaatccttgccataagggggcactgtgtgataccaaccccctg
aacgggcagtatatttgcacctgcccccaaggctacaaaggcgctgactgcacagaagat
gtggatgaatgtgccatggccaatagcaatccttgtgagcatgcaggaaaatgtgtgaat
acagatggtgccttccactgtgaatgtctgaggggctatacagggcctcgttgcgagttg
gatatcaatgagtgccattccgacccctgccagaacgatgcgacctgtctggataagatt
ggaggcttcacgtgtctgtgcatgccaggtttcaaaggtgtgcattgtgaattggagata
aacgaatgtcagagcaacccttgtgtgaacaatggtcagtgtgtagataaagtcaatcgc
ttccagtgtctgtgtccgcctggtttcactgggccagtttgccagattgatattgatgac
tgttccagtactccgtgtctgaatggggcaaagtgtattgatcacccaaatggctatgaa
tgccagtgtgccacaggattcactggtgtgttgtgcgaggagaacatcgacaactgtgac
cctgatccttgccaccatggccagtgtcaggatgggattgattcctacacctgcatctgc
aacccggggtacatgggtgccatctgcagtgaccagatagatgaatgttacagcagccct
tgcctgaatgatggtcgctgcattgaccttgtaaatggctaccagtgcaactgccagccg
ggcacgtcaggtgttaattgtgaaatcaattttgatgactgtgcaagtaacccttgtgtc
cacggagtctgtatggatggcattaatcgttatagttgtgtctgctcaccgggattcaca
gggcagagatgtaacatcgacattgatgagtgtgcctccaatccctgtcgcaagggtgcg
acgtgcatcaacgacgtgaatggtttccgctgtctatgccccgaggggccccatcacccc
agctgctactcgcaggtgaacgagtgcctgagcagtccctgcatccacgggaactgtacc
ggaggcctcagcggatacaagtgtctctgtgatgcaggctgggttggcatcaactgcgaa
gtggacaaaaatgaatgtctttctaacccatgccagaatggaggaacttgtgacaatctg
gtgaacggatacaggtgtacttgcaagaagggctttaaaggctataactgtcaggtgaat
attgatgaatgtgcttcaaatccctgcctgaaccaaggaacctgctttgatgacataagt
ggctacacttgccactgtgtgctgccatacacaggcaagaattgtcagactgtgttggct
ccctgttccccaaacccatgtgagaatgctgctgtttgcaaagaggcaccaaattttgag
agctacacctgcctgtgtgcccctggctggcaaggtcagcggtgtacagttgacattgat
gagtgtgtctccaagccttgcatgaaccacggtctctgccataacacccagggcagctac
atgtgtgagtgtcctccaggcttcagcggtatggactgtgaggaggacatcgatgactgc
cttgccaatccttgccagaatggaggttcctgtgtagatggagtaaatactttctcctgt
ctgtgccacgctggctttattggggataagtgtcagacagacatgaatgagtgtctgagt
gaaccgtgtaagaatggagggacctgctccgactatgtcaacagttacacttgcaagtgc
caggcgggatttgatggagtccactgtgagaacaacatcgatgagtgcactgagagctcc
tgtttcaatggtggcacgtgtgtcgacgggattaactccttctcttgcttgtgccctgtg
ggcttcactggccccttctgcctccatgagatcaatgaatgcaactctcatccatgccta
aatgaaggagtatgtgttgatggcctgggtacctaccgctgcacctgccccttgggctac
actggcaaaaactgtcagaccctggtgaacctctgtagtcggtctccatgtaaaaacaaa
ggtacttgcgttcaggaaaaagcagagtcccggtgtctgtgtccgtctggatgggctggt
gcttactgtgatgtgcccaatgtatcctgtgaggtggcggctttccacagaggggtgtcc
attgaccacctgtgccagcactctggcatctgcatcaatgctggaaactcgcatcactgc
cagtgccccctgggctacactgggagctactgtgaggagcagctcgatgagtgctcatcc
aacccctgccagcacggagccacttgcagggacttcatcggcgggtatagatgtgagtgt
gtcccaggatatcagggtgtcaattgtgagtatgaagtggatgagtgccagaatcagcca
tgccagaatggaggcacctgtgtcgaccttgtgaaccatttcaagtgctcctgtccacca
ggcactcgaggcctgctctgcgaagagaacgttgacgactgtgccggcggtccccactgc
cttaatggtggtcagtgtgtggataggattgggggctacagttgccgctgcttgcccggc
tttgcaggagaacggtgtgagggggacatcaatgagtgcctctccaacccctgcagctct
gagggcagcctggactgcatacagctgaccaacgactacctgtgtgtctgccgcagtgcc
ttcactggtcgtcactgtgaaactttcgtcgatgtgtgtccacatatgccttgcctgaat
ggggggacttgtgctgtggccagcaacatgcccgatggtttcatttgtcgttgtcccccg
ggattctccggggcaagatgccagagcagctgtggacaagtgaagtgcaggagaggggag
cagtgtgtgcacacggcctcaggaccccgctgcttctgccccaacccccaggactgcgag
tcaggctgtgccagtagcccctgccagcatgggggtagctgctaccctcagcgccagcct
ccttattacttctgccagtgttctccaccattctggggcagccactgtgagctttacacg
gcccccaccagcacccctcctgccacctgtctgagccagtattgtgccgacaaagctcgg
gacggcgtctgcgatgaggcatgcaacagccatgcctgccagtgggatgggggtgactgt
tccctgaccatgaagaacccctgggccaactgctcttccccacttccctgctgggattac
atcaacaaccagtgtgatgagctgtgtaacacagccgagtgcctttttgacaactttgaa
tgccaagggaacagcaagacgtgcaagtatgacaaatactgtgcagaccacttcaaagac
aaccactgtgaccagggatgcaacagtgaggagtgtggctgggatgggttggactgtgct
gctgaccggccggagaacctggcggaggggaccctggttatagtggtgctcatgcccccg
gagcagcttctccaggatgcccgcagctttttgcgggcactgggcaccctgctccgtacc
aacctgcagattaaacgggactcccagggggcattcatggtctacccctattatggtgag
aagtcggctgccatgaagaagcagaggatgatacgcaggtcccttcctggtgaccaagaa
caggaggtggttggctctaaggtgtttctggaaattgacaaccgccaatgtgttcaagat
tcagaccagtgtttcaagaacacggatgcagcagcagctcttctggcctctcacgccatc
caggggaccttatcctaccctcttgtgtccgtcgtcagtgaatctctggctccaaaaggt
acccagcttctctatctacttgctgttgccgttgtcattatcctgtttattatcttgctg
ggagttatcatggcgaaacgaaagcgtaagcatggctccctctggctgcctgaaggtttc
acccttcgccgagactccagcaatcacaagcgccgtgagccagtgggacaggatgccgtg
gggctgaaaaatctctcagtgcaagtctcagaggctaacctaattggttctggaacaagt
gaacattgggttgatgatgaagggccccagccaaagaaagccaaggctgaagatgaggct
ttgctctcagaagaagatgatgccattgatcgacgtccatggacacagcagcaccttgag
gctgcagatatccgcaggacgccatcgctggcactcactcctccacaggcggagcaggag
gtggatgtgttggacgtgaatgtccgtggcccagatgggtgcaccccactgatgctggct
tccctccgaggaggcagctcagatatgagtgatgaagatgaagatggagaggactcttct
gccaacatcatcacagacttggtctaccagggtgccagcctgcaggcccagacagaccgg
actggtgagatggctctgcaccttgcagcgcgctactcaagggctgatgctgccaagcgt
ctcctggatgcaggtgcagacgccaacgcccaggacaacatgggccgctgccctctccat
gctgcagtggcagctgatgcccagggggtcttccagattctgatccgcaaccgagtaact
gatctggacgccaggatgaacgatggcactacaccactgatcctggctgcccgcctggct
gtggagggaatggtggcagaactgatcaactgccaagcagatgtgaatgcagtagacgac
catggaaaatccgcccttcactgggcagctgctgtcaataacgtggaggcaacccttttg
ctgttgaaaaacggggccaaccgagacatgcaagacaacaaggaagagacacctctgttt
cttgctgcccgggagggaagctatgaagcagccaagatcctgttagaccattttgccaat
cgggatatcacagaccacatggatcgtcttccccgggatgtggctcgggaccgcatgcac
catgacatcgtgcgcctcctagacgagtacaatgtgacaccgagccctccaggcactgtg
ctgacttcggccctctcacctgtcatctgtgggcccaacagatctttcctcagcctaaag
cacaccccaatgggcaagaagcctagacggcccaataccaagagtgccatgcccactagc
ctccctaaccttgccaaggaggccaaggatgccaagggtaataggaggaagaagtctctg
agtgacaagggtcagctgtctgagagttcagtgactttatccccagttgattccttagag
tctcctcacacatatgtttctgacaccacatcctctccaatgattacatcccctggaatc
ttacaggcctcacccaaccctatgttggccactgctgcaccccctgccccagtccatgca
cagcatgcactgtctttctctaacctgcatgaaatgcagcctttggctcacggggccaac
cctgtgcttccctcagtgagccagctgctatcccaccaccacattgttcccccaggcagt
agcagtacggggagcttgggtaggctccatccagtcactgttccagcagattggatgaac
cgcatggagatgaatgagacccagtacaatgagatgtttagtatggttctggctccagct
gagggcacgcaccctggcatagctccccagagcagaccacctgaagggaagcatataact
acccctcgggagcccttgccccccattgtgactttccagctaatccccaaaggcagtatt
tcccaaccagcagggactccccagcctcagtccaactgccccccacctgttacaggccct
gtgcccaccatgtaccagattccagaaatggctcgtttgcctaatatggcttttcccact
gccatgatgccccagcaggatgggcaggttgctcagaccattctcccagcctatcatcct
ttcccagcctctgtgggcaagtatcccacaccaccttcacagcatagttatgcttcctca
aatgctgctgagcgaacacccagtcacagtggtcacctccagggtgagcatccctacctg
acaccatccccagagtctcctgaccagtggtcaagttcatcaccccactctgcttctgac
tggtcagatgtgaccaccagccctacccctgggggtgctggaggaggtcaacggggacct
ggaacacacatgtctgagccaccgcgcagcaacatgcaggtgtatgcatga
DBGET
integrated database retrieval system
