Panthera leo (lion): 122229980
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Entry
122229980 CDS
T10741
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3 isoform X1
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
plez Panthera leo (lion)
Pathway
plez00230
Purine metabolism
plez00670
One carbon pool by folate
plez01100
Metabolic pathways
plez01523
Antifolate resistance
Module
plez_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
122229980 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
122229980 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
122229980 (GART)
Enzymes [BR:
plez01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
122229980 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
122229980 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
122229980 (GART)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
ATP-grasp_3
ATP-grasp_2
CPSase_L_D2
ATP-grasp_4
Dala_Dala_lig_C
CbiJ
RimK
Motif
Other DBs
NCBI-GeneID:
122229980
NCBI-ProteinID:
XP_042811545
UniProt:
A0A8C9D2Z0
LinkDB
All DBs
Position
C2:11662686..11691715
Genome browser
AA seq
1009 aa
AA seq
DB search
MAARVLVIGGGGREHTLAWKLAQSNRVKHVLVAPGNAGTACLEKISNTAISISDHTALAQ
FCKDENIEFVVVGPEAPLAAGIVGNLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TARWRAFTRPEEACSFIMSADFPALVVKASGLAAGKGVIVAKSTEEACRAVQEIMQEKAY
GAAGETIVIEELLEGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDHGPNTGGMGAYCPAP
QVSKDLLLKIKNTVLQRTVDGMQQEGMPYTGVLYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTFDGLLHTSLPVWLENRTALTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKDGKVVTSGGRVLSVTAIQENLISALEEAKKGLAAIKFEGAIYRKD
IGSRAIAYLQQPRGLTYKESGVDIAAGNMLVKKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFKDPLLACGTDGVGTKLKIAQQCNRHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLDTTEAVVAGIARACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVIGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKFGVDLDAQTWRIPRIFSWLQQEG
HLSEEEMARTFNCGVGAVLVVSKDRTEQILRDIKQHSEEAWVIGKVVACPEGSPRVKVKH
LIETMQANGSVLENGTLKNHFSVQPKKARVAVLISGTGSNLQALIDNTREPSSCAHIVVV
ISNKAAVAGLDKAERAGIPTRVINHKLYKSRVEFDTAIDQVLEEFSTDIVCLAGFMRILS
GPFVRKWNGKMLNIHPSLLPSFKGSNAHEQVLEAGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVTTLSERVKLAEHKLFPAALQLVASGTVQLGENGKIRWVTE
NT seq
3030 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgcgtacttgtaattggcggtggcggaagggaacatacactggcctggaaa
cttgcacagtctaatcgtgtcaaacatgtgttggttgccccgggcaatgcaggcactgcc
tgcttggaaaagatttcaaatactgccatctcgataagtgatcacactgcccttgctcag
ttctgcaaagatgagaacattgaattcgtagttgttggaccagaggcacctctggctgct
ggaattgttgggaacctgacctctgcaggagtgcgatgctttggtcccacagcagaagca
gctcagttagagtccagcaagagatttgccaaagagtttatggaccgacacggaatcccg
accgcacggtggagagctttcaccagacctgaggaggcctgcagcttcattatgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcagctgggaaaggggtgattgtt
gcaaagagcacagaagaagcctgcagggctgtacaggagatcatgcaggagaaagcttat
ggagcagctggagaaacaattgtcattgaagaacttcttgaaggagaagaggtttcttgt
ctgtgcttcactgatggcaagaccgtggcccccatgcccccagcacaagaccataaacga
ttgctggagggcgatcatggccccaacacagggggaatgggagcctattgtccggcacct
caggtttcgaaggatttgctgctgaaaataaaaaatacagttcttcagaggacagtggat
ggcatgcagcaggagggtatgccatacacaggtgtcctctatgctggtataatgctgacc
aaggatggcccaaaagttctggagtttaattgccgtttcggtgatccagagtgccaagtg
atcctcccgctgcttaaaagtgatctttatgaagtgattcagtctacctttgatggcctg
ctccacacatctctgcccgtctggctggaaaaccgcaccgccctaactgtcgtgatggca
agtaagggctacccaggagattataccaagggtgtggagataacaggctttcctgaggct
caagctttaggactggaggtgttccacgcaggcactgccctgaaagatggcaaggtggtg
actagtgggggtagagtcctttcggtaacagccatccaggaaaatctcatttcagccctt
gaagaagccaagaaaggactagctgctataaaatttgagggagccatttacaggaaggac
attggctctcgtgccatagcttatctccaacagcccaggggcctgacttacaaggaatct
ggggtagacattgcagctggaaatatgctggtcaagaaaattaaacctttagcaaaagct
acctccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcctgtggaacagatggtgtggggactaaactg
aagattgcccagcagtgtaatagacatgataccattggccaagatttggttgcaatgtgt
gtaaatgacattctggcccaaggggcagagcccctcttcttccttgattacttttcctgt
ggaaaacttgacctcgatacaactgaagctgttgttgctggaattgccagagcctgtggg
aaagctggatgtgctctccttggaggtgaaactgcagaaatgcctgacatgtatcctcct
ggagagtatgacctggccggttttgccgtcggtgccatggagcgggatcagaaactccct
cacctggaaagaatcaccgaaggggatgttgttattggaatagcttcatctggtcttcac
agcaatggatttagccttgtgaggaaaattgtagcaaaatcttccctccagtactcctct
ccagcacctgatggctgtggtgaccagaccttaggggacttacttctgactccaacgaga
atctacagccattcgctattacctgtcctacgttcaggacatgtcaaggcctttgcccat
attactggtggaggattgctagaaaacatccccagagtccttcctgagaaatttggagtg
gatttagatgcccagacctggaggatccccaggatcttctcgtggttacagcaagaagga
cacctctctgaggaagagatggccagaacatttaactgtggggttggggccgtcctcgtg
gtgtcaaaggataggacagagcagattctgagggatatcaagcagcacagcgaagaagcc
tgggtgattggcaaggtggttgcgtgtcctgaaggttctcctcgtgtgaaagtcaagcat
ctgattgaaaccatgcaagcaaatggatcagtattggagaatggcactctgaaaaatcat
ttctctgtccaaccaaaaaaggcaagagtggctgtcttaatatctggaacaggatcaaac
ctccaagccctcatagacaatactagggagccaagtagctgtgcacacattgttgttgtt
atctccaacaaagctgcagtggctggcttagataaagcagaaagagccggaattcccacc
agagtaatcaatcataaattatataaaagtcgtgtagaatttgacactgcaattgaccaa
gtccttgaagagttctccacagacatagtctgtcttgcaggattcatgagaattttatct
ggcccctttgtcagaaaatggaatgggaaaatgctcaacatccatccatccttgctgccg
tcttttaagggttcaaatgcacatgagcaagtcctagaagccggggtcacagtcactggg
tgtactgtgcactttgtagctgaagatgtagatgctggacagattatcttacaagaagct
gttccagtgaagaggggcgacaccgttacaactctgtctgaaagagtgaaattagcagag
cacaaactatttcccgcagccctccagctggtagccagtggaactgtacagcttggagaa
aatggcaagattcgttgggtcacagagtag
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