KEGG   Perognathus longimembris pacificus (Pacific pocket mouse): 125346549
Entry
125346549         CDS       T08928                                 
Symbol
Mapk8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
plop  Perognathus longimembris pacificus (Pacific pocket mouse)
Pathway
plop01522  Endocrine resistance
plop04010  MAPK signaling pathway
plop04012  ErbB signaling pathway
plop04014  Ras signaling pathway
plop04024  cAMP signaling pathway
plop04068  FoxO signaling pathway
plop04071  Sphingolipid signaling pathway
plop04137  Mitophagy - animal
plop04140  Autophagy - animal
plop04141  Protein processing in endoplasmic reticulum
plop04210  Apoptosis
plop04215  Apoptosis - multiple species
plop04217  Necroptosis
plop04310  Wnt signaling pathway
plop04380  Osteoclast differentiation
plop04510  Focal adhesion
plop04530  Tight junction
plop04620  Toll-like receptor signaling pathway
plop04621  NOD-like receptor signaling pathway
plop04622  RIG-I-like receptor signaling pathway
plop04625  C-type lectin receptor signaling pathway
plop04657  IL-17 signaling pathway
plop04658  Th1 and Th2 cell differentiation
plop04659  Th17 cell differentiation
plop04660  T cell receptor signaling pathway
plop04664  Fc epsilon RI signaling pathway
plop04668  TNF signaling pathway
plop04722  Neurotrophin signaling pathway
plop04723  Retrograde endocannabinoid signaling
plop04728  Dopaminergic synapse
plop04750  Inflammatory mediator regulation of TRP channels
plop04910  Insulin signaling pathway
plop04912  GnRH signaling pathway
plop04914  Progesterone-mediated oocyte maturation
plop04917  Prolactin signaling pathway
plop04920  Adipocytokine signaling pathway
plop04926  Relaxin signaling pathway
plop04930  Type II diabetes mellitus
plop04931  Insulin resistance
plop04932  Non-alcoholic fatty liver disease
plop04933  AGE-RAGE signaling pathway in diabetic complications
plop04935  Growth hormone synthesis, secretion and action
plop04936  Alcoholic liver disease
plop05010  Alzheimer disease
plop05012  Parkinson disease
plop05016  Huntington disease
plop05017  Spinocerebellar ataxia
plop05020  Prion disease
plop05022  Pathways of neurodegeneration - multiple diseases
plop05132  Salmonella infection
plop05133  Pertussis
plop05135  Yersinia infection
plop05142  Chagas disease
plop05145  Toxoplasmosis
plop05152  Tuberculosis
plop05161  Hepatitis B
plop05162  Measles
plop05166  Human T-cell leukemia virus 1 infection
plop05167  Kaposi sarcoma-associated herpesvirus infection
plop05169  Epstein-Barr virus infection
plop05170  Human immunodeficiency virus 1 infection
plop05171  Coronavirus disease - COVID-19
plop05200  Pathways in cancer
plop05208  Chemical carcinogenesis - reactive oxygen species
plop05210  Colorectal cancer
plop05212  Pancreatic cancer
plop05231  Choline metabolism in cancer
plop05415  Diabetic cardiomyopathy
plop05417  Lipid and atherosclerosis
plop05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:plop00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    125346549 (Mapk8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125346549 (Mapk8)
   04012 ErbB signaling pathway
    125346549 (Mapk8)
   04014 Ras signaling pathway
    125346549 (Mapk8)
   04310 Wnt signaling pathway
    125346549 (Mapk8)
   04668 TNF signaling pathway
    125346549 (Mapk8)
   04068 FoxO signaling pathway
    125346549 (Mapk8)
   04071 Sphingolipid signaling pathway
    125346549 (Mapk8)
   04024 cAMP signaling pathway
    125346549 (Mapk8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    125346549 (Mapk8)
   04137 Mitophagy - animal
    125346549 (Mapk8)
  09143 Cell growth and death
   04210 Apoptosis
    125346549 (Mapk8)
   04215 Apoptosis - multiple species
    125346549 (Mapk8)
   04217 Necroptosis
    125346549 (Mapk8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    125346549 (Mapk8)
   04530 Tight junction
    125346549 (Mapk8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    125346549 (Mapk8)
   04621 NOD-like receptor signaling pathway
    125346549 (Mapk8)
   04622 RIG-I-like receptor signaling pathway
    125346549 (Mapk8)
   04625 C-type lectin receptor signaling pathway
    125346549 (Mapk8)
   04660 T cell receptor signaling pathway
    125346549 (Mapk8)
   04658 Th1 and Th2 cell differentiation
    125346549 (Mapk8)
   04659 Th17 cell differentiation
    125346549 (Mapk8)
   04657 IL-17 signaling pathway
    125346549 (Mapk8)
   04664 Fc epsilon RI signaling pathway
    125346549 (Mapk8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    125346549 (Mapk8)
   04920 Adipocytokine signaling pathway
    125346549 (Mapk8)
   04912 GnRH signaling pathway
    125346549 (Mapk8)
   04914 Progesterone-mediated oocyte maturation
    125346549 (Mapk8)
   04917 Prolactin signaling pathway
    125346549 (Mapk8)
   04926 Relaxin signaling pathway
    125346549 (Mapk8)
   04935 Growth hormone synthesis, secretion and action
    125346549 (Mapk8)
  09156 Nervous system
   04728 Dopaminergic synapse
    125346549 (Mapk8)
   04723 Retrograde endocannabinoid signaling
    125346549 (Mapk8)
   04722 Neurotrophin signaling pathway
    125346549 (Mapk8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    125346549 (Mapk8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    125346549 (Mapk8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125346549 (Mapk8)
   05208 Chemical carcinogenesis - reactive oxygen species
    125346549 (Mapk8)
   05231 Choline metabolism in cancer
    125346549 (Mapk8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    125346549 (Mapk8)
   05212 Pancreatic cancer
    125346549 (Mapk8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    125346549 (Mapk8)
   05170 Human immunodeficiency virus 1 infection
    125346549 (Mapk8)
   05161 Hepatitis B
    125346549 (Mapk8)
   05171 Coronavirus disease - COVID-19
    125346549 (Mapk8)
   05162 Measles
    125346549 (Mapk8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    125346549 (Mapk8)
   05169 Epstein-Barr virus infection
    125346549 (Mapk8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125346549 (Mapk8)
   05135 Yersinia infection
    125346549 (Mapk8)
   05133 Pertussis
    125346549 (Mapk8)
   05152 Tuberculosis
    125346549 (Mapk8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    125346549 (Mapk8)
   05142 Chagas disease
    125346549 (Mapk8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125346549 (Mapk8)
   05012 Parkinson disease
    125346549 (Mapk8)
   05016 Huntington disease
    125346549 (Mapk8)
   05017 Spinocerebellar ataxia
    125346549 (Mapk8)
   05020 Prion disease
    125346549 (Mapk8)
   05022 Pathways of neurodegeneration - multiple diseases
    125346549 (Mapk8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125346549 (Mapk8)
   05418 Fluid shear stress and atherosclerosis
    125346549 (Mapk8)
   05415 Diabetic cardiomyopathy
    125346549 (Mapk8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    125346549 (Mapk8)
   04936 Alcoholic liver disease
    125346549 (Mapk8)
   04932 Non-alcoholic fatty liver disease
    125346549 (Mapk8)
   04931 Insulin resistance
    125346549 (Mapk8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    125346549 (Mapk8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    125346549 (Mapk8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:plop01001]
    125346549 (Mapk8)
Enzymes [BR:plop01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     125346549 (Mapk8)
Protein kinases [BR:plop01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   125346549 (Mapk8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH DUF530
Other DBs
NCBI-GeneID: 125346549
NCBI-ProteinID: XP_048195167
LinkDB
Position
2:59640873..59711299
AA seq 427 aa
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAMINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacaacaatttttatagtgtagaaattggagattctacattc
acagtactgaaacgataccagaatttgaaacccataggctccggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaatgttgctatcaagaagctaagccggcca
tttcagaaccaaacacatgctaagcgggcctacagagagttagttcttatgaaatgtgtt
aatcacaaaaatataattggtcttttgaatgttttcacaccacagaaatctctagaagaa
tttcaagatgtttacatagtaatggagctcatggatgcaaatctttgccaagtgattcag
atggaactagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactcagctggaattattcatcgggacttaaagcccagtaatatagtagtgaaa
tcagactgcactttgaagattcttgactttggcctggcgaggactgcaggaacaagtttt
atgatgacaccttatgtagtaactcgctactacagagcacctgaggtcatcctaggcatg
ggctacaaggagaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacgccatgtcctgagttcatgaagaaactgcagccaacagtaaggacatacgtt
gagaacagacccaaatatgctgggtacagctttgagaagctcttccccgatgtgctgttt
ccagccgactcagagcacaacaaactgaaagccagtcaggcaagggatttgttgtccaaa
atgctggtaatagatgcatccaaaaggatctcagtagatgaagcgctgcagcacccctat
atcaacgtctggtatgacccttcagaagcagaagccccaccaccaaagatccctgacaag
cagttggatgaaagggaacacacaatagaagaatggaaagaattgatatacaaggaagtg
atggatttagaagagagaaccaagaatggagttatacgggggcagccatctcctttaggt
gcagcaatgatcaatggctctcagcatccatcgtcatcgtcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgacgttggcctcggatacagacagcagtctggaagcctcagct
ggacctctgggctgctgtagatga

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