KEGG   Perognathus longimembris pacificus (Pacific pocket mouse): 125357039
Entry
125357039         CDS       T08928                                 
Symbol
Mapk12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
plop  Perognathus longimembris pacificus (Pacific pocket mouse)
Pathway
plop01522  Endocrine resistance
plop04010  MAPK signaling pathway
plop04015  Rap1 signaling pathway
plop04068  FoxO signaling pathway
plop04071  Sphingolipid signaling pathway
plop04114  Oocyte meiosis
plop04148  Efferocytosis
plop04218  Cellular senescence
plop04261  Adrenergic signaling in cardiomyocytes
plop04370  VEGF signaling pathway
plop04380  Osteoclast differentiation
plop04517  IgSF CAM signaling
plop04550  Signaling pathways regulating pluripotency of stem cells
plop04611  Platelet activation
plop04613  Neutrophil extracellular trap formation
plop04620  Toll-like receptor signaling pathway
plop04621  NOD-like receptor signaling pathway
plop04622  RIG-I-like receptor signaling pathway
plop04625  C-type lectin receptor signaling pathway
plop04657  IL-17 signaling pathway
plop04658  Th1 and Th2 cell differentiation
plop04659  Th17 cell differentiation
plop04660  T cell receptor signaling pathway
plop04664  Fc epsilon RI signaling pathway
plop04668  TNF signaling pathway
plop04670  Leukocyte transendothelial migration
plop04714  Thermogenesis
plop04722  Neurotrophin signaling pathway
plop04723  Retrograde endocannabinoid signaling
plop04728  Dopaminergic synapse
plop04750  Inflammatory mediator regulation of TRP channels
plop04912  GnRH signaling pathway
plop04914  Progesterone-mediated oocyte maturation
plop04917  Prolactin signaling pathway
plop04926  Relaxin signaling pathway
plop04932  Non-alcoholic fatty liver disease
plop04933  AGE-RAGE signaling pathway in diabetic complications
plop04935  Growth hormone synthesis, secretion and action
plop04936  Alcoholic liver disease
plop05014  Amyotrophic lateral sclerosis
plop05020  Prion disease
plop05022  Pathways of neurodegeneration - multiple diseases
plop05132  Salmonella infection
plop05133  Pertussis
plop05135  Yersinia infection
plop05140  Leishmaniasis
plop05142  Chagas disease
plop05145  Toxoplasmosis
plop05152  Tuberculosis
plop05161  Hepatitis B
plop05163  Human cytomegalovirus infection
plop05167  Kaposi sarcoma-associated herpesvirus infection
plop05169  Epstein-Barr virus infection
plop05170  Human immunodeficiency virus 1 infection
plop05171  Coronavirus disease - COVID-19
plop05205  Proteoglycans in cancer
plop05208  Chemical carcinogenesis - reactive oxygen species
plop05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
plop05415  Diabetic cardiomyopathy
plop05417  Lipid and atherosclerosis
plop05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:plop00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125357039 (Mapk12)
   04015 Rap1 signaling pathway
    125357039 (Mapk12)
   04370 VEGF signaling pathway
    125357039 (Mapk12)
   04668 TNF signaling pathway
    125357039 (Mapk12)
   04068 FoxO signaling pathway
    125357039 (Mapk12)
   04071 Sphingolipid signaling pathway
    125357039 (Mapk12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    125357039 (Mapk12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    125357039 (Mapk12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    125357039 (Mapk12)
   04218 Cellular senescence
    125357039 (Mapk12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    125357039 (Mapk12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    125357039 (Mapk12)
   04613 Neutrophil extracellular trap formation
    125357039 (Mapk12)
   04620 Toll-like receptor signaling pathway
    125357039 (Mapk12)
   04621 NOD-like receptor signaling pathway
    125357039 (Mapk12)
   04622 RIG-I-like receptor signaling pathway
    125357039 (Mapk12)
   04625 C-type lectin receptor signaling pathway
    125357039 (Mapk12)
   04660 T cell receptor signaling pathway
    125357039 (Mapk12)
   04658 Th1 and Th2 cell differentiation
    125357039 (Mapk12)
   04659 Th17 cell differentiation
    125357039 (Mapk12)
   04657 IL-17 signaling pathway
    125357039 (Mapk12)
   04664 Fc epsilon RI signaling pathway
    125357039 (Mapk12)
   04670 Leukocyte transendothelial migration
    125357039 (Mapk12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    125357039 (Mapk12)
   04914 Progesterone-mediated oocyte maturation
    125357039 (Mapk12)
   04917 Prolactin signaling pathway
    125357039 (Mapk12)
   04926 Relaxin signaling pathway
    125357039 (Mapk12)
   04935 Growth hormone synthesis, secretion and action
    125357039 (Mapk12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    125357039 (Mapk12)
  09156 Nervous system
   04728 Dopaminergic synapse
    125357039 (Mapk12)
   04723 Retrograde endocannabinoid signaling
    125357039 (Mapk12)
   04722 Neurotrophin signaling pathway
    125357039 (Mapk12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    125357039 (Mapk12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    125357039 (Mapk12)
  09159 Environmental adaptation
   04714 Thermogenesis
    125357039 (Mapk12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    125357039 (Mapk12)
   05208 Chemical carcinogenesis - reactive oxygen species
    125357039 (Mapk12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125357039 (Mapk12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    125357039 (Mapk12)
   05161 Hepatitis B
    125357039 (Mapk12)
   05171 Coronavirus disease - COVID-19
    125357039 (Mapk12)
   05163 Human cytomegalovirus infection
    125357039 (Mapk12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    125357039 (Mapk12)
   05169 Epstein-Barr virus infection
    125357039 (Mapk12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125357039 (Mapk12)
   05135 Yersinia infection
    125357039 (Mapk12)
   05133 Pertussis
    125357039 (Mapk12)
   05152 Tuberculosis
    125357039 (Mapk12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    125357039 (Mapk12)
   05140 Leishmaniasis
    125357039 (Mapk12)
   05142 Chagas disease
    125357039 (Mapk12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    125357039 (Mapk12)
   05020 Prion disease
    125357039 (Mapk12)
   05022 Pathways of neurodegeneration - multiple diseases
    125357039 (Mapk12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125357039 (Mapk12)
   05418 Fluid shear stress and atherosclerosis
    125357039 (Mapk12)
   05415 Diabetic cardiomyopathy
    125357039 (Mapk12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    125357039 (Mapk12)
   04932 Non-alcoholic fatty liver disease
    125357039 (Mapk12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    125357039 (Mapk12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    125357039 (Mapk12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:plop01001]
    125357039 (Mapk12)
Enzymes [BR:plop01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     125357039 (Mapk12)
Protein kinases [BR:plop01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   125357039 (Mapk12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 125357039
NCBI-ProteinID: XP_048209631
LinkDB
Position
1:552558..562706
AA seq 367 aa
MSSPPPARRGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELYAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHETLSEDRIQFLVYQMLKGLKYIHAAGLIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMK
VTGTPPAEFVQKLQSDEAKNYMKGLPELEKKDFASVLTNASPMAVNLLEKMLVLDAEQRI
TAVEALAHPYFESLQDTEDEPKAQKYDDSFEDVDRTLEEWKRVTYKEVLSFKPPRNLGAR
ASKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctccccgccgcccgcccgccgcggcttctaccgccaggaggtgaccaagacggcc
tgggaagtgcgcgccgtgtaccgggacctgcagcccgtgggctcgggcgcctacggcgcg
gtgtgctccgcggtggacagccgcacgggcgccaaggtggccatcaagaagctgtaccgg
cctttccagtcggagctgtacgccaagcgcgcctaccgggagctgcggctgctcaagcac
atgcgccacgagaacgtgatcgggctgctggatgtgttcactcctgacgagaccctggat
gacttcacagacttctacctggtaatgccgttcatgggcaccgacctgggcaagctcatg
aagcatgagactctgagtgaggacagaatccagttccttgtttatcagatgctgaaaggg
ctgaagtatatccatgctgctggcctcatccacagggacctcaagcctggcaacctggct
gtgaacgaagactgtgaactgaagatcctggactttggcttggccagacaggcagacagt
gagatgacaggatatgtggtaacacggtggtaccgggcccctgaggtcatcttgaattgg
atgcgttacacacagacagtggacatctggtcagtgggctgcattatggcagagatgatt
accgggaagatactgttcaagggcaatgaccacctggaccagctgaaggagatcatgaag
gtgacagggacgccccctgctgagttcgtgcagaaactgcagagcgatgaggctaagaac
tacatgaagggtctcccagagctggagaagaaggattttgcctctgtcctgaccaatgca
agccctatggctgtgaatctcctggagaaaatgttggtgctggatgcagagcagcggata
actgcagttgaggccctggcccatccctactttgagtctctgcaggacacagaggatgag
cctaaggcccagaagtacgacgactcctttgaggatgtagatcgcacccttgaggagtgg
aagcgtgtcacttacaaagaagtcctcagcttcaaacctcccaggaacctgggggccagg
gcctctaaggagactgctctgtga

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