KEGG   Perognathus longimembris pacificus (Pacific pocket mouse): 125358819
Entry
125358819         CDS       T08928                                 
Symbol
Raf1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
plop  Perognathus longimembris pacificus (Pacific pocket mouse)
Pathway
plop01521  EGFR tyrosine kinase inhibitor resistance
plop01522  Endocrine resistance
plop04010  MAPK signaling pathway
plop04012  ErbB signaling pathway
plop04014  Ras signaling pathway
plop04015  Rap1 signaling pathway
plop04022  cGMP-PKG signaling pathway
plop04024  cAMP signaling pathway
plop04062  Chemokine signaling pathway
plop04068  FoxO signaling pathway
plop04071  Sphingolipid signaling pathway
plop04072  Phospholipase D signaling pathway
plop04140  Autophagy - animal
plop04150  mTOR signaling pathway
plop04151  PI3K-Akt signaling pathway
plop04210  Apoptosis
plop04218  Cellular senescence
plop04270  Vascular smooth muscle contraction
plop04360  Axon guidance
plop04370  VEGF signaling pathway
plop04371  Apelin signaling pathway
plop04510  Focal adhesion
plop04540  Gap junction
plop04550  Signaling pathways regulating pluripotency of stem cells
plop04613  Neutrophil extracellular trap formation
plop04625  C-type lectin receptor signaling pathway
plop04630  JAK-STAT signaling pathway
plop04650  Natural killer cell mediated cytotoxicity
plop04660  T cell receptor signaling pathway
plop04662  B cell receptor signaling pathway
plop04664  Fc epsilon RI signaling pathway
plop04666  Fc gamma R-mediated phagocytosis
plop04720  Long-term potentiation
plop04722  Neurotrophin signaling pathway
plop04726  Serotonergic synapse
plop04730  Long-term depression
plop04810  Regulation of actin cytoskeleton
plop04910  Insulin signaling pathway
plop04912  GnRH signaling pathway
plop04914  Progesterone-mediated oocyte maturation
plop04915  Estrogen signaling pathway
plop04916  Melanogenesis
plop04917  Prolactin signaling pathway
plop04919  Thyroid hormone signaling pathway
plop04921  Oxytocin signaling pathway
plop04926  Relaxin signaling pathway
plop04928  Parathyroid hormone synthesis, secretion and action
plop04929  GnRH secretion
plop04935  Growth hormone synthesis, secretion and action
plop05010  Alzheimer disease
plop05022  Pathways of neurodegeneration - multiple diseases
plop05034  Alcoholism
plop05132  Salmonella infection
plop05152  Tuberculosis
plop05160  Hepatitis C
plop05161  Hepatitis B
plop05163  Human cytomegalovirus infection
plop05164  Influenza A
plop05165  Human papillomavirus infection
plop05167  Kaposi sarcoma-associated herpesvirus infection
plop05170  Human immunodeficiency virus 1 infection
plop05200  Pathways in cancer
plop05205  Proteoglycans in cancer
plop05206  MicroRNAs in cancer
plop05207  Chemical carcinogenesis - receptor activation
plop05208  Chemical carcinogenesis - reactive oxygen species
plop05210  Colorectal cancer
plop05211  Renal cell carcinoma
plop05212  Pancreatic cancer
plop05213  Endometrial cancer
plop05214  Glioma
plop05215  Prostate cancer
plop05218  Melanoma
plop05219  Bladder cancer
plop05220  Chronic myeloid leukemia
plop05221  Acute myeloid leukemia
plop05223  Non-small cell lung cancer
plop05224  Breast cancer
plop05225  Hepatocellular carcinoma
plop05226  Gastric cancer
plop05230  Central carbon metabolism in cancer
plop05231  Choline metabolism in cancer
plop05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:plop00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125358819 (Raf1)
   04012 ErbB signaling pathway
    125358819 (Raf1)
   04014 Ras signaling pathway
    125358819 (Raf1)
   04015 Rap1 signaling pathway
    125358819 (Raf1)
   04370 VEGF signaling pathway
    125358819 (Raf1)
   04371 Apelin signaling pathway
    125358819 (Raf1)
   04630 JAK-STAT signaling pathway
    125358819 (Raf1)
   04068 FoxO signaling pathway
    125358819 (Raf1)
   04072 Phospholipase D signaling pathway
    125358819 (Raf1)
   04071 Sphingolipid signaling pathway
    125358819 (Raf1)
   04024 cAMP signaling pathway
    125358819 (Raf1)
   04022 cGMP-PKG signaling pathway
    125358819 (Raf1)
   04151 PI3K-Akt signaling pathway
    125358819 (Raf1)
   04150 mTOR signaling pathway
    125358819 (Raf1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    125358819 (Raf1)
  09143 Cell growth and death
   04210 Apoptosis
    125358819 (Raf1)
   04218 Cellular senescence
    125358819 (Raf1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    125358819 (Raf1)
   04540 Gap junction
    125358819 (Raf1)
   04550 Signaling pathways regulating pluripotency of stem cells
    125358819 (Raf1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125358819 (Raf1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    125358819 (Raf1)
   04625 C-type lectin receptor signaling pathway
    125358819 (Raf1)
   04650 Natural killer cell mediated cytotoxicity
    125358819 (Raf1)
   04660 T cell receptor signaling pathway
    125358819 (Raf1)
   04662 B cell receptor signaling pathway
    125358819 (Raf1)
   04664 Fc epsilon RI signaling pathway
    125358819 (Raf1)
   04666 Fc gamma R-mediated phagocytosis
    125358819 (Raf1)
   04062 Chemokine signaling pathway
    125358819 (Raf1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    125358819 (Raf1)
   04929 GnRH secretion
    125358819 (Raf1)
   04912 GnRH signaling pathway
    125358819 (Raf1)
   04915 Estrogen signaling pathway
    125358819 (Raf1)
   04914 Progesterone-mediated oocyte maturation
    125358819 (Raf1)
   04917 Prolactin signaling pathway
    125358819 (Raf1)
   04921 Oxytocin signaling pathway
    125358819 (Raf1)
   04926 Relaxin signaling pathway
    125358819 (Raf1)
   04935 Growth hormone synthesis, secretion and action
    125358819 (Raf1)
   04919 Thyroid hormone signaling pathway
    125358819 (Raf1)
   04928 Parathyroid hormone synthesis, secretion and action
    125358819 (Raf1)
   04916 Melanogenesis
    125358819 (Raf1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    125358819 (Raf1)
  09156 Nervous system
   04726 Serotonergic synapse
    125358819 (Raf1)
   04720 Long-term potentiation
    125358819 (Raf1)
   04730 Long-term depression
    125358819 (Raf1)
   04722 Neurotrophin signaling pathway
    125358819 (Raf1)
  09158 Development and regeneration
   04360 Axon guidance
    125358819 (Raf1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125358819 (Raf1)
   05206 MicroRNAs in cancer
    125358819 (Raf1)
   05205 Proteoglycans in cancer
    125358819 (Raf1)
   05207 Chemical carcinogenesis - receptor activation
    125358819 (Raf1)
   05208 Chemical carcinogenesis - reactive oxygen species
    125358819 (Raf1)
   05230 Central carbon metabolism in cancer
    125358819 (Raf1)
   05231 Choline metabolism in cancer
    125358819 (Raf1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125358819 (Raf1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    125358819 (Raf1)
   05212 Pancreatic cancer
    125358819 (Raf1)
   05225 Hepatocellular carcinoma
    125358819 (Raf1)
   05226 Gastric cancer
    125358819 (Raf1)
   05214 Glioma
    125358819 (Raf1)
   05221 Acute myeloid leukemia
    125358819 (Raf1)
   05220 Chronic myeloid leukemia
    125358819 (Raf1)
   05218 Melanoma
    125358819 (Raf1)
   05211 Renal cell carcinoma
    125358819 (Raf1)
   05219 Bladder cancer
    125358819 (Raf1)
   05215 Prostate cancer
    125358819 (Raf1)
   05213 Endometrial cancer
    125358819 (Raf1)
   05224 Breast cancer
    125358819 (Raf1)
   05223 Non-small cell lung cancer
    125358819 (Raf1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    125358819 (Raf1)
   05161 Hepatitis B
    125358819 (Raf1)
   05160 Hepatitis C
    125358819 (Raf1)
   05164 Influenza A
    125358819 (Raf1)
   05163 Human cytomegalovirus infection
    125358819 (Raf1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    125358819 (Raf1)
   05165 Human papillomavirus infection
    125358819 (Raf1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125358819 (Raf1)
   05152 Tuberculosis
    125358819 (Raf1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125358819 (Raf1)
   05022 Pathways of neurodegeneration - multiple diseases
    125358819 (Raf1)
  09165 Substance dependence
   05034 Alcoholism
    125358819 (Raf1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125358819 (Raf1)
   01522 Endocrine resistance
    125358819 (Raf1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:plop01001]
    125358819 (Raf1)
Enzymes [BR:plop01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     125358819 (Raf1)
Protein kinases [BR:plop01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   125358819 (Raf1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 125358819
NCBI-ProteinID: XP_048212249
LinkDB
Position
10:complement(69417025..69460679)
AA seq 648 aa
MEHVQGAWKAISNGFGLKDAVFDGSSCISPTIVQQFVYQRRASDDGKLTDSSKTNNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRAPPSSYYRHSTPHAFTF
SPSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDGRVIEDALRSHSESASPSALSSSPNNL
SPTGWSQPKTPAPVQRERAPGSGMQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINSCTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacgtacagggagcctggaaggcgatcagcaatggttttggactcaaagacgcg
gtgtttgatggctccagctgcatctctccaacaatagtccagcagtttgtctatcagcgc
cgggcatcagatgatggcaaactcacagattcttctaagacaaacaacactatccgtgtt
ttcttgccaaataagcaaagaacagtggtcaatgtgcgaaatggaatgagcctgcacgat
tgccttatgaaagctctcaaggtgaggggcctccagccagagtgctgtgctgtgttcaga
ctcctccacgaacacaaaggtaaaaaagcacgtttagattggaatactgatgctgcctcc
ttgattggagaagaacttcaagtagactttctggatcatgttcccctcacaacacacaac
tttgcccggaagacatttctgaagcttgcattctgtgacatttgtcagaagttcctgtta
aatgggtttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaacatcagacagctcttgttgtttcccaattccact
attggcgatagtggcgtcccagccctaccgtctttgacaatgcggcggatgcgagagtct
gtctcccgggcgccacctagctcctactacaggcattccacaccccacgccttcaccttc
agcccctccagcccctcctcagaaggctccctctcccagaggcagcggtccacgtccacg
cccaacgtccacatggtcagcaccaccctgcctgtggacggcagggtgatcgaggatgca
cttcgaagtcacagtgaatcagcctctccttcagccctgtccagcagccccaacaacctg
agccccacaggctggtcccagcccaaaacccctgcgccagtacaaagggaacgggcacca
ggatccgggatgcaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggagatcgaagccagtgaagtgatgctgtccactcggattgggtcgggctccttt
ggaaccgtgtataagggcaagtggcatggcgacgtcgcagtgaagatcctgaaggttgtc
gaccccaccccagagcagttccaagcgttcaggaacgaggttgccgtgctgcgcaaaacc
cggcacgtgaatatcctgctcttcatggggtacatgacgaaggacaacctggccatcgtg
acgcagtggtgcgagggcagcagcctctacaaacacctgcacgtccaggagaccaaattc
cagatgttccagctgatcgacattgcgcggcagacggctcaggggatggactatctgcat
gcaaagaacatcatccacagagacatgaaatccaacaacatatttctccacgaaggcctc
acggtgaagattggagactttgggctggcaacggtgaagtcgcgctggagcggctctcag
caggtggagcagcccactggctctgtgctgtggatggcccccgaggtgatccgcatgcag
gataacaacccgttcagcttccagtcggacgtctactcctacggcatcgtgctgtacgag
ctcatgaccggggagctgccctactcccacatcaacaaccgagaccagatcatcttcatg
gtgggccgagggtacgcctccccagatctcagcaggctgtacaagaactgccccaaagca
atgaaacggctggtggcggactgcgtgaagaaggtgaaggaggagaggcccctcttcccg
cagatcctgtcctccatcgagctgctccagcactcgctgccgaaaatcaaccggagcgcg
tctgagccttccctgcaccgcgcggcccacaccgaggacatcaactcctgcacgctgacc
acgtccccgcggctgccggtcttctag

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