KEGG   Perognathus longimembris pacificus (Pacific pocket mouse): 125366778
Entry
125366778         CDS       T08928                                 
Symbol
Ryr2
Name
(RefSeq) LOW QUALITY PROTEIN: ryanodine receptor 2
  KO
K04962  ryanodine receptor 2
Organism
plop  Perognathus longimembris pacificus (Pacific pocket mouse)
Pathway
plop04020  Calcium signaling pathway
plop04024  cAMP signaling pathway
plop04260  Cardiac muscle contraction
plop04261  Adrenergic signaling in cardiomyocytes
plop04371  Apelin signaling pathway
plop04713  Circadian entrainment
plop04911  Insulin secretion
plop04921  Oxytocin signaling pathway
plop04972  Pancreatic secretion
plop05020  Prion disease
plop05022  Pathways of neurodegeneration - multiple diseases
plop05410  Hypertrophic cardiomyopathy
plop05412  Arrhythmogenic right ventricular cardiomyopathy
plop05414  Dilated cardiomyopathy
plop05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:plop00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    125366778 (Ryr2)
   04020 Calcium signaling pathway
    125366778 (Ryr2)
   04024 cAMP signaling pathway
    125366778 (Ryr2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    125366778 (Ryr2)
   04921 Oxytocin signaling pathway
    125366778 (Ryr2)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    125366778 (Ryr2)
   04261 Adrenergic signaling in cardiomyocytes
    125366778 (Ryr2)
  09154 Digestive system
   04972 Pancreatic secretion
    125366778 (Ryr2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    125366778 (Ryr2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05020 Prion disease
    125366778 (Ryr2)
   05022 Pathways of neurodegeneration - multiple diseases
    125366778 (Ryr2)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    125366778 (Ryr2)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    125366778 (Ryr2)
   05414 Dilated cardiomyopathy
    125366778 (Ryr2)
   05415 Diabetic cardiomyopathy
    125366778 (Ryr2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:plop04040]
    125366778 (Ryr2)
   04990 Domain-containing proteins not elsewhere classified [BR:plop04990]
    125366778 (Ryr2)
Ion channels [BR:plop04040]
 Voltage-gated cation channels
  Ryanodine receptor
   125366778 (Ryr2)
Domain-containing proteins not elsewhere classified [BR:plop04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   125366778 (Ryr2)
SSDB
Motif
Pfam: RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8
Other DBs
NCBI-GeneID: 125366778
NCBI-ProteinID: XP_048223442
LinkDB
Position
18:2363793..2649090
AA seq 4969 aa
MADGGEGEDEIQFLRTDDEVVLQSTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP
DLSICTFVLDQSLSVRALQEMLANTVERPEGKFMMKTAQGGGHRTLLYGHAILLRHSYSG
MYLCCLSTSRSSTDKLAFDVGLQEATTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS
SERYLHLSYGTGSLHVDAAFQQTLWNVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTV
PSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLS
LLEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVD
TGLWLTYQAVDAKSARMGSGQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFN
RFIRGLDALSKKAKAPSVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQN
LFQEEGVISLVLECIDHLHVYSSAAHFADVAGREAAQSWKSILNSLYELLAALIRGNRKN
CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN
HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGS
AQYKKWYYELMVDHTQPFVTAEATHLRVGWASTEGCSPYPGGGEEWGGNGVGDDLFSYGF
DGLQLWAGCVARTVSSPNQHLLRTDDVVSCCLDLSAPSISFRINGQPVQGMFENFNIDGL
FFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYT
RDLLGPTVALTQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPV
RDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLP
KNYQLTSGYKPAPMDLSFIKLTSSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNR
RNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYSLEAPDQDHAARAEAGGGGPGERFR
IFRAEKTYAVRSGRWYFEFEAVSAGDMRVGWSRPGCQPDLELGSDERAFAFDGFKAQRWH
QGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEVLLDDAGSELAFKDFDVGDGFIPVCS
LGVGQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPANHE
HIEVTRIDGTTDTSPCLKVTQKSFGSQNSTTDIMFYRLSMPIECAEVFSKTVPGGLSGAG
LFAPKNDLEDYDADSDFEVLMKTAHGHLVPDRLEKDKEATKSEFNNHKDYAQEKPSRLKQ
RFLLRRTKPDYSASHSARLTEDVLADDRDDYEYLMHTSTYYYSVRIFPGQEPANVWVGWI
TSDFHQHDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLE
IGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPL
SAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQ
FMSLHIPEENRSVDILELTEQEELLRFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLL
YAIESKYMPGLLRAGYYDLLIDIHLGSYATARLMMNSEFIVPMTEETKSITLFPDARKKH
GLPGIGLSTSLRPRMRFSSPSFVGVGGDGYQHSPEFPLDVLKAKTIRMLTEAVEEGGLRA
RDPVGGTTEFLFVPLIKLFYTLLIMGLFHSEDLKQLLQLIEPSVFKEAAGPEERRRRRGD
RPEPGLAADDARLEGEDEARAVKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEA
IVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKS
ECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSSDLTIRGRLMSLVEKVTYLKKKPA
EKPVASDTAKSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPK
TYTINGVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRA
LGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLEN
SSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCRMLLTKG
YPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLL
AAMEEAIKIAEDPSRDGPSPASGSSRTLDTEEEEDDTIHMGNAIMTFYAALIDLLGRCAP
EMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISVAFQMPTIAKDGNVVEPDMSAGFCPDH
KAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAV
LPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDAIEVCLLSICGQLRPSM
MQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWRYYCLPGGWGSFGAASEEELRLSRKL
FWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNLMEKQSSMDSEGNFNPQ
PVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLS
EKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPR
AIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAK
DREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFD
GGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNKEKEMV
TSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRAFLDNA
AEDLEQTLENLKQGQFTHTRSQPKGVTQIINYTTVALLPVLSSLFEHLGQHQFGEDLMLE
DVQVSCYRILTSLYALGTSKSIYVERQRSALGACLAAFAGAFPVAFLETHLDKHNAYSIY
NTKSSRERAALSLPANVEDVCPNIPSLEKLLGEIVELAESGVRYAQAPHAMEAVLPMLCS
YVSRWWEHGPESNPERAGTCCTALGSEHMNTLLGNILKIIYNNLGVDEGAWMKRLAVFSQ
PIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLAR
DLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVADVFIYWSKSHNFKREEQNFVVQNE
INNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNVCAPG
DQELIALAKTRFSLKDTEDEVRDIIRSNIHFQGKLEDPAIRWQMALYKDLPNRTEVASDP
ERTVERVLDIANVLFHLEQRSKNTGRGYYSLGSTVEHPQRSKKAVWHKLLSKQRKRAVVA
CFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGMKRV
DPLHQLILLFSRTALTEKCKLEEDYLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEK
QKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGGNSTVQQKMLDYL
KEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFR
FLQLLCEGHSSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQ
GQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQD
SSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFL
KLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYE
EFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQTFLELAESVLNYFQPFLGRIEIMGS
AKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQ
LAAQISESDLNERSANKEEGDREKPEEQGPRMGFFSILTVRSALSALRYNVLTLLRMLSL
KSLKKQVKKAKKMTVKDLLAALLASYCGVFLALLHFLASVCRGFFRIACGLLLGASLVEG
AKKIKVAELLANMPDPTQDEVRGDAEDGDRKPLEAALPSEDLMDLKELTEESDLLSDIFG
LDLKREGGQYKLIPHNPNAGLGDLMASPAPAPEEQDGLQEQKANEEEKEEKEETKSEPEK
AEGEDGEKEEKAKEDKGKPKSRQLHTHRYGEPEAPESAFWKKIIAYQQKLLNYFARNFYN
MRMLALFVAFAINFILLFYKVSTSSVVEGKEPPASRSPSEPTPAAVGLEGGRPPRAITVR
FVLEESSGYMEPTLRILAVLHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYIT
EQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALD
FSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFF
FAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSED
GDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVIL
LAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANY
LFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN
NT seq 14910 nt   +upstreamnt  +downstreamnt
atggccgacgggggcgaaggcgaggacgagatccagttcctgcgcacggacgacgaggtg
gtcctgcagtccaccgccaccatccacaaggagcagcagaagctgtgcctggcggcagag
ggcttcggcaaccggctgtgcttcttggagtccacgtccaattccaagaatgtcccccca
gacctgtccatctgcaccttcgtcctggaccagtccctgtcggtgcgggccctgcaggag
atgctggctaacaccgtggagagaccggaagggaaattcatgatgaagacggcccagggt
ggcggccatcggaccctcctctacggacacgccatactgctccgccattcgtacagcggc
atgtatctgtgctgcctgtcgacctcccggtcatcaacggacaaactggcttttgacgtg
ggcctgcaggaggccaccacaggcgaggcgtgctggtggaccatacacccagcctccaag
cagcggtcggaaggagagaaagtccgggtgggagatgacctcatcttggtcagcgtgtcc
tcggagaggtacttgcacctgtcctacggcaccggcagcctgcacgtggacgcggccttc
cagcagaccctgtggaacgtggcccccatcagctcggggagcgaggccgcccaagggtac
ctgatcggcggcgacgtcctccggctgctccacggccacatggacgagtgcctcaccgtc
ccgtcgggggagcacggagaagagcagaggagaactgttcactatgaaggtggcgctgtc
tctgttcacgctcgctccctttggagactggagacgctaagggttgcgtggagcgggagc
cacatccgctggggccagcccttccgcctgcgccacgtcaccaccggcaagtacctgagc
ctcctggaagacaagaacctgctgctcatggacaaagagaaggcggacgtgaaatcaaca
gcctttaccttccggtcttccaaggaaaaattagatgttggagtgagaaaagaagtagac
ggcatggggacgtccgagatcaagtacggagactcggtctgctacatccagcacgtggat
acgggcctgtggctcacctaccaggccgtggatgcgaaatccgccaggatggggtctggg
cagcgcaaggccattatgcaccacgaaggacacatggacgacggcttgaatctctccaga
tctcagcacgaggagtcgcgcacggcccgcgtcatccgcagcaccgtcttcctcttcaac
agattcataaggggcctcgacgctctgagcaagaaagccaaggcgccgagcgtggacctg
cccatcgagtcggtgagcctgagcctgcaggacctcatcggctacttccacccgccggac
gagcacctggagcacgaggacaagcagaaccggctgcgcgccctgaagaaccggcagaac
ctcttccaggaggagggcgtgatcagcctggtgctggagtgcatcgaccacctgcacgtc
tacagcagcgccgcgcacttcgccgacgtggcgggccgggaggcggcgcagtcctggaag
tccatcctcaactccctgtacgagctgctggctgccctcattagaggaaatcgcaagaac
tgtgctcagttttctggctccctggactggcttatcagcagactggaaagactagaagct
tcctcaggcatcctcgaagtgctgcactgcgtgctggtggagagcccggaggccctgaac
atcatcaaggaagggcacatcaagtccatcatctcgctcttggacaagcacgggcggaac
cacaaggtcctggacgtcctgtgctcactctgcgtgtgccacggggtggccgtgcggtcc
aaccagcacctcatctgtgacaatctcctgccgggaagagaccttctgttgcagacgcgt
ctcgtgaaccacgtcagcagcatgaggcccaacatcttcctgggcgtgagcgagggctcg
gcgcagtacaagaagtggtactacgagctcatggtggaccacacgcagcccttcgtgacc
gccgaggccacgcacctgcgcgtgggctgggcctccaccgagggctgctccccctacccg
gggggcggcgaggagtggggcggcaacggcgtgggcgacgacctcttctcctacggcttc
gacggcctccagctctgggcagggtgcgtggcccggaccgtcagctccccaaaccagcac
ctgctgcggaccgacgacgtggtcagctgctgtttggacctcagcgcacccagcatctcc
ttccgcatcaacgggcagcccgtgcaggggatgtttgagaacttcaacatcgacggcctc
ttcttccccgtggtcagcttctccgcgggcatcaaggtccgctttttgctgggagggcgg
cacggagaattcaagttcctccccccgcccgggtacgcgccgtgttacgaagccgttctc
cccaaagagaagctgaaagtggagcacagccgagaatacaagcaggaaaggacgtacacg
cgggacctgctgggacccaccgtggccctcacccaagcggccttcaccccggtgcccgtg
gacaccagccagatcgtcctgccccctcacctggaaaggatcagagagaagctggcagaa
aatatccatgagctctgggtgatgaataagattgaacttggctggcagtacggtccggtg
agagatgataacaagagacagcacccgtgtctggtggagttctgcaagctgcccgaacag
gaacgtaattacaacttgcagatgtctctggagaccctgaagacgctgctggcgctgggg
tgtcacgtgggaatagccgacgagcacgcggaagagaaggtgaagaaaatgaagcttccc
aagaattaccagctgacgagcggctacaagcccgcgcccatggacttgagcttcatcaaa
ctcacgtcctctcaggaagccatggtggacaagctggccgagaacgcgcacaacgtgtgg
gcgcgggaccgcatccgtcagggctggacctacggcatccagcaggacgtaaagaacagg
agaaacccccgcctagtgccttacaccctcctggatgaccggaccaagaaatccaacaag
gacagccttcgggaggccgtgcgcacactgctgggctacggctacagcctggaggccccc
gaccaggaccacgcggcccgcgccgaggcgggcggcggcggccccggcgagcggttccgc
atcttccgcgccgagaagacgtacgcggtgcgcagcgggcgctggtacttcgagttcgag
gcggtgtcggccggggacatgcgcgtgggctggagccgccccggctgccagcccgacctg
gagctgggctccgacgagcgcgccttcgccttcgacggcttcaaggcgcagcggtggcac
cagggcaacgagcactacgggcgctcgtggcaggccggggacgtggtgggctgcatggtg
gacatgaacgagcacaccatgatgttcaccctcaacggggaggtcctgctggacgacgcg
ggctccgagctggccttcaaggacttcgacgtgggcgacggattcattcccgtgtgtagc
ctcggagtggggcaagtgggcaggatgaacttcgggaaggacgtcagcaccctgaaatac
ttcaccatctgtggcctgcaggagggttacgagccgttcgccgtcaacaccaaccgggac
atcaccatgtggctcagcaagagactcccgcagttcctccaggtgccggccaaccacgag
cacatcgaggtgaccaggatcgacggcaccaccgacacgtccccgtgtctgaaggtcacc
cagaagtccttcggctcccagaacagcaccaccgacatcatgttctaccgtctgagcatg
cccatcgagtgcgccgaggtcttctccaagaccgtgcccgggggcctctccggcgccggc
ctcttcgcgcccaagaacgacctggaagactacgacgcggattctgacttcgaggttctc
atgaagacggcccacggccacctcgtgcccgaccgcctcgagaaagacaaagaagccacc
aagtccgagtttaataaccataaggactatgctcaggagaagccctctcgcctgaagcaa
agatttttacttagaagaacaaagccggattacagcgccagccactctgcccggctcacc
gaggacgtcttggccgatgatcgcgatgactacgagtacctcatgcacacctccacgtat
tactactcagtgaggatcttccctgggcaggagcccgcgaacgtctgggtgggctggatc
acgtctgatttccatcagcacgacaccggctttgacttggaccgagtccggacggtgacc
gtcaccctgggggatgagaagggaaaagtccacgaaagcatcaaacgcagcaactgctac
atggtgtgtgcaggcgagagcatgagccccgggcaaggccgtaacaacaacggcttggag
atcggctgtgtggtggatgcggccagcgggctgctcacgttcatcgccaatggcaaggag
ctgagcacctactaccaggtggagccaagcacaaaattgtttcctgctgtgtttgcacaa
gctacaagccccaatgtgttccagtttgagctgggaagaataaagaacgtgatgcctctc
tcggcgggcttgttcaagagcgagcacaagaaccccgtgccgcagtgcccgccgcgcctg
cacgtgcagttcctgtcgcacgtcctgtggagccggatgcccaaccagtttttgaaggtg
gatgtctctcgcatcagtgagcgccagggctggctggtgcagtgtttggacccactgcag
ttcatgtccctgcacatccccgaggagaacaggtccgtggacatcctggagctgacggag
caggaggagctgctgaggttccactaccacacgctgcggctctactcggccgtgtgcgcc
ctggggaaccaccgggtggcccacgccctgtgcagccacgtggacgagccgcagctgctc
tacgccatcgagagcaagtacatgcccggcctgctgcgcgcaggctactacgacctgctc
atcgacatccacctgggctcctacgccaccgcccggctcatgatgaacagcgagttcatc
gtccccatgaccgaggagaccaagagcatcacgctgttccccgacgcgcgcaagaagcac
gggctgccgggcatcggcctgagcacctccctgcggccccgcatgcggttctcctccccc
agcttcgtgggcgtgggcggcgacggctaccagcacagccccgagttcccgctggacgtc
ctgaaggccaagaccatccgcatgctgacggaggcggtggaggagggcggcctccgcgcg
cgggaccccgtcgggggcaccaccgagttcctcttcgtgcccctcatcaagctcttctac
accctgctcatcatgggcctcttccacagcgaggacctcaagcagctcctgcagctcatc
gagcccagcgtgttcaaggaggctgccggccccgaggagcggaggcggcggcggggggac
cggcccgagccggggctcgctgccgacgacgccaggctggaaggggaagacgaggccaga
gcggtcaagaggcccaaggagggcctcctgcagatgaagctgcccgagcccgtgaaactg
cagatgtgcctgctgctccagtacctctgcgactgccaggtgcgccaccggatagaagcg
atcgtggccttctcggacgacttcgtggcgaagctccaggacaaccagcgctttcgctac
aacgaggtgatgcaggccttgaacatgtccgccgcgctcacggccaggaagaccaaggaa
ttccgctcgccccctcaggagcagatcaacatgctcctcaacttcaaagatgacaaaagc
gaatgtccctgtcccgaagaaatccgtgaccagctcctggatttccacgaggatttgatg
acgcattgcggcattgagctggatgaagatggctctctggacggaagcagcgacctaacc
atcaggggacgcctgatgtccctggtagaaaaggtgacctacctgaagaagaagccggcg
gaaaagccggtggccagcgacaccgccaagtcctccaccctccagcagctgatttcggat
accatggtccggtgggcgcaagagtctgtcatcgaggaccccgagttggtgagggccatg
ttcgtgctgctgcaccggcagtacgatggcatcgggggcctggtccgggccctgccgaag
acctacaccatcaacggcgtgtcggtggaggacaccattaacctgctggcctcgctgggg
cagatccgctccctgctgagtgtgcggatgggcagagaggaggagaagctgatgatccgt
ggactgggagacatcatgaacaacaaagtgttttatcagcacccgaacctcatgagagcc
cttgggatgcacgagacggtgatggaggtgatggtgaacgtcctgggcgggggagagtcc
aaggagatcacctttcccaagatggtggccaattgttgccgttttctctgttacttctgt
cgtataagtaggcagaatcaaaaggctatgtttgatcatctcagttatttactggaaaac
agcagtgttggtcttgcctcccctgccatgaggggctctaccccgctggatgtagccgcg
gcttcagtgatggataataacgagcttgccctagccttgcgggagccagatctggagaag
gtcgttcgctacctggccggctgtgggctgcagagctgccggatgctgctcacaaaaggc
tacccggacatcggctggaaccccgtggagggggagcgatacctggactttctcagattc
gctgtcttctgcaacggggagagcgtggaagagaacgccaatgtcgtggtgagactgctc
atccggagacccgagtgcttcgggcccgccctgcggggggaaggcgggaacggactcctg
gcggccatggaggaagccatcaagatcgcggaggacccttcccgcgacggcccgtccccc
gccagcggctccagcaggacgctagatacggaagaggaagaagacgataccatccacatg
gggaacgcgatcatgaccttctacgcggccttgatcgacctcctgggtcgctgtgcgcct
gagatgcacttgattcatgccgggaagggagaagccatcagaatcaggtctattttgaga
tctctcattcccctgggagacttggtgggtgtgattagcgtcgcttttcagatgccaacc
atcgccaaagatgggaatgtggtggaacctgacatgtctgcggggttttgcccagatcac
aaggcagccatggttttgttccttgacagggtctatgggattgaggtgcaagacttcctc
ctccacctcctggaggtgggctttctgccagatctccgagccgctgcttctctagacacg
gccgcgctgagcgctacagacatggccttggccctcaataggtacctttgcacggccgtc
ctgcctttgctgacgcgctgcgctcccctgttcgcgggcacggagcaccacgcctccctc
atcgactctctgctccacacggtgtaccgactgtccaagggctgctccctcaccaaagcc
cagcgggacgccatcgaagtgtgcctgctctccatctgcggccaattgagaccttctatg
atgcagcacttgctgagaagactagtgtttgacgtcccattgctaaatgaacacgcgaag
atgcccctgaagctgttgacaaaccactacgagcgatgctggagatactactgcctgccg
ggcggctggggcagcttcggggccgcctccgaggaagagctgcgtttatcccggaagctg
ttctggggcatctttgatgccttgtcccaaaagaaatacgaacaagaacttttcaaactg
gcactgccctgcctgagcgccgtcgcaggagctctgccccccgactacatggagtcaaac
tatgtgaatctgatggaaaaacagtcgtccatggattctgaagggaactttaaccctcag
cctgttgatacctccaatattacaattcctgagaagttggaatacttcattaacaaatat
gcagagcattcccatgacaaatggtcaatggacaagttggcaaatggatggatttatgga
gaaatatattcagactcttctaaggttcaaccattaatgaagccatataaactattgtct
gaaaaggaaaaagaaatttatcgctggccaatcaaggaatccttaaaaacgatgctggct
tggggctggaggatcgagagaacccgggagggagacagcatggcgctgtacaaccggacg
cgccggatttcccagacgagccaggtttctgtggacgcggcccatggttacagcccccga
gccattgacatgagcaatgtcacactgtccagggacctgcatgcaatggcagaaatgatg
gctgaaaactatcataatatatgggcaaagaaaaagaaaatggagttggaatccaaagga
ggtgggaaccaccccctgctcgtgccctacgacacgctgacagccaaggagaaagccaaa
gacagggagaaggcgcaggacatcctcaagttcttgcagatcaacggttacgccgtgtcc
agaggattcaaggacctggaactggacacgccttccatcgagaagcgcttcgcttacagc
ttcctccagcagctgattcgctatgtcgatgaagctcaccagtatatcctggagttcgac
ggtggcagcagaagcaaaggagagcatttcccttacgaacaggaaatcaagttcttcgcc
aaagttgttcttcccttgatcgatcagtacttcaaaaaccaccgcctgtacttcctgtcg
gcggcgagcaggccgctctgcacgggagggcacgcctccaacaaggagaaggagatggtc
accagcctattctgcaaacttggagtacttgtcaggcataggatttcactatttggaaac
gacgccacatcaattgtcaactgtcttcacattttgggtcagaccttggatgccaggacg
gtgatgaagaccggcctggacagcgtcaagagcgcgctccgcgccttcctggacaacgcg
gccgaggacctggagcagaccctggagaacctgaagcagggccagttcacgcacacgcgg
agccagcccaagggggtcacgcagatcatcaactacaccaccgtggcgctgctgcccgtg
ctctcctccctgttcgagcacctcggccagcaccagttcggagaagacctgatgctggaa
gacgtgcaggtgtcttgctacagaatcctcacgagcttgtacgccctgggaaccagcaag
agcatttacgtggagaggcagcgctcggcgctgggcgcgtgtctggcggctttcgcgggc
gccttccccgtggcgtttctggaaactcatttggacaagcacaacgcctactccatctac
aacaccaagtcctcccgggagagggcagcgctcagtttgccggcgaacgtggaggacgtg
tgccccaacatcccgtccctggagaagcttctgggggagatcgtggagctggcggagtcc
ggggtccgctacgcgcaggcgccgcacgccatggaggccgtgctgcccatgctgtgcagc
tacgtgtcccggtggtgggagcacggccccgagagcaaccccgagagggcgggcacctgc
tgcacggccctcggctcggagcacatgaacacgctgctgggcaacatcctgaagatcatc
tacaacaacctgggcgtcgacgagggcgcgtggatgaagcggctggcagtgttctcccag
cccatcatcaacaaagtgaagcctcagctcttgaagacgcacttcctgcccctgatggag
aagctgaagaaaaaggcggccatggtggtctctgaggaagaccatctgaaagccgaggcc
agaggggacatgtcggaggccgagctcctcatcctcgatgagttcaccacgctggccagg
gatctctacgccttctacccgctcctgattcgatttgtggactataacagggcaaagtgg
ctgaaggagccgaacccggaggcggaggagctgttccgcatggtggccgacgtcttcatc
tattggtccaagtcccacaatttcaaaagagaagaacagaacttcgtcgtgcagaacgaa
atcaacaacatgtctttcctcattaccgacaccaaatcaaagatgtccaaggccgcagtt
tcggaccaggaaaggaagaaaatgaagcgcaagggggaccggtactctatgcagacgtct
ctcatcgtggctgctctgaagcggttgctgcccatcggcctcaacgtctgtgcccctggc
gaccaggaactcatagcgctggccaaaaccagattcagcctgaaagacaccgaggacgaa
gtgcgagacatcattcgcagcaatattcacttccaaggcaagctggaggaccctgctatc
cggtggcagatggcgctttacaaagacttgcccaacaggaccgaggtcgcctcggatcca
gagaggacggtggagagagtgctggatatcgcaaacgtgcttttccaccttgagcagaga
tctaaaaatactggccgtggctattacagtctgggaagtacagtggagcatcctcagaga
tctaagaaagctgtgtggcacaagctcctgtctaagcagaggaaaagggccgtggtggcc
tgctttcggatggctcccttgtacaacctgccaaggcaccgggccgtcaatctctttctc
cagggatacgaaaagtcgtggatcgagacagaagagcattactttgaagataaactgatt
gaagatttagccaaacctggggctgagccccccgaggaggatgaaggcatgaagagagtc
gaccccctgcaccagctcatccttctgttcagccgcacggctttgaccgagaaatgcaaa
ctggaggaagattatttatatatggcttatgcggatattatggcaaagagttgtcacgat
gaggaagacgatgatggcgaagaggaagtgaagagctttgaagaaaaagaaatggaaaag
caaaagctcctgtaccagcaagccagactgcacgaccggggagcggcggagatggttctg
cagacgatcagcgccagcaaaggggacacggggccaatggtagctgctactctgaaacta
ggaattgctatcttaaatggcggcaactccacagtgcaacagaagatgctggactacctg
aaggagaagaaggacgtgggattcttccagagcctggccggcctgatgcagtcctgcagt
gtccttgacctaaatgcattcgagaggcagaacaaagcggaaggcctgggcatggtgacg
gaggaaggatcaggcgagaaggtgctgcaggacgacgagttcacctgcgatctcttccga
ttcctgcagctgctgtgtgagggacacagctcagattttcagaattatctgaggactcag
accggcaacaataccacggtcaacatcattatctccaccgtggactacctgctcagggtt
caggaatccattagtgacttctattggtattactctgggaaagatgtcattgacgagcag
ggacagcggaacttctccaaagccattcaagtagcaaaacaagtctttaacactctcacg
gagtatattcagggtccgtgcacgggcaaccagcagagcttggcccacagccggctgtgg
gacgccgtggtgggcttcctccacgtctttgcccacatgcagatgaagctgtcgcaggat
tccagccagatcgagttgttgaaggagctgatggacctccagaaggacatggtcgtcatg
ctgctctccatgttagaaggtaatgttgtcaatggaacaatcggcaagcagatggtggac
atgctcgtggagtcttccaacaacgtggagatgatcctgaagttcttcgacatgttctta
aagctgaaggacttgacgtcttcggacacgtttaaggagtatgacccggacggcaaaggc
gtcatttccaagcgagatttccacaaagccatggagagccacaagcactacacgcagtcc
gagaccgagttcctcctgtcctgcgcggagacggacgagaacgagaccctggattacgag
gagttcgtcaagcggttccacgagccggccaaggacatcggcttcaacgtggccgtgctg
ctcaccaacctttccgagcacatgcccaacgactcgcggctgcagaccttcctggagctg
gcggagagcgtgctcaactacttccagcccttcctgggccgcatcgagatcatgggcagc
gccaagcgcatcgagcgggtgtacttcgagatcagcgagtccagccgcacgcagtgggag
aagccgcaggtgaaggagtccaagcgccagttcatcttcgacgtggtcaacgagggcggc
gagaaggagaagatggagctgtttgtgaacttctgcgaggacaccatcttcgagatgcag
ctggccgcgcagatctccgagtcggacctgaacgagcgctcggccaacaaggaggagggg
gacagggagaagccggaggagcaggggccccgcatgggcttcttctccatcctgaccgtc
cggtcggccctgtcggcgctcaggtacaacgtgctgaccctcctgcgcatgctcagcctg
aagagcctgaagaagcaggtgaagaaggccaagaagatgacggtgaaggacctgctggcc
gccctgctcgcgtcctactgcggcgtcttcctggcgctcctgcacttcctggccagcgtc
tgcaggggcttcttccgcatcgcctgcggcctgctgctgggggccagcctcgtcgagggc
gccaagaagatcaaggtggccgagctcctggccaacatgcccgaccccacgcaggacgag
gtgcggggcgacgccgaggacggggacaggaagcccctggaggccgccctcccctccgaa
gacctcatggacctgaaggagctcacggaggagagcgacctgctctccgacatcttcggc
ttggatctgaagcgggagggagggcagtacaagctcattccccacaaccccaacgcgggc
ctcggggacctgatggccagcccagcccccgcccctgaggagcaggacgggcttcaggag
cagaaggcaaacgaagaagaaaaggaagaaaaagaagaaactaaatcggaaccagaaaag
gctgagggggaggatggagagaaagaagaaaaagccaaggaggacaagggcaagcccaag
tccaggcagctccacacgcacagatacggggagccagaggccccggagtcggcgttctgg
aagaagatcatagcgtaccaacagaaactgctgaactattttgctcgcaacttttacaac
atgaggatgctggccctcttcgtcgccttcgccatcaatttcatcctgctgttttataag
gtctccacttcttctgtggttgaaggaaaggagccgcccgcttcgcggagccccagcgag
cccacgcccgcggccgtcgggctggagggcggccgcccgccgcgcgccatcaccgtgcgc
ttcgtgctggaggagagcagcggctacatggagcccaccctgcgcatcctggccgtcctc
cacaccgtcatctccttcttctgcatcatcggctactactgcctcaaggtcccactggtt
attttcaagcgggagaaggaggtagcccggaaactggaatttgacgggctctacatcacc
gagcagccgtcggaggacgacatcaagggtcagtgggacaggctggtcatcaacacacag
tcatttcccaacaactactgggataaatttgtgaagagaaaggttatggacaagtacggg
gagttctacggccgcgacaggatcagcgagttgctaggcatggacaaggcggccctggac
ttcagcgacgccagggagaagaagaagcccaagaaagacagctccttgtcggcggtgctg
aactccattgacgtgaagtatcagatgtggaaactgggagttgttttcaccgacaattcc
ttcctctacctagcctggtacatgaccatgtccgtccttggacactacaacaacttcttc
ttcgctgctcatcttctcgacatcgccatgggattcaagaccctgagaaccatcttgtcc
tcggtgactcacaatggcaagcagctggtcttgaccgtgggcttgttagccgtcgtggtg
tacctctacacggtggtggcgttcaacttcttccggaaattctacaataaaagtgaagat
ggggacaccccggacatgaaatgtgacgacatgctgacgtgttacatgttccacatgtat
gtgggggtccgcgccggagggggcatcggcgacgaaatcgaggaccccgcgggcgacgag
tacgagatctacaggatcatcttcgacatcaccttcttcttcttcgtcatcgtcatcctc
ctggccatcatacaaggtttaatcatcgacgcctttggcgagctgagagaccagcaggag
caggtcaaggaggacatggagaccaagtgtttcatctgtggcatcggcaatgattacttc
gacacggtgccgcatggctttgagacccacacgttacaggagcacaacctggccaattac
ctgttttttctgatgtatctcataaacaaggatgagacggagcacacaggtcaggaatcg
tatgtctggaagatgtatcaagagagatgttgggagtttttcccagctggagattgtttc
cggaagcaatacgaagaccagctaaattga

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