Poecilia mexicana (shortfin molly): 106914059 Help Entry 106914059         CDS       T08022                                  Name (RefSeq) ryanodine receptor 2-like   KO K04962   ryanodine receptor 2 Organism pmei  Poecilia mexicana (shortfin molly) Pathway pmei04020   Calcium signaling pathway pmei04260   Cardiac muscle contraction pmei04261   Adrenergic signaling in cardiomyocytes pmei04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:pmei00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     106914059    04020 Calcium signaling pathway     106914059  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     106914059    04261 Adrenergic signaling in cardiomyocytes     106914059  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pmei04040]     106914059    04990 Domain-containing proteins not elsewhere classified [BR:pmei04990]     106914059 Ion channels [BR:pmei04040]  Voltage-gated cation channels   Ryanodine receptor    106914059 Domain-containing proteins not elsewhere classified [BR:pmei04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    106914059 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_6 Motif Other DBs NCBI-GeneID:  106914059 NCBI-ProteinID:  XP_014836101 Ensembl:  ENSPMEG00000020183 LinkDB All DBs Position Unknown AA seq 4951 aa AA seqDB search MTATKEAEDEGQFLRTGDEVVLQSTFTSHNEHLKLCLAAEGFGSRLCRLEPTSNCKNVPP DLSVCGFILAQCLSVRALQEMLAHSEQLAAEAKAGVAHRTLLYGQAVMFTHSFSGLYLSC LSSSQTSPDKLAFDVGLQEDKAGEACWWTVHPASRQRSEGEKVRVGDDLILVSVSSERYL HLSFAPVSDNKSLSDSLIVSASFQQTLWSVAPICSGGAIAQGYLKGGETLRLLHSHSDAC LTIPCSEQGEELQRVMHYEIGSVSGHGRSLWRLEILHVAWSGRHTCWGEPFRLCHVTTGR YLGLTEENGLHLVDRDKANINTTSFCFRSSKEKLDAGKNTNSDCMGIPEIKYGDSMCYLQ HLYSGLWLTYQATDAKCRLGGNVRKAILHSEGHMDDGLTLSRSQREESHTAGLIRNTVSL FTRFIRKLDCFSHEGSLSSLCLPMKTVTCSLQDLIKYFQSPLDGQSHEDKQKKMAALRKR QNMFKEEGVIDLVLDCIDHLHHYSSDSSITDPAQWEAVVHLFYELLAALIRGNRVNCAHF SSSVDWLIGRLDHLEASSGVLEVLHCVLVESPEAINVIKDGHIQSIISFLEKHGHDNKVL EVLCSLCVCHGVAVRSNQNLICDSLLPDRDLLLQTRLTNQVTSMRANIFLAMGEASAQHR RWYYELVVDHADPFLTAEPTHLRVGWAFTKGYLPRPTGGERWGANGVGDDLYSFGFDGLH LWSGCVGRKVSSPFSHLLKDNDVVSCCLDLTVPCISFRVNGLPVQGMLENFNANGLLYPV VSFSAGVRVRFLFGGGHGEFRFLPPPGYASCSEALLPKVKLRVEPCQKYISDCEEGKKEL IGPSVPVTPLTFTPTPVDISKVVLPPQLEDIREKMAENFHELWVKDRIDLGWTNGPVKDE GKQHDPCLVEFSKLPEQERNQNLHMAEDILKTVLALGFHIGLADDHAEERVKYTRLHTKY ELPCGYRPAPIDLRQITLSSADQDVVTLLAENHHNIWARERIKQGWTYGPEQDIKGKRSP HLVPYSLVDERMRKAGMESVREAVRLLLAFGYSLESLSQEQTPLSKTCLFSVEKSRVFRP DKSYAVTMGKWYFEFEVLTAGNMRVGWARPGCAPDKELGSDDQAYVFDGFEAQWCHQGGE PLGRRWLRGDVVGCLVDMFEGTMMVTLNGELLFNDRGSELAAKDLDVGDGLLPVVSVGVN QVGRMNLGRQVESLQYFNVCGQQEGYKPFAFNMTRDPSLWMSWKLPLFTSVLPDDHSLQV TRRRGSMDSLSSLRVSQRAFVQHGGGSEMGFYRLSMPIQCAATLRSPAEGGLQVPSSSLT PTSVRKELEDTDSDFEVLMKSARSFAGSRDELDHKDHSHDKTSKLKQRFMMKRTKPGLVS SNSSARLLEDVIVEKDNYDHLIQSSRYYYAVRILPGQEPFSVWIGWVTSDFHQHGSTFDT DSVGTVTVTLGDDSGKVQESVKRSNCFVVCAGEATGLSQSRRSAGLEIGCLIDTATGLLT FTSNGIEMSTFFQLEAGTKLFPAVFVKPTTTNMFQFELESIQNAMPLSSAFLRGQRRNPS PQCPPRFQVQYLKPVTWTRVPDGGLKVFVDWPDEHHGWRVQCFDPQQVMTLQIPDENRCV DILELSELDDLLSFHQNVLLLYCSLCALGNTRVCHALCSHVDQSQILYAIQNPHLAGPLR LAYYQLFIQVYLSSHTTACLTMNHEYIIPMTDQTAEASFYLDPVVGVSDRGNGQTPEGTC RSTCLKPQMRFSSPCFVRGDGMEAEGAVEIACPDSPEIPLDTLRNLTADMLTAGVVAVGQ AVRDPAGGSVELLLVPLLRLLYNLLVMGVFEDEDLARVLRLIEPNVFSKNVKTVEEAKDG KQRGESINIKDDAIKQGLLQMELPEPVQLELCHLLSYLCDCQVRHRVEAVTAFSGNFVRQ LQENQRFRYTQVMQALNMSAALTARKTKEFRLPPQEQINLLLSFREDEQQENCPCPVELQ QLLHDFHHLLNTHCGTKTVPDSEEEDDTKMSLKDRLFSRAAKAVGLKKKPAEVEKYKSPK LKSLRRLISDMTVCWAQEREMEDPELVRAIFTLLYRQYQGLEGQMEGSLSKAYAISQSSV EDTMALLSSLGQIRSLLSVRMGKEEEKLMIRKLGDIMNNKVFYQHPNLMRSLGMHETVME VMVHVLGEGESKEITFPKMVASCCRFLCYFCRISRHNQGALFDRLSYLLENSRVGLASPS MRGSTPLDVAAASVMDNNELALSLKEADLEKVVQYLAGCGLQSCSLLLAKGYTDIGWNPV EGERYVDFLRFAVFCNGESVEENAYVVLRLLIRRPECFGPALRGDGGDGLLAAMKEAISI SQDPSMDGPFPAQHPSKTTDGVHSNEDDLIHMGHAIMTFYSALIDLLGRCAPEMHLIQGG KGEAIRIRAILRSLIPVQDLEGVISICFQLPSVSEDGVLVEPDLSTAFCPDHKAAMVLFL DRVYGVESQRFLLHLLEVGFLPDLHAAVSLDTTDLGSTDMALALNRYLCTAVLPLLTKCS ALFHDLEDHALLVDSLIQAIYRLSRALSLTRAQRDTTEDCLLALCSKLQPSTMQPLLQRL VFDVLHLSHHSKLPLKMLTSHYEQMWKYYSYSGSQDKQKLASEGELQLSRKLFWGVFKAL TKKSFIPQLLSLCVQCLVAVAKALPPDYVEPGCLSQVDRITSVDTDGYFEPHPVDTSNVS VPERLDFVVNKYAEHTHEKWSLEKFASGWVHGDQLCENAKVHPLLKPYRALAEKEKDSYR WAIKETIKSMLAFGWTIERTKEGDAFGILACARRVSQAGQLSFEGASTFSPKPLDMSSIT LSWEQCAMAEQLAENYHNVWAKTKKLELESRGGGHSMLVPYDALTAKEKTKFREKAQEIL KFLLLHGYTVWRDRKSMEIDFPATANCFGHIFLQRMLYYTEETQENMLKLEVIQARGQMP KGERAQDQQPIIFFQKVVLPLLEQYVKSHRLYFLSSSLKSSENRSHASKREKEMVLCLFC KLAALVRHRISLIGDEASAVTSCLRILAQALDARILTAAASESLQTSLHSFFEAAAADLE MTVGKISETLPHSRGQLSKGVVNTLNYTTSILMPTLTSLFHHLANQNYGVDVLVGGIQVS CYKILNSLYSLGTSKSFYMEGQRSAAGACVAALTGAFPVCFLEPTLDHSNPHSIYNVMSP TEIKDQGLPDRMENACRPLPSLGEALEKVEELAGAGSVAHQMQYIHVAEVTLPMLCSYIS HWCRWGPEGHPEGPVLSSVVAQHASDLIGHILRIIHNHVGASQGDWMKQLAVFSQPIVCK ADSELLRSHFLPLMEKLKKRAECVQSEEEVMKAEDCCTSEAELQIQEKYRVLVQDLYAFY PLLIQFVDFNRARWLKETIPEAEQLFSMVAEVFVFWAKSHHFKWEEQSYVVQNRINNLAF LLSSNNLLEFDHKNKGMKRKGDRYSAHTSLIVAAIKKMVPVGLRVCFPCDQNLIMLVKNC YSQNNLEDEIREQILRYLKHFFGQASNSVSRGILSADLPAQLEAPADTQRTVDRVLQIAR VLYYLDQVEHPQRSKKPAWKNVLSKRRKRAVVACLRMTPLYNLPRHRAVNLFLQGYNRSW ISTEGNDLVEMLVEDLAKGRVTKPWEGEKGEVKEVEEGAKAIDPLLQLIMLFSRSALTES SNLDNDNLYKDYAAIMAKSCRRESHDDAEQEVESFEEKEMEKQKLLYQQARLHCRGASEM VLQAISASNGTMGFMIGPTLKLGIALLNGGNATVQQKMLDYLREKRNVGFFQSMAGLMRS CSVLDLNAFERQNKAEGLGMATDESSGEKVMPDKDLTCDLLRFLQLLCEGHNSDFQNYLR TQTGNNTTVNIVISTVDYLLRVQESISDFYWYYSGKDVIDPLGQHYFSKAIEVAKQVFNT LTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSRQIKLLKELMDLLKDMV VFLLSMLEGNVINGTIGKQMVDMLVESSSNVEMVLKFFDMFLKLKDLTSSEGFREYDSDY KGSICRKDFQKAMENCKYFSQAEIHFLLSCIETNDSEILEYQTFVDRFHDPAKDIGFSIA VLLTNLSEHMPKESRLKTFTELAECALTYFQPSLGRIEILGSGKRFERVYFEISEYSRTQ WEKPQVKESKRQFIFDVVNKGGDKEKMEMFVNFCEDTIFEMQLAAQISGSNSGEKCNGKT EVETRELEEYSPPDYKRWTLIYYWWLMLTCALSVKNLKTLMKTTPKDFLLAAVRFIRFIC ALQIRCISAVICRIMYLLYITFVNSGLIEAAKRMKVSDLLGGILEPTLDEVTEVSSNVDQ LRKYSASFSSQKELREIGQMASLTFPKEVDILSDIFGLKLKKEGDQYRLVTQDLSDSLTD LFSSTSRTIIDTDVCEEHHTLQFTDYLDKEKTQDKKKENLQEKEWKKTEKERRNAKEETT HGAKRGCNGSKEPQRQHSALWETMSSHSKSLLNYFARNFYNMRLLALFVAFAINFILLFY KVAFLPASKEEQATTSAYGKEQLSATTNASNGRVYFVLEESSGYMELCLHFLSIAHTIIS FCCIIGYYCLKVPLVIFKREKEVARKLEFDGLYVTRQPPEEDVKGQWDRLVINTLSFPSN YWDKFVKRKVMDKYGEFYGRKKISELLGLDQAALDFSTERKEKKKLRRDSAWSVLSAVCS RFNSLDAKYQVWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTI LSSVTHNGKQLVLTVGLLAVVVYLYTVIAFNFFRKFYNHSRGKETEDMKCNDMLTCYMFH MYVGVRAGGGIGDEIEDPAGDEFEVERIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQ QEQVKEDMETKCFICGIGSEYFDKIPHGFETHTLQEHNLANYLFFLMHLINKDETEHTGQ ESYVWKMYQERCWEFFPVGDCFRKQHEDQLG NT seq 14856 nt NT seq  +upstreamnt  +downstreamnt atgaccgccacaaaagaggctgaagatgagggacagtttttacgaacgggagacgaggtg gttttgcagagcacctttacctcccataatgaacatttgaagctctgtcttgctgctgaa ggatttggcagcaggctttgcaggcttgagcccacttcaaactgcaagaatgttcctcca gacttgtctgtgtgtggcttcatcctggctcagtgtctctctgttcgagccctgcaggag atgctggcccacagcgaacaactggcagcagaggcaaaagctggagttgctcatcgcact ctgctgtacggccaggcagtgatgttcacacactccttcagcggcttgtatcttagttgc ttgtcttcgtctcagacttcacctgacaagttggcgtttgacgtgggtctgcaagaggat aaagcaggagaggcatgttggtggactgtccatccggcttccaggcagaggtcagagggc gagaaggtgcgtgtcggagatgacctcatactggtcagtgtctcctctgagagatatctg catttgtcctttgcccctgtatctgacaacaaaagcctgagcgacagtctgattgtcagt gcctccttccagcagactctttggagtgttgctcccatctgctctggaggtgccattgct caaggctatctaaaggggggagaaacgttgcgtctgctccacagccatagtgatgcttgt ctgactattccttgttcagagcagggagaggagcttcaaagagtgatgcattatgagatt ggatccgtgtctggtcatggacggtccctctggaggctggaaattctgcatgtcgcgtgg agtgggaggcacacatgttggggtgagccttttcgcctgtgccatgtaacaacggggagg tacctgggtctgacggaggaaaacggattgcacctagtcgatcgggacaaggccaacatc aacacgacctccttctgcttccgatcatcaaaggagaaactcgatgctggcaaaaacaca aatagtgattgcatgggaatcccagaaatcaaatatggagactcgatgtgttaccttcag catctgtactcaggactgtggctaacctatcaagctacagatgccaaatgccgcctgggt ggaaatgtgcgcaaggccattttgcacagcgagggtcacatggacgatggactgacgtta tctcgctctcagagagaagaatctcacaccgccggactcatccgaaacactgtctctttg tttactcgctttataaggaaactcgactgttttagtcatgaaggaagcctctcctcactc tgtctgccaatgaagacggtaacctgcagcctccaggatctcatcaagtacttccagtct ccacttgatgggcaaagccatgaagataaacagaaaaagatggctgcccttaggaaacgc cagaatatgtttaaagaagagggtgtaatagatctggtcttagattgcattgatcatctg caccactacagcagtgattcttctataaccgatcctgctcagtgggaggccgtcgtccat ttgttctatgagttacttgctgctttgatccgtgggaaccgtgtaaactgtgctcatttc tcaagctccgtggactggctcataggcaggctggaccatctagaagcatcttctggagtc ttggaggttctgcactgtgttcttgtagagagtcctgaggcaattaatgtcataaaagat ggacacattcaatctattatctcttttctggaaaagcatggacacgacaacaaggtgctg gaggttctgtgctcgctgtgtgtgtgccatggtgtggcggtgcgctccaatcagaacctc atctgcgacagcttgctgccagacagagatttgctacttcagacgcgactgactaatcag gtcaccagcatgagagcaaacatcttcctggccatgggagaggcctcggctcagcatcgg aggtggtactacgagttggtcgttgatcatgctgacccgtttctcacagctgaaccgaca cacctgcgtgttggctgggccttcaccaaaggctacctgcccaggcccacaggaggagag cgatggggggccaatggagttggagacgacctctattcgtttggcttcgatgggctacac ctgtggtcaggttgtgtgggccgtaaagtcagttcccccttctcgcatctgctgaaagat aatgatgtggttagctgctgtctcgacctcacggttccatgcatctccttccgggtcaac ggtctgccagtgcagggcatgctggagaacttcaatgctaatggacttctgtatcctgtg gtcagcttctcagctggagtcagggttcgttttctgtttggcgggggacatggagagttt cgcttcctgcccccaccaggctacgcttcatgctctgaggctttgctccccaaagtcaaa ctgagggtggagccgtgtcagaaatacatttcggactgtgaagagggaaaaaaagagctc attggcccctcggtgccagtcactccacttaccttcacccccactccagtagacatcagc aaggttgtgttacctccacaacttgaagacatccgagaaaaaatggcagaaaattttcat gaactctgggtaaaggacagaattgacctcggatggacaaatggaccagtgaaagatgaa ggtaaacaacacgacccttgtctcgtggagttctccaagcttccagagcaggagagaaac cagaaccttcacatggctgaggacatacttaagacggtgcttgcccttggtttccacatt ggtttggcagatgaccacgctgaagaacgcgtcaaatacacgagactacacacaaagtat gagttgccctgcggctacaggcctgcaccaatagatttaagacaaattactctgagttca gctgaccaggatgtggttaccctcttggccgagaaccatcataatatctgggccagagag cgcatcaaacagggatggacctatggacctgagcaggatataaagggtaaacggagtcct catctcgtgccttacagccttgttgatgaaaggatgaggaaagcaggcatggagagcgtg agagaggccgtccgtctcctgctggcatttggctacagcctggagtccctaagccaggaa cagactcctttatcaaagacatgcctcttttctgtggagaagagcagagtgttcagacca gataaatcctacgcggtgaccatggggaagtggtattttgaatttgaagtactgacagcc gggaatatgagagtgggctgggcccgaccgggctgtgctccagataaagagctcggctca gatgaccaggcctatgtctttgatgggtttgaggctcagtggtgccatcagggtggcgag cccctgggacggcgctggctcagaggcgatgtggtgggttgcttggtggacatgttcgaa ggcaccatgatggtcacgctcaatggagagctgctgtttaatgacagaggatcagagctg gctgccaaggatttggatgtcggagatggcctgttgcctgtggtcagtgttggggttaac caggtggggaggatgaatctgggccgccaggtggagtctctgcagtactttaacgtgtgt gggcagcaagaaggttacaaaccctttgcctttaacatgaccagagacccgtctctgtgg atgagttggaaactgcccctgtttacttcagttctgcctgatgatcacagcttacaggtt actcgacgtaggggctcaatggattccttatccagcctgagggtctctcagcgggcgttt gtgcaacatggtggaggaagtgagatgggcttttaccggctcagcatgcccatccaatgt gctgccacactcagaagccctgcagaggggggccttcaagtcccctccagctctctaact ccaacttcagtgaggaaggagctggaggacacagactctgactttgaagttctgatgaag tcagcacgcagcttcgccggctcaagagatgaactggaccacaaggatcacagtcatgac aaaacatctaaactgaaacagcggttcatgatgaaaaggactaaaccaggcttagtcagc agcaactcctctgcacggcttctagaagacgttattgttgaaaaggataactacgatcac cttatccagagctccagatattattatgcagtgaggattcttcctggccaggagccgttc agtgtgtggataggctgggtgacctctgactttcatcagcacggctcaacgtttgacacg gacagcgttggcacagtaactgtcacccttggcgatgacagtggcaaagttcaagaaagt gtgaagcgaagcaactgtttcgtggtttgtgctggagaagctacaggcttgtctcagagc cgtcggagtgcggggttggaaattggctgcttgattgacacagcgaccggacttctcact ttcacttctaacggcattgagatgtcgactttcttccaactggaggctggtaccaagctg tttccggctgtttttgtcaagcccaccaccaccaacatgttccagttcgaactggaaagc atccagaatgccatgcccttgtcatcagctttccttcgcggtcagagaaggaatccgagt cctcagtgccctccaaggtttcaggttcagtatttgaaaccagtgacctggacaagagta ccagacggtggattaaaggtgtttgttgattggcctgatgaacaccatggctggagagtc cagtgctttgacccccaacaagtgatgacccttcagattcctgatgaaaacagatgtgtt gacattttggagctgtccgagctcgacgacctcctctcttttcatcaaaatgtcctcctg ctctactgctcgctctgtgccctgggtaacaccagagtttgccacgctctctgcagtcac gttgaccagtcgcagatcctttatgctattcagaatcctcacctcgcagggccgctccgc ttggcatattatcagctgtttattcaggtctatctaagcagtcacaccacagcatgcctc acgatgaaccatgaatacatcatcccaatgacggaccagactgcagaagcctcattttac cttgaccctgtcgttggcgtttcagacagagggaatggtcaaacaccagaaggcacttgt agaagcacatgccttaaaccacagatgcgtttttcatctccttgttttgtcaggggtgat gggatggaagcagaaggtgcggttgaaatagcctgcccagacagcccagaaatccctctg gacactctgaggaatttgacagcggacatgctgactgccggggttgtggctgtcggtcaa gcagtgagggatcctgcgggaggcagtgttgaactgttgctcgtacctcttttaagattg ctctacaaccttctggtcatgggggtgtttgaggacgaagaccttgcgagggtgctcagg ctaattgaaccgaatgtcttctccaaaaatgtcaaaaccgttgaggaagccaaggatgga aaacaaagaggagaaagcatcaacataaaagatgatgccattaaacaaggacttcttcaa atggagcttccagagcctgtccaactagagctctgtcatctgctgtcctacctgtgtgac tgccaggtgcgacacagggtcgaagcagtgactgcattctctggaaactttgtgcgtcag ctgcaggagaaccagcgatttcgctacactcaggtcatgcaggcactcaacatgtctgca gcactgaccgctcgcaaaaccaaggagttccgacttcctccgcaagagcagatcaatttg ctgctgagcttcagagaagatgagcaacaggagaactgtccgtgtccggtcgaactccag cagctcctgcacgactttcatcacctcctcaacacacactgtggcactaaaacggtccca gactctgaggaggaagatgataccaagatgtctttgaaagatcgactattcagtcgagca gcgaaagcagttggacttaaaaagaaacccgctgaagtggagaaatataaatcacccaaa ctcaagtccctcagaaggctaatttctgatatgacggtgtgctgggctcaggagagagag atggaagaccctgaactggtcagggctattttcaccttgctataccgccagtatcagggc ctcgagggccaaatggaagggtcgctctcaaaggcatatgctatcagccagtcgtccgtg gaggacaccatggcactcctgtcctctctgggccaaattcgttctctcctgagtgtccgc atggggaaagaagaagagaagctgatgattagaaaactaggagatattatgaataataaa gttttctaccaacatcccaatttaatgagatctttgggcatgcatgagacggtgatggaa gtgatggttcatgttctgggagaaggggagtctaaggagattaccttccccaagatggta gccagttgctgtcgattcctctgttacttttgtcgtatcagtcgtcacaatcagggagcg ctgttcgaccggctctcatacttactggaaaacagcagagttgggctagcttcaccgtcc atgcgtggctccactcctcttgatgtggcagcagcctctgttatggataacaacgagctg gctttatcgctgaaggaagctgacctagagaaggttgttcagtaccttgctgggtgtggt ctccagagctgttcgctgctactggcaaaaggctacactgatattggatggaaccctgtg gagggagaacgctatgtggattttttacggtttgctgtgttctgcaatggcgagagtgta gaggagaatgcatatgtggttttgaggttgctgatccgtcggcctgagtgcttcggccct gcgctcagaggagacgggggagacgggctgctagccgccatgaaggaagccatcagcatc tctcaggacccatctatggacggaccgttccccgctcagcaccccagcaaaacaacggat ggagtccacagcaacgaggatgaccttattcacatggggcacgccatcatgaccttctac tcggcacttattgacttactgggacgctgtgctccagagatgcatttaattcagggcggc aaaggagaagccattcgcatcagggccatcctgagatctctcatcccagttcaggatctt gaaggagtcatcagcatctgctttcaactcccatctgtgtcagaagatggtgtgttggtg gagcctgacctgtccacagctttctgtcctgaccacaaggcagccatggttttattcctg gatcgtgtttatggggtggagagtcaacgttttctgctgcaccttctggaagttggcttt ctgcccgaccttcacgcagctgtttctctggacactactgacctgggatctactgacatg gctcttgccctcaatagatacttgtgcacagctgtccttcccctgctcaccaaatgttca gccctctttcacgatttagaggatcatgccttgctggtagattctctcatccaggcaatc taccggctctcaagggctctaagcttgaccagggctcagagagacactacggaggattgt ttgctggctttgtgcagtaaactccagccatctacgatgcagcctctccttcaaaggctt gtgtttgatgttctccatctctcacatcacagcaaattacccctgaaaatgttgaccagt cattatgagcagatgtggaagtattactcctactctggaagtcaggataaacaaaagtta gcctctgaaggggagctccagctgtctaggaagttattctggggtgtgtttaaggccttg acgaaaaagtccttcattcctcagctgcttagtttgtgtgtgcagtgtcttgttgcagtt gccaaagccttgcctcctgactatgtggagcctggctgtttgtctcaagtggacagaata acctcggtggacacggacggatattttgagccgcatcctgtagatacatcaaatgtttct gtgcctgagcgactggactttgtagttaacaagtacgcagagcacactcatgagaagtgg tctctagaaaagtttgccagtggctgggtgcacggtgatcagctgtgtgaaaacgccaag gtccaccctctcctgaagccatacagggctctggctgagaaggagaaggattcatatcgc tgggccatcaaagagacaataaagagcatgttggcctttggatggaccatagaacgtacc aaagaaggagatgcatttggcattctcgcctgtgcccgcagggtctctcaggccggtcag ctctcatttgaaggagcatccacctttagccctaaacctttggacatgagcagcatcacc ttatcatgggaacagtgtgcaatggccgaacagttggctgaaaactatcataatgtctgg gccaagactaagaagttggaacttgagagcagagggggaggccattcgatgctggttcca tacgatgctctgactgccaaggagaagaccaagttcagagaaaaagctcaggagatactg aagttccttttgctccatggctacactgtgtggagggatcgaaaatccatggaaattgac ttccctgctactgcaaactgctttggacacatttttctccaacgcatgctgtattacacc gaggagactcaggagaacatgctaaagcttgaggtgattcaagccagaggacagatgcct aaaggagaaagggctcaagatcagcagccaattattttttttcagaaggtcgttcttcca ctattggagcagtatgtaaaaagccaccgtctgtattttttgtcctcttctctgaagtca agtgaaaacagaagtcatgcctccaaaagggaaaaggagatggttctgtgtctcttctgt aagcttgctgctttggtaagacacagaatctcactaattggagacgaagcctctgctgtt acaagctgcctccgcattctggctcaggcgcttgatgcaagaatattgacggcagcagct tcggagtccctacagacgtctctgcattcatttttcgaagcagccgcagcagatttggag atgactgtggggaaaatatcggagaccttgcctcacagtagaggtcagctgtctaaagga gttgtcaacactcttaactacacaacgtccatcctaatgccaacacttacctccctcttc catcatcttgccaatcaaaactatggagtggatgttctggtcggtggtatccaggtgtcg tgttacaagattttaaacagcctctactctctggggaccagtaaaagcttctacatggag gggcagcggtcagccgcaggcgcctgtgtagcagctctgaccggagcttttcctgtatgc ttcctggagccaactctagaccacagcaatccacattctatctacaatgtcatgagtccc actgagattaaagatcagggactgccggaccggatggagaacgcgtgtcgccctcttcct tcactgggagaggcgctggagaaagtggaggagctggctggtgctggttctgtagctcat cagatgcagtacattcatgtggcagaggtcactttgcccatgttgtgcagctatatttca cactggtgtcgctggggccctgagggccacccagagggccctgtcctcagctctgttgtt gctcagcatgcgagcgacctgattggccacatccttcgcatcatccacaaccatgtgggc gctagccagggtgactggatgaagcagcttgcagttttttcgcagccgatcgtatgcaaa gccgacagcgagctgctgagaagtcactttctccccctgatggagaagctgaagaaacgg gcagagtgtgtccagtcagaagaggaagtgatgaaagcggaagactgctgtacttctgaa gcagagctgcagatacaggagaagtacagagttctggtccaggatctctacgccttttat cctcttctcatccagtttgttgattttaatcgagccagatggctgaaagagacgatcccc gaggctgagcagctgttcagcatggtggcagaggtctttgtattctgggccaaatctcat catttcaaatgggaagagcagagttacgtggtccagaatcgaatcaacaatttggctttt ttgctctccagtaacaacctgctggagtttgaccataaaaacaaagggatgaagaggaag ggggatcgttactctgcacacacttctctcatagtggctgccataaagaagatggtgcct gtgggactcagagtttgttttccatgtgaccagaaccttatcatgttggtgaagaactgc tattctcagaataacctggaagatgagattcgggagcaaattttgagatacctcaagcat ttttttggtcaggcatcaaacagcgtcagccgtgggattctgtctgctgatctcccagca cagcttgaggccccagctgacacacaaaggacggtggacagggttctacaaatagctcgg gtgctttattacctggatcaggtagagcacccacagaggagcaaaaaacctgcttggaaa aatgttttatccaaacggaggaaacgtgcggtggtggcttgcctgaggatgactcccctc tacaatctgccacggcaccgagctgtcaaccttttcctgcaaggctacaacagatcttgg atatcaaccgagggaaatgacttagtagaaatgcttgtggaggatttagctaaggggcga gtgacgaaaccgtgggaaggtgagaaaggggaagtaaaggaggtggaagaaggcgcaaag gcaattgatcctctcctccagctcattatgctcttcagtcgaagtgcgttgacggaaagc agcaaccttgataatgacaacctctacaaagattatgctgctattatggccaagagctgc cgcagagagagccatgatgatgcggagcaggaagtagaaagctttgaagagaaggagatg gaaaagcaaaagctgttgtaccaacaggccaggctgcattgtcgtggagcctctgaaatg gtcctgcaagccattagcgccagcaatggcaccatgggattcatgattggtcctactctg aaattaggtattgctcttcttaatggagggaatgcaacagttcagcagaaaatgctggat tatctgagagagaagcgcaatgttggcttttttcagagcatggctggactcatgcggtca tgtagcgttctggatttgaatgcatttgagaggcagaacaaagcagaaggattaggcatg gccacggatgagagctcgggagagaaggtaatgcccgacaaggacctgacttgtgacctc ctccgtttcctgcagctgctctgcgaaggacacaattcagatttccagaactatttaaga actcaaactgggaacaacaccaccgtcaacattgttatatcaacggttgactatttacta agggtacaggaatcgatcagtgatttctactggtactactcagggaaagacgtcattgat cctctgggtcaacactacttctccaaggccattgaagttgccaaacaggtcttcaacaca ctcaccgagtatatacagggtccgtgtattgggaaccagcagagtctggctcacagtcgt ctgtgggatgctgtcgtgggattcctccatgtctttgctcacatgcagatgaagctctct caggattcaaggcagataaaactcctaaaggaactcatggacttactgaaggacatggtt gtgttcctcctttccatgttagaaggcaatgttatcaatggaacaattgggaagcagatg gtggatatgttggtggaatcatcaagcaatgtggaaatggtcctcaagtttttcgatatg ttcctcaaactaaaagacctgacttcatctgagggcttcagagagtacgactctgactat aagggcagtatatgcaggaaggacttccagaaagccatggaaaactgcaaatacttctca caagccgagatccacttcctgctctcttgcattgaaacaaatgacagcgaaatcttggaa taccaaacgtttgtggatcgcttccacgatccggcgaaagacatcggcttcagcatcgct gttctcctcaccaatttgtcggagcacatgcccaaagagtccagactgaagacattcacg gagctcgcagaatgcgccctgacctactttcagcccagtcttggacgcattgagattctt ggcagcgggaagcgctttgaacgggtctactttgagatcagtgaatacagtcgcacgcag tgggagaagccacaggtgaaggaatccaagaggcagttcatctttgatgtggtcaataag ggaggagacaaagagaaaatggagatgttcgtcaacttctgtgaggacaccatatttgag atgcaacttgcagcccagatatccggatccaactctggagagaagtgcaacgggaaaaca gaggtggagacgagagagcttgaagaatattcgcccccagattacaagaggtggactttg atctactattggtggctgatgttgacttgtgccctctctgtgaaaaacctgaaaacactg atgaagacgacgccaaaggatttcctcttggcagcagttcgattcatcagattcatttgc gcgcttcagatccgctgcatttctgccgtcatctgccgcatcatgtatttgctgtacatc acatttgtcaacagtggtctcatagaggcagcaaaaagaatgaaggtgtcagacttgctc gggggtatacttgagccaactcttgatgaggtcacggaggtgtcgagcaatgtggatcaa ctgagaaagtactctgctagtttctcttcccagaaagaattgagggagatcgggcagatg gcttcattgacttttcccaaggaggtggacatattgtcagacatatttggtctcaagctg aagaaggagggagatcagtacagacttgtaacgcaagatctctctgacagtctgactgat ctgttcagttcaacttccagaacaataatcgacacggatgtttgtgaggagcaccacacg ttgcagtttacagactacttggacaaagagaaaacacaagataagaaaaaggagaacttg caggaaaaagaatggaagaaaactgaaaaggagcgtaggaatgcaaaagaagagacaaca cacggagccaagagaggctgtaatgggtcaaaggaaccacagagacaacattctgctctc tgggaaacgatgagctcacatagcaagagtcttctgaactactttgcaagaaatttttat aacatgcgtttgctggcgttgtttgttgcttttgcaatcaacttcatcctcctgttctat aaggtagcatttttgcctgcatccaaagaagaacaggcgactacatcggcatatggaaaa gaacagctctctgccacgacaaacgccagcaatggcagagtttattttgtgcttgaagaa agcagtggttacatggagctgtgtctccatttcctttccatcgcacacacaatcatctca ttctgctgcattattggttactactgcctcaaggtgccgttggtgatcttcaaacgtgaa aaggaggtggccagaaaactggagtttgacggactgtacgtgactcggcagcctcctgag gaagacgttaaagggcaatgggaccgcctggtcatcaacactctatcatttccaagtaat tactgggataaatttgtgaaaaggaaggtgatggataagtatggagagttttatggccgc aagaagatcagtgaactgctaggcctggaccaagctgctttagacttcagcaccgagcgg aaagaaaagaagaagctcagaagagacagtgcctggagtgtcctttctgctgtttgttcc agattcaactccctcgacgcaaagtaccaggtctggaagctaggagtcgtgttcactgac aactccttcttgtacttggcgtggtacatgaccatgtcagttttgggtcattataacaac ttcttctttgctgcccaccttttggacatcgccatgggctttaagacactccgtaccatc ctttcctccgtcacacacaatggaaaacagctggtgctgactgtgggtctgttggcggtc gtggtgtatctctacaccgtcatagccttcaatttcttcagaaagttttacaaccacagc cgtggcaaggaaactgaagatatgaagtgcaatgatatgcttacttgttacatgttccac atgtacgtgggagtgcgagcaggtggcgggattggcgacgagatcgaggatcctgctgga gacgagttcgaagtcgaacggatcgtctttgatattacttttttctttttcgtcattgtc atcctgctcgccattatccagggcttaataattgatgcctttggtgagcttcgagaccag caggagcaggtgaaggaggacatggagaccaaatgtttcatatgtggaataggaagcgag tattttgacaagattcctcacggcttcgagactcacactctgcaggagcacaacttggcc aactatctatttttcctgatgcatctcattaacaaggatgaaactgagcacacgggacag gaatcctatgtgtggaaaatgtaccaggagcgttgctgggaattctttcctgtgggagac tgtttccgtaagcagcatgaggatcaactcggctga

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