Proteus mirabilis BB2000: BB2000_0165
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Entry
BB2000_0165 CDS
T02789
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
pmib
Proteus mirabilis BB2000
Pathway
pmib00260
Glycine, serine and threonine metabolism
pmib00261
Monobactam biosynthesis
pmib00270
Cysteine and methionine metabolism
pmib00300
Lysine biosynthesis
pmib01100
Metabolic pathways
pmib01110
Biosynthesis of secondary metabolites
pmib01120
Microbial metabolism in diverse environments
pmib01230
Biosynthesis of amino acids
Module
pmib_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
pmib_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
pmib_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
pmib_M00526
Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine
Brite
KEGG Orthology (KO) [BR:
pmib00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
BB2000_0165 (thrA)
00270 Cysteine and methionine metabolism
BB2000_0165 (thrA)
00300 Lysine biosynthesis
BB2000_0165 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
BB2000_0165 (thrA)
Enzymes [BR:
pmib01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
BB2000_0165 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
BB2000_0165 (thrA)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
AGS58682
LinkDB
All DBs
Position
176618..179071
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AA seq
817 aa
AA seq
DB search
MLKFGGTSVANAERVLNVADIAEKKREQGQVALVLSAPAKITNYLVAMIEKTAEGEEPLT
QVREAEQIFANLLQGLRENQPGFDYQGLKDKVEREFAEIKHILHGISLLGQCPDSINAAM
ICRGEKLSIAIMESVLQARGYNVTVIDPVKNLLAQGHYLESTVDIPESTRRISALNIPKD
HMILMAGFTAGNEKNELVVLGRNGSDYSAAVLAACLRAQCCEIWTDVDGVYTCDPRLVPD
AHLLKGMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPEAPGTLIGDGQKDD
STPVKGITNLNNMAMINVSGPGMKGMVGMAARVFSVMSRAGISVVLITQSSSEYSISFCV
PQKELIRAQKALSEEFYLELKDGVLDPLDIMNNVAIISVVGDGMRTLKGISARFFSALTR
GNINIVAIAQGSSERSISAVIANDAATNAVRLCHQMLFNTNQIVEVFIVGVGGVGSALIE
QIHRQQAWLKNKHIDLRVCGIANSRAMLTNMQGIDLDNWQQALQAAKEPFSFSQLIRLEK
EYHFLNPVIVDCTSNEMIAQQYANFLQNGFNVVTPNKKANTMSMDYYHQIRQSAEASRRK
FLYDTNVGAGLPVIENLQNLLNAGDELVQFNGILSGSLSYIFGQLDEGKSLSEATLSAKE
KGFTEPDPRDDLSGMDVARKLLILAREAGYQLELSDIDVEPVLPSSFDSTGDVESFLNRL
PQVDVEFDAKVEEAQKSAKVLRYVGSINEGKCQVKIMAVDANDPLFKVKNGENALAFYTR
YYQPIPLVLRGYGAGNDVTAAGVFADVLRTLSWKLGV
NT seq
2454 nt
NT seq
+upstream
nt +downstream
nt
gtgttaaaatttgggggaacttcagttgccaatgcagaaagggtactgaatgttgctgat
atcgctgagaaaaaacgagagcagggacaagtcgctctggtattatcagcacctgccaag
ataacgaattacttggtggcaatgattgaaaaaacggcagaaggagaagaacctctcact
caagtacgagaagcagagcaaatcttcgctaatctattgcaaggtttacgagaaaatcaa
cctggttttgattaccaaggcttaaaagacaaagttgagcgtgagtttgctgagattaaa
catatcctgcatggtatctccctattagggcaatgtcctgatagcatcaatgctgcgatg
atttgtcgtggtgaaaagctttcgattgccattatggagtcggtgttacaagctagaggg
tataacgttaccgtcattgatccggttaaaaatctccttgctcaaggtcattatctcgaa
tcgacagtggatattcctgaatcaactcgccgtatttccgcccttaatattccgaaagat
catatgatcttgatggcaggtttcactgccggtaatgaaaaaaatgagcttgtggttctc
ggtcgtaatggctcagattattcagccgccgtattagccgcgtgtttacgtgcacaatgt
tgtgaaatttggacggatgttgatggtgtttacacctgtgatccacgccttgtcccagat
gcacacctactaaaaggcatgtcctatcaagaggcgatggaactttcctactttggtgcc
aaagtccttcatccacgcactattgcacctattgctcaatttcaaatcccttgtttaatt
aaaaatacgggcaatccagaagcaccgggtacgttaattggtgatggtcaaaaagatgac
agcacgccggtaaaagggatcactaacctgaataatatggcaatgatcaatgtatcaggg
ccaggtatgaagggaatggtgggtatggcggctcgtgtcttttctgtaatgtcgcgtgca
ggaatatcggtagtattaattactcaatcttcatctgaatacagtattagtttttgtgta
ccgcaaaaagagctaattagagcgcaaaaagcactgtcagaagagttctatctagagtta
aaagatggcgtacttgatccgttagatattatgaacaatgttgctatcatctcggttgtc
ggtgatggtatgcgcacccttaaagggatctcagcccgtttcttctctgctttaactcga
ggcaatattaatattgttgctattgctcagggctcttctgaacgttctatctctgcagtt
attgccaatgatgcagcgacgaatgcggtgcgtttatgtcaccaaatgctctttaacact
aaccaaatcgtagaagtctttattgtcggtgtcggtggtgttggcagcgcgctaatcgag
cagatccatcgtcaacaagcatggttaaaaaacaaacatatcgacctacgtgtttgtggg
attgccaattcacgtgcgatgctaaccaatatgcaaggtatcgatttagataattggcaa
caagcgctacaagcagctaaagagccttttagctttagtcagcttattcgcttagaaaaa
gagtaccacttcctcaatcctgtgattgttgattgcacttcaaacgaaatgattgcacag
caatacgccaatttcttacaaaatggctttaatgttgttacgcctaataagaaagccaat
acgatgtcgatggattactatcatcaaattcgccaatcagcggaagcatcacgtcgtaaa
ttcttatatgacactaatgttggtgcgggtttacctgttattgaaaacttacagaacttg
cttaatgctggcgatgagttggtacaatttaatggtattctttctggctcactctcttat
atttttggtcagctagatgaaggaaaaagcttgtctgaagcgacactttctgcgaaagaa
aaagggtttacagagccagatccaagagatgatctctcgggaatggatgttgctcgtaaa
ctgcttattctcgctcgtgaagcgggctatcaattagagttgagtgatattgatgtagag
cctgttttacctagttcatttgatagtacaggtgatgtcgagagtttcttaaaccgctta
cctcaagtagatgttgagtttgatgctaaagtcgaagaagcccaaaagtcagcgaaggta
ttacgttatgtggggagcatcaatgaggggaaatgccaagtcaaaataatggccgttgat
gctaacgatcctctctttaaagtaaaaaatggtgaaaatgcactagccttctacactcgc
tactatcaaccaattcctttagttttacgtggatatggtgcaggaaatgatgtcactgct
gctggggtatttgcagatgtattacgtacactatcatggaaattaggagtttaa
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