Passer montanus (Eurasian tree sparrow): 120501123 Help Entry 120501123         CDS       T07277                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism pmoa  Passer montanus (Eurasian tree sparrow) Pathway pmoa04020   Calcium signaling pathway pmoa04260   Cardiac muscle contraction pmoa04261   Adrenergic signaling in cardiomyocytes pmoa04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:pmoa00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120501123 (RYR2)    04020 Calcium signaling pathway     120501123 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     120501123 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     120501123 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pmoa04040]     120501123 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:pmoa04990]     120501123 (RYR2) Ion channels [BR:pmoa04040]  Voltage-gated cation channels   Ryanodine receptor    120501123 (RYR2) Domain-containing proteins not elsewhere classified [BR:pmoa04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    120501123 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  120501123 NCBI-ProteinID:  XP_039562801 LinkDB All DBs Position Unknown AA seq 4971 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWSAQGGGHRTLLYGHAILLRHSY SGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGHMDECL TVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITTGKY LSLLDDKSLLLTEKEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSMCFIQH VDTGLWLTYQSADAKSVRMGSLQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRSTVFL FNRFIRGLDALSKKVKSSTIDLPIESVSLSLQDLIGYFHPPDEHLEHENKQNRLRALKNR QNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNR KNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHG RNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISE GSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSY GFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNID GLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKERLKVENSREYKQDRS YTRDLLGPTVSLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYG PVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADERAEEKVKKMK LPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVK NRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHATRLDVCSGIMEKF RIFRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRW HQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVADGFLPVC SLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNH EHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAGGLPSS GLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEKPSRLK QRFMLRRTKPDYSMSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGW ITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGRNNNGL EIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMP LSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQCMNPL QFMALHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHALCSHVDESQL LYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKK HGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQEGSLH VRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPRVFKEAVSQDDEVDFSE KEFSSDELKSEEGEEEIRGEQMPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIV AFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNDC PCPEEIRDQLLDFHEDLMTHCGIELDEDGTLDGNSDSTIRGRLLYLMEKVTNMKKKQDEK TVDEDDKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTY TINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALG MHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSS VGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLICKGYP DIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAA MEEAIQISEDRTRDGPSPSNGSSKTLEIEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEM HLIHAGKGEAIRIRSILRSLIPLEDLVGVISIAFHMPTIAKDGTVVEPDMSAGFCPDHKA AMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLP LLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQ HLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPSGWGNFGAASEEELHLSRKLFW GIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNPQPV DTSNITIPEKLEYFINKYAEHAHDKWSMEKFANGWTYGETFSESAKVQPLMKQYKLLSEK EKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGYTPRAI DMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKVGGGNHPLLVPYDTLTAKEKAKD REKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDG GSRGKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSSASRPLSSGGHASNKEKEMVT SLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVRMALRAFLDNAA EDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILED VQVSCYRILASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYN TKNARDRAVLNLPTSVEEVCPNIPSLMKLMEEIVELAESGIRYTQMPHIMEVILPMLCSY MSHWWEHGPENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQP IISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARD LYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEI NNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGD QELIALAKNRFSMKDTEDEVRDVIRSNLHLQGKLEDPAIRWQMALYKDLPNKTEDSSDPE KTVERVLDIANVLFHLEQKSACVGRGYFFWVEHPQRSKKAVWHKLLSKQRKRAVVACFRM APLYNLPRHRAVNLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKRVDPLH QLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEK EMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKM LDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTC DLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDV IDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMK LSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFF DMFLKLKDLTSSDAFKEYDPDGKGIISKRDFHRAMESHKHYTQSETEFLLSCAETDENET LDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIE IMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTI FEMQLAAQISESDLNERSANKEENEKDNPEEEDPRMGFFSLVTMKSALVALKYNLMTLMK MLSMKSLKKQMKKVKKMTMKDMVMALFSSYWSILVGLLHFACSVVRGFFRIICSLLLGGS LVEGAKKIKVAELLANMPDPTQDEVRGEEEEGERKPTEAALPAEDLTDLQTLTEESDLLS DIFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSLAPMPEVQEKIQEKVKEDEKEEKEETK SEPEKAEGEDGEKEEKTKEDKGKQKLRQMHTHRYGEPEVQESVFWKNIIAYQQKLLNYFA RNFYNMRMLALFVAFAINFILLFYKVSTSAVTEEKELPVVSDGESTKLNILESDDERVIA VHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLY ITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAA LDFSDAREKKKPKKDSSFSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNN FFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKS EDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIV ILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLA NYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14916 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcactgcaactgttcacaaggagcaacagaaattgtgtcttgctgcagaa ggatttggcaacaggctttgctttttggaatccacatctaattctaagaatgttccacct gatttgtccatctgcacctttgtgctggagcagtctctgtcagtacgggccctccaggag atgctggctaacacagaagaaaaggcagaagggctagttgatgtggaaaaatggtctgca caaggtggtggacatcgaacactgctctacgggcatgcaatcctgctgcgccattcctac agcggcatgtacctatgctgtctctctacatctcgatcatcaatggataagctggcattt gatgtaggattgcaagaagacacaacaggtgaggcttgctggtggaccatacatcctgct tccaaacaacggtcagaaggagaaaaagtgcgtgttggagatgatctgattttagtcagt gtctcttcagaaagatatttgcatctctcctatggcaatggtagcttacatgttgatgca gccttccagcagacgctctggagtgtagcaccaatcagttcaggaagtgaagttgcccaa ggatacctgataggaggggatgttctgaggctattgcatggtcacatggatgaatgtttg acagtgccttcgggtgaacatggagaagaacaaagaagaactgtccattatgaaggtggt gctgtgtccattcatgctcgttccctttggcgactagagactctaagagttgcgtggagc ggaagccacattagatggggacagccattcaggctaagacatataacaacaggaaaatat ttaagtctcctggatgacaagagtcttcttcttacagaaaaagagaaggcagatgtaaaa tctacagcattctgttttcggtcttccaaggaaaagttggacatagggacaagaaaggag gtggatggaatgggagcacctgaaataaagtatggggattcaatgtgcttcatacaacat gtagatacaggcttgtggctcacgtaccagtctgctgatgcaaagtctgtaaggatgggt tctctgcagcgaaaggcaataatgcaccatgaagggcacatggatgatggtttaacactg tccagatctcagaatgaagaatcccgtactgcacgtgtcatccgtagtacagtcttcctt ttcaacaggttcataaggggccttgatgctctcagcaagaaagtgaagtcttccaccatt gatttgcctattgagtcagtcagtctgagccttcaggacttgattggctactttcacccc cctgatgaacatttggagcatgaaaacaaacaaaacaggctccgagcactgaagaatcgc cagaacctcttccaagaagagggtatgatcaaccttgttcttgaatgtattgatcgcttg aatgtatacagcagtgcagctcactttgcagatgtagctgggaaggaagctggagaggca tggaaatctattctgaattctttgtatgaattactagcggctctaattcgaggaaatcgt aaaaactgtgctcaattttctggatcccttgactggctgatcagcagattagaaagactg gaagcctcttctggaattctagaggttttacactgcgtgttggtagaaagcccagaagct ctaaacatcattaaggaaggacatattaagtcaattatctgtcttttggacaagcatgga aggaaccataaggttttggatgttttgtgttctctctgtgtttgtcatggagtagctgtg cggtctaatcaacatctaatctgtgataatctcctgccaggaagagatctgctcttacag acacgccttgtcaaccatgtgagcagtatgcgacccaacatcttcttggggattagtgaa ggctcggcccagtacagaaaatggtactatgaactgatggtggaccatctagagcccttt gtgactgcagaatcaactcacctacgagtgggctgggcttcaacagaaggctactcaccc tacccagggggaggagcggaatggggaggaaatggtgttggtgatgacctatattcctat ggatttgatggtctacatctgtggtcaggttgtgtagcacgaacagtaaattctcccaac cagcatctattaagaactgatgatgttattagctgctgtttggacctgagtgcccccagc atctctttccgaataaatggtcagccagttcaaggaatgtttgaaaacttcaacatagat ggcctcttcttcccagttgtcagcttctctgcaggaataaaggttcgtttcttgcttgga ggtcgccatggagagttcaagtttcttcctccacctggatatgctccatgctttgaagct gtcctaccaaaagagaggctgaaagtggagaacagccgagagtacaaacaggatcgtagc tacacaagagacctgttgggtcccactgtctctctctcacaagcagctttcactccagtt cctgtagatactagccagattgttttgcctccccacctggaaaggattagagaaaaatta gcagagaacatccatgaactttgggttatgaataagattgaacttggctggcagtatgga ccagttagagacgacaacaaaaggcaacacccatgcttagtggagttctcaaaattgccg gagcaggaaagaaattataacttgcaaatgtcacttgaaacactgaaaaccctgctggca ttaggctgccatgttggaattgctgatgaacgtgctgaagaaaaagtgaaaaaaatgaaa cttccaaagaactatcagttgttgagtggatataagccagcacccatggatctgagtttt atcaaactgaccccctcacaagaagctatggtggataaactagcagagaatgctcacaat gtgtgggcaagggaccgtataaggcaaggctggacatatggcatccagcaggatgtaaaa aaccgacgaaaccctcgccttgttccgtacgctcttttggatgatcggactaagaagtcc aacaaagacagtcttcgggaagcagtccgcacccttctaggctatggttacaatctggaa gctcctgatcaagatcatgcaacaagactggatgtgtgcagtgggataatggaaaagttc aggatcttccgcacagaaaagacgtacgcagtgaaggctgggaagtggtactttgagttt gaggccgttactgcaggagacatgagagttggctggaccaggcctggttgtctgccagat caggaacttggctcagatgaagaagcttttgtttttgatggctttaaggcacagcggtgg catcaaggtaatgagcattttggccgctcttggttggcaggagatgttgttggatgtatg gttgacatgaatgagcacactatgatgttcaccttaaatggtgaaatcctgcttgatgac tcaggctcagaacttgcgttcaaggactttgaggttgctgatggatttctacctgtgtgc agcctggggccatctcaagtgggaagaatgaattttggaaaagatgtcagcacgctaaaa tatttcactatatgtggcttacaggaagggtatgaaccctttgctgttaatacaaacaga gacatcaccatatggctgagtaaaaggcttcctcagtttctaccagtgccacaaaaccat gaacatattgaggtgatgagaattgatggcaccatagacagctgcccctgtctgaaggtc acgcagaagtcctttggttcgcagaacagtaaaacagatgtcatgttttttcgattgagc atgcccattgaatgtgctgaggtgttctctagatcagctgcaggagggttaccaagctct ggtctttttggcccaaaaaatgacttggaggattatgatgctgattctgattttgaggtt cttatgaaaactgctcatggtcatttagttcctgaccggacagaaagggaaaaagatgcc acaaaaccagagctgaataaccataaagattatgttcaagaaaagccctcacgtcttaag caaagatttatgctcaggaggacaaagccagattatagcatgagtcactctgcacggctt actgaggatgtgctagcagatgatagggatgactatgattatttgatgcaaacttccacg tactattattctgtgagaatatttcctggtcaagaacctgctaatgtctgggtgggctgg attacatccgactttcaccagtatgacacaagctttgacttggacagagtgcgtactgtc acagttacactgggagacgaaaaagggaaggttcatgagagtataaaacgcagcaactgc tatatggtgtgcgcaggagagagcctgagccctggacaaggacgtaataacaatggtctg gagattggttgcttggttgatgctgccagtggcctgctgaccttcacagctaatggcaag gagctaggcacatactatcaggttgaaccaagtacgaagttgtttcctgctgtatttgct caagctacaagccccaatgttttccagtttgaattgggaagaataaagaatgtaatgcca ttatctgctggattattcaaaagtgaacacaaaaacccagtctctcaatgtcccccacgt ctccatgtccaatttttgactcatgtgctttggagcagagtgccaaaccatttcttgaag gtggatgtgtctcggatcagtgaacgtcaaggctggatgatacagtgcatgaatcctttg cagttcatggcccttcatattcctgaggaaaacagaaccattgatattttagagctgaca gaacaagaggaactgctgaaatttcactaccacaccctccgattgtattcagctgtttgt gctttaggcaacaaccgagtggcccatgctctgtgcagccatgtggatgaatctcagctc ctctatgctattgagaataagtacatgccaggattgttacgtgcaggatattatgattta ctcattgacatccatctcaatacctatgcaactgccaggctgatgatgaataatgaattt atagttccaatgacagatgagaccaagagtattactttgtttcctgatgaaaacaaaaaa cacggccttcctggtataggacttagcacttcattacggccaagaatgcagttttcctct ccgagttttgtaagcattagcagtgaatgctttcagttcagtcctgaattccctctggaa attttgaaggccaaaaccatagagatgctgactgaagcggtccaggagggaagcctccat gtcagagatccagttgggggttctacggaatttctgtttgttcctctcatcaagctcttt tataccctactaattatgggaatcttccacaatgaggatctgaaacacatcttgcagttg attgagccccgagttttcaaagaagcagtgagccaggatgatgaagttgatttctcagag aaggagttcagttcagatgagctcaagtcagaagaaggagaagaagaaatcagaggagag caaatgccaaaggaaggactccttcagatgaaacttccagaacctgttaaattgcagatg tgtcacctactccagtacctgtgcgattgccaagtgcgacaccgaatagaagccattgta gcattttctgatgattttgtggccaagcttcaagagaatcagcgcttccggtacaatgaa gtgatgcaggccttgaacatgtctgctgccctgacagctaggaaaacaaaagaatttcga tcccctcctcaagagcagattaacatgctgctgaactttaaagatgataaaaatgattgt ccatgccctgaagaaattcgggatcaactcttggatttccatgaagacctaatgacacac tgtggaattgaactagatgaagatggaaccttggatggcaacagtgattcaaccattagg ggtcgcctcctataccttatggaaaaagttacaaatatgaagaagaaacaagatgagaag acagttgatgaggatgataagacatcctctactctgcagcaattgatttcagacacgatg gtgcgttgggcccaggagtcagtgatagaagacccggagttagtgagggccatgtttgtg ctgctgcatcgccagtatgatggtattggtggtctggttcgagccctacccaagacttac accatcaatagcgtgtctgtggaagacaccatcaatcttctggcatcccttggccaaatc cgctccttgcttagtgtcagaatggggaaggaagaggagaaacttatgattcgtggatta ggagacatcatgaataataaagtattttaccaacatccaaatctcatgagagctttaggc atgcatgaaactgtcatggaagtgatggtgaatgtgcttggtggaggagaatccaaggaa atcactttcccaaagatggtggcaaactgctgtcgttttctatgttatttttgccgcatc agcaggcagaatcaaaaagctatgtttgatcatctgagctatttattggaaaacagcagt gttggcctcgcctctccttctatgcgagggtcaactcctttagatgttgctgcagcatct gtaatggataacaatgaacttgctctggctttaagggagcctgatctggagaaggtggtt cgctacttggctggatgtgggttgcagagttgtcctttgttgatttgtaaaggctaccca gacattggatggaatccagttgaaggagaaagatatttggattttcttcgttttgctgtt ttttgcaatggagagagtgtggaggagaatgctaatgttgtagtcagactgcttattcgc cgacctgagtgttttggtcctgctctaagaggagaaggaggcaatgggctgcttgctgcc atggaggaggcaatacaaatatcagaagatcgaacaagagatggaccttccccaagtaat ggatctagcaaaacccttgaaatagaagagcaggaagatgacactattcacatgggaaat gcaatcatgaccttttatgcggccttaattgatctcttaggacgttgtgctcctgaaatg catctaattcatgctggtaaaggagaagccattagaatcagatcaattctacggtctttg attccacttgaagatttggtgggagtaatcagtattgctttccacatgccaaccatagca aaagatggtactgtggtggaacctgacatgtctgcggggttttgcccagatcacaaggca gccatggttttgttccttgacagggtctatggaattgaggaccaggattttcttctacac cttcttgaagttggctttctgccagaccttcgtgctgctgcctcattagatacagctgct ttaagtgctacggatatggctttggctctgaatcgatatctttgcacagcagtcttgcct ctcctgaccagatgtgctcccctgtttgctggcacggagcaccacgcttccctcatcgat tccttattacacactgtgtacagactctccaagggatgctctcttaccaaagctcagaga gattctattgaagagtgtttgctgtccatctgtgggcagttgcggccttccatgatgcag catttgctgaggagattagtatttgatgtacctctgttaaatgaacatgcaaagatgcct ctcaagttgctgacaaatcattatgaaagatgctggaagtattattgtttgccaagtgga tggggtaactttggtgctgcatcagaagaagaacttcatttatccagaaaattgttctgg ggtatttttgatgctttatctcaaaagaagtatgaacaagaactcttcaaattggctttg ccttgtctgagtgcagtcgcaggggccttacctccagattatatggaatcaaattatgtc aatatgatggaaaaacagtcttcaatggattcagatgggaattttaatcctcaacctgtt gatacctcaaatattacgatccctgaaaagctggaatatttcattaacaaatatgcagag catgctcatgacaaatggtcaatggaaaagtttgccaatggatggacctatggtgaaaca ttttctgaatctgcaaaagtgcaaccactaatgaaacaatataagttactgtctgaaaag gagaaagaaatttatcgatggccaatcaaagaatcactcaaaaccatgttggcatgggga tggagaattgaaagaacacgagaaggagattccatggcactgtataatcggacgcgtcgc atatctcaaaccagtcaaatctctgtagatacagcccatggttacactcctcgagcaatt gacatgagcaatgtcaccctctccagagacttacatgctatggctgagatgatggctgaa aactaccataacatatgggcaaagaaaaagaagctggagcttgaagcaaaagtaggagga ggcaaccatccccttcttgtcccttatgatacactcacagccaaagaaaaagccaaggat agagaaaaagcacaggatattctgaaatttctacagattaatggatatgttgtctccaga ggacttaaggacctggaattagacacgccttccattgagaaacgctttgcctatagtttc cttcagcagcttataagatatgtggatgaagcccatcagtacattttggagtttgatggt ggcagcagaggcaaaggagagcaattcccatatgaacaagaaatcaagttttttgccaaa gttgtgctccctttgattgatcagtattttaaaaatcatcgcctgtatttcttatcttca gcaagtaggcctctcagcagtggaggtcatgcctctaataaagagaaagaaatggtgaca agcctgttctgcaaacttggagttcttgtcaggcataggatttcactgtttggaaacgat gcaacatcaatagtcaactgtcttcacatactgggacagaccttggatgcaaggactgta atgaaaactggtctggaatctgttaggatggcattgagagcatttttggacaatgctgct gaggatctggagaaaacaatggaaaatcttaagcaaggccagtttacacacagcagaaac cagccaaaaggagttacacaaatcattaattataccacagttgctctcctgccagtgcta tcttcattatttgagcatattggacagcaccagtttggggaagatttgatactggaagat gttcaggtctcttgttacagaatattggccagtttatatgctctgggaaccagcaagagt atctatgtagagaggcaacgatcagcactaggagagtgcttggctgctttctcaggggcc tttcctgtggcttttttggaaactcatttgaacaaacataatatctactcaatctacaat accaagaatgcaagagatagagcagttctcaatttgccaactagtgtagaagaggtttgc ccaaacattccttccttgatgaagctgatggaagaaatagtggagctggcagaatccggt attcgttacacacaaatgccacatatcatggaagtcatactgcctatgctgtgtagttac atgtctcactggtgggagcatgggccggagaacaatcctgacaaggctgaaatgtgttgc acagccttgacatcagagcacatgaacactctcttgggtaacatattgaaaatcatctat aacaaccttggtattgatgaaggagcctggatgaagagattagcagtgttttcccagccc atcataagtaaagcgaagccacagctcttaaagacacacttccttccactgatggataaa ctaaagaaaaaggcagcagtggttgtatcggatgaagagcatctaagagcagaaggcaga ggtgacatgtcggaggctgaactgctcatcctagatgagttcaccactttggcacgggac ctctatgccttctaccctttgttgattagatttgtggactataacagggcaaaatggctg aaagagcccaatcctgaagcagaagagttgttccgcatggtggctgaggttttcatttac tggtcaaaatctcataatttcaaaagggaagagcagaactttgtggtacaaaatgaaatc aacaacatgtctttccttatcagtgacaccaaatctaagatgtcaaaggcagcagtttct gaccaggaaaggaagaagatgaagcgaaaaggtgaccgctactctatgcagacctctctc attgtggcagcactgaagagattgcttccaataggcctaaacatttgtgctcctggagac caagagctaattgcactggccaaaaatcgttttagcatgaaagacactgaagatgaagta cgagatgtcatccgcagtaatcttcaccttcagggcaagcttgaggatcctgccattaga tggcagatggcactttacaaagatttgccaaacaagactgaagattcctcagatcctgag aagactgtggaaagggtccttgatatagctaatgtgctgtttcacctggaacagaaatct gcttgcgtgggccgaggctatttcttttgggttgagcatcctcagcggtccaaaaaagca gtatggcataaactgctgtctaagcagaggaaaagagcagtagtggcctgctttagaatg gcaccgttgtataatcttccgagacaccgagccgtcaatctctttcttcaaggctatgac aaatcttggattgaaacagaagaacactatttcgaagacaaactgatagaagacttagca aaacctggagaggaaccaccagaagaagatgaaagccttaaaagagttgatcctttacat cagcttattctgctattcagtcgaacagccttgactgaaaaatgcaaattggaagaagat ttcctgtatatggcttatgctgacattatggcaaagagctgccatgatgaagaagatgat gatggtgaagaagaagtgaagagttttgaagtgacaggatcacaacgcagcaaggaaaaa gaaatggaaaagcaaaaacttctgtatcaacaagccagactgcatgatcggggtgctgct gagatggttctgcagacaatcagtgcaagtaaaggcgagatggggccaatggttgcagca accttaaaactaggaattgccatcctaaatggaggaaattctactgttcaacagaaaatg cttgactacctcaaggataaaaaggatgtggggttctttcagagccttgctggtcttatg cagtcctgtagtgttcttgacctaaatgcgtttgaacgtcagaataaagcagaaggcctt ggcatggtgactgaagagggatcaggagaaaaggtgatgcaggatgatgagttcacctgt gacctcttccgcttccttcagttgctttgtgaaggacacaattcagattttcagaattac ctgagaactcaaactggtaacaacacaactgttaatattataatttctactgtggattac ttattgagagttcaggagtccatcagtgatttctattggtattattctgggaaggatgtt attgatgaacaaggacaacgaaatttttccaaagccatccaggttgcaaaacaagttttc aatactctcacagaatatatccaggggccatgtaccggtaatcagcaaagtctggcacac agcaggctgtgggatgctgtagttggtttccttcatgtgtttgcccacatgcagatgaag ctctctcaggattccagtcaaattgaactattgaaggaattaatggatcttcagaaagat atggttgtcatgttgctgtctatgctggaaggtaatgtcgtgaatggaactattggaaag cagatggttgatatgcttgtggaatcgtcaaacaatgtggagatgattctgaagtttttt gacatgttcttaaaattgaaagatttgacttcctctgatgcattcaaagaatatgaccct gatggtaaagggataatttcaaagagggattttcacagggcaatggaaagccataagcat tacactcagtctgaaacggagtttctgctgtcatgtgctgaaacagacgagaatgagact ttggactatgaggagtttgtgaaacggtttcatgagcctgcaaaagacattggtttcaat gttgctgttctcctgaccaacctgtcagaacacatgccccatgatacgcgtttgcaaact ttcctggagctctcagagagtgtgctgaattactttcagcctttcctcggacgtatagaa atcatgggcagtgcaaagcgcattgaacgagtttattttgaaataagtgagtcaagtcgg actcagtgggaaaaacctcaggtaaaagagtcaaagagacagtttatatttgatgttgta aacgaaggtggggagaaagaaaagatggagctttttgttaacttctgtgaggatacgatt tttgaaatgcaactggctgcccagatctctgagtcagatctgaatgaaaggtcagctaat aaagaggagaatgagaaagacaatcctgaggaagaagatcctagaatgggtttcttctct ctcgtgaccatgaagtcagctttagtagctctcaagtataatttaatgactcttatgaaa atgctcagcatgaagagtctaaagaaacaaatgaaaaaagtgaagaaaatgaccatgaag gacatggtcatggctttgttttcttcctactggagcattttggtgggcttactacatttt gcttgcagtgttgtccggggtttttttcgcatcatatgcagtttgctgcttggaggaagc ctagtggaaggagccaagaaaatcaaggtggctgaactgttggctaatatgccagatccc actcaggatgaagtgcgtggggaagaagaagaaggggagaggaaaccaacggaagctgca ttgcctgcagaagacttgacagatctgcagactctaacagaagagagtgatctactctca gatatatttggtttggatttgaaacgagaaggtggacagtataaattgatccctcacaat ccaaatgctggtttgagtgatttactgagcactccctccttagccccaatgcccgaggtg caggaaaaaatccaggagaaggtgaaagaagatgaaaaggaagagaaagaagaaacaaaa tcagaacctgaaaaagctgaaggagaagatggagaaaaagaagagaaaaccaaggaagac aaagggaaacagaaattaagacagatgcatacacacagatatggagaaccagaagttcag gaatcagttttctggaagaatatcattgcatatcagcagaagcttcttaattattttgca cgaaacttttacaacatgaggatgttggcgttatttgttgcttttgccatcaacttcatc cttcttttctataaggtctccacatctgctgtgacagaagaaaaggagcttcctgtggta tctgatggtgaaagtaccaagttgaacatcctggaaagtgatgatgagagggtcattgca gtgcattatgtcctggaagaaagcagtggctacatggagcccacactgaggattttggcc atcctacacacagtcatctcattcttctgcatcatagggtattattgtttgaaagttcca ctggttatttttaagagagaaaaggaagtggcaaggaaattggaatttgatgggctgtat ataactgagcagccatcagaggatgatattaagggacagtgggatagacttgtaatcaac acacagtcttttccaaataactattgggacaagtttgtgaaaagaaaggtaatggataaa tatggtgaattctatggccgtgacagaatcagcgaattactcggaatggacaaagctgct cttgattttagtgatgctcgagaaaagaagaaaccaaagaaagatagctccttttctgct gtgctaaattccattgatgttaaatatcagatgtggaaattaggagttgttttcactgat aattctttcctttacctagcatggtacatgaccatgtcagtccttggccattacaacaat tttttctttgctgctcatctccttgacattgcgatgggattcaagacattgcggactatc ctgtcatcagttacccacaatggcaaacagcttgtcctaacagtggggttactggcagta gtagtatacttgtatacagtagtggcattcaattttttccgcaagttctacaacaagagt gaagacggtgacatgccagatatgaaatgtgatgatatgctaacatgctacatgtttcat atgtatgttggagtacgtgcaggaggaggcattggtgatgaaatagaagatccagcagga gatgaatatgaaatctatcggattatctttgacatcactttcttcttctttgtgattgtc atcctgcttgcaattatccaaggtttaattattgatgcttttggtgagttaagagatcag caagagcaagttaaggaagacatggagacaaagtgctttatctgtggaataggaaatgac tactttgatacggtgcctcatggctttgaaacacacacactacaggagcacaacttggcc aattatttgtttttcctgatgtatcttattaacaaagatgaaactgaacatacaggacag gaatcatatgtatggaaaatgtatcaagaacggtgctgggaattttttcctgctggtgat tgcttccgaaaacaatatgaagaccagctcaactaa

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