Petromyzon marinus (sea lamprey): 116941682
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Entry
116941682 CDS
T09614
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
pmrn
Petromyzon marinus (sea lamprey)
Pathway
pmrn00270
Cysteine and methionine metabolism
pmrn00480
Glutathione metabolism
pmrn01100
Metabolic pathways
pmrn01240
Biosynthesis of cofactors
pmrn04216
Ferroptosis
Module
pmrn_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
pmrn00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
116941682 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
116941682 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
116941682 (GCLC)
Enzymes [BR:
pmrn01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
116941682 (GCLC)
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Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
116941682
NCBI-ProteinID:
XP_032808893
UniProt:
A0AAJ7T2B4
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Position
12:13101050..13134555
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AA seq
631 aa
AA seq
DB search
MGLLSQGSPLSWADTKKHADYVREHGVRQFINIYNRLKERQGDVLKWGDEVEYILVAFDH
SAQRARVLLKGEDVVETLQALGENVNPNHPSLWRPEYGSYMVEGTPGQPYGCTMADFNTV
ESNMRLRRKEVLAQLRSNETIFSITTFPRLGCPGFTVPEFEPKQDEAGASKSLFFPDQAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKKTPSPFVDHFSNDDGEAARAAKPNHIYMD
AMGFGMGNCCLQVTFQACSIAEARYLYDQLAPLCPIMMALSAAAPFYRGYVSDVDCRWGV
ISASVDDRTREERGLEPLKTCKFRISKSRYDSIDSYLSQCGAKYNDIELTKDEAVYQQLL
DAGIDHLLAQHIAHLFIRDPLTLFEEKIYLDDEHESDHFENIQSTNWQTMRFKPPPPNST
IGWRVEFRPSEAQLTDFENSAYVVFVVLLTRVILSYNLNFLIPLSKVDENMKKAQKRDAV
RQEMFYFRKDIGAVCNPVLDSCPPCANGTDSQDESYILMSVDTIINGKEGVFPGLIPIIN
SYLENMEVDVETRCSIYNYLRLIRKRASGELMTMARWLREFVGAHPEYRHDSVITDRINY
DLLVHCDDIARGKADCPELFDKPIHKPPEHS
NT seq
1896 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctcagctgggccgacaccaagaagcatgcggac
tacgtgcgcgaacacggagtgcggcaattcatcaacatctacaaccggctcaaggagcgc
cagggtgacgtgctcaagtggggcgacgaggtggagtacattcttgtggcgtttgaccac
agtgctcagagggcacgcgttttgctaaaaggggaagacgtagtggaaactctgcaagcc
cttggcgagaatgttaatccgaaccacccgtcgctgtggcgccccgagtacggcagctac
atggtggaaggcaccccgggccagccgtacggatgcaccatggccgacttcaacaccgtc
gagtcgaacatgaggctacgccgcaaggaggtgctcgcgcagctgcggagcaatgagacc
atcttctccatcaccacctttcccagacttggctgtcctggattcacggtgcccgagttt
gagcccaagcaagatgaagcgggggcttccaagtccctctttttccctgaccaagccatc
aacaagcaccccaggtttagtacgctgacaagaaacattcgacacagacgtggagaaaaa
gttgtgataaatgtcccaattttcaaggacaaaaagactccatcgccgtttgttgaccac
ttctccaacgacgatggcgaagcggcacgtgcagccaaacccaaccacatctacatggac
gccatgggcttcggcatgggcaactgttgtctgcaggtaacattccaggcatgcagcata
gcggaagcgaggtatttgtatgaccagctggcacctctctgccccatcatgatggctctc
agcgctgctgccccgttctatcggggctatgtgtcggacgtcgactgccggtggggcgtc
atctcggcttcggttgatgaccgcacgcgagaggagagaggcctggagcccctaaaaacg
tgcaagttccgcatcagcaaatcgcgttacgactccatcgacagctacctctcccagtgc
ggagcgaagtacaacgacatcgagctgaccaaggatgaggctgtttaccagcagctgctg
gatgctggcatcgatcacctgctcgctcagcacattgcccacctgttcatccgggatccc
ctcaccctgtttgaggagaagatttacctcgatgatgagcacgagtccgaccactttgag
aacattcagtcaacaaactggcaaaccatgcgattcaagccacccccgccaaactctaca
attgggtggcgtgtggagttccgaccatcggaggcacaactcacggactttgaaaactca
gcctacgtggtgttcgtggtgctgctcacgcgcgttattctatcctacaacctcaacttc
ctcatcccactctcaaaggtcgatgaaaatatgaagaaggcacagaagagggatgcagta
cgccaggaaatgttttacttcagaaaggacattggggcagtgtgtaacccagtactggac
agctgtccaccctgtgccaatggaacagattctcaggatgagtcgtatatactcatgagt
gtcgacaccatcatcaacgggaaggagggggttttccctggtctcatccccatcatcaac
agctacctcgagaatatggaagtggatgtggagacacgatgcagcatttacaactaccta
aggcttatccgcaagcgggcatcaggcgagctgatgacaatggcgcggtggctgcgcgag
tttgtgggcgctcaccccgagtacaggcacgacagcgtcatcaccgatcgcattaactat
gacctgcttgtacattgcgacgacattgcgcgcggaaaggcggactgtccagagctcttc
gacaagcccattcacaagcctcctgagcacagctaa
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