Petromyzon marinus (sea lamprey): 116953421 Help Entry 116953421         CDS       T09614                                  Symbol MDN1 Name (RefSeq) midasin isoform X1   KO K14572   midasin Organism pmrn  Petromyzon marinus (sea lamprey) Pathway pmrn03008   Ribosome biogenesis in eukaryotes Brite KEGG Orthology (KO) [BR:pmrn00001]  09120 Genetic Information Processing   09122 Translation    03008 Ribosome biogenesis in eukaryotes     116953421 (MDN1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03009 Ribosome biogenesis [BR:pmrn03009]     116953421 (MDN1) Ribosome biogenesis [BR:pmrn03009]  Eukaryotic type   Pre-60S particles    Other pre-60S particles     116953421 (MDN1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AAA_5 AAA_lid_7 AAA_lid_5 AAA AAA_3 AAA_22 AAA_7 AAA_16 TsaE nSTAND3 ABC_tran NACHT Sigma54_activat AAA_6 Sigma54_activ_2 AAA_14 DUF815 AAA_25 AAA_29 bpMoxR MDN1_4th AAA_33 PduV-EutP AAA_8 VWA ATPase HEAT FtsK_SpoIIIE Motif Other DBs NCBI-GeneID:  116953421 NCBI-ProteinID:  XP_032829499 UniProt:  A0AAJ7U5F5 LinkDB All DBs Position 51:complement(3648507..3731302) Genome browser AA seq 5699 aa AA seqDB search MDLVAVPMDAVLRLASVSDQCRAGLGHLAGRPQQQAWSPSERGALLDTLSALLLEPDSTL HVARALRPLLPVLLERLGEESERRGEESEQETRESKASNRWMGFHERFCVALGKLLPLSP DAVQFAERYFKTAPPAFVRLGHGGAAPAKEKGKRKRSKLIPLADLMEASYRLLKGCHTVL SDQWDWSVCVPLLQDPDSRVRWYTANCLALLCAMSDRQRMQFLCRVLSEDELISHRIALM EESAAEVAEGALTLVASDCPLWSRGVLPQGPRASTGSEFLSSDLSERVVPVCGVVLPRSG HREGTAGQTPCPLVPVPSTCALLRALASAVASRRAALIEGPVGCGKTALVERLAALTGRT APPGLLTVQLGDQTDSRTLLGMYRCTDVPGEFTWRAGALTQAVSRGDWILLEDIDYAPLD VISVLIPLLESGVLSVPGRGDCVRAAPGFQLFATRRLHGATLRRHALGSHDTLLDKACTR VRVECMARPELKEVLMSRFSLPSPAAERLLLIYCQLTGDEVDSCAGTEGPQMTPAQPRRL NMEGRVISLRDLLKWCQRVAHLFKGTAEANALCIFQEALDCFCAVLSQPENRQMLAEIIG FQLNIIREKVEFFCRHYKPEIVVTETTVTVGRATLPRQLREAVTLTRDAATFAATRPSAV LLEQVVVCVAREEPVLLVGETGTGKTSTVQHLATSLGRTLRVINMNQQSDTADLLGGYKP VDARRLVKPLREAFEELFVRSFSSRQNSTFLGHLQTCVRQKRWSDLVRLMLHVQAKACGR NGEHGDGTALHAQWEALGLRLAQIQRQMKVAEKTLLFSFVEGSLAQAVRAGDWVLLDEIN LASAETLECLSGLLEGSRGSLVLLDRGDTEPISRHPDFRLFACMNPATDVGKRDLPPGIR NRFTELYVDEIEDTGDLGILISDYLKGLNVTRPTIQGIISFYLAVRKVARESLVDSTGHR PHFSLRTLCRALQYAARNPCGNLARSLYEGFCLSFLTQLDRGSHPVVENLVCKHVVGTRI VKALLKQPLPDPCPGKFVQVEGYWLPLGDKEVALDPSYILTASVRQNLKDIARVVAAGRH PVLLQGETSVGKTSLVRWLAGATGNACVRINNHEHTDLQEYLGSYVSDRDGRLVFREGLL ITAMRRGHWIVLDELNLAPTDVLEALNRLLDDNRELLVAETQEVVRAHPRFTLFATQNPP GLYGGRKVLSRAFRNRFVELHFDELPSSELQTILHQRCHLPPSYCAKLAAVMADLQAHRR GSSVFAGKHGFITLRDLFRWAERYRLAEHGDKTYDWQLHLANDGYMLLAGRVRKEEEASV IRSVLEKNFKRKINPAQLFSLESLRQMLDARASVGGRGPELPEEFRHVVWTSGMRRLAVL LGRALRFKEPVLLVGETGCGKTTLCQIFAALAGQKLHTVNCHLHMETSDFLGGLRPVRHQ TSAQEGDSQRLFEWHDGPLVLAMRNNGAFLMDEISLADDSVLERLNSVLEVEKSLLLAEK GSGEDGEEVELVMAGETFCILATMNPGGDFGKKELSPALRNRFTEIWCPQTSERDDMMQI VRHNLAPSLSPGSPLAQGVDVAASMLDFIAWLSSQDFGRRCVVSARDLLAWALFVNAASG ARGDEGAGAREPLDVPCAFAHGACLVYVDAIGSGTTAGSSDVVAEARASCLCFLRKLLCA AGATLGPAALTLLAPGEGEQRAKEQLGPRWSSGSFGVPPFHIPTGPLGPSSRLPDYALDA STTARNAQRVLRALQLGKPVLLEGSPGVGKTSLVAAVARAAGHELVRINLSEQTDVTDLF GTDLPVEGGQGGQFAWRDGPLLAALKAGHWVVLDELNLASQSVLEGLNACFDHRAEVFVP ELGMTFHVQRDSTRIFGCQNPLRQGGGRKGLPRSFLNRFTQVYVDEMSGGDMEFIANAMF PNIGSHIVAKMVEFNNKMVQAVTAERRWGQRGGPWEFNLRDVFRWCQLLEADQDPGRYSP GRHVALVYADRMRSAEDRDKVYELYREVFTEEEDLLEESLHLHVTPALVQAGFSCLRRHS RGVPGSGVGALAGPHALQLLPGCVPRLSPLLRCVERGWMVLLVGPAGAGKSALLSSLATL AGRRLRVMAVNSDMDTTELLGGFEQVDARRPWLALLADARDAVASLARAALPASSQHAER LLRLRTSLLAIGGGATPEVTVSDVETLHSILGEVELVNGDHRALSATVLSDLRERLGNFQ RRFCSSPLSTAAGSRAGGAGSAGEVGGGGGAFEWVDGVLVEALRAGDWLLMDNVNFCSPS VLDRLNALLEPGGVLTISERGVIDGTVPTIVPHPDFRLFLSMDPVHGEISRAMRNRGVEI FLPVVAMPPEPGPEPTAAVDTEMAMDVEVPAERCAGTGEGGEPQGRAATPCLAGGGGEAA ERARIAEMDLKLMLLGLGVVADSLASQLIALHRQMGSSLLGGCPLSQLLQAAALLVQQLH RGQGLHSAFVSACADVYASTQPSPSTRQWALETVEAHAAHVTCDEPQLLAPGRYPEPVPS VASLARDASLCTVRRDGALLLHCLAAAGQRGYALTLGDLRRSIGVVGLPNDQPGVPTAAP STPPTDNSALLPFAARLVAERASPQDWLLRVRWLNDLANGDAINAGQVGTVLRAASEALD SVSKTGLVSRIVACQQHLAQQAGDSSSLADFPLDIRWNLQYLEVVSNRARRAGLDPCPAQ LFSLANRMSLLLERRAKSYVESLALESGLRTFKDLNSSVLKTSYALSKGALGSESLPHPA VAFVFPFLSLWDDWLGRWASGGKEEVSDEDLTKLLQSVRRRDWFWEACEVTSCEQGMLGM LALHWHWLRKAGCGDEALLPSGCPAELKTMVSALDQHLGRPDARHSALSRMRKSLGWPLP FKQREAVEVALGLSEAWNRLCTPLAHAPRSPEEALIALTRLRAVCDRAGPAHGDGVRSAL TRVWEQLLLLQHGGAEVGAEALRELTSSWTTLKQGVLERALEAGDTGVPGDAADDAALLA LESRVQLWPVLEQLALRSQCRLVAALLNVPTSDSVGEEPPWGAGEDVRHLVSFSSRFTPS CPRQLGLLRGLLGLPSRQVLPSVRWDLLLAALSQLWCNTAASRPELWLGWKSRTDLQDSP KSTQSLSPAFGEILKGPGVLSCAALSGCLFRILGNDGHWSPQEDPAGHVTLGAWQQRTQQ LEVVGRVAWCNMSSAALPDFTEGDRRLLRSVLRVLLSRAAESLGPASEPTATALGDRGEA SAGDEERLADAAARCLRGASALPADVAELLEDCVASLGDSCSRDAPGGGQKELLHRAELW AKLGLVAVLTWRPRTHFDPMVKRAQKLRHTEEELHELESEWRARETLSHIVSGRDLRVDS HCHPRIRFVQQRMEVLRTRVHELSKKQAHRPEPRAYERLSRDVAHFVSSICQPQRALRLL ARITESLSRPAETASASASLLREEAAWQTSLERFRARLAEGYAGFPDVVTPLLCGVAQLQ HGVRLAATELRRVGAADRSAASLVPSLVSCLAKLPSVSAEFPSFLAHADALSRRDASRAV ADALGRAGEGGAGVVGAGGEGSEVARRATERLVVLALLFLRNHMRLRGEMDAASLGLLQH LLQVVVNAFDDQERRAAERAQQQASVFRYRSQGHGSGLSPEEQEERDFRRRFPQHDQDFA DLTATLSLDGCGEAAPRPNGTDGGDDDAGDGGDGGSPLVSEECSRVAVLVHAEAFRGLTH TAWYRPSGATAHPPPDHMATFAAAYQLAGTVMAQAYPVVDASLERDTMCAHLLMSKLIRD NVAESPGGPDVVESSRAHYDFYHSPNAAQALQCLLPLKAFTVRVSQLLDEWPEHPTLSQL VIVMTRILGFSLSSPLSKFLYGLELLLAKAQDWESNASRSVSLRPHLDAITQLIIQFRKL ELSCWAQCLDNVASRCAEKTNVSWFSLHQLVENGVSAEDSPLASVASTLQAFMEGATLGE FPCRLDLLLSFHCQAVHLPPSASREALLGLLWNLHQYYSQFSESVHSALAQKRKAIEKEL KDFVKICRWNDASFWAMKEAVNKTHRTLFRFSRKFEEALSEPCRPALTEPGPAVAADAAQ SHDSVAVVTLLRNQRSWVSPSLQDVAPGDEDSPQESLQGRLPVLSARTWKFCKKLRRESS LPDLIQGLDQFTGEVASSVREMQVLSVNPASDKDKQRSEAKQIQQQKQRALAELFRLLRR AGLSYRKGLTVARISSDDEWMSLPPVDVPTALRDAPLGESLKGMVEHVERSWTDCQRYFY RSVARRCSLRTVLTAPSKDMGPGNLDRCRGFSEHLLQMLVAHRKQLTTLTEQHMALRQLI RAMEKVGGGPAAGEAVAAVAPPVEEARRRASGLLRVSAQALTVLEQTRLVLRCCPQHDHG SGDAESGAPGGQAWGVPSPVAPSRLPPAASLVRDSAAWVAAERLVSRLLGEVAAVKSAAA AVAAVAAAPGHIVGPTATHVLTWEEVDRCGAGLTTLGSVTSQMGDLQRLFTPPGEQCSSA EQRSPVADSIAFVREEVQRELADFTTWRTQTLSLQSAADGDLADAASQALVDVFSADVEG AITAVLCAVQTLVARAKEDREEQKRADGVKGGDAGGELGDGGGTGGGDGESEEGAEPPLR VDHISAALEGRLWADVRSLALPRVLALASQLLQRILKPGVGAQAALRCRRRLSRALPLLG AYADLASFYLVASVASHRALAKLLCVLLGLFTELVHKGFCQPAELTEGEAGEGSGKFQDV EGGGIGAGEGVKDVSDQIENEDQVEDTFQRDQQHEEEPEQQSELNDEENAIEMSEDFQGK LHNGELGDSDDEGKSDEEEKEELDKQMGNLGEGPSETLDERMWGDNEEGDEDGDEGQQEE SGPGMDEEESELVAQGDNEESGENKRKDDKKREQQQGEEEEGMDEGEEGEEKKKINEQKD ERDFDENESDPYQNQQKPCDPEPLELPDDLALDKDQEGEEGGDQSEEDESGDNPLEIEER PMELDKEKDSGKGTEEGEAGERQEEEASADAGTQQAEEEEEEEKEQGAEDSEKEAMENEA NSDEVKEEDEEGEGGEERGEGAEASGETEEGDADEDKKQGEEADKEDERREETTAGTSDR GMEPKGEEEGEEDEEAAEERAERATDGEAADGSLQSELALERAGSTAQEEQGKEEYGTGA AESCEAEGHESDRVAPLASRRDTRDNTQSYKRKPGETNERRTLGDREHDSRANKRLKTVD AEERTERQGDAEEKARDEDAELYQHMPEPSGQHDRVTFDAATLEQQELSRAVTDGAEQQE DEGTDDAATDEVPPPDEADDAVDEELRAVEAKEMTAQDKPASCSVPGKESAEPSSELEGA TKEDGDVEMTEIEPGSGPTERSRESTFHTSLTALTETDPQSVEVIRQQLEQQLEVWRHPT DERLEEARVASEAWQRYIHLTSPLAQQLCEHLRLILEPTQAAKLRGDFRTGKRLNMRKVI PYVASGFRKDKIWLRRTQPSKRRYQVCVAVDDSSSMLDNHSKQLAFESLAVIGNALSLLE VGQIAVCSFGETMRLLHPFHEPFTEQGGAAVLRSCTFQQKKTHIAQFLEEVTRMFLSARQ NQQSGIKGALETSQLLLVVSDGRGLFLEGKQRVQAAIRAARDAGVFLIFVALDNPDSKDS LLDIKVPIFGGPGTLPEIRSYMDEFPFPFYVVLRDVNALPETLSDALRQWFELVTASDH NT seq 17100 nt NT seq  +upstreamnt  +downstreamnt atggacctcgtggcggtgccgatggacgcggtgcttcgcctggcgagcgtgagcgatcaa tgccgagccggcttgggccacctcgctggccggccccagcagcaggcttggtcaccctcc gagcgcggggctctgctggacactctctcggcgctgctgctggagcccgactccacgctg cacgtggcacgggccctgcgcccgctgctgcccgtgctgctcgagcgtctgggggaagag tcggagcgtcgcggggaggaatccgaacaggagacgcgagagtcgaaagcctcgaatcga tggatgggcttccacgagcgcttctgcgtcgcgctggggaaactcttgccactgagccca gatgcggtgcagtttgcggagcgatatttcaaaacggcaccgcccgcatttgtgcggctc ggccatggcggtgcagcgcccgccaaggaaaaggggaagagaaaacgatccaaactcatc cctctggccgacctgatggaggcctcgtataggctactcaagggatgtcacacggtgctc tccgaccaatgggactggagtgtgtgcgtgccccttttgcaagatccagacagccgtgtt cgatggtacacggccaactgcctggcgctgctctgcgcgatgagcgaccggcagaggatg cagttcctctgccgggtcctcagcgaagatgagctcatctcccaccgcatcgcgctgatg gaggagagcgccgccgaggttgcggagggagccctgacgctcgtggcgtctgactgcccc ctctggagccgcggggtgcttccccagggtcctcgtgcgagcacggggagcgagttcctc tccagcgacctctcggagcgcgtcgtgcccgtgtgtggcgtcgtgctgccgcggagcggg cacagagagggcacggctgggcagaccccgtgcccgctggtgccggtcccctctacgtgt gcgctgctgcgggccctggcgtcggcggtggcctctcgccgcgccgctctcatcgagggc cccgtgggctgcggcaagacggcgctcgtagagcggctggcggcgctgaccggacggacg gcgccgcccggactcctcaccgtgcagctcggggatcaaaccgacagccgaacgctgctg ggcatgtaccgctgcacggatgtcccgggggagttcacgtggcgagcaggcgccctgacg caggccgtgtcgcgcggcgactggatcctgctcgaggacatcgactacgccccgctcgac gtgatctcggttctcatcccgctgctggagtcgggcgtgctgtccgtgcctgggcggggg gactgcgtccgcgcggcgcccggtttccagctgttcgccacgcggcgcctgcacggggcc acgctgcgccgccacgccttgggctcgcacgacacgctgctcgacaaggcgtgcacgcgc gtgcgcgtcgagtgcatggcgcgcccggagctcaaggaggtgctgatgagccgcttcagc ttacccagccctgctgccgagcggctgctgctcatctactgccagctgacgggagacgaa gtggacagctgtgcgggaacggagggaccccagatgaccccggcacagccgagacgcctc aacatggaggggcgagtcatctcgctgagggacctcctcaagtggtgccaacgcgtcgcc catctcttcaagggcacggctgaagcgaacgcgctctgcatcttccaggaggcgctggac tgcttctgcgcggtgctgtcccagcccgagaaccggcagatgctggcggagatcatcggc ttccaactcaacatcatccgcgagaaggtggaatttttctgtcgccactacaagcccgag atcgtcgtcacggaaaccacggttacagtcggacgagcgacgctgcctcgacagctgaga gaggccgtgactctgaccagggacgcggcgacgtttgcagcgacgcggccctccgcggtg ctgctggagcaggtggtggtgtgcgtggcacgcgaggagcccgtcctgctggtgggcgag accggcacggggaagacgtccacggtgcagcacctggccaccagcctcggtcgcaccctc cgagtgatcaacatgaaccagcagagtgacacggctgacctgctgggaggttacaagccc gtggacgcgcggcgcctcgtgaagccgctgcgcgaagcattcgaggagctgttcgtgcgc agcttctcgagccgccagaactccactttcctgggccacctccagacgtgcgtgcggcag aagcgctggagcgacctcgtcaggctcatgctgcacgtgcaggccaaggcgtgcggccgc aacggcgagcacggcgacggcaccgccctccacgcccagtgggaggccctgggactccgc ctcgcgcagatccagaggcagatgaaagtggccgagaaaaccctgctcttcagcttcgtg gagggcagcctcgcgcaagcggtgcgcgcgggtgactgggtgctgctcgacgagatcaac ctggcgtcggcggagacgctggagtgtctgagcgggctgctcgagggcagccgcggctcg ctggtgctgctggaccgcggcgatacagagccaatctcgcgtcacccggacttccggctc ttcgcctgcatgaacccggccacggacgttggcaagagggaccttcccccaggaatacgg aaccggttcacggagctctatgtggatgagatcgaggacacgggagacctgggcatcctc atctcggactacctgaaggggttgaatgtcactaggccaaccatccagggcatcatcagc ttttacctggccgtgcgcaaggtggcacgggagagcctggtggacagcacaggccaccgg cctcacttcagcctccgcacgctatgccgtgccctgcagtacgccgccaggaacccatgc ggcaacctcgcgcgctccctctacgagggcttctgcctgagcttcctgacgcagttggac cgagggtcgcacccggtggtggagaatctcgtgtgcaagcacgtcgttggcacccgcatt gtgaaggctctactcaagcagcccctcccggacccttgtcccggaaagttcgtgcaggtg gagggctactggctgcctcttggggacaaggaggtggctctcgatccctcgtacatcctc acggcctccgtgaggcagaacctcaaggacatcgcccgtgtcgtggcggctggccgtcac ccggtgctgctgcagggagagacgtcggttggcaagacgagcctcgtgcgctggctggcg ggcgccacgggcaacgcgtgcgtgcgaatcaacaaccacgagcacacagacctgcaggag tatctgggcagctacgtctcggaccgcgatggcaggctcgtcttcagggagggcttgctg atcacggcgatgcgtcgcggccactggatcgtgctggacgagctgaacctggcgcccacc gacgtgctggaggcgctcaaccgcctcctcgacgacaaccgtgagctgctcgtggccgag acgcaggaggttgtgcgcgcgcacccgcgcttcacgctgttcgccacgcagaacccgccg ggcctctacggcggtcgcaaggtcctgtcgcgcgcgttcaggaaccgcttcgtggagctg cactttgacgagctgccgagctccgagctgcagaccatcctgcaccagcgctgtcacctg ccgccctcctattgcgccaagctcgctgccgtcatggccgacctgcaggctcaccggcgc ggctccagcgtgtttgccggcaagcacggcttcatcaccctgcgcgacctcttccgctgg gccgagcgctaccgcctggccgagcacggcgacaaaacctacgactggcagctgcacttg gccaacgacggctacatgctgctggcggggcgcgtgcgcaaggaagaggaagcgagcgtc atacggagcgttctggagaagaactttaagaggaagatcaacccggcgcagctcttttcc cttgagagcctgcggcagatgctggatgcgagggcgtcggtcggcgggcgcggtccggag ttgccggaggagttccggcacgtggtgtggacgtccggcatgcgccgcctcgccgtgctc ctgggccgggccctgcgcttcaaggagccggtgctgcttgtcggagaaaccgggtgtggc aagaccacgctgtgccagatcttcgccgcgctcgctgggcagaagttgcacaccgtcaac tgccacctgcacatggagacgtccgacttcctgggtggccttcgtcccgtgcggcaccag acgtcggcccaggagggcgacagtcagaggctgttcgagtggcacgatggaccgctggtg ctggccatgcggaataacggcgcgttcctcatggatgagatctcgctggcggacgactcg gttttggagcgcctcaacagcgtgctggaggtggagaagagcctcctgctggccgaaaag gggagcggcgaagacggcgaggaggtggaactcgtcatggccggcgagacgttctgcatc ctcgccaccatgaaccccggcggagacttcggcaagaaggagctctcgccggcgctgcgg aaccgattcacggagatctggtgtccgcagacgagcgagcgcgacgacatgatgcaaatc gtgcggcacaacctggctcccagcctctctccgggctccccgctcgcgcaaggcgtggac gtggctgcctccatgctggacttcatcgcgtggctctcgagccaggactttggccgtcgc tgcgtggtgagcgcccgtgacctcctcgcctgggcccttttcgtgaacgcggcgagcggg gcccgcggggacgagggggcgggcgcgcgagagccgctcgacgtgccctgcgccttcgcg cacggcgcctgcctcgtctacgtggacgccatcggctccggcacgacggcggggtccagc gacgtcgttgcggaggctcgggcctcctgcctgtgcttcctccgcaagctgctgtgtgcc gcgggcgccacgctcggccccgcggcgttgaccctgctggcgccgggagagggggagcag cgggccaaggagcagctgggcccacgctggagtagcggctccttcggggtgccgccattc catattcccacgggacccctggggccgtcctcgcggctgcccgactacgcgctggatgcg agcacgacggcgcggaacgcccagcgcgtgctgcgggcgctgcagctcggcaagccagtg ctgctcgagggatcgccgggcgtcggcaagaccagcctggtggcggccgtggcgcgcgcc gcggggcacgaactcgtgcgcatcaacctgtccgagcagacggacgtcaccgatctgttt ggcacggaccttcccgtggaggggggccaggggggccagttcgcgtggcgtgacgggcct ctcctcgccgccctcaaggccggtcactgggtggtcctggacgagctgaacctggcgtcg cagtcggtgttggaggggctcaacgcctgcttcgaccaccgcgccgaggtgttcgtcccc gagctgggcatgacgttccacgtccagcgcgacagcacccgcatcttcggttgccagaac ccgctgaggcagggcggcggcaggaaaggcctgccccgctccttcctcaatcgcttcact caggtgtacgtggacgagatgagcggcggcgacatggaattcatcgccaacgctatgttc cccaacatcggcagccacatcgtcgccaagatggtggagttcaacaacaagatggtgcag gcggtgacggcggagcggcgctggggccagcgcggcgggccctgggagttcaacctgcgc gacgtcttccgctggtgccagctcttggaggccgaccaggacccgggccgctactcgccg ggccgccacgtggcgctggtgtacgccgaccgaatgcggagcgccgaggatcgcgacaag gtgtacgagctgtaccgggaggtgttcacggaggaggaggatttgctggaggagtcgctg cacctgcacgtcactcctgcacttgtgcaggctggcttcagctgcctgcggcgccactcg cggggcgtcccggggtccggcgtcggcgccctcgcgggtccgcacgccctgcagctgttg ccgggctgcgtgccgcgcctgtcgccgctgctgcgctgcgtggagcgcggttggatggtt ctgctggtcgggccggccggcgccgggaagtcggcgctgctgagctcgctcgccacgctg gccggccgccgcctgcgcgtcatggccgtcaacagcgacatggacacgacggagctgctc ggagggtttgagcaggtggacgcgcgtcgcccgtggctcgcgctgcttgcggacgcccgc gacgccgtcgcttcgctcgcccgtgccgccctccccgcctcctcccagcatgccgagcgg ctgctgcgactgcgcacgtcgctgttggcaatcgggggtggcgccacgccggaggtcacg gtttcggacgtagaaacgctgcacagcattctgggagaggtggaacttgtcaacggcgat caccgcgcgctgtctgcgacagtgctgtcagatctccgggaacggctcggcaacttccag cggaggttttgctcatcgccgctttccaccgccgcgggatccagggcgggcggcgctggc tctgcgggggaggttggaggtggcggcggtgcctttgagtgggtggatggtgttcttgtg gaggcgctgcgcgcgggcgactggctgctcatggacaacgtcaacttctgcagcccttcg gtcctggaccggctcaacgcactgctggagccggggggagtcctgaccatcagcgagagg ggagtcatcgacggcaccgtgccaaccatcgttcctcaccccgatttcagactcttcctc tctatggacccggtgcacggggaaatctctcgagccatgcgcaaccgcggcgtcgagatc ttccttcccgtcgtggcaatgccgccggagccaggccccgagcccacggctgccgtcgac actgagatggccatggatgtggaagtgccggcggagcgctgcgccggcacgggcgaggga ggggagcctcaaggacgtgcggccacgccatgcctcgcgggaggcggaggggaggccgca gagagggcccggattgccgagatggacctgaagctgatgctgctcggactgggggtggtg gcagactctctagcttcacagctgatagcgctgcaccggcagatgggaagcagtctgctt ggaggatgcccgctgtctcagctgctccaggccgccgccctgctggtgcagcagctgcat cgaggccaggggctgcactcggcgtttgtgagcgcgtgcgccgatgtctacgcttccacg cagccctcgcccagcacccggcagtgggccctggagacggtggaggcgcacgctgcccac gtgacgtgcgatgagccgcagctgctggcgcctggccgctaccccgagcccgtgccctcg gtggcgtcgctggcgagggacgcgtcgctctgcaccgtgcgccgtgacggggctctgctg ctgcactgcctggccgctgcaggtcaaagggggtatgcgctgacgttaggggacctgcga cgaagcatcggggtcgtcggtttgccgaacgaccaacctggggtccccaccgccgctcca tcgacgccacccacagacaactccgccctcctcccgttcgccgcgagactcgtcgccgaa cgagcctcccctcaggattggctgctgcgggtcaggtggttgaatgacctggccaatggc gacgccataaatgcaggccaagttgggacggtactgcgggcggcgtccgaggctctcgac tctgtgtccaagaccggcctcgtgagccgtattgtggcctgccagcagcaccttgcacag caagccggagactcctcgtctctggccgacttccctctggacatcaggtggaacttgcag tacctggaagtcgtgtccaacagggcccgaagagccggccttgacccctgccctgcccag ctcttctcgttggcaaacaggatgagccttctgctggagaggagagcgaagtcgtacgtg gagtcgctggcactggagtcgggcctgaggacgtttaaagacttgaactcgtcggtgctg aagacgtcctacgccctgagtaaaggtgccctgggctccgagtctctgccacacccagcc gtcgctttcgtgttcccgttcctctcgctgtgggacgactggctcggccgctgggcgagc ggtggcaaagaggaggtgtccgatgaggacctaacgaagctgctgcagagtgtgcggcga cgcgattggttctgggaagcatgtgaggtcacttcctgcgaacaagggatgctgggaatg ctggcgctgcactggcattggctgagaaaggcgggctgtggcgatgaagcgttactcccc tctgggtgtcctgctgaactgaagacgatggtgtcggccttggaccagcacctgggccga cccgacgcacgccattcggcgctgagcaggatgcggaagtcactcggatggcccctgcct ttcaagcagcgggaggcggtggaggtggcgctggggctgagcgaggcctggaaccgcctc tgcacgccgctcgcccacgccccgcgatccccagaggaggcactcatcgcactcacgagg ctcagggccgtgtgcgaccgcgcgggcccggcgcacggcgacggcgttcggagcgccctg acgcgcgtctgggagcagctgctgctgctgcagcacggaggggcggaggtcggagctgaa gccctgagggagctgacatcatcgtggaccaccctgaagcaaggcgtgctggaacgcgcg ctggaagcgggcgacaccggcgtgccgggcgatgcggcggacgacgccgcgctgctcgcg ctggagagccgcgtgcagctgtggccagtcctggagcagctcgccctgcgctcccagtgc cgactcgtggccgccctcctcaacgtgccgacgtccgacagcgtgggtgaggagccgccg tggggcgctggcgaggatgtgaggcacctggtgtcgttctcctcgcgcttcacgccctcg tgcccacgacagctcggcctcctgcgcgggcttctcggcctcccgtcacgccaggtgctg ccctctgttcggtgggacctgctgctggctgccctctcccagctatggtgcaacacagcc gccagtcgccctgagctttggctgggctggaaatcgaggaccgacctccaagattccccc aaatcgacccagtccttgtcacctgcgttcggcgagattctcaagggccccggcgtgctg agctgcgccgccctctcgggctgcctcttccgtatccttggcaacgacggccattggtcg ccccaggaggaccccgcgggtcacgtgaccctgggggcctggcagcagcgcacccagcag ctggaggtcgtgggtcgagtcgcgtggtgcaacatgtcatctgccgcgctgcccgatttc acggagggcgaccgccgtctcctgcgctccgtgctgcgcgtgctcctctcccgcgcggct gagtcgctgggcccggcctctgagcccacggcgacggcgctgggagaccgcggcgaagcg agcgccggggacgaggagcgactcgcggacgcggcggcccggtgtctacggggggcgtcc gccctgcccgcggacgtcgccgagctgctcgaggattgcgtcgcctccctcggcgactcc tgctcgcgtgacgcgccagggggcgggcaaaaagagctgctgcacagagcggagctgtgg gccaagctgggcctggtggccgtgctgacgtggcgacctcgcacgcactttgaccccatg gtgaagagagcgcagaagctccggcacacggaggaggagctgcacgagctggagagtgag tggcgagcccgggagacgttgtcccacatcgtctcaggccgagacctccgcgtggattct cactgccacccacgcatccgcttcgtgcagcagaggatggaggtgctgcgcacgcgcgtg cacgagctttccaagaagcaggctcaccgccccgagcctcgcgcctacgagcggctctcg cgagacgtcgcccacttcgtgagcagcatctgccaaccgcagagggcgctccggctgctc gcgcgcatcaccgagtccctctcgcgtccggcggagaccgcctcggcctccgcctccctg ctgcgcgaagaggccgcctggcagacgtcgctggagcggttccgcgctcggctggcggag ggatacgcgggcttcccggacgtcgtcacgcccctgctgtgcggagtggcgcagctgcag cacggcgtgcgtctggccgcgaccgagctgcgccgcgtgggtgccgccgatcgctcggcc gcgagcctcgtcccgagcctcgtctcgtgcctcgcgaagctgccctcagtctcggccgag ttcccgtcgttcctggcgcacgccgacgcgctgagccggcgcgacgcgtcccgcgccgtc gcggacgccctcggccgcgccggagagggcggcgccggcgtcgtcggtgctggcggcgag gggtcggaggtcgcccggagagctaccgagcggctcgtggtgctcgcgctgctcttcctg aggaaccacatgcgtctgcgcggagagatggacgcggcctcgctcgggctgctccagcac ctgctgcaggtcgtggtgaacgcgttcgacgatcaggagcggcgggcggctgagcgcgcc cagcagcaggcgagcgtcttccgctaccggagccaggggcacggctccggcctctcgccc gaagagcaggaggagagagacttccggcggcgcttcccgcagcacgatcaggactttgcc gacctgaccgccacgttaagcctggacggctgcggcgaggccgcccctcggcccaacggc acggacggcggcgacgacgacgccggcgacgggggggacggcggctcgccgctcgtgtcg gaggagtgctcccgcgtggcggtcctcgtgcacgccgaggccttccgcggcctcacccac acggcctggtaccgcccctccggagcgaccgcccacccgcccccggaccacatggccacc ttcgcggcggcctaccagctcgccggcaccgtgatggcacaggcgtaccccgtggttgac gcaagcctggagcgggacacgatgtgcgcccacctgctcatgtcgaagctcatccgagac aacgtcgccgagtcaccgggcggccccgacgtcgtcgaatcctcgcgggcccactacgac ttctaccacagccccaacgcggcccaggcactgcagtgtctgctcccgctgaaggccttc acggtgcgcgtctcccagctgctggatgagtggccggagcacccgacgctctcgcagctg gtgatcgtgatgacaaggatcctgggattctcgctgtccagccccctctccaagttcctg tacggcttggagctcctcctggccaaggctcaggactgggagagcaacgcgagccgttcc gtgagcctgcgaccccacctggacgccatcactcagctgatcatccagttccgcaagctc gagctcagctgctgggcccagtgtctggacaacgtggcgtcacggtgcgcggagaagacc aacgtcagctggttctcgctgcaccagctcgtggagaacggcgtctccgcggaggactcg ccgctggcgtccgtggcctccaccctgcaggccttcatggagggggctaccctgggggag ttcccgtgccgcctcgacttgctgctctccttccactgccaggccgtgcacctgccgccc tccgccagcagagaggcactgctgggattgctgtggaacctgcatcagtactacagccag ttctccgagtccgttcactcagccctggcgcagaaacgcaaggccatcgagaaggagctg aaggactttgtgaagatctgccggtggaacgacgccagtttctgggccatgaaggaggct gtgaacaagacgcacaggacgctgttccggttttcgcgcaagttcgaggaggcgctctcc gaaccgtgccgaccggcgctcaccgagccgggcccggcggtagcggccgacgctgcccag tcgcacgactccgtggccgtggtgacgttgctgaggaaccagcggagctgggtctccccc tctctgcaggatgtggcaccgggagacgaggactctccccaggagtccctgcaggggcga ctgcccgtgctgtctgcccgcacgtggaagttctgcaagaagttgcgcagggagagttcc ctgcccgacctcatccaggggctcgaccagttcacaggcgaggtggcgtcgtccgtccga gagatgcaggtgctgtcggtgaacccggcgtccgacaaggacaagcagaggtcagaggcc aagcagatccagcagcagaagcagcgagccctggctgagctgttcaggctcctgcgcagg gctggcctctcttatcgcaagggtctcacagtggcccggatctcgagcgacgacgagtgg atgtcgcttccccccgtggacgtccctaccgctctgcgggacgcgccgctcggggaatcg ctcaaggggatggtggagcacgtggagaggagctggacggactgccagcgctatttctac cgatcggtggctcgtcgctgcagtctgcgcactgtcctcactgccccctctaaggatatg ggaccgggtaacctggatcgctgccgtgggttctccgagcacctgctgcagatgctggtg gcgcacaggaagcagctcaccacgctcaccgagcagcacatggctctgcggcagctgatc agggcgatggagaaggtcgggggcggcccggcggccggtgaggcggtggccgccgtcgcc ccacccgtggaggaggcgcgtcgccgggcgagcgggctgctgcgcgtgtccgcccaggcg ctgaccgtgctggagcagactcggctcgttctgcggtgctgcccccaacacgatcacggc agcggagatgcagagtccggggcccctggcggccaggcttggggagttccgagccccgtg gcgccgtctcgtctgccgccggccgcctcgctcgtgcgcgacagcgcggcgtgggtagcg gcggagcggctggtgtcgcggctgctcggtgaggtcgctgcggtgaaatcggcggcggcg gcggtggcggcggtagcggcggcaccggggcacatcgtcggcccgacggcaacgcacgtc ctgacctgggaggaggtggatcgctgtggcgccggcctcaccacgctgggaagcgtgacg tcgcagatgggtgacctgcagcgcctcttcacgccccccggcgagcagtgttcctccgcc gaacagcgtagtcccgtagccgatagcatcgcgtttgtccgcgaggaagtccaacgggag ctcgccgacttcaccacctggagaacgcagacgctgagcctgcagtcggcagcggatggc gatttggcagatgcggcgtcgcaggcgctggttgacgtgttcagcgccgacgttgaggga gccatcacggccgtgctgtgcgccgtgcagaccctggtcgcccgcgccaaggaagaccgg gaggagcagaagcgagccgacggtgtaaaaggcggtgacgctggtggtgaactcggtgac ggcggcggtactggcggcggtgatggtgaaagcgaagagggcgcggaaccgcccctgcgt gtggaccacatatcggcggcgctggaagggcggctctgggcggacgtgcgatccctggcc ttgcctcgggtcctggcgctcgcgtcccagctgctgcagcggatcctgaagcccggcgtg ggagcgcaggccgcgctgcggtgccgccgccggctgtcccgcgcgctgccgctgctgggc gcctacgcggacctcgcgtccttctacctggtcgcgtcggtggcgtcgcaccgcgccctc gccaagctgctgtgcgtgctgcttggcctcttcaccgaactcgtgcacaagggattttgt cagccggccgagctgacggagggcgaggccggggaggggtcgggcaagttccaggatgtg gaggggggcggcattggggccggtgagggtgtgaaggacgtcagcgaccagatcgagaac gaggaccaggtggaggacaccttccagcgtgaccagcagcacgaggaggagcccgagcag cagtccgagctgaacgacgaggaaaacgccatcgagatgtcggaagacttccaggggaag ctccacaatggcgagctcggagactcggacgacgaaggcaaatcggacgaggaggagaag gaggagttggacaagcagatgggcaacctgggtgaggggccctccgagacgctggacgag aggatgtggggcgacaacgaggagggggacgaggatggagacgagggacagcaggaggaa tctgggcctggcatggacgaggaggagtcggagctggtggctcaaggtgacaacgaggag agtggggaaaacaagcggaaagacgacaagaaacgggagcagcagcagggggaggaggag gagggcatggatgagggcgaggagggtgaggagaaaaagaaaatcaacgagcagaaggat gagcgggactttgacgagaacgagtcagacccgtaccagaaccagcagaagccgtgtgac cccgagccccttgagctcccggatgaccttgccctggacaaggaccaagagggggaggaa gggggtgaccagagcgaggaggacgaatctggagacaaccccctcgaaattgaggagagg ccgatggagctcgacaaagagaaggacagcgggaaagggacggaagagggggaggcgggc gagcggcaggaagaggaggcctctgctgacgcaggcacacagcaggcggaggaggaggag gaggaggaaaaagagcagggagctgaagactccgagaaagaggccatggagaatgaagcg aatagcgacgaggtgaaagaggaggacgaagaaggggagggcggcgaagaacgtggagaa ggagccgaggcctccggcgagaccgaggaaggagacgccgacgaagacaaaaagcaggga gaggaggcggacaaagaggatgaacgcagagaggagacgacggccggcacaagcgaccgc gggatggagcccaagggggaagaggagggcgaggaggacgaggaagcggcggaggagcgc gcggagcgagcgacggacggcgaagcggccgacgggagcctgcagagcgagctggcgctg gagcgtgcgggcagcacggcccaggaggagcagggcaaggaggagtacggcacgggcgcc gccgagagctgcgaggccgaggggcacgagtccgacagggtggcgccgctcgcctcccgc cgggacacgcgcgacaacacgcagagctacaagcgcaagccgggcgagacgaacgagcgg aggaccctgggcgaccgcgagcacgacagccgagccaacaagaggctgaagacggtggac gcggaggagcgcacggagcggcagggagacgctgaggagaaggcgcgggacgaagacgca gagctgtaccagcacatgccagagccgagcgggcagcacgaccgcgtcacgttcgatgcc gccacgctggagcagcaggagctgtcccgggcggtcacggacggcgccgagcagcaggag gacgagggcacggacgatgccgccacggacgaggttccaccaccggacgaggcggacgat gctgtggacgaggaactgcgcgccgtggaggccaaggagatgacggcgcaggacaagccg gcgtcgtgcagcgtgccagggaaagagtccgcggagcccagctcggagctggagggggcc actaaggaggacggtgacgtggaaatgacggagatcgagccggggagcgggcccaccgag cggagccgggagtccaccttccacacctcgctcaccgccctcaccgagaccgacccacag agtgtggaggtcattcgccagcagctggagcagcagctggaggtgtggagacaccccacg gacgagcgactggaggaggcgcgagtggcgtccgaggcctggcagaggtacatccacctg acgagcccgctggctcagcagctgtgcgagcacctacgcctcatcctggagcccacgcag gcggccaaactccggggagacttccgcaccggcaagcggttaaacatgcgcaaggtgatc ccctacgtggcgagcggcttccgcaaggacaagatctggctgcggcgcacacagcccagc aagcggcgctaccaggtgtgcgtggcggtggatgactcgtccagcatgctcgacaaccac tccaagcagctcgcctttgagtctctggccgtgattggcaatgcgctgagcctgctggaa gtcgggcagatagcggtttgcagcttcggggagacgatgcgcctgctgcaccccttccac gagccgttcacggagcagggcggcgccgcggtgttgcgcagctgcaccttccagcagaaa aagactcacatcgcccagtttctggaggaggtgacgaggatgtttctctctgcgcggcag aaccagcaaagtggaattaaaggagccctggagacgtcgcagctgctcctggtcgtgtcg gacggccgggggctcttcctcgaggggaagcagcgcgtgcaggcggcgattcgcgccgcc cgggacgccggcgtcttcctcattttcgtcgccctcgacaacccggacagcaaggactcg ctgctcgacattaaagtgccgatcttcgggggtcccgggacgctgcccgagatccgctct tacatggacgagttcccgttcccgttctacgtcgtcctgcgcgacgtcaacgccctcccc gagacgctgagcgacgccctccgccagtggttcgagctcgtgacggcgtccgatcactga

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