Petromyzon marinus (sea lamprey): 116958574
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Entry
116958574 CDS
T09614
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit-like isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
pmrn
Petromyzon marinus (sea lamprey)
Pathway
pmrn00270
Cysteine and methionine metabolism
pmrn00480
Glutathione metabolism
pmrn01100
Metabolic pathways
pmrn01240
Biosynthesis of cofactors
pmrn04216
Ferroptosis
Module
pmrn_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
pmrn00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
116958574
09106 Metabolism of other amino acids
00480 Glutathione metabolism
116958574
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
116958574
Enzymes [BR:
pmrn01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
116958574
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Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
116958574
NCBI-ProteinID:
XP_032837174
UniProt:
A0AAJ7UIZ9
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Position
80
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AA seq
661 aa
AA seq
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MLARPRHLPHLLPSSPPPLTPSTSSPPQPRHFTSLPRMAPQLRGTTLRWSDTKALAEFVR
ARGLQQLVRVLTQRGHGDHPLLWGDEVEYMLISFDHTARRARVLFNAEELINDLRAMDEE
ANPGYPSRWHLEYASYMLEGIPAQPYGSSMAELTNVEQSMRVRRRDMLARLRSNETICSL
TTFPRLGCPGFSQPECVPKHRDGQSASLFLPDEAISYHPRFSTITRNIRERRGEKVVVNV
PIFRDRNTPSPFIDQIPHGDEEAAIAMKADHIYMDATGFGLGNCCLQVTLQARNIEEARH
IYDQLAPLCPIMMALSAAAPFYRGLVSDVDCRWSIACAASDDRTRQERGLEPLTTCKWRI
PKSRYDSIDSFLSPGGAQFNDLELLKDEDVHLQLLDAGIDPLLAQHFAHLFIRDPLVLFC
EKIHADDDENEAYHFECIQSTNWQTLRFKPPPPNTNIGWRIEFRPMDCVVQVQLTDFENA
AYVVFVVLLTRVILSYGLNFLVPLSKVDQNIRKAQKRNAVLEEMFYFRKDIQAEVDTPPA
EEVGILMSIDTIINGKVGVFQGLVPIVNSFLEDMEVDVETRCTISDYMELISKRASGELG
TMAQRLRAFVSGHPDYAHDSVISERVNYDLMLRCDALARSRPHRHGVDPLHELSHGAFQT
G
NT seq
1986 nt
NT seq
+upstream
nt +downstream
nt
atgttggccagaccccgtcacctccctcatctcctcccctcgtcacccccccccctcact
ccctccacctcgtccccaccccaacctcgtcacttcacctcgttaccgaggatggcgccg
caactgagagggacgacgctgcgctggagcgacacgaaggcgctcgcggagttcgtgcgc
gcacgcggcctccagcagctcgtgcgagtcctcacgcagcggggccacggggaccacccg
ctcctctggggcgacgaggtcgagtacatgctcatctccttcgatcacacggcacgcagg
gcccgcgtcctgttcaacgcagaggagctgatcaacgacttgagagccatggacgaggag
gccaacccagggtacccatcgcggtggcacctggagtatgcaagctacatgctggagggg
atcccagcacagccttacggaagctccatggctgaactgaccaacgtggagcagagcatg
agggtgcggcggagggacatgctggctcggctgcgctcgaacgagacgatatgctccctc
accaccttccccagactcggctgcccaggtttctctcagcccgagtgtgtgcccaagcac
cgagatgggcaatccgcatccctgttcttgccggacgaggctatcagctaccacccgcgc
ttcagcacgattacgaggaacatccgcgagaggcgaggagagaaggtcgtggtgaacgta
ccgattttcagggacagaaacactccatccccattcatcgaccaaatcccgcacggtgac
gaggaggcggccatcgcgatgaaggctgaccacatttacatggacgcgacgggattcggc
ttgggaaactgctgcctgcaggttacactgcaggccagaaacatagaagaagcgcgacat
atctatgaccagctggctcctctgtgtcccatcatgatggcccttagcgccgccgccccc
ttctaccgggggctcgtgtcggatgttgattgccgctggagcatcgcctgcgccgcaagc
gacgaccgcacgcgacaggaaagagggctagagcccctgacaacgtgcaagtggcgaatc
cccaagtcgcggtatgactccattgacagcttcctgtcacccggcggagcgcagttcaat
gacctggagcttctcaaggacgaggacgtccacctgcagctcctggacgcaggcatcgat
ccgctgctcgctcagcactttgctcacctcttcatccgcgaccccctcgtgctgttctgc
gagaagatccacgccgacgatgatgagaatgaggcctaccactttgaatgcatccagtcc
acaaactggcagacattgcgcttcaaacctccgccgccgaacaccaacatcgggtggcgc
atcgagttccggccgatggactgtgtggtgcaggtgcagctcacggacttcgagaacgcg
gcgtacgtagtgttcgtggtgctgctcacgcgcgtcatcctctcctatggcctcaacttc
ctcgtgccactctccaaggtagatcagaacatcaggaaggcgcagaagaggaacgctgtg
ctggaggagatgttttatttcaggaaggacattcaggcagaggtggacactccgccagca
gaggaggtggggatcctcatgagcattgacaccatcatcaacggcaaggtaggggtgttc
cagggcctcgtccccatagtcaacagcttcctggaggatatggaggtggacgtagagact
cggtgcacgatctccgactacatggagctcatcagcaagcgtgcgtccggcgagctgggg
acgatggcccagcggcttcgcgccttcgtgagcggccaccctgactacgcacacgacagc
gtcatctcggagcgcgtcaactacgacctgatgctgcgctgcgacgccctggcgcgttcg
cgaccccaccgccatggcgtggaccccttgcacgagctcagccacggcgctttccagact
ggctag
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