KEGG   Protobothrops mucrosquamatus (Taiwan habu): 107290170
Entry
107290170         CDS       T05763                                 
Symbol
RYR2
Name
(RefSeq) ryanodine receptor 2
  KO
K04962  ryanodine receptor 2
Organism
pmur  Protobothrops mucrosquamatus (Taiwan habu)
Pathway
pmur04020  Calcium signaling pathway
pmur04260  Cardiac muscle contraction
pmur04261  Adrenergic signaling in cardiomyocytes
pmur04371  Apelin signaling pathway
Brite
KEGG Orthology (KO) [BR:pmur00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    107290170 (RYR2)
   04020 Calcium signaling pathway
    107290170 (RYR2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    107290170 (RYR2)
   04261 Adrenergic signaling in cardiomyocytes
    107290170 (RYR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:pmur04040]
    107290170 (RYR2)
   04990 Domain-containing proteins not elsewhere classified [BR:pmur04990]
    107290170 (RYR2)
Ion channels [BR:pmur04040]
 Voltage-gated cation channels
  Ryanodine receptor
   107290170 (RYR2)
Domain-containing proteins not elsewhere classified [BR:pmur04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   107290170 (RYR2)
SSDB
Motif
Pfam: RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8
Other DBs
NCBI-GeneID: 107290170
NCBI-ProteinID: XP_015674514
LinkDB
Position
Unknown
AA seq 4976 aa
MKEECQKESKWLRGNTLVRLCNMEMRDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLE
STSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKTAQGGGH
RTLLYGHAILLRHSYSGMYLCCLSTSRTSMDKLAFDVGLQEDTTGEACWWTIHPASKQRS
EGEKVRVGDDLILVSVSSERYLHLSYGNSSLRVDAAFQQTLWSVAPISSGSEVAQGYLIG
GDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVTWSGSHIR
WGQPFRLRHITTGKYLNLMDDKSLLLTDKEKADVKSTAFCFRSSKEKLDIGIRKEVDGMG
TPEIKYGDSVCFIQHVDTGLWLTYQSVDAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQH
EESRTARVIRSTVFLFNRFIRGLDALSKKAKSSIVDLPIESVSLSLQDLIGYFHPPDDHL
EHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGETWKSIL
NSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIK
EGHIKSIICLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVN
HVSSMRPNIFLGISEGSAQYRKWYYELMADYVEPFTTAEATHLRVGWASTEGYSPYPVGG
EEWGGNGVGDDLYSYGFDGLHLWSGCIARSVNSPNHHLLRTDDVISCCLDLSAPSISFRI
NGQPVQGMFENFNTDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAILPKE
KFKVEPSREYKQDCNCSRDLLGPNISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIH
ELWVMTKIELGWQYGPIRDDNKRQHPCLVEFAKLPEQERNYNLQMSLETLKTLLALGCHV
GIADEHAEEKVKKLKLPKNYLLSSGYKPAPMDLSCIKLTPSQESMVDKLAENAHNVWARD
RIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLINYGYNLEAPDQD
HAARPDVFDGMIERFRIFRTEKTYAVKTGKWYFEFEAVTAGDMRVGWTRPGCQPEQELGS
DDQAFVFDGFKAQRWHQGNEHFGRTWLTADIVGCMVDLNEHTMMFTLNGEILLDDSGSEL
AFKDFEVGDGFIPACSLGLSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIW
LSKRLPQFLPVPGNHEHIEVTRIDGTADSSPCLKVTQRSFGSQNSKTDIMFYRLSMPIEC
AEVFSKMPGGGMPNSNLFGPKTDLDDYEAESDFEVLMKTAHGHLVPDRAEKEAAKSEFNN
HKDYTQEKPSRLKQRFMLKRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVRI
FPGQEPANVWVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGE
SMSPGQGRNNNGLEIGCLVDAATGILSFTTNGKELSTYYQVEPSTKLFPAVFAQATSPNV
FQFELGRIKNVMPLSAGLFKSEHKNPLPQCPPRLHVQFLTHVLWSRVPNQFLKIDISRIN
ERQGWSIQCLESLQFMSLHIPEENRSVDILELSEQEELLKFHYHTLRLYSAVCALGNNRV
AHAMCSHVDESQLLYAIENKYMPGLLRAGYYDLLIDIHLNSYATARLMMNNEFIVPMTDE
TKSITLFPDEHKKHGLPGIGLSTSLRPRIHFSSPSFVRINSECYQYSPEFPLEILKSKTI
EMLTEAVQEGSLHVRDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFK
EDNGREDETRILVKELVTESLNVEAGMDEIRREKVPEEGLLQMKLPEPVKLQMCHLLQYL
CDFQIRHRIEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTAKKTKEFRSPPQEQI
NMLLNFKDDKNDCPCPEEIRDHLLDFHEDLMAHCGIQLDEDGILDGNNDLTIKGRLLYLV
ERVTHLKKKQAEKLVDDNNKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYD
GVGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNK
VFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKA
MFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCG
LQNCPLLISKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGP
ALRGEGGNGLLAAMEEAINISEDPTRDGPSSTNGSTRTPSEVEEEDDTVHMGNAIMTFYA
ALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGNVAE
PDMSGGFCPDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTVALSATDMA
LALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECL
LSICGQLRPSMMQHLLRRLVFDIPLLNEHAKMPLKLLTIHYERCWKYYCLPGGWGNFGAA
SEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVGVMEKQA
SMDSDGNFNPQPVDTSNITIPEKLDYFINKYAEHSHDKWCMEKFANGWIYGETYSESSKV
QPLMKQYKLLSEKEKEIYRWPIKESLKTMLAWGWRVERTREGDTMALYNRSRRISQTSQI
SVDTVHGYTPRAIDMSNVTLSRELHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLV
PYDTLTAKEKAKDREKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRY
VDEAHQYILEFDGGSRGKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSS
GGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLES
VKMALRTFLDNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPVLSSLFEHI
GQHQFGEDLILEDVQISCYRILASLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLE
THLNSHNIYSIYNTKTTRTDLPNSVKELSPNIPSLEKLMEEIVELAESGIRYTQMPHVME
VILPMLCSYMSHWWEHGPENSHNKSEMCCTALTSDDMNTLLGNILKIIHNNLGIDEGAWM
KRLAVFSQPIISKVKPELLKTHFLPLMEKLKKKAAMVIADEEHLRAEGRGDMSEAELLIL
DEFTTLSRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREE
QNFVVQNEINNMSFLITDTKSKMSKTAVSDQERKKMKRKGDRYSTQTSLIVAALKRLLPI
GLNICAPGDQELIALAKNRLSMKDTEDEVRDIIRNNLHLQGKLEDPAIRWQVALYKDLPN
RTDITSDPEKTVERVLDIANVLFHLEQVRCIIGILILICFTYSVVEHPQRSKKAVWHKLL
SKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWVETEDHYFEDTLIEDLAKPGAEP
TEEDECIKRVDPLHQLILLFSRTALTEKCKLDEDYLYMAYADIMAKSCHDEEDNNDGEEE
VKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLG
IAVLNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTE
EGSGEKVMQDDEFTCDLFRFLQLLCEGHNSGFQNYLRTQTGNNTTVNIIISTVDYLLRVQ
ESISDFYWYYSGKEVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWD
AVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDM
LVESFNNVEMILKFFDMFLKLKDLTFSDAFKEYDPDGKGIISKRDFHKAMESHKHYSQSE
TEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELA
DSVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGE
KEKMELFVNFCEDTIFEMQLAAQISESDLNERSMNKEENENEKLEEQDPRIGFFSLVTIT
SALIALRHNIMTLMKMLSMKSIKKQMKKMKKMTMKDMVMALFSSYWTILMGFMHFLSSVF
RGFFQIMYSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEVERKPAEAALPAED
LTDLKALSEDSDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSSPSLLPLPDVQEKIQ
DQEMSEDGKDEKEDTKFEHEKAEGEDGEKEEKTKEDKEKQKPRQHHKHRHGELEMQESAF
WKKIIAYQQKVLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVTEEKEVQVVNTVQ
KMKLNSLESPSHRIITVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIF
KREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEF
YGKDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFL
YLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYL
YTVVAFNFFRKFYDKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYE
IYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMEGRRGLGLSKMGLCAA
LVEKQFVEFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN
NT seq 14931 nt   +upstreamnt  +downstreamnt
atgaaggaagaatgtcaaaaagaatcaaaatggctacgtgggaatacacttgtgcgactt
tgtaatatggaaatgagagatgatgaagtggttctgcagtgtactgctactgttcacaag
gaacaacagaaattgtgtcttgctgcagaaggatttggcaacaggctctgcttcttggaa
tcaacttctaattccaagaatgttcctccggatctctccatctgcacttttgttctagag
caatcattgtcagtcagagctctccaagaaatgctggctaacacagaggagaaagcagaa
gggctagttgatgtggaaaaatggaaatttatgatgaagactgctcagggtggtggtcat
agaactcttctctatggacatgcaatattactgcgccattcttacagtggcatgtatctg
tgttgtctctccacatcacgaacatcaatggataaattggcttttgatgtaggcttgcaa
gaagataccacaggggaagcctgctggtggactatacatcctgcttccaaacagcgttca
gaaggagaaaaagtgcgtgttggggatgatctcatccttgtcagtgtttcttcagaaaga
tatttgcatttatcttatggcaacagcagtttgcgtgtggatgcagctttccagcaaaca
ctttggagtgttgccccaatcagttccggaagtgaagtagctcaaggctatctaatagga
ggtgacgtactgaggttattacatggtcatatggatgaatgtctgacggttccttcagga
gaacatggagaagagcagagaagaactgtccattatgagggtggtgctgtgtcaattcat
gctcgttctctttggagactggagactttgagggttacatggagtggaagtcacattaga
tgggggcagccattcagattaagacatataacaacagggaaatatttaaatctcatggat
gacaagagtcttcttctaacagacaaagaaaaagctgatgtgaaatctacagcattttgt
tttcgatcttccaaggagaaattagatatagggataagaaaagaagtggatggcatggga
accccagaaataaagtatggagattcagtctgctttatacagcatgtagacacaggtttg
tggcttacctaccaatcagtggatgcaaagtctgtaagaatgggatctgtgcagcgcaag
gctatcatgcaccatgaaggccatatggatgatggattgacattatccagatctcagcac
gaagaatcacgtacagcacgagttattcgcagtactgtcttccttttcaacaggttcata
aggggccttgatgctctcagcaagaaagctaagtcttccatagttgatttacccattgaa
tcagtcagccttagccttcaggacttgattggttacttccacccaccagatgaccactta
gagcatgaagacaaacagaaccgcctaagagctctgaagaatcgacaaaatctcttccaa
gaagagggtatgatcaatttagtgcttgaatgtattgatcgcttacatgtatacagcagt
gcagctcattttgctgatgtcgctggaaaggaagcaggagaaacttggaaatctattcta
aattcattgtatgaattattagcggctttgattagagggaatcgtaaaaattgtgctcag
ttctccggatctcttgattggctcattagtagattggagagattggaagcatcttctgga
attcttgaagtattacactgtgtgttggtggaaagtccagaagcattgaatattattaaa
gaaggacatattaaatcaatcatttgtcttttggacaaacatgggagaaaccataaggta
ttagatgttctgtgctcattgtgtgtatgtcatggagtagctgtgcgatccaatcaacat
ttgatctgtgacaatcttctgccagggagagatctccttcttcaaactcgccttgttaat
catgtgagcagcatgcgaccaaatattttccttggaatcagcgagggctctgctcagtac
aggaaatggtattatgaattaatggctgattatgtggagccatttacaacagcagaagct
actcaccttcgtgtaggttgggcatcaacagaaggttattcaccatatcctgtgggtgga
gaagaatggggtggcaatggtgttggtgatgacttatattcctatggttttgatggactt
catctatggtcaggttgtatagcaagatctgtcaattctcctaatcatcatctactcagg
acggatgatgtcatcagctgctgccttgacctgagtgctccaagcatttcattccgaata
aatggacagccagtccagggaatgtttgagaatttcaacacagatggtcttttctttcca
gttgtcagcttttcagcagggataaaagtacgatttttgctcggaggccgccatggggaa
tttaaattccttccacctccaggatatgctccatgttttgaagctattctgcccaaagaa
aagtttaaagtagaacccagcagggaatataaacaagattgcaattgctcaagggatctc
ttgggaccaaatatctctttgtcacaagcagcattcactcctgtacctgtagataccagt
cagattgtattacctccacatctggaaagaattagagaaaaactagctgagaatatccat
gaactttgggtgatgactaaaattgaacttggatggcagtatggaccaattagagatgac
aacaagcgacagcatccctgtttggtagagtttgctaaactgcctgaacaagaacggaat
tacaatcttcagatgtcactagaaacattaaaaacattgctggcattaggttgtcatgtt
ggaattgctgatgagcatgctgaagaaaaggtgaagaaactaaaacttcccaaaaattat
ctattatcaagtggatataaacctgctcctatggacctaagttgcatcaagttgactcca
tctcaggaatccatggttgataaacttgcagagaatgctcacaatgtatgggcaagagat
cgaataaggcagggatggacatatggaatccaacaggatgtgaagaaccgtcgaaatccc
cgccttgtcccctatacacttctagatgatcgcactaagaaatcaaacaaagatagcctc
cgggaagcagttcgtactctcatcaactatggctataaccttgaagctccagatcaagac
catgctgcaagacctgatgtgtttgatggcatgattgaaaggttcaggatattccgaaca
gaaaaaacatatgctgtaaaaaccgggaagtggtactttgaatttgaggcagtaactgct
ggagatatgagagttggctggaccagaccaggttgtcagccagagcaagagcttggctca
gatgatcaagcatttgtatttgatggtttcaaggcccagcgatggcaccagggaaatgag
cattttgggcgtacttggctaacagcagatattgtgggatgcatggtggatctgaatgag
cataccatgatgtttacgctaaatggtgaaatccttcttgatgactcaggttctgaactt
gcatttaaagattttgaggttggtgatggctttatacctgcctgtagcctgggattgtca
caggtgggcagaatgaactttggcaaagatgttagcactttgaaatatttcactatttgt
ggcttacaagaaggctatgaaccttttgctgtgaatacaaatcgtgacattactatatgg
ctgagcaagagattacctcagtttcttccagtaccaggaaatcatgaacatatagaggtt
accaggattgatggaacggccgatagttctccatgcttgaaagtcacacagaggtccttt
ggatctcaaaacagcaaaacagatatcatgttttatcgtctaagcatgcccattgaatgt
gcagaagtcttttctaaaatgcctggaggaggaatgccaaattctaatctttttggccca
aagactgatttggatgattatgaagcagaatctgattttgaagttctcatgaagactgct
catggtcatcttgtacctgaccgtgcagaaaaagaagctgcaaaatcagagttcaataac
cataaagactatacacaagagaaaccttcacgcctcaagcaaagatttatgctgaaaagg
acaaagccagactacagcacaagccattctgcaagactaactgaagatgtcctagcagat
gaaagagatgattatgattatctaatgcaaacttctacatattattactctgtacgtata
tttcctggacaagaacctgctaatgtttgggtaggctggattacatctgatttccatcaa
tatgacacaagctttgatttggacagagtccgtactgttacagtaaccttaggagatgaa
aaagggaaagttcatgagagtatcaaacgaagcaattgctatatggtgtgtgccggagaa
agcatgagtccagggcaaggacgcaataataatggattagagattggttgcttggttgat
gctgcaactggtatcctatccttcactaccaatggcaaagagttaagcacttattatcag
gtggagccaagtactaaattatttcctgcagtatttgcacaagccacaagccctaatgtt
ttccaatttgagttgggacgaataaagaatgtaatgccattgtcagctggattgttcaaa
agtgagcacaaaaatccacttcctcaatgcccgccccgtctccatgttcagtttctgaca
catgttctttggagcagagtgccaaatcagtttctgaagattgatatatcacggatcaat
gaacgtcagggctggtcaatacagtgcctggagtctttgcagttcatgtcccttcacatt
ccagaggaaaacaggtctgtagatattttagaactgtcagaacaagaagagctgctaaag
tttcattatcatactctcagactatactcagcagtgtgtgcccttgggaataaccgagtt
gcacatgctatgtgcagccatgttgatgaatctcagcttctctatgcaattgagaacaaa
tatatgccaggcttgttacgtgcgggctattatgatcttctcattgatattcatcttaat
agctatgccactgcaaggttgatgatgaacaatgaattcattgtcccaatgacagatgag
actaaaagtattactttgtttcctgatgaacacaaaaagcatggcctaccaggtatcggg
cttagtacatctttacgacccagaatacacttttcttctcccagttttgtaagaattaac
agtgagtgctaccaatatagtcctgaatttcctctagaaattttaaagtctaaaaccata
gagatgttgacagaagcagttcaggagggtagccttcatgtcagagatccagtaggtggt
actacagaatttctgtttgttcctttgatcaagcttttttatacccttcttataatgggt
atcttccacaatgaagatctgaagcatatcttgcagctcattgagcccagtgtgtttaaa
gaagataacggtcgtgaagatgaaacccgaatattagtgaaggaactggttacagaaagt
ctaaatgtagaggcaggtatggatgaaatcagaagagagaaggttccagaagaaggactt
cttcaaatgaaacttcctgagcccgtaaaattacagatgtgccatttactccaatatctg
tgtgacttccagatacgccatagaatagaagccattgtagcattttcagatgattttgta
gcaaaacttcaagaaaatcagcgtttccgatataatgaagttatgcaggctttaaatatg
tctgcagctctgacagccaagaaaacaaaagaatttcgatccccaccacaggagcagatc
aacatgctgctgaattttaaggacgataaaaatgattgtccttgtcctgaagaaataaga
gatcatctcctggattttcatgaagatctgatggcacattgcggaattcagctagatgaa
gatggaattctagatggaaacaatgatttaactattaaaggtcggctgctatatcttgta
gaaagagtcacacacttgaaaaagaaacaagcagagaagctagttgacgataataacaag
aaaccatcaactctccaacagctgatatcagaaactatggtacgttgggctcaagaatct
gtaatagaagacccagagttggtgagggccatgtttgttttgctacaccgccaatatgat
ggggttggtggcctggttcgagccttgcccaagacatacactataaatggtgtatcagtg
gaagataccatcaacttgcttgcatctcttggccagatccgttctctcctcagtgttagg
atgggcaaggaagaagagaagcttatgattcgtggattaggggacattatgaacaataaa
gttttttatcagcatcctaatcttatgagggcactagggatgcatgagactgtaatggaa
gtaatggtgaatgtacttggaggaggagaatcaaaggaaatcacctttcctaagatggtg
gcaaattgctgtcgttttctatgttatttttgccgcatcagcagacagaatcagaaagcc
atgtttgatcatcttagctatcttttggaaaacagcagtgttggacttgcttctccttct
atgcgtggatcaacacctttagatgttgcagcagcatcagtaatggataataatgaactt
gcattggctttacgagaacctgacttagagaaggtagtccgctacttggctggctgtggt
ttgcagaactgtcctttactaatttctaaaggctatccagatattggatggaacccagtt
gaaggagaacgatacctggatttccttcgttttgctgttttttgcaatggagagagtgtt
gaagaaaatgctaatgtggtggttagactgctcattcgacgtcctgaatgttttggacca
gcactgagaggtgaaggtggaaatggcttgcttgctgccatggaagaagccataaatata
tcagaagatcccacaagagatggtccttcatcaactaatggatccactagaacaccaagt
gaagtagaagaagaggacgatactgttcacatgggaaatgccatcatgactttttatgct
gccctgattgatctcttgggacgctgtgctccagaaatgcatctcatccatgctggcaaa
ggggaagccattagaatcagatctattctaaggtctttgattcctttggaggacttggtg
ggtgtaattagcattccttttcatatgccaacaatagcaaaagatggcaatgttgcggaa
cctgatatgtcagggggtttttgccctgatcacaaggcagcaatggtattgtttctcgat
agggtctacggaattgaagaccaagattttcttcttcatcttctagaagttggctttctg
ccagatcttcgtgcagctgcttcattagatacggttgccctgagtgccacagatatggcc
ctggctcttaatcggtatctctgcactgctgttttgcctttattaacaagatgtgctcct
ctttttgctggaacagagcatcatgcttcccttatagattccttgctacatactgtatat
cggctttccaaaggctgttctcttaccaaagctcagcgggattctattgaagagtgccta
ctctccatttgtggtcagctaagaccttcaatgatgcaacatttgttgagaagattagta
tttgatatccctcttctaaatgaacatgccaaaatgcctcttaagttgctgacaattcat
tatgaaagatgctggaaatattactgtttaccaggagggtggggcaactttggtgctgcc
tcagaagaggaacttcatttgtccagaaagttattctggggtatttttgatgctttatct
caaaagaaatatgaacaagaactattcaaattagcactgccatgcctgagtgctgtagct
ggggctttacctcctgattacatggaatcaaattatgttggtgttatggaaaaacaggct
tccatggattcagatgggaacttcaatccacagcctgttgatacttcgaacattacaatt
cctgaaaaactagactactttataaacaaatatgctgaacattctcacgataaatggtgc
atggaaaagtttgcaaatgggtggatatatggtgaaacatattcagaatcttccaaagtg
cagccattaatgaaacaatataaactattatcagaaaaggaaaaagaaatttatagatgg
ccaatcaaagagtctctgaaaaccatgcttgcttggggatggcgggttgaaagaacgagg
gaaggagatactatggctctttataatcgttcgcgtcggatatcacagacaagtcagatt
tctgtagatactgtccatggctataccccccgtgcaattgacatgagtaatgttacactg
tccagagagttacatgcaatggctgagatgatggctgaaaattatcataacatatgggcg
aagaaaaagaaaatggagcttgaagccaaagtgggaggaggaaatcaccccctgcttgta
ccctatgatacactgacagccaaagaaaaagctaaggatagagagaaagcccaagatatt
ctgaagttcctccagatcaatggctatgttgtgtccagaggcttaaaggatttagaatta
gacacaccatccattgaaaaaagatttgcttacagttttctccagcaattgatacgctat
gtagatgaagcccatcagtatattctggaattcgatggtggcagcagagggaaaggagaa
cagtttccttatgaacaagaaatcaaattctttgctaaagttgtacttcctttaattgat
cagtatttcaaaaatcaccgactgtatttcctatctgcagcaagcagacctctgagcagt
gggggtcatgcttctaacaaggagaaagaaatggtaaccagccttttctgcaaacttgga
gttcttgtcaggcataggatttcactgtttggaaatgatgcaacttccattgtcaattgt
cttcatatcttgggtcagaccttggatgcaaggacagtgatgaagacaggtttggaatct
gttaagatggctttgaggacatttttggataatgctgcagaggacctggaaaaaacaatg
gaaaatcttaagcaggggcaattcacacataccaggagtcagccaaaaggagtaacacaa
attattaattacacaacagtggctctcttgccagtattgtcttcactatttgaacacatt
ggacagcatcagtttggtgaagatttgatattggaagatgttcaaatctcttgttataga
atactggccagcttatatgctttgggaaccagcaagagcatctatgtggaacgtcaacga
tcagctttaggtgaatgtttagctgcttttgctggtgcctttcctgtggcatttttagaa
actcatttgaatagtcacaatatttattctatatacaataccaagacaacaagaacagat
ttgccaaacagcgtaaaggaacttagtccaaatattccatctctggaaaaattaatggaa
gaaattgtggaattagctgaatcaggcattcgctatacacaaatgcctcatgtaatggaa
gttatattgcccatgctttgtagttatatgtcacattggtgggaacatggaccagaaaac
agtcataacaagagtgaaatgtgctgcacagcattgacttcagatgatatgaatactctt
ctgggaaacattctaaaaatcatacataacaatttgggcatagatgaaggagcctggatg
aagagattggcagtgttttcgcagcctatcataagtaaagtgaagccggagcttctgaaa
acacattttcttccactgatggagaaactgaagaaaaaagcagctatggtgatcgctgat
gaagaacacttacgagcagaaggcaggggtgatatgtctgaggcagaactgctcatccta
gatgaattcactacactttcccgggacctttatgccttctatccattgttaatcagattt
gtggactacaacagagcaaaatggctcaaagagcccaaccctgaagccgaagatttgttt
cgtatggttgcagaagttttcatttactggtcgaaatcccataattttaaaagggaagaa
cagaactttgtggtgcaaaatgaaatcaacaatatgtctttccttattactgacactaaa
tcgaagatgtccaagacagctgtttctgatcaggaaagaaaaaaaatgaaacggaaagga
gatcgttactcaactcagacttctctgattgtggctgcattaaaaagattgcttcctatt
gggctaaatatttgtgcacctggtgaccaagaattaattgctctggcaaaaaatcgattg
agcatgaaggacaccgaggatgaagttcgagatattattcgcaacaaccttcatttacag
ggcaagcttgaagatcctgcaattagatggcaggtggccctttacaaagatctaccgaac
agaactgatatcacttcagatccagaaaagactgtggaacgggttctggatatagctaat
gtacttttccatctggaacaggttagatgtattattggcattttaatattaatttgtttt
acatattcagtagttgagcatcctcaaaggtcaaaaaaggcagtatggcataaactcttg
tccaaacagagaaaaagagctgtggtggcttgcttcagaatggcgccactatataatctt
ccacggcaccgagctgtcaatctttttcttcagggatatgaaaagtcctgggtggaaaca
gaagaccattattttgaagatacgttgatagaagacttagcaaaacctggagcagaacca
acagaagaagatgaatgtattaagcgagttgatcctttgcatcaacttattttactattc
agtcgaacagctttaactgaaaaatgtaaattggacgaagattacttgtatatggcatat
gctgatattatggcaaagagttgccatgatgaagaagataacaatgatggtgaagaggaa
gtgaagagctttgaagtcacaggatcccaacgcagcaaggaaaaagaaatggaaaagcaa
aagctcctgtaccagcaagcaagactccatgatcggggggctgcagaaatggtcctgcag
acaattagtgccagcaaaggtgaaatgggaccaatggttgcagccaccctcaaacttggg
attgctgtcttgaatggaggaaattcaactgttcagcagaaaatgcttgactatctcaag
gacaaaaaagacgtaggcttctttcagagccttgctggtcttatgcagtcttgcagtgtt
cttgacctaaatgcttttgaacgtcagaataaagcagaaggccttggaatggtaacagaa
gaaggatcaggagaaaaggtgatgcaggatgacgaatttacctgtgatctcttccggttc
cttcagttgctttgtgaaggtcataattcaggttttcaaaattacctgagaactcagact
ggtaataatacaactgtcaacattatcatatccactgtggattatttattgagagttcag
gaatcaattagtgatttttattggtattattctggaaaggaagttattgatgaacaagga
caacgtaatttctctaaagctattcaagttgcaaagcaggtcttcaatactctgacagaa
tatattcagggcccatgtacaggtaatcaacagagtctagcacacagcaggctttgggat
gctgtggttggttttcttcatgtctttgcccacatgcagatgaagctctctcaggattct
agtcaaattgaattactgaaagaattaatggatcttcagaaagatatggtggtcatgctg
ctatctatgttggaaggtaatgttgtaaatggaacaatcggcaagcaaatggttgacatg
ctggtggaatcgttcaacaatgtagaaatgattctaaagttttttgatatgtttctaaaa
ctgaaggatttaactttctctgatgcattcaaagaatatgatccagatggtaagggcatt
atttccaaaagagatttccataaagcgatggagagccacaaacattatagtcaatcggaa
actgagtttctactctcctgtgctgaaacagatgagaatgaaactttggactatgaggaa
tttgtgaaacggtttcatgagccagctaaagacattggcttcaacgttgctgttttgctg
acaaacttgtcagagcacatgccccatgatacgagactgcaaactttccttgaattggca
gacagtgttctaaactacttccagccctttctaggtcgcatagaaataatgggcagcgca
aagcgcattgaacgagtttactttgaaatcagtgaatcaagtcggacgcaatgggagaaa
cctcaggttaaagagtcaaagaggcagtttatttttgatgttgtaaacgagggaggggaa
aaggaaaaaatggaactttttgttaacttttgtgaagataccatctttgaaatgcaattg
gctgctcagatctcagaatcagatctgaacgagcggtctatgaataaagaagaaaatgaa
aacgagaagctggaagagcaagacccccgaataggattcttctctctagtgaccatcacg
tcagcattaatagccctcaggcataacataatgactctcatgaaaatgttaagcatgaaa
agtataaagaagcaaatgaagaagatgaaaaaaatgaccatgaaggacatggtcatggct
ttgttttcttcctactggaccattttaatgggtttcatgcattttttatcaagtgtcttc
agaggcttctttcaaatcatgtacagcttgctgcttggagggagcctggttgaaggagcc
aagaaaattaaagtagctgaacttctagctaatatgccagaccccactcaggatgaagtc
cgtggtgatggagaagaagtagaaaggaagccagccgaagctgctctgcctgcagaagac
ctgactgatctcaaagctctgtcagaagatagtgacctcctctcagatatttttggctta
gatttaaaacgggagggaggacaatataaactaattccacataatccaaatgcaggcttg
agcgatttgttaagcagtccttctttactccctttacctgatgtgcaagaaaaaatacag
gaccaggagatgagtgaagatggaaaagatgaaaaagaagatactaaattcgaacatgaa
aaagcagagggcgaagatggagaaaaagaagaaaaaacaaaagaagataaggaaaagcag
aaaccaaggcagcatcacaaacataggcatggtgaactagaaatgcaagaatccgccttc
tggaaaaaaattattgcatatcaacagaaagttcttaattattttgctcggaatttttac
aatatgaggatgctggctttatttgttgcatttgccattaatttcattcttttgttctac
aaggtgtctacatcttcagtgacagaagaaaaggaagtacaagtagttaatactgttcag
aagatgaagctaaacagcctagaaagcccttctcatagaatcatcacagtacactatgtc
cttgaagaaagcagtggctacatggaacctacacttcgcattttagcgattttacacact
gtcatttcctttttttgcatcattgggtattactgtctgaaagttccattggtaatattt
aagcgagaaaaagaagttgcgaggaaattggaatttgacgggctatatattacagaacag
ccttcagaagatgatattaagggacagtgggacagacttgtcatcaatacacagtctttt
cctaataactattgggacaagtttgtgaaaagaaaggttatggataaatatggagagttc
tatggcaaagacaggatcagtgaattgctgggaatggacaaggctgctctagatttcagt
gatgctcgagaaaaaaagaaacccaaaaaggatagttctttatcagctgtgctgaattct
attgacgtaaagtatcaaatgtggaaactaggtgttgttttcactgataattcttttctg
tacctggcctggtatatgaccatgtcaatccttggtcattacaacaactttttctttgct
gcacacctccttgacatagcaatgggatttaaaacattacgaacgattctatcgtcagtg
acccacaatggaaaacagcttgtactaactgtgggattgctagcagtggtagtttaccta
tacacagtagttgctttcaatttcttccgaaaattctacgataagagtgaagatggagat
atgccagatatgaaatgtgatgacatgctaacgtgctatatgtttcacatgtatgtggga
gtacgtgctggtggtggaattggtgatgaaattgaagatcctgcaggcgatgaatatgaa
atatatcgaatcatctttgatattacatttttcttttttgtaattgttattctactagct
atcatacaaggcttgattattgatgcatttggagaattaagagatcagcaagaacaagtt
aaagaagacatggagggtcgtcggggtttggggctctcgaagatgggactctgtgcggcg
ttggttgaaaagcagtttgtggaattttttctgatgtatctcattaataaagatgaaact
gaacacactggtcaagagtcatatgtgtggaaaatgtatcaagaacgatgctgggaattt
tttcctgccggtgattgttttcgaaagcagtatgaagatcagcttaattaa

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