Populus nigra (Lombardy poplar): 133671338 Help Entry 133671338         CDS       T10372                                  Name (RefSeq) midasin isoform X1   KO K14572   midasin Organism pnz  Populus nigra (Lombardy poplar) Pathway pnz03008   Ribosome biogenesis in eukaryotes Brite KEGG Orthology (KO) [BR:pnz00001]  09120 Genetic Information Processing   09122 Translation    03008 Ribosome biogenesis in eukaryotes     133671338  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03009 Ribosome biogenesis [BR:pnz03009]     133671338 Ribosome biogenesis [BR:pnz03009]  Eukaryotic type   Pre-60S particles    Other pre-60S particles     133671338 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AAA_5 AAA_lid_7 AAA_3 AAA AAA_lid_5 AAA_7 AAA_16 AAA_22 AAA_6 AAA_28 AAA_18 nSTAND3 TsaE AAA_2 ABC_tran AAA_14 bpMoxR Sigma54_activat Sigma54_activ_2 RuvB_N AAA_25 RNA_helicase Rad17 RsgA_GTPase Dynein_heavy IstB_IS21 NACHT AAA_29 PduV-EutP AAA_24 MDN1_4th ATPase_2 SRP54 KAP_NTPase cobW AAA_17 Motif Other DBs NCBI-GeneID:  133671338 NCBI-ProteinID:  XP_061948045 LinkDB All DBs Position 13:2602653..2640886 Genome browser AA seq 5452 aa AA seqDB search MAMDGSFSLESALERFLTRCPKLATIDKLQRFVEAGHTVTEEEVVKLLAELFLNPNYTIP LIGSFRPVARKIVNQAVALLRNCNLSSDSDDIEGDFVDADVLYVIEHYERSGRGLELHEL ACLAFCRALDLDHSLLGSVTTYFKFAPPPFERILRNKVVSEAQLFQAANHYLLAVRISYR LLLMQPEFFSEQWNWSCFLDHVKKLVNLDLVHVAKDAKAIADIKWCGIQILCTILGMSDK AVENFGVGAEEATLCLLRWEEFCQDVAIEKFCLCVGSSEQANFGSFTGGIKFGQQNFLKS CGLNSLISSHCHQIEPVIKSRRVVTWDERSTAYPFVVTSMMSKGFEMVLLAVSQKWPVLL YGPPGAGKTALINKLAQDAGNQVLSIHMDDQIDGKTLIGSYVCTEQPGEFRWQPGSLIQA VLNGYWVVFEDIDKAPSDVQSILLPLLEGEITFITSHGEEIRVAESFQLFSTITTSKSNV SHTAEVAGGSSLSTLWRRVMIGLPSNDDLENIMKAWYPSLGPLTGRLIETMERVNPSPSG NSACLSCLNRFSLRDLLKWCKRIAELGLNGDMLTAYQCHLIYQEAVDIFASFSAPSENRL TVMRDIAKLWGVPISEAAILYPCKPEIQNLFTEVRIGRVTLQRTETVVHGQERLVGMRSS LYVLEQIACAVKYNEPILLVGETGTGKTTLVQNLAMMLGQKLTVLNLSQQSDIADLLGGF KPIDSLSICIPLYKEFEILFSKTFSMKENDKIFAYLQKQMKKKNWKTLLNGFKKYVDNFQ KKLQTERSGSGKKRKKPLDENIRAWESFSVKLEAALRQIEASSGMLFSFVEGSFITALRN GEWILLDEVNLAPPETLQRVIGVLEGEYGSLCLAERGDVSQIPRNPSFRIFACMNPATDA GKRDLPYSLQSRFTACFVHDVLDRDDLKLFINKFMEESISNIELEKKIIDFYEAAKKNSE ERLQDGANQKPQYSLRSLYRALEYTRGAKGKFGFPKAIYDGFCMFFLTMLDRPSAKIMKK MIKEKLLGGNKPSPVPFDAYLRITKISGFDDLYKNYVLTKSVKKQLENLARAVFIKRYPV LLQGPTSSGKTSLVQYLAARTGHEFVRINNHEHTDLQEYLGSYISDAQGKLVFQEGILVK AVRNGHWIVLDELNLAPSDVLEALNRLLDDNRELFLPELRETVRAHPNFMLFATQNPPTF YGGRKMLSRAFRNRFVEVHVDEIPDDELSTIIEKRCKIPGSRARLMVEVMKELQFHRQSS KVFAGKHGFITPRDLFRWANRLRAFGDSKEVMAEHGYYLLADRLRDERERHVVQEVLERH LRVKIVRDHLYKESVARESESIGSDLQSLGDVILTRSMRRLYFLVKRCFELREPVLLVGE TGGGKTTVCQLLSRALGLKLHILNCHQYTETSDFIGGFFPVRERSRLASEFKYIIEKWMH SKAYTHFAQDLDLSSDIGQASSTLDHLNLIITSYRQGQVSCPNVSAKDIDTLEQMKWDLT CLLQKWQTIFMWQDGPLVQAMKAGDLFLVDEISLADDSVLERLNSVLEPERKLSLAEKGG PVMENITAHENFFVLATMNPGGDYGKKELSPALRNRFTEIWVPPVCDLDELGDIASKRLS NPELSYIVGAMLKFWEWFNKLEKGRALTVRDLLSWIQFIMVTKEGLGPDCAFLHGLFLVL LDGISLGTGISRKDAGLFRETCLSFLLKELKEDSNLHELSFIENYGWGDLGETGNISCSD DMQCDNSFGIDPFYIEKGYEKCEAGGFEFLTPTTRRNALRVLRAMQLPKPVLLEGSPGVG KTSLIIALGKYSGHKVVRINLSEQTDLMDLLGTDLPVESDEGMKFAWSDGILLQALKEGC WVLLDELNLAPQSVLEGLNAILDHRAEVFIPELSLTFKCPSSFRIFACQNPFSQGGGRKG LPKSFLNRFTKVYIDELVEGDYLSICNSLYPSIPRPLLSKLIVFNKRLHEDTMLYHKFGQ DGSPWEFNLRDVIRSCQIIEGVPEKLKVDCFLNILYVQRMRTAADRKEVLRIYEEVFGVK PFINPHPRVQLNSKYLIVGNTVIKRNISRSSKLSNSGLNIIPSIRHSMEAVVHCIKHQWL CILVGPPCSGKTSLIRLLAQLTGNVLNELSLSTTTDISELLGCFEQYNAFRNFRSVIAQV ERYVSEYCNLQLEFSKVAFMSERTDLITKWLAFLSTMNSSSMASCTSIHLENWESMMNSL SLLVEIIQQMKLDIVQNELPFSWSTEELNKTIKVISKLQDDQQRRSRSVKFEWVAGLLIK AIENGEWIVLENANLCNPTVLDRINSLVEPSGSITVNECGIVDGSSVVLHPHHNFRIFLT VNPSHGEVSRAMRNRGVEIFMMPPYWLHNDESGCSGADFELKDVKRFLVSSGIPMDRLVD SMAKAHVYAKNEGLHVNVQITYLELAHWVQLFHQLLINGNQPFWSLQLSWEHTYLSSLGE AVGWDIVNHAKVAYFSSATLSESDLPTEFSFYLPGGLPVPMKLRDFMWYSKEASVRQNLM YLEYLVSQYELGSSRNRSCVDDALSATSHKGNGLMDMNMKGQLMFPKALNCMNANSVRNT EIDMKLTKRMLLFAANWTIEQATGSDYKLYLLHFSWFSSKLQSCDHFFRSFLHLLEQELE HPIWKCIFHSFHELASLPAANSSLHLTPLLSVDFVDLTMSYDRPEVSHKFLCNAINCIDL LRLSYQQWNAQSEHEYTNEAQHFKPVLDALQELEKEILNMLVESPSYNVLIKLYSDILED HLTFWDAFTSSGFEKLPVSWHSLMKDVLKLRDFCPGAVDNLFMIAGNIDKKLNQHSQQSL LWIHGGHPILPASAELFKQQQLFIELCESVWPTKANPYNQGDDCLVELATSSTPELRFLA VQGICMSAYITSRFDEDSGEVALHLADMSQMLLKRFEYEKSNLEAKLKSVESATIEGNSI SCCDFSPEARCTKPGFACWLETRPIIDNTSFFLDMDLLQKLSMIVLVDHKECQLALGSVS NLIESAMKHSLTFSTRPPQNFIPHQKILWTLDAWMSVDAVNAKIASYVLEMWFWWHSSLW SHCPVFSENFGKVDGYHTPLPDMLVQSVRTASVVQSLRRTCAIKDYSVHCLKLKAASCNL WQSSLPGMDLSSFLLSVTRSLFQQIIYAHRKAFDADKFAAIKSIFCSFHKNGATQDDIQR LVSILGSSNHQKLNSLVSLFIEPILKKLYLHCSSTEVYLDMGHACLKIGALRFSLLLSCD DFDPAMKYSFKHSQLEERISSLELEIKVRQECDYLAGRLSSIEADKKRADSLERLEFERR RIQKKMVFRCNPLKFNALRKECGEFLKPARMVVGLVDNIEGMDLQQVLEQASNWQATATS FIDRLSDEYKEYIDLAQPFQVAVYEMKLGLSLVLSFALLKNVLNRIKEDNMDRVMESIYS FMRFPRVRAFVPSSSHSIGSPATFWDREMGFLEKLIMLSSEVTHEKMGSILQLKTGLYQN IVVRVAHFVADAQRIDDASFKILDKMFHEFANMWINMKVQVKCKEGEDAQQYKFRPRALE IKSIVDVDFSTLDQFFPNDSFSEWQEFLSEEESLEKLEASNEHESVQDEWNLMQETIMKN MICIHNQLFGSTNLVLYAGTCHVVEADRLHSFTNSYTLGVGMIEGLGGLLTSSLDGKLIP EHLLRLCLEHGSKLVSSQKSSANYNFYKDSNAPMMAKMVKLVANLQQQIHSFLSEWEDHP GLQKITDTIQMLLAIPVETPLAKALLGLQFLLNRARALQENESKFPLSDQLEPISALVCS WQKMEFDSWPALLHEVQEQYDVNAGKLWFPLFSVLHHSHFADIAGYEQSTIESLEEFIRT SSIGEFRARLQLLFSLHGQITAGRCLEVQNYLSTRQEKNLQILYNVFGYYIQFLPRILED IEANRKGIEMELKDILKLFHWERTEICLSVENSKRTRQKLRKLILKYTDLLQQPVMLILD REAQQKEPKIHSLQFPKALKDNKNTISDPTQFCEKDRSIWLADWRKKVTDTLQDMHFKNT LGLSFLDNKDVTSITRQCLASHSSHLSRDEQWNVLCWTVEKIFKTAMDCDDLWNDTGKGV GKKRALSELLKLLDTSGLHKHKFEIMKISNSSNWLFIQPSYNAQHLLLTPSRLSGEAFDV STSSELQCLPDDYVDTMWKSANEFYFKSVASVQFMQRICLKPHGDITYDQASRAVSFLNH LIIIQQSQRAAAYGFSKQLKCLRECTYAFENSYVKCTDIDERTSSEYSIVQNQHAFFQCM WKQKQLFDGLTTLLAEESLLLRTVESTHLKSCRSVRPAANHVLQFIEKFIPVTQKSKESL DNYLLGQLGGLQSLLQESLDKSLLGRVVTISAGPSRPYIISKQMEQLVYKNFQVIKEFEE HFFDFRKQDWNRSFIIETLLGHFDDVFKEGKMLADQFESALKQRSQSRDLSEEVDYNSGN NYQLEADFDSALKKAHNLVMEALEKQISPGDGGALSEESLENISSWEYLFKSSVQSLNVE ELCDILLNIITCVKKMVDHSGSETSHISFHIGRCFQHLHLLLELILGFCDGLLQDLLAMH KTVSIMTRELANVLASLFSKGFGIPVKDEVDEASHDKSQTASGTGMGEGSGLNDVSDQIT DEDQLLGTSEKACDEQDASGEVPNKNEKGIEMEDLTADTFSVSDDSGEENEEDGEDEQLD SAMGEAGLDSEVVDEKLQNKDEDDNPNNTNERYESGPSVRDNDTSSRELRAKEDSAAIAD DEPGEPDKQNNEIGNQDDLDDREENTDDMNMDKEAAFTDPTGLKLDESNQGAEEDMEMDE DMNEEGDLDSKEEISPEEGDESAEHGNYEEDNTISADETMEEPDSEPVDGTSVKDEPGRD REERSETNAMEPRNDEFDLGISDLISDHVHGAESATQPNGPSQASDSKNVTAEANMSNIS EAHNDLALRSLPSGNTSQNDLMVSDSSNSGGFTNDKKQAQFPERESSSDQRAQPNPYRNV GDALEEWKERVKVSVDLPGDTTEASGEIEDKNADDYAFVSEFEKGTDQALGPATSEQVES NVNVTRSDEDGLAAQRDEVTKMEIEERDAKEWHLNNSASILKNKMEEQLQISDFKSEKEG PPEVQDHDGVDPQNLPESAISVRKSYLSEDIYQPDNLHVDDNDLGKAQGPEEVPLDVISS ASALWSRYELRTTRLSQELAEQLRLVLEPTVASKLQGDYKTGKRINMKKVIPYIASHYRK DKIWLRRTRPNKRDYQVVIAVDDSRSMSESCCGDVAVEALVTVCRAMSQLEMGNMAVASF GKKGNIRSLHDFDQPFTGEAGKKIISSLTFKQENTIADEPVVDLLKYLNNMLDAAVAKAR LPSGQNPLQQLVLIIADGRFHEKEKLKRCVRDFLSRKRMVAFLVLDSPQESIMDQMEASF VGEGEKRVLKFTKYLDSFPFPYYIVLKNIEALPRTLADLLRQWFELMQYSRE NT seq 16359 nt NT seq  +upstreamnt  +downstreamnt atggcgatggatggaagtttcagtcttgaatcggctctggaaagattccttactcgttgc ccgaagcttgcgacgattgacaagctccaacgttttgtagaagcggggcatactgtgacg gaagaagaagtggtgaagttgttggcagagctgtttctgaaccctaattatactatccct ttaattggttcttttcggccggtagctcgaaagatagtaaatcaagctgtggctttgctt aggaactgcaatctaagttctgattcagatgatatagaaggggattttgttgatgctgat gttctttatgttattgagcactatgaacggagtgggaggggtttagagcttcacgagctt gcttgcctggccttttgtcgggcccttgacttggaccattctttattggggtctgtcaca acttactttaagtttgctccgcctccttttgaacgcatattgaggaacaaagtagtttct gaggctcaactgttccaggctgcaaatcattacttacttgctgtgaggatatcataccgc ctcctccttatgcaacctgagttcttttctgaacagtggaactggtcctgttttttggac cacgtaaagaagttagtaaatcttgatctggtccatgttgccaaggatgcaaaggcgatc gcagatataaaatggtgtgggatacaaattctgtgtacaattttgggaatgagtgacaaa gcagttgaaaattttggtgttggagctgaggaagcaactttgtgtttgttgcgctgggag gagttttgtcaggatgtagctatagagaagttttgcttatgcgttggatcttctgagcag gctaactttggttctttcactggaggcatcaagttcggtcaacaaaacttcctaaagtct tgtggtcttaattctctgatatcatcacattgtcatcagattgagccagtgattaagagt cgaagggtggtgacatgggatgaaaggtcaactgcctatccatttgtcgtaacatctatg atgagtaaaggctttgagatggtgctcttggcagtgagtcaaaaatggcctgtgctactg tatggcccccctggggctgggaaaactgctctcattaacaagttggctcaggatgctggg aatcaagttctatctattcacatggatgatcaaattgatggcaaaacactgattgggagt tatgtgtgtactgagcaacctggtgaatttagatggcaacctgggtcacttatccaggct gttctgaatggatattgggttgtatttgaggacattgacaaagcaccatcggatgtgcag tcgatcttgttgcctttgttggaaggtgaaatcactttcattactagtcacggagaggaa ataagggtggcggagagttttcaactattttctaccatcactacttccaagagtaatgta tctcacacagcagaagttgcaggtggaagttcacttagcacactttggagaagagtgatg attggactgccaagtaatgatgacttggaaaatataatgaaagcatggtatccaagtttg ggacctctcaccggaagactcatagaaacaatggaaagagttaatccttctccatctgga aattctgcctgcttaagctgccttaacaggttctcattaagggacctccttaaatggtgc aaacgaatagcagaattaggtttgaatggggatatgctgacagcttatcagtgccatctt atctatcaagaggctgtagacatattcgcgtccttttcagccccttctgaaaatcgactc actgtaatgagagacattgcaaagttgtggggagttcccatctcagaggcagcaatcctt tatccttgtaaacctgaaattcagaatttgttcacagaagtaagaattggtcgagttacc cttcaacgcactgaaactgtggtgcatggccaagagagacttgttgggatgcggagttct ttgtatgtgctcgagcaaatagcttgcgctgttaagtacaatgagcccattctcttggtt ggtgaaacgggaacaggaaagacaacacttgtacaaaatctagccatgatgctgggtcag aagcttactgttttgaacttgagtcaacaaagtgatattgctgatttgttggggggattt aagcccatagattcactatctatatgtattcctctgtataaggagttcgagattctattt tccaaaacattttcgatgaaggaaaatgataaaatttttgcttacctacaaaagcaaatg aagaagaagaactggaaaactttattaaatggatttaaaaagtatgttgataatttccaa aaaaaattacagacagaaagatctgggtctgggaagaaacggaaaaaacctttggatgaa aatatcagagcttgggagagtttctctgtaaaacttgaagctgctcttcgtcaaatcgaa gcttcatctggaatgctattttcatttgtagaaggatcctttataactgctcttagaaat ggggagtggattttgcttgatgaggtgaatttggctccacctgagaccttgcaaagagtt attggtgtccttgaaggagaatatgggtcactttgcttagctgaaagaggggatgttagt cagatacctagaaatcctagtttccgtatatttgcatgcatgaatcctgcaactgatgct gggaagcgagacttgccatactcattgcagagtagatttacagcatgctttgtccatgat gtgttggatagagatgatttgaagttatttattaacaaatttatggaggaaagcatatca aatattgaacttgaaaagaaaataattgatttctatgaagcagccaaaaagaactctgaa gaaaggctgcaagatggggccaatcagaagccacaatacagtttaaggtctttataccgt gcactagaatataccaggggggcaaagggaaaatttggatttccaaaagcaatttatgat ggattctgcatgttctttcttactatgttggacagacctagtgccaagattatgaaaaag atgataaaggagaaattgctgggaggaaataaaccttcacctgtaccttttgatgcttac ttgaggattacaaaaatctctggttttgatgatttatataagaattatgttctaacgaag agtgttaagaagcaacttgagaacttggcacgtgcggtttttattaagagatatcctgtt ctgttacagggtcccacttctagtgggaaaactagccttgtccagtatcttgctgcaaga actgggcatgaatttgtacggataaataatcatgaacatactgatctacaggaatatttg ggttcctatatatccgatgctcaagggaagcttgtatttcaggaaggcattttagttaag gctgttcgcaatggtcattggattgttctggatgagctcaatcttgctccttcagatgtg ctggaagcattgaatcgattgttagatgacaatagagaactttttttgcctgaattgcga gaaactgttcgggcacatccaaattttatgctttttgccacccaaaatccacctacgttc tatggtgggcgtaaaatgctttcccgagccttccgaaaccgttttgtggaggttcatgtg gatgaaattccagatgatgagttgagcacaataatagagaaaaggtgtaaaatacctgga agccgtgctaggttgatggttgaagtaatgaaggagttacagtttcacaggcagagtagc aaagtttttgctgggaaacatggattcataactccacgagacttgtttcgctgggcaaat cgtttgagggcttttggagattctaaagaagtcatggctgagcatggttattatcttttg gctgacagattgcgggatgaaagagagaggcatgtggttcaagaagttttggaaaggcat ctacgtgtgaaaattgtgagagatcacttgtacaaggaatcagttgcaagggaatcagaa tcaattggaagcgatttgcagagtttgggcgatgtcatactcacccgaagtatgaggaga ttgtatttccttgtcaagcgttgttttgagttgcgtgaacctgtacttcttgttggcgaa actggtggcgggaagactactgtctgtcagttactgagtagagcattggggttaaaatta cacatcttgaattgccaccaatacaccgaaacatctgatttcattggggggttctttcct gttcgagagagatcacgactagcatcagaattcaaatatataattgaaaaatggatgcat tcaaaagcttatacccactttgctcaggacttggatctttcttctgatattggtcaggct tcttccactcttgatcacctcaatctaataataacaagctatagacaaggccaagtttca tgtcctaatgtcagtgcgaaagacatcgacactcttgagcagatgaagtgggacctgact tgtttacttcagaagtggcaaacaatatttatgtggcaagatgggcctctagtgcaagca atgaaggctggtgatctgtttcttgttgatgaaatttctttggctgatgatagtgtattg gaaaggttgaacagtgtcttggagccagagagaaaattgtcattggctgagaaaggaggg ccagtcatggaaaatattactgctcatgaaaattttttcgtccttgcaactatgaatcct ggtggggattatggtaagaaagaattatctccagctcttcgcaacaggttcaccgaaatt tgggttcctcctgtttgtgatttagatgaacttggagatattgcttcaaaaagactttcc aatccagaactctcatacattgtgggtgctatgctgaagttctgggagtggttcaacaag ctagagaaagggagggcgctcactgtgagagatctcctctcttggattcagtttattatg gtgaccaaagaaggtttaggacctgattgtgcattcctccatgggcttttccttgtttta cttgatggaataagcctaggtactggtatttccagaaaggatgcaggattatttagagag acatgcctgtcttttcttttgaaagaattgaaggaggatagtaatctacatgaactttca tttattgaaaattatggttggggtgatcttggagaaactggcaatatttcatgcagtgat gatatgcagtgtgacaatagctttggtatagatccgttttacattgaaaaaggttatgaa aaatgtgaggctggtggttttgaatttttgacaccaacaacacgaagaaatgctttgcgt gttttgcgagctatgcagcttccaaagcctgttttactggaaggcagtcctggtgttggt aagacaagcttgattattgccttgggaaaatattctgggcacaaagttgtccgcataaat ttgtctgagcagactgacctaatggatctgctgggaacggacctacctgttgaaagtgat gaagggatgaaatttgcatggtctgatggaatcttgctacaggctctaaaggagggttgt tgggttttgctggatgagcttaatcttgccccacagtctgtcttagagggcttgaatgct atactggatcatcgtgctgaggtcttcattccagagcttagccttacctttaaatgtcca tcatctttcagaatatttgcatgtcaaaatcctttttctcaaggtggtggcagaaaaggc cttcccaaatcctttctgaaccgtttcactaaggtgtacatagatgagttagtagaaggt gattatctttccatctgtaattcgctttatccctctattccaaggcccttgctttcaaaa ctgattgtcttcaataaaaggctacatgaagacactatgttatatcacaagttcggtcaa gatggctccccttgggagttcaatttgcgtgatgtgattcgttcatgtcagatcattgaa ggtgtgcctgagaagttgaaggttgattgctttctcaacattctctatgttcagagaatg cgtactgctgctgaccgcaaagaagtcctgcggatctatgaagaggtatttggggttaaa ccattcattaatcctcacccacgagtgcagctaaattctaagtatttgattgtggggaac actgtcatcaaaaggaacatttcacggtcatccaagctttcaaacagtggattgaatatt atccccagtattcgccacagcatggaagctgttgtccattgtataaaacatcaatggttg tgcatcctggttggtccaccttgttcagggaagacttcattgataagactattagctcag ctcactggcaatgtgctaaatgaattgagcctttcaactacaactgatatatctgagttg cttggatgttttgagcagtataatgcctttcgcaattttaggtccgtcattgctcaagtt gagcgctatgttagtgagtactgcaacttgcaattggagttttcaaaggtggcatttatg agtgaaagaactgatttgattaccaaatggctagctttcttatctactatgaattccagc tccatggcaagttgtacttctattcatctggagaactgggagagcatgatgaactctctt agtttgcttgttgagatcattcaacaaatgaagttggatattgtacaaaatgaattacct ttttcttggtcaactgaagagctaaataaaaccatcaaggtaatctcaaagctgcaagat gatcaacaaagaaggtcacgttcagttaagtttgaatgggtggcaggattactcatcaag gcaatagaaaatggggaatggatcgttctagagaatgcaaatctttgcaatcccacggtt cttgatagaatcaactctttggtggagccgagtggttcgattacagttaatgagtgtggg atagttgatggaagctcagtggttcttcatccacaccataattttcgaattttcctcaca gttaatccaagccatggtgaagtgtcccgagcaatgcgaaacagaggagttgaaatcttt atgatgccgccatactggctacataacgacgaaagtggctgcagtggtgcagactttgaa cttaaggatgtaaaaagatttcttgtttcatctggcattcctatggatagattagttgat tcaatggccaaagctcacgtttatgccaagaatgaaggcttgcatgttaatgttcaaatc acatatcttgagcttgcccactgggtccagttatttcatcagcttctcataaatggtaac cagcctttctggagcctccaactaagttgggaacatacttatttatcttctttaggtgaa gctgtgggatgggatattgtcaatcacgcaaaagttgcttacttctcatccgcaacgttg tcagaatctgatttgcccacagagttttcattttatttgcctggggggttgccagtgcca atgaagttgagggattttatgtggtactcaaaagaagcttctgtcagacagaatctcatg tatttggagtaccttgtgtctcagtatgagttaggatcttcaaggaacaggagctgtgtg gacgatgctttgtctgctactagccacaagggaaacggtttgatggatatgaacatgaaa gggcagctcatgtttcctaaggctctgaactgcatgaatgctaactctgttaggaacaca gaaattgacatgaagctgacgaagaggatgctattgtttgctgccaactggacaattgaa caagcaactggaagtgattataaactttatcttctccactttagctggtttagttccaaa ctgcaatcatgtgatcattttttcagatcttttctgcatttactcgaacaagaattggag catcctatttggaagtgtatttttcattccttccatgagcttgcgtcccttcctgctgca aattctagcctgcatctgacaccgttgctttcagttgattttgttgatttaactatgtca tatgacaggccagaagtgtcacataaattcctttgcaatgctattaactgtatagacctt ctgaggctttcatatcaacagtggaatgctcaaagtgagcatgaatatactaatgaagct cagcatttcaaacctgtcttggatgctctgcaggagttggaaaaggaaattcttaatatg cttgttgaatctccatcttacaatgtcctgataaaattatacagtgacattcttgaagat cacttgacattttgggatgcgtttacctcatccgggttcgagaaattgcctgtttcttgg cattctttgatgaaggatgttttgaaattgcgggatttctgtcctggagctgttgacaat ctattcatgattgctgggaatatagataaaaaacttaatcaacactcacaacaatctttg ctctggattcatggtggtcatccaattttacctgcatctgctgaattatttaagcagcag cagttgtttatagagctatgcgagtcagtttggccaacaaaggcaaatccctataatcaa ggggatgattgtctcgttgagttggccacatcttccacccctgaacttcgcttccttgca gttcaaggtatatgcatgtcagcatatattaccagtagatttgatgaagatagtggtgaa gttgctctgcatttggcggacatgagtcaaatgctgttgaaaagatttgaatatgagaaa agcaatttggaggcaaagttaaagtccgttgagtctgctactatcgagggaaattcaata tcttgctgtgatttctctcctgaagcacggtgtacaaaacctggctttgcttgttggctg gaaacgcgtcctattattgacaatacaagttttttccttgacatggatctacttcaaaag ctttcaatgattgttttggttgatcacaaagaatgtcagctggctttgggcagtgtatct aacctgatagagtctgccatgaaacattctttaaccttttcaacaagacctccccaaaat tttatacctcatcaaaaaattttgtggacacttgatgcatggatgtcagtggatgcagtg aatgcaaaaattgccagttatgttcttgaaatgtggttttggtggcattcgtctttgtgg agccattgccctgttttttctgagaactttggaaaagttgatggttatcatactccactg cctgatatgctagttcaatctgtgcggactgcatctgttgtccaatctctgcgaagaaca tgtgctattaaggattactctgtgcactgcttgaagcttaaagctgcttcgtgcaacttg tggcaaagttctttaccagggatggacttatccagttttctcttatctgttactcgctct ctcttccaacagattatatatgcacacagaaaggcatttgatgctgataagtttgctgca atcaagtccatattttgctccttccataagaatggggcaacgcaagatgacatacagcgt ttggtatcaattcttggatcgtcaaaccatcaaaagctgaactccttggtgtctttgttc attgagccaatacttaaaaagctttatcttcactgctcatccaccgaggtgtacttggac atgggccatgcatgcttaaaaatcggggctttacgttttagtctcttgcttagctgtgat gatttcgaccctgccatgaaatattctttcaagcactctcaactagaagaaaggatttca tctcttgagcttgaaataaaggtgcggcaagaatgtgactatcttgcagggcggttatcc tcaatagaggctgataaaaagcgagcagattcattagaaaggcttgaatttgagcgtaga aggattcagaaaaagatggtgttccgctgtaatcctttaaaatttaatgctttgagaaag gaatgtggagagttccttaaacctgctaggatggttgtgggtttggtggataacattgaa ggtatggatttacaacaagttcttgaacaagcatccaattggcaggcaacagcaacctct tttattgaccgattatcagatgaatacaaggagtacattgatttagctcagccatttcaa gttgcagtatatgaaatgaaattgggcctgtcgctggtcctatcatttgccttgctcaag aatgttctgaatagaatcaaagaggataacatggatagagtcatggaatcaatttattca tttatgagatttcctcgtgtacgtgcattcgtaccaagttcttctcatagcataggcagt cctgctaccttttgggaccgtgaaatgggttttctggaaaagctgattatgctttctagt gaagtcactcatgaaaaaatggggtctatcttgcaactcaaaactggtctttatcagaat attgttgtccgtgttgcacattttgtagctgatgcacagaggattgatgatgcttctttc aagatattggataagatgttccatgaatttgccaacatgtggatcaatatgaaagttcaa gtaaaatgcaaagaaggcgaggatgctcaacaatacaagttcaggcctcgtgccttagag atcaaaagcattgttgatgttgatttttctactcttgaccaattctttccaaacgatagc ttttcagaatggcaggagtttctctctgaagaggaatctttagaaaagttggaagctagc aatgagcatgagagtgtccaggatgaatggaaccttatgcaggaaaccatcatgaagaat atgatctgcatacacaaccaattatttgggtccaccaatcttgttctatatgctggaact tgccatgttgttgaggctgataggttgcattcattcaccaactcttacacattaggggtg gggatgattgaagggttaggaggtctgctaacctccagtttggatggaaaactcatacca gagcatttacttcgcctttgtttagagcatggttcgaaacttgtctcttctcaaaaatca tcggccaattacaatttttacaaggattcaaatgcacccatgatggctaaaatggtgaag ttagttgctaatcttcaacagcaaatacatagctttttgagtgagtgggaagatcaccct ggtctccaaaaaatcacggataccattcaaatgctgttggctattccagtggagacccct cttgccaaggctcttttgggattgcaattcttacttaacagggccagagcattacaggaa aatgaatcaaaattccctctctctgatcaattggaacctatttctgctctggtatgctca tggcaaaagatggaattcgactcatggcccgctttgcttcatgaagtgcaggagcaatat gacgttaatgctggcaagttgtggtttcctctattttcagttttgcatcacagtcatttt gctgatattgctggatatgagcaatctactatagaaagtttagaggagttcattcgaact tccagcatcggtgaatttagagcgcgtcttcaacttcttttttctctccacggtcaaatc actgctggcagatgcctagaagtgcaaaattatttaagtacgcggcaggaaaaaaatcta cagattctgtataatgttttcggatactacattcagttcttgccaagaatattggaggac attgaagctaacagaaaaggtattgagatggaactgaaggacattttgaagctattccat tgggaacgaacagagatttgcttgtctgttgaaaactcaaaaaggacccgacagaagctt agaaagctaatactaaagtacacagatttgctgcaacaacctgtaatgcttattcttgac cgagaagcacagcagaaagaaccaaaaattcattctctacaatttccaaaggccttgaag gataacaagaacactatttcagatccgacacagttctgtgaaaaagacaggtctatatgg ttagctgattggaggaaaaaagtaactgatactttgcaggacatgcacttcaaaaacact ctgggattaagttttcttgataataaagatgtcacaagtatcaccaggcaatgcctcgct tcccattcttctcacctatcacgtgatgaacagtggaatgttttgtgttggacagtggaa aagatattcaaaactgctatggattgtgatgatctctggaatgacacaggaaaaggtgta gggaagaaaagggctttatctgaactactaaaattattagatactagtgggttgcataaa cacaagtttgaaattatgaagatatccaacagctccaactggttgttcattcaaccatca tacaatgcacagcatttgttgctgacaccaagtagactatctggtgaagcttttgatgtt tctacttccagtgaattgcaatgtttgcccgatgactatgtggatactatgtggaaatca gccaatgagttttacttcaaaagtgtggcatctgtgcagtttatgcaaaggatatgcctg aaaccccatggtgatattacttatgatcaggctagtagggcagtctcttttcttaaccat ctcattattatacaacaatcacaacgtgcagctgcctatggtttttctaagcaattgaag tgcttgcgggaatgtacatatgcttttgaaaactcgtacgtaaagtgcactgacattgat gaaagaactagcagtgagtactctattgtacaaaatcagcatgccttctttcagtgcatg tggaaacaaaagcaactttttgatggtctaactactctgttggctgaggaatcactgttg ctgagaacagtggaaagcacccatttgaagtcttgtcgaagtgtcagacctgctgcaaat catgtgcttcaattcattgaaaaatttatcccagttacgcagaaatccaaggagtcattg gataactatcttcttggtcaactaggaggcctgcaaagtcttctccaggaatcattggat aaatctctacttggccgtgttgttactatatctgctggaccttcacgtccttacattatt tcaaaacaaatggaacagttggtgtataaaaacttccaagtcattaaggagtttgaggag catttctttgatttccgtaagcaagactggaatagaagcttcatcatagagacactgctt ggtcattttgatgacgtatttaaagaggggaagatgttggctgaccagtttgagtctgct ctgaagcaaaggagccagtcaagagatttaagtgaagaggttgactacaacagtggaaat aactatcagcttgaagctgattttgacagtgccctcaagaaagcgcacaaccttgttatg gaggctttggaaaaacaaatttctccaggtgatggaggcgctctatctgaagaatcattg gaaaatatttcttcatgggaatatttatttaaatcatctgttcaaagcttgaatgtggaa gaattatgtgatattcttctcaatataataacttgtgtgaaaaaaatggtggaccattct ggcagtgaaacttcccatatttcttttcacattggaaggtgttttcagcatcttcattta cttttggagctaatattaggtttctgtgatggattacttcaagatcttttagcgatgcat aaaacagtatctataatgacccgtgagctggcaaatgttttggcttcattgttctccaaa ggtttcggcattcctgtcaaagacgaggtagatgaagctagtcatgataaatctcaaact gcaagtggaactggcatgggggaaggttctggacttaatgatgtcagtgatcagataact gacgaagatcaacttcttggaacttctgaaaaggcatgtgatgaacaagatgcctcaggt gaagttccaaataagaatgagaaaggtattgagatggaggatcttacggctgatacattt agtgtgagtgatgactctggagaggagaatgaggaagacggtgaggatgagcaactggat tctgcaatgggggaagctggattagacagtgaagttgttgatgagaaacttcagaataag gatgaagatgataaccctaataacactaatgaaagatacgaatctgggccgtcagttagg gacaatgatacaagtagccgggagcttagggccaaggaggattctgctgctattgctgat gatgaacctggagaacctgataaacaaaataatgaaattggaaaccaggatgatcttgat gatagagaagagaacacagatgacatgaatatggataaggaagcagcatttactgatcca actggattaaagcttgatgaatcaaatcaaggtgctgaagaggatatggagatggatgag gacatgaatgaagaaggtgacttggattcaaaggaagaaataagtccagaagagggtgat gagtctgctgagcatggaaactatgaggaagacaacacaatttctgctgatgaaactatg gaagaaccagatagcgaaccagttgatggaacttctgtaaaagatgaaccagggagggat agagaagagagatctgagaccaatgcaatggaaccaagaaacgatgaatttgatctggga atttctgatctaattagtgatcatgtgcatggtgcagaatctgcaacacagccgaatggt ccctcccaggcatctgattcaaaaaatgtgacagcagaagcaaacatgtctaacataagt gaagctcacaacgacctcgctctgagaagcttaccttctggaaatacttctcagaatgat ctgatggtctcagattcatcaaacagtggaggatttactaatgataaaaaacaagctcag ttccctgagagggaatcatcatctgatcagagagcccaaccaaatccttacagaaatgtt ggggatgcccttgaggagtggaaagaaagagtcaaagtgtctgttgatctgccaggagac accactgaggcgtcaggtgagatagaggacaagaatgctgatgactatgccttcgtctct gagtttgaaaagggaacagatcaagcattgggacctgccacctctgagcaggttgagtcc aatgtcaatgtaactaggagtgatgaagatggtctcgctgctcaaagagatgaagtcacc aagatggagattgaggagagagatgctaaagaatggcatctgaataactctgcctcaatc ctaaaaaataagatggaagaacagttgcagatctcagattttaagtcggaaaaggaggga ccccctgaagttcaggatcatgatggtgttgatccacaaaatctgcctgagagtgcgatc tctgtcaggaagtcttatttgagtgaggacatatatcaacccgataatcttcatgtagat gacaacgacttgggaaaagcccagggtcctgaagaagttcctcttgatgtcataagtagt gcttctgctctttggagcagatacgagttgcgcacaacaaggttgtcccaagaattggct gaacagttacgtcttgttttggaacctactgtagccagtaagcttcaaggggattataag actggcaaacgaattaacatgaagaaggtaattccttacatagcaagtcactaccgaaaa gataaaatatggctgaggcgaactcggcctaacaaacgtgattaccaagtcgtcattgct gtggatgattctcgcagtatgtctgagagttgctgtggggatgtcgcagttgaagcttta gtgacagtatgtcgtgccatgtctcaattggaaatgggtaacatggctgttgcaagtttt gggaagaagggaaatataagatccctgcatgattttgatcagcccttcacgggggaggct gggaaaaagatcatctccagtttgacattcaagcaagagaataccattgcagatgaacct gttgtagatcttttaaagtatctaaacaacatgctggatgctgcagttgcaaaagcacga cttccttctgggcagaacccgctgcaacagcttgtcttgattattgcagatggtcggttc catgaaaaggagaaattgaagcgttgtgttagggactttttaagtcggaagcgaatggtg gcatttctggtgctggacagcccgcaggagtcaatcatggaccagatggaagcatcattt gtgggtgaaggtgaaaaaagagtgctcaaatttacaaaataccttgattcctttcccttc ccatattatattgtactgaagaacatcgaagctcttccaaggactcttgccgatttatta agacagtggtttgagctcatgcagtattcaagggagtga

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