Pongo abelii (Sumatran orangutan): 100433973 Help Entry 100433973         CDS       T01416                                  Symbol TOP2A Name (RefSeq) DNA topoisomerase 2-alpha   KO K03164   DNA topoisomerase II [EC:5.6.2.2] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon01524   Platinum drug resistance Brite KEGG Orthology (KO) [BR:pon00001]  09160 Human Diseases   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     100433973 (TOP2A)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:pon03032]     100433973 (TOP2A)    03036 Chromosome and associated proteins [BR:pon03036]     100433973 (TOP2A) Enzymes [BR:pon01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.2  DNA topoisomerase (ATP-hydrolysing)      100433973 (TOP2A) DNA replication proteins [BR:pon03032]  Eukaryotic type   DNA Topoisomerases    100433973 (TOP2A) Chromosome and associated proteins [BR:pon03036]  Eukaryotic type   Chromosome condensation proteins    Other regulators of chromosome condensation     100433973 (TOP2A)   Centrosome formation proteins    Centriole proteins     100433973 (TOP2A) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim Microp_apicomplexa_20 Motif Other DBs NCBI-GeneID:  100433973 NCBI-ProteinID:  XP_024090653 Ensembl:  ENSPPYG00000008460 UniProt:  H2NU77 LinkDB All DBs Position 19:complement(70660160..70689553) Genome browser AA seq 1531 aa AA seqDB search MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ VQLNKKCSAVKHNRIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDK YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE ELAPNQYVISGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA KGKKTQMAEVLPSPCGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGMELEGLKQ RLEKKQKREPGTKTKKQTTLPFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLTNKELKPQKSAVSDLE ADDAKDSIPLSSSPPATRFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF NT seq 4596 nt NT seq  +upstreamnt  +downstreamnt atggaagtgtcaccattgcagcctgtaaatgaaaatatgcaagtcaacaaaataaagaaa aatgaagatgctaagaaaagactgtctgttgaaagaatctatcaaaagaaaacacaattg gaacatattttgctccgcccagacacctacattggttctgtggaattagtgacccagcaa atgtgggtttacgatgaagatgttggcattaactatagggaagtcacttttgttcctggt ttgtacaaaatctttgatgagattctagttaatgctgcggacaacaaacaaagggaccca aaaatgtcttgtattagagtcacaattgatccggaaaacaatttaattagtatatggaat aatggaaaaggtattcctgttgttgaacataaagttgaaaagatgtatgtcccagctctc atatttggacagctcctaacttctagtaactatgatgatgatgaaaagaaagtgacaggt ggtcgaaatggctatggagccaaattgtgtaacatattcagtaccaaatttacggtggaa acagccagtagagaatacaagaaaatgttcaaacagacatggatggataatatggggaga gctggtgagatggaactcaagcccttcaatggagaagattatacatgtatcacctttcag cctgatttgtctaagtttaaaatgcaaagcctggacaaagatattgttgcactaatggtc agaagagcatatgatattgctggatccaccaaagatgtcaaagtctttcttaatggaaat aaactgccagtaaaaggatttcgtagttatgtggacatgtatttgaaggacaagttggat gaaactggtaactccttgaaagtaatacatgaacaagtaaaccacaggtgggaagtgtgt ttaactatgagtgaaaaaggctttcagcaaattagctttgtcaacagcattgctacatcc aagggtggcagacatgttgattatgtagctgatcagattgtgactaaacttgttgatgtt gtgaagaagaagaacaagggtggtgttgcagtaaaagcacatcaggtgaaaaatcacatg tggatttttgtaaatgccttaattgaaaacccaacctttgactctcagacaaaagaaaac atgactttacaacccaagagctttggatcaacatgccaattgagtgaaaaatttatcaaa gctgcaattggctgtggtattgtagaaagcatactaaactgggtgaagtttaaggcccaa gtccagttaaacaagaagtgttcagctgtaaaacataatagaatcaagggaattcccaaa ctcgatgatgccaatgatgcagggagccgaaactccactgagtgtacgcttatcctgact gagggagattcagccaaaactttggctgtttcaggccttggtgtggttgggagagacaaa tatggggttttccctcttagaggaaaaatactcaatgttcgagaagcttctcataagcag atcatggaaaatgctgagattaacaatatcatcaagattgtgggtcttcagtataagaaa aactatgaagatgaagattcattgaagactcttcgttatgggaagataatgattatgaca gatcaggaccaagatggttcccacatcaaaggcttgctgattaattttatccatcacaac tggccctctcttctgcgacatcgttttctggaggaatttatcactcccattgtaaaggtg tctaaaaacaagcaagaaatggcattttatagccttcctgaatttgaagaatggaagagt tctactccaaatcataaaaaatggaaagtcaaatattacaaaggtttgggcaccagcaca tcaaaggaagctaaagaatactttgcagatatgaaaagacatcgtatccagttcaaatat tctggtcctgaagatgatgctgctatcagcctggcctttagcaaaaaacagatagatgat cgaaaggaatggttaaccaatttcatggaggatagaagacaacgaaagttacttgggctt cctgaggattacttgtatggacaaactaccacatatctgacatataatgacttcatcaac aaggaacttatcttgttctcaaattctgataacgagagatctatcccttctatggtggat ggtttgaaaccaggtcagagaaaggttttgtttacttgcttcaaacggaatgacaagcga gaggtaaaggttgcccaattagctggatcagtggctgaaatgtcttcttatcatcatggt gagatgtcactaatgatgaccattatcaatttggctcagaattttgtgggtagcaataat ctgaacctcttgcagcccattggtcagtttggtaccaggctacatggtggcaaggattcc gctagtccacgatacatctttacaatgctcagctctttggctcgattgttatttccacca aaagatgatcacacattgaagtttttatatgatgacaaccagcgtgttgagcctgaatgg tacattcctattattcccatggtgctgataaatggtgctgaaggaattggtactgggtgg tcctgcaaaatccccaactttgatgtgcgtgaaattgtaaataacatcaggcgtttgatg gatggagaagaacctttgccaatgcttccaagttacaagaacttcaagggtactattgaa gaactggctccaaatcaatatgtgattagtggtgaagtagctattcttaattctacaacc attgaaatctcagagcttcccatcagaacatggacccagacatacaaagaacaagttcta gaacccatgttaaatggcaccgagaagacacctcctctcataacagactatagggaatac catacagataccactgtgaaatttgttgtgaagatgactgaagaaaaactggcagaggca gagagagttggactacacaaagtcttcaaactccaaactagtctcacatgcaactctatg gtgctttttgaccacgtaggctgtttaaagaaatatgacacggtgttggatattctaaga gacttttttgaactcagacttaaatattatggattaagaaaagaatggctcctaggaatg cttggtgctgaatctgctaaattgaataatcaggctcgctttatcttagagaaaatagat ggcaaaataatcattgaaaataagcctaagaaagaattaattaaagttctgattcagagg ggatatgattcggatcctgtgaaggcctggaaagaagcccagcaaaaggttccagatgaa gaagaaaatgaagagagtgacaatgaaaaggaaactgaaaagagtgactccgtaacagat tctggaccaaccttcaactatcttcttgatatgcccctttggtatttaaccaaggaaaag aaagatgaactctgcaggctaagaaatgaaaaagaacaagagctggacacattaaagaga aagagtccatcagatttgtggaaagaagacttggctacatttattgaagaattggaggct gttgaagccaaggaaaaacaagatgaacaagtcggacttcctgggaaaggagggaaggcc aaggggaaaaaaacacaaatggctgaagttttgccttctccatgtggtcaaagagtcatt ccacgaataaccatagaaatgaaagcagaggcagaaaagaaaaataaaaagaaaattaag aatgaaaatactgaaggaagccctcaagaagatggtatggaactagaaggcctaaaacaa agattagaaaagaaacagaaaagagaaccaggtacgaagacaaagaaacaaactacattg ccatttaagccaatcaaaaaaggaaagaagagaaatccctggtctgattcagaatcagat aggagcagtgacgaaagtaattttgatgtccctccacgagaaacagagccacggagagca gcaacaaaaaccaaattcacaatggatttggattcagatgaagatttctcagattttgat gaaaaaactgatgatgaagattttgtcccatcagatgctagtccacctaagaccaaaact tccccaaaacttaccaacaaagaactgaaaccacagaaaagtgctgtgtcagaccttgaa gctgatgatgctaaggacagtataccactgtcttcaagccctcctgctacacgtttccca gatgaaactgaaattacaaacccagttcctaaaaagaatgtgacagtgaagaagacagca gcaaaaagtcagtcttccacctccactaccggtgccaaaaaaagggctgccccaaaagga actaaaagggatccagctttgaattctggtgtctctcaaaagcctgatcctgccaaaacc aagaatcgccgcaaaaggaagccatccacttctgatgattctgactctaattttgagaaa attgtttcaaaagcagtcacaagcaagaaatccaagggggagagtgatgacttccatatg gactttgactcagctgtggctcctcgggcaaaatctgtacgggcaaagaaacctataaag tacctggaagagtcagatgaagatgatctgttttaa

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