Pongo abelii (Sumatran orangutan): 100438508
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Entry
100438508 CDS
T01416
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X3
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon00790
Folate biosynthesis
pon01100
Metabolic pathways
pon01240
Biosynthesis of cofactors
pon01523
Antifolate resistance
pon04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
100438508 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
100438508 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
100438508 (FPGS)
Enzymes [BR:
pon01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
100438508 (FPGS)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
100438508
NCBI-ProteinID:
XP_024108153
Ensembl:
ENSPPYG00000019632
UniProt:
H2PTG9
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Position
13:119125532..119136930
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AA seq
587 aa
AA seq
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MSRARSHLRAALFLAAASARGVTTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWHLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDHHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSVQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSTSLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQSPSP
PKGLLTHPVAHSGAGVLREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
NT seq
1764 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcgtgcgcggagccacctgcgcgccgctctattcctggcagcggcgtctgcgcgc
ggcgtaacgacccaggtcgcggcgcggcggggcttgagcgcgtggccggtgccgcaggag
cccagcatggagtaccaggatgccgtgcgcatgctcaataccctacagaccaatgccggc
tacctggagcaggtgaagcgccagcggggtgacccccagacacagctggaagccatggaa
ctgtacctggcacggagtgggctgcaggtggaggacttggatcggctgaacatcatccac
gtcactgggacgaaggggaagggctccacctgtgccttcacggaatgtatcctccgaagc
tatggcctgaagacgggattctttagctctccccacctggtgcaggttcgggagcggatc
cgcatcaatgggcagcccatcagtcctgagctcttcaccaagtacttctggcacctctac
caccggctggaagagaccaaggatggcagctgtgtctccatgcccccctacttccgcttc
ctgacactcatggccttccacgtcttcctccaagagaaggtggacctggcagtggtggag
gtgggcattggcggggcttatgactgcaccaacatcatcaggaagcctgtggtgtgcgga
gtctcctctcttggcatcgaccacaccagcctcctgggggatacggtggagaagatcgca
tggcagaaagggggcatctttaagcaaggtgtccctgccttcactgtgctccaacctgaa
ggtcccctggcagtgctgagggaccgagcccagcagatctcatgtcctctatacctgtgt
ccgatgctggaggccctggaggaaggggggccgccgctgactctgggcctggagggggag
caccagcggtccaacgctgccttggccttgcagctggcccactgctggctgcagcggcag
gaccaccatggtgctggggagccgaaggcatccaggccagggcttctgtggcagctgccc
ctggcacctgtgttccagcccacatcccacatgcggctcgggcttcggaacacggagtgg
ccgggccggacgcaggtgctgcggcgcgggcccctcacctggtacctggacggtgcgcac
accgccagcagcgtgcaggcctgcgttcgctggttccgccaggcgctgcagggccgcgag
cggccgagcggtggccccgaggttcgagtcttgctcttcaatgctaccggggaccgggac
ccggcggccctgctgaagctgctgcagccttgccagtttgactatgccgtcttctgccct
aacctgacagaggtgtcatccacaggcaacgcagaccaacagaacttcacagtgacactg
gaccaggtcctgctccgctgcctggaacaccagcagcactggaaccacctggacgaagag
caggccagcccggacctctggagtgcccccagcccagagcctggtgggtccacatccctg
cttctggcgccccacccaccccacacctgcagtgccagctccctcgtcttcagctgcatt
tcacatgccttgcaatggatcagccaaggccgagaccccatcttccagtcccccagtccc
ccaaagggcctcctcacccaccccgtggctcacagtggggccggcgtactccgtgaggct
gctgccatccatgtgctagtcactggcagcctgcacctggtgggtggtgtcctgaagctg
ctggagcccgcactgtcccagtag
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