Pongo abelii (Sumatran orangutan): 100440374
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Entry
100440374 CDS
T01416
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon05012
Parkinson disease
pon05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
100440374 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
100440374 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pon01001
]
100440374 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
pon04131
]
100440374 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
pon04147
]
100440374 (LRRK2)
Enzymes [BR:
pon01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100440374 (LRRK2)
Protein kinases [BR:
pon01001
]
Serine/threonine kinases: TKL group
LRRK family
100440374 (LRRK2)
Membrane trafficking [BR:
pon04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
100440374 (LRRK2)
Exosome [BR:
pon04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
100440374 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
COR
LRR_4
Roc
Ras
LRR_14
LRR_9
WDR55
LRR_13
Arf
Beta-prop_EML_2
Beta-prop_RSE1_2nd
WD40_CDC20-Fz
Ank_2
T2SSE
LRR_NXF1-5
nSTAND3
AAA_22
Beta-prop_BBS7
Beta-prop_WDR19_1st
AAA_7
G-alpha
ABC_tran
AAA_16
MMR_HSR1
Kdo
NACHT
TrwB_AAD_bind
PduV-EutP
MobB
WD40_Prp19
cobW
Septin
AAA_29
FtsK_SpoIIIE
ResIII
AAA_23
ARM_LIN_2nd
TniB
WD40_WDHD1_1st
LRR_6
Motif
Other DBs
NCBI-GeneID:
100440374
NCBI-ProteinID:
XP_054383097
Ensembl:
ENSPPYG00000029445
LinkDB
All DBs
Position
10:37834197..37979055
Genome browser
AA seq
2557 aa
AA seq
DB search
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
HVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPGTMQSLMGPQDVGNDWEVLGVHQLILK
MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFLLIFDAMHSFPANDEVQKLG
CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
VLMSGNVRCYNIVVEAMKAFPISEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
AAVVPKIITVMKHHETSLPVQLEALRAILHFIVPGMPEESREDTESHRKLNMVKKQCFKN
DIHKLVLAALNRFIGNPGIQKCGLKVISSIAHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
EIQCLGLSLIGYLITKKNLCVGTGHLLAKILVSSLYRFKDVAEVQTKGFQTILAILKLSA
SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDDLKNVMLERACDQN
NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLSSGSREQDVRKALTISIG
KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
RMVIRYQMKSAVEEGTASGSDGNFSEDMLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELHQ
NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMNCIANLDVSRNDIGPSVVLDPTV
KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
LDMSSNDIQYLPGPAHWKSLNLRELLFNHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQGATVGIDVKDWPIQI
RGKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKV
NVTESKYQQECEQAQFESKHKRVLCLSLQARASSSPVILVGTHLDVSDEKQRKACISKIT
KELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVEL
EKIILSERKNVPVEFPVIDQKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPAL
QLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQYF
KLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLIN
RLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSC
RKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDL
MKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSF
GSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELA
SKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAA
IIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTG
GRIVEGLKFPNEFDELAIQGKLPDPVKEYGCAPWPMVEKLIKKCLKENPQERPTSAQVFD
ILNSAELVCLMRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYT
SEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYC
NSFSKQSKQKNFLLVGTADGNLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNST
ERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNS
PVVEVWDKKTEKLCELIDCVHFLREVTVKENKESKHKMSYSGRVKTLCLQKNTALWIGTG
GGHILLLDLSTRRLIRVIYNFCDSVRVMMTAQLGNLKNVMLVLGYNRKSTEGTQQQKEIQ
SCLTVWDINLPHEVQNLEKHIEVRKELAEKMRGTSVE
NT seq
7674 nt
NT seq
+upstream
nt +downstream
nt
atggctagtggcagctgtcaggggtgcgaggaggacgaggaaactctgaagaagttgata
gtcaggctgaacaatgtccaggaaggaaaacagatagaaacgctggtccaaatcctggag
gatctgctggtgttcacgtactccgagcacgcctccaagttatttcaaggcaaaaatatc
catgtgcctctgttgatcgtcttggactcctatatgagagtcgcgagtgtgcagcaggtg
ggttggtcacttctgtgcaaattaatagaaatctgtccaggtacaatgcaaagcttaatg
ggaccccaggatgttggaaatgattgggaagtccttggtgttcaccaattgattcttaaa
atgctaacagttcataatgccagtgtaaacttgtcagtgattggactgaagaccttagat
ctcctcctaacttcaggtaaaatcaccttgctgatattggatgaagaaagtgatattttc
ctgttaatttttgatgccatgcactcatttccagccaatgatgaagtccagaaacttgga
tgcaaagctttacatgtgctgtttgagagagtctcagaggagcaactgactgaatttgtt
gagaacaaagattatatgatattgttaagtgcgttaacaaattttaaagatgaagaggaa
attgtgcttcatgtgctgcattgtttacattccctagcgattccttgcaataatgtggaa
gtcctcatgagtggcaatgtcaggtgttataatattgtggtggaagctatgaaagcattc
cctatcagtgaaaaaattcaagaagtgagttgctgtttgctccataggcttacattaggt
aattttttcaatatcctggtattaaatgaagtccatgagtttgtggtgaaagctgtgcag
cagtatccagagaatgcagcattacagatctcagcgctcagctgtttggccctcctcact
gagactattttcctaaatcaagatttagaggaaaagaatgagaatcaagagaatgatgat
gagggggaagaagataaattgttttggctggaagcctgttacaaagcattaacgtggcat
agaaagaacaagcacgtgcaggaggccgcatgctgggcactaaataatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccatttcccagctcatagggaa
gtgatgctctccatgctgatgcattcttcatcaaaggaagttttccaggcatctgcgaat
gcattgtcaactctcttagaacaaaatgttaatttcagaaaaatactgttatcaaaagga
atacacctgaatgttttggagttaatgcagaagcatatacattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatctttttgaaggaagcaacacttccctggatataatg
gcagcagtggtccccaaaataataacagttatgaaacatcatgagacatcattaccagtg
cagctggaggcgcttcgagctattttacattttatagtgcctggcatgccagaagaatcc
agggaggatacagaatctcatcgtaagctaaatatggttaaaaaacagtgtttcaagaat
gatattcacaaactggtcctagcagctttgaacaggttcattggaaatcctgggattcag
aaatgtggattaaaagtaatttcttctattgcacattttcctgatgcattagagatgtta
tccctggaaggtgctatggattcagtgcttcacacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatacttgattacaaagaagaatttatgc
gtaggaactggacatctgctggcaaaaattctggtttccagcttataccgatttaaggat
gttgctgaagtacagactaaaggatttcagacaatcttagcaatcctcaaattgtcagca
tctttttctaagctgctggtgcatcattcatttgacttagtaatattccatcagatgtct
tccaatatcatggaacaaaaggatcaacagtttctaaacctctgttgcaagtgttttgca
aaagtagctatggatgatgacttaaaaaatgtgatgctagagagagcgtgtgatcagaat
aacagcatcatggttgaatgcttgcttctattgggagcagatgccaatcaagcaaaggag
ggatcttctttaatttgtcaggtatgtgagaaagagagcagtcccaaattggtggaactc
ttactgagtagtggatctcgtgaacaagatgtacgaaaagcgctgacgataagcattggg
aaaggtgacagccagatcatcagcttgctcttaaggaggctggccctggatgtggccaac
aatagcatttgccttggaggattttgtataggaaaagttgaaccttcttggcttggtcct
ttatttccagataagacttctaatttaaggaaacaaacaaatatagcatctacactagca
agaatggtgatcagatatcagatgaaaagtgctgtggaagaaggaacagcctcaggcagc
gatggaaatttttctgaagatatgctgtctaaatttgatgaatggacctttattcctgac
tcttctatggacagtgtgtttgctcaaagtgatgacctggacagtgaaggaagtgaaggc
tcatttcttgtgaaaaagaaatctaattcaattagtgtaggagaattttaccgagatgcc
gtattacagcgttgctcaccaaatttgcaaagacattccaattccttggggcccattttt
gatcatgaagatttactgaggcgaaaaagaaaaatattatcttcagatgattcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttctctggcttctgag
agagaatatattacatcactagacctttcagcaaatgaactaagagatattgatgcctta
agccagaaatgctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcactcacgagctttccacaacagctatgtgaaactctgaagagcttgacacatttg
gacttgcacagtaataaatttacatcatttccttcttacttgttgaaaatgaattgtatt
gctaaccttgatgtctctcgaaatgacattggaccctcagtggttttagatcctacagtg
aaatgtccaactctgaaacagtttaacctgtcatataaccagctgtcttttgtacctgag
aacctcactgatgtggtagagaaactggagcagctcattttagaaggaaataaaatatca
gggatatgctcccccttgagactgaaggaactgaagattttaaaccttagtaagaaccac
atttcatccctatcagagaactttcttgaggcttgtcctaaagtggagagtttcagtgcc
agaatgaattttcttgctgctatgcctttcttgcctccttccatgacaatcctaaaatta
tctcagaacaaattttcatgtattccagaagcaattttaaatcttccacacttgcggtct
ttagatatgagcagcaatgatattcagtatctaccaggtcctgcacactggaaatctttg
aacttaagggaactcttatttaaccataatcagatcagcatcttggacttgagtgaaaaa
gcatatttatggtctagagtagagaaactgcatctttctcacaataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctctggatgtcagttacaacttggaa
ctaagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcgtcttaactttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcggttaaaaaaggctgtgccttataaccgaatgaaacttatgattgtg
ggaaatactgggagtggtaaaaccaccttattgcagcaattaatgaaaaccaagaaatca
gatcttggaatgcaaggtgccacagtcggcatagatgtgaaagactggcctatccaaata
agaggcaaaagaaagagagatctcgtcctaaatgtgtgggattttgcaggtcgtgaggaa
ttctacagtactcatccccattttatgacgcagcgagcattgtaccttgctgtctatgac
ctcagcaagggacaggctgaggttgatgccatgaagccttggctcttcaatataaaggtg
aatgtcacggaaagcaaatatcaacaggaatgtgagcaggcccaatttgaaagcaaacac
aagagggttttgtgtctttccctccaggctcgcgcttcttcttcccctgtgattcttgtt
ggcacacatttggatgtttctgatgagaagcaacgcaaagcctgcataagtaaaatcacc
aaggaactcctgaataagcgagggttccctgccatacgagattaccactttgtgaacgcc
accgaggaatctgatgctttggcaaaacttcggaaaaccatcataaacgagagccttaat
ttcaagatccgagatcagcttgttgttggacagctgattccagactgctatgtagaactt
gagaaaatcattttatcggagcgtaaaaacgtgccagttgaatttcctgtaattgaccag
aaacgattattacaactagtgagagaaaatcagctgcagttagatgaaaatgaacttcct
cacgcagttcactttctaaatgaatcaggagtccttcttcattttcaagacccagcactg
cagttaagtgacttgtactttgtggaacccaagtggctttgtaaaatcatggcacagatt
ttgacagtgaaagtggaaggttgtccaaaacaccctaagggaattatttcgcgtagagat
gtggaaaaatttctttcaaagaaaaggaaatttccaaagaactacatgtcacagtatttt
aagctcctagaaaaattccagattgctttgccaataggagaagaatatttgctggttcca
agcagtttgtctgaccacaggcctgtgatagagcttccccattgtgagaactctgaaatt
atcatccgactatatgaaatgccttattttccaatgggattttggtcaagattaatcaat
cgattacttgagatttcaccttacatgctttcagggagagaacgagcacttcgccctaac
agaatgtattggcgacaaggcatttacttaaattggtctcctgaagcttattgtctggta
ggatctgaagtcttagacaatcatccagagagtttcttaaaaattacagttccttcttgt
agaaaaggctgtattcttttgggccaagtcgtggaccacattgattctctcatggaagaa
tggtttcctgggttgctggagattgatatttgtggtgaaggagaaactctgttgaagaaa
tgggcattatatagttttaatgatggcgaagaacatcaaaaaatcttacttgatgacttg
atgaagaaagcagaggaaggagatctcttagtaaatccagatcaaccaaggctcaccatt
ccaatatctcagattgcccctgacttgattttggctgacctgcctagaaatattatgttg
aataatgatgagttggaatttgaacaagctccagagtttctcctaggtgatggcagtttt
ggatcagtttatcgagcagcctatgaaggagaagaagtggctgtgaagatttttaataaa
catacatcacttaggctgttaagacaagagctggtggtgctttgccacctccaccacccc
agtttgatatctttgctggcagctgggattcgtccccggatgttggtgatggagttagcc
tccaagggttccttggatcgcctgcttcagcaggacaaagccagcctcactagaacccta
cagcacaggattgcactccatgtagctgacggtttgagatacctccactcagccatgatt
atataccgagacttgaaaccccacaatgtgctgcttttcaccctgtatcccaatgctgcc
atcattgcaaagattgctgactatggcattgctcagtactgctgtagaatggggataaaa
acatcagagggcacaccagggtttcgtgcacctgaagttgccagaggaaatgtcatttat
aaccaacaggctgatgtttattcatttggtttactactctatgacattttgacaaccgga
ggtagaatagtagagggtttgaagtttccaaatgagtttgatgaattagcaatacaagga
aaattacctgatccagttaaagaatatggttgtgccccatggcctatggttgagaaatta
attaaaaagtgtttgaaagaaaatcctcaagaaaggcctacttctgcccaggtctttgac
attttgaattcagctgaattagtctgtctgatgagacgcattttattacctaaaaatgta
attgttgaatgcatggttgctacgcatcacaacagcaggaatgcaagcatttggctgggc
tgtgggcacaccgacagaggacagctctcatttcttgacttaaatactgaaggatacact
tctgaggaagttgctgatagtagaatattgtgcttagccttggtgcatcttcctgttgaa
aaggaaagctggattgtgtctgggacacagtctggtactctcctggtcatcaataccgaa
gatgggaaaaagagacataccctggaaaagatgactgattctgtcacttgtttgtattgc
aattccttttccaagcaaagcaaacaaaaaaattttcttttggttggaaccgctgatggc
aatttagcaatttttgaagataagactgttaagcttaaaggagctgctcctttgaagata
ctaaatataggaaatgtcagtactccattgatgtgtttgagtgaatccacaaattcaacg
gaaagaaatgtaatgtggggaggatgtggcacaaagattttctccttttctaatgatttc
accattcagaaactcattgagacaagaacaagccaactgttttcttatgcagctttcagt
gattccaacatcataacagtggtggtagacactgctctctatattgctaagcaaaatagc
cctgttgtggaagtgtgggataagaaaactgaaaaactctgtgaactaatagactgcgtg
cactttttaagggaggtaacagtaaaagaaaacaaggaatcaaaacacaaaatgtcttat
tctgggagagtgaaaaccctctgccttcagaagaacactgctctttggataggaactgga
ggaggccatattttactcctggatctttcaactcgtcgacttatacgtgtaatttacaac
ttttgtgattcggtcagagtcatgatgacagcacagctaggcaaccttaaaaatgtcatg
ctggtattgggctacaatcggaaaagtactgaaggtacacaacagcagaaagagatacaa
tcttgcttgactgtttgggacatcaatcttccacatgaagtgcaaaatttagaaaaacac
attgaagtgagaaaagaattagctgaaaaaatgagaggaacatctgttgaataa
DBGET
integrated database retrieval system
