Pongo abelii (Sumatran orangutan): 100445190 Help Entry 100445190         CDS       T01416                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:pon00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     100445190 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:pon03036]     100445190 (SYNE1) Chromosome and associated proteins [BR:pon03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     100445190 (SYNE1) SSDB OrthologParalogGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH Spectrin_SYNE1_2 SR_desmoplakin_3 SYNE3 Motif Other DBs NCBI-GeneID:  100445190 NCBI-ProteinID:  XP_054414303 Ensembl:  ENSPPYG00000017113 LinkDB All DBs Position 5:complement(153767811..154280202) Genome browser AA seq 8827 aa AA seqDB search MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTD IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSLVSSETPSPPSKRKVT TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLEKVKGR PNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNAGTDGQ EDDEILPGFPSFANSIQNFKREDKLIFKEMKVWIEQFERDLTRAQVVESNLQDKYQSFKH FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT IGAWLYRAEVALREEITIQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY TDCVVTLSAFATEAHKKISEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK IDEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD QTRLQRQIADVHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL CEKRLQLIEELCVKLPVRDPVRDTPGTCHTTLKELKAAIDSTYRKLMEDPDKWKDYTSRF SEFSSWISTNETQLKGIKGEAIDTASHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGREE LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYWEELQEHAQCLEGTILGHLSQ QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQTLESLSSAITAFS ASARKVVNRDSCVQEAAALQQQYEDILRRVKDRQTVLENLLAHWQRLEKELSSFLTWLER GEAIASSPEMGISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE ISVMDHQVALTRHKDHAAAVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF EEASQVVERRQLALSHLAEFLQSHASLSGILHQLRQTVEATNSMNKNESDLIEKDLNDTL QDAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRAMADQLCGEVERIQNLLGTKQSEA DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSSRDEIEGWS NNSVPQMAENISNLDNRLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD LQFIEADLRQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWLTKVEESLMNCAQT ETCEGLKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAMS QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLEELLAARES LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL QSMWSWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDHLERKNQLEQWMESVD QKVEHPLQPQPGLKEKFALLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA QGELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEEFSALLKTWAQQLTLLEGKNTDE EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE SENGQHKLNMMLSKGELLSTLPTKEKAKGIQAKVAAAKEDWKHFHSNLHQKESALENLKI QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFALGIKELQ DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDDVRQFSGWMDSMEANLN ESERQHAELRDKITMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF NNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD EVEEVGARAQEILDESHVNSGMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS LSSYSDWYGSTHKNFKNVATKIDKVDTAMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLK DKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLET SSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGT KDSYSAICSTAQRVYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAV KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQRLVQAQNLTQGWE EIKHLKAELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFMKKLQSKQASVNTII EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL EKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKEL VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ SPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSH VNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV KTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHR LQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESTELHTQLAKYQHILEQSP EYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPQQFNVIVALAKDKFYKVQEAILAR KEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRGILDEVAGLGEAVDEL NQKKEGFRSTGQPWQPDKMLHLVTLYHRMKRQTEQRVSLLEDTTSAYQEHKQMCQQLERQ LKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGILLKRVTIHLEDLAPHLDPLAYEK ARHQIQSWQEELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYL DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSEL DGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQEMLQLAGNGLDVESAEENLK SHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKMASLELRSQRMSRDSAAQV DLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVN SFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEW TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ QALSMLQDGAASTPGGEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQIN SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKDKYLGLYTILP SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKIAKDLTTILTKLKAKTD NLVQAKTDQKVLGEELDGCNSKLMELDAAVQKFSEQNGQLGKPLAKKIGKLTELHQQTIR QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL EESKEIDSDLEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKD MKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQ SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQL IEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHAT MLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI SSPPARRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSTSQEFYEPGLEPSA TAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAER MSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEAEELDSWLLSTKATLDTALSPP KEPMDMEAQLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLK GSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED QMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTS LLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETE TCLFNQENLAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVN QRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL KELDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMTIGSRRSGLNQNLTLKSQYER ALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIIS FAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELGRQLEVVESSIP SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLG ERWLSNTNKVSKELHRLETILKHWTRYQSESADLIQWLQSAKDRLEFWTQQSVTVPQELE MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSHIDSQWTDLLT NIPAIQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKY KGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEK IQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKA KEKEVEKIEQNGLALIQNKKEDVSGIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWS NHKAAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKHERSLQKFGSI TNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLHSSKALLQLWQRYKDYSKQCAS TVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFVLHELGEQLKQQ VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEE ILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQ RRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPVSGLGSVPIPLQQARTLFDEVQFKEKV FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELTEIQDKWKSASMRLEEQKKKLAFLLK DWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL LKDTLSAYISADDISILNERIELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC EWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKAS EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQ KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRL PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNPSLSLAQPLRSERSGRD TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP EAYVKLTESAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSY KGYMKLLGECSGSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALS KELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQK AVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALM QCQDFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIRHELLESQLRVA SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLRLLLKEVSRHIKELEKLLDVSSSQQDLS SWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSE PGPGRSGRAFLFRVLRTALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRY TNGPPPL NT seq 26484 nt NT seq  +upstreamnt  +downstreamnt atggcaacctccagaggggcctcccggtgtcctcgggatatcgccaatgtgatgcagagg ctgcaagatgagcaagagatagtacaaaaacgaactttcacaaaatggatcaactctcat ctggccaagcggaaacctccaatggtggtggatgatctttttgaagacatgaaagatggt gtaaaactgcttgcccttctggaggtcctgtctgggcagaaactgccttgtgaacaagga cgccggatgaagcgaatccatgctgtggctaacattggcacggcactcaagttcctcgaa ggaagaaagtccatgcacagaggatcaccgattaaattagtcaacattaactccaccgat atagctgatggccgaccctcaatagttcttggattgatgtggaccattattctatatttc cagattgaagagttgaccagcaacctgccccagctccagtctttgtccagcagcgcatcc tccgtggacagcttagttagctctgagactcccagcccaccaagtaaacggaaggtgacc accaagatccaaggaaatgccaagaaggctttattaaagtgggttcagtacacggctggc aagcagactggaatagaagtaaaagattttgggaagagttggagaagcggagttgccttt cattcagttattcatgccattcgacccgaactggtggacttggagaaagtgaaaggcaga cccaaccgagaaaatctggaggatgctttcactatcgccgaaacggaactggggatccca agactgctagatcctgaagatgttgacgtggataaaccagatgagaagtctattatgacc tatgtagcccagtttctgaaacattatcctgacatccacaatgcaggcactgatgggcaa gaggatgatgaaatacttccaggtttcccatcttttgcaaattctatacaaaattttaag agagaagacaagctaatttttaaggaaatgaaagtttggatagaacaatttgagagagat ttgacaagagcacaggtggtggaatcaaatttacaggataaatatcagtcatttaagcac ttcagagttcaatacgaaatgaagaggaaacagattgaacatttaatacaaccattacat agagacggtaaattgtcacttgaccaagcattggtaaaacaatcttgggatagagtgacc tccaggctctttgactggcatatacagcttgataaatctcttcctgcacctctgggcacc ataggtgcctggctgtacagagcagaggtggccctgagagaggaaataaccattcaacag gtccacgaggaaacagcaaacacgatacaacggaaacttgagcaacataaggatctgctt caaaacacagatgcccacaaaagagcattccatgaaatctaccggaccaggtctgttaac gggattccagtgccacctgatcaattagaggacatggccgagaggtttcattttgtttcc tccacatcagagctacacctaatgaaaatggaatttttagaattaaagtaccgtctgctc tcactgctggttcttgcagagtcaaagctgaagtcttggatcattaagtacgggaggaga gagtcagtggagcagcttctacaaaactacgtgtcttttatagaaaatagcaagttcttt gaacaatatgaagtgacataccagatcttgaaacagacagctgagatgtatgtcaaagca gatggttcagtggaagaagctgagaatgtgatgaaattcatgaatgaaaccaccgctcag tggaggaatctctcagtagaagttaggagtgtgaggagcatgctggaagaagtgatctct aactgggatcgctatggcaatacagtggctagtctgcaagcctggctagaggatgctgaa aaaatgctcaatcaatcagaaaatgccaaaaaggatttttttcgaaatttacctcattgg attcagcagcatactgccatgaacgatgctggcaattttctaattgaaacctgtgatgag atggtttcccgtgacctgaagcagcaattactgttgctaaatgggcggtggagggagttg tttatggaagtcaagcaatatgctcaagctgatgagatggacagaatgaagaaggaatac acagactgtgttgttaccctgtctgcttttgcaacggaagcccataagaaaatttctgaa cccttagaagtctcttttatgaatgtcaagttattaattcaagacttggaggatattgag cagagggtgcctgtgatggatgcccaatacaagataattaccaagacagcacacctcatt accaaagaaagcccccaagaagaaggaaaagaaatgtttgcaaccatgtcaaagctcaaa gagcagctaaccaaggtcaaagaatgttactccccactcctttatgagtctcagcagctg ttgattccgttggaggaattagaaaagcagatgacgtccttttatgactcacttgggaaa atcgatgaaattatcacagttcttgagcgtgaggcacaatcgagtgctctttttaaacaa aaacatcaggaactgttagcttgtcaagaaaactgtaagaaaaccttgacacttattgag aaaggcagtcaaagtgttcaaaagtttgtgaccttgagcaacgtgttaaagcattttgat cagacgaggctacaaagacagattgcagatgttcatgttgcttttcagagtatggtaaag aaaactggagattggaagaagcatgtggaaaccaacagtcgcttgatgaagaagtttgag gagtctcgagcagagttggagaaggtactgcggattgctcaggagggcctggaggaaaag ggggatccggaggagctcctgcggagacacactgagtttttcagtcagctggatcagagg gtgctcaatgctttcctgaaagcttgtgatgaactcaccgacatccttccagagcaggag cagcaggggctgcaggaagctgttcgaaagctccacaaacagtggaaggatcttcaagga gaagccccttatcatttgcttcatctgaagattgatgtggagaagaataggttcttagcc tctgtagaagaatgcagaactgagctggatcgagagaccaagctgatgccccaggaaggc agtgaaaagataattaaagagcacagggttttcttcagtgacaaaggtcctcatcatctc tgtgagaaaaggttacagctcatcgaggaactctgcgtgaaactcccagtccgggaccca gtaagggacacacctggaacctgtcacacgacactcaaagagctcaaagctgccattgac agcacctacaggaagctcatggaagacccagacaagtggaaggactacactagcagattc tctgagttctcatcttggatatctacaaatgagacacaattaaaggggatcaagggtgag gccatcgatactgccagccacggagaggttaaacgtgccgttgaagagatcagaaatggc gttaccaaaaggggcgagaccctcagctggctgaaatccaggctgaaagttttgacagaa gtttcttctgaaaatgaagcccaaaagcaaggagatgagctggcaaaattatccagctct ttcaaggctcttgtgacgctgctgtcagaggttgaaaagatgctaagcaattttggggac tgtgtccagtacaaagaaatagtcaaaaattctcttgaagaattaatttctggctctaaa gaagtccaggaacaagctgagaagatcttggatactgaaaatctgtttgaagcacagcag ttacttcttcatcaccagcaaaagacaaagcggatctcagcaaagaagagagatgtgcag cagcagatcgcgcaggcgcagcagggagaaggggggctgcctgaccgaggccgcgaggag ctgcggaagctggagagcacgctggatggcctggagcgcagccgggagaggcaggagcgc cgcatccaggtcacattaagaaaatgggagcgatttgaaacaaacaaagaaacagtagta agatacctttttcaaacaggttccagtcatgaacgcttcttgagttttagcagtttggaa agtttatcttcagaactggaacaaacaaaggagttttctaaacggacagaaagtattgca gtccaggctgagaaccttgtaaaggaagcttcagagataccacttgggccccaaaataag cagctgcttcaacagcaggccaagtcaatcaaagaacaagtcaaaaaattagaagacacg cttgaagaagatattaaaaccatggaaatggtgaaaaccaagtgggatcattttggcagt aattttgagactctgtccgtctggataactgagaaagaaaaagaactcaatgccttggaa acttcgtcatctgccatggacatgcaaatcagccaaattaaggtcacaattcaggaaata 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gagagcaaaaagggcgaattgcagagtctgcagggtcacttagcaaagttgggttctctg ggccgtgctgaggacctccacctcctgcagggcaaggctgaggactgcttccagctgttt gaggaggccagccaggttgtggagaggcggcagcttgccctgtctcatttggcagaattc ctccagagccatgcctctctgtctggcattctccaccagctgaggcaaacagtggaagca accaacagtatgaataagaatgagtctgatttgatagaaaaggacctcaatgatactctt caagatgctaaagcattagaatctgccgccgtcagtctcgatggcattctttccaaagcc caataccatctgaaaatcgggagctctgagcaaaggacttcctgcagagccatggctgat cagctctgtggagaggtagagaggatccagaaccttctgggaaccaagcagagtgaggca gatgccctggcagtgctgaaaaaagcattccaagaccagaaagaggagcttctgaaaagc attgaggacattgaagaaaggactgacaaagagcgattgaaagaacctacccgccaagct cttcagcagaggttaagagtgtttaatcagctagaagatgaattgaattctcatgagcat gaactatgttggttgaaagacaaagccaagcaaattgcccagaaagacgtagcttttgca cctgaagttgacagggagataaaccgcttagaggtcacctgggatgataccaaaagacta attcatgaaaatcagggtcagtgctgtggacttattgacttaatgagagaatatcagaac ctgaaatcagctgtatctaaagtcttagaaaatgccagcagtgtgattgtaaccagaact accataaaagatcaggaggatcttaaatgggctttttccaagcatgaaactgccaagaac 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gaatcggaaaggcagcatgcggagctgcgggataaaataactatgctcggaaaagccaag ttattaaatgaagaagtgctgagttacagcagcttgctggagaccattgaagtcaaaggg gctggcatgacagaacactatgtcacccagctagaactccaggatctacaggaacgatac agagccatccaagagagggccaaggaagctgtaaccaagtctgaaaaacttgtccgcctg caccaagagtatcagagagacctaaaggcatttgaagtttggttggggcaagaacaagaa aaactcgaccagtattcagttcttgaaggtgatgcccacactcatgagacaacattgcgt gatcttcaggagctacaggtacactgtgcagaggggcaggccctgttgaactcagtgctg cacaccagagaggatgtgatcccatcaggtatcccacaggcagaggaccgggctttagag tctctccggcaagactggcaggcttaccagcacaggctgtccgagacccgaactcagttc aataacgtggtgaacaaattgaggctaatggagcaaaagtttcagcaagtagacgaatgg ctcaaaacagcagaggagaaagttagtcccaggaccagacgtcagtctaacagggcaacc aaggagatacaattacatcagatgaagaagtggcacgaagaagtgactgcgtacagagat gaagttgaggaagtgggtgctagagctcaggagatactggacgagagccacgtgaacagc ggaatgggttgccaggccacccagctgacttccagataccaggccctgcttctccaagtg ctagaacaaataaaattcctggaggaagagattcagagtttggaggaatcggaatcatcc ctcagctcctattctgattggtatggctctacgcataaaaacttcaagaacgtggctacc aagattgacaaagtagatacagcaatgatgggaaagaaattgaagacgttggaggttttg ctcaaagacatggagaaaggtcacagtttgctgaaatcagcccgggagaaaggagagagg gctgttaaatacttggaggaaggcgaggcagagaggttaagaaaggagattcatgatcac atggagcagttgaaggaactgaccagcactgtccggaaagaacacatgacgctggaaaaa ggtcttcatttagcaaaggaattctcagataaatgcaaagcactgacacagtggatagca gaataccaggaaatcctacatgttcctgaagaacccaaaatggaattatatgagaaaaaa gctcagttatctaaatacaagtcacttcaacaaacggtgctgtcccatgaaccatcagta aagtcagtcagagagaagggtgaagctcttttggaactggtgcaggatgtcactttaaag gacaaaatagatcaacttcaaagtgattaccaggacctgtgcagcataggaaaggagcat gtcttcagtctggaggcgaaagtcaaagaccatgaagactacaacagtgagctccaagag gtcgaaaagtggctgctgcagatgtccggcagactggtggcacctgacctcctggagacg agcagcctggagacaatcacccagcaactggcccaccataaggcaatgatggaagaaatt gctggttttgaagaccgtttgaacaatcttcaaatgaaaggtgatactttgattggccaa tgtgcagaccacctgcaagcgaaacttaaacaaaatgtgcatgctcatctgcagggcaca aaggacagctactcagcgatctgcagcacagctcagagggtgtaccagagtttggaacat gaacttcagaagcacgtcagccgacaagacaccctgcagcagtgccaggcctggctttct gcagtccagccggatttagagccaagtcctcagccacctcttagcagggcagaagccgtt aagcaggtcaaacacttcagagctttgcaagagcaggcaaggacctacctagatctcctt tgttccatgtgtgacctgtcaaatgcttcggtcaaaaccacagcaaaagacattcaacaa acagagcaaacgattgaacaaaggcttgtccaggcccagaacttaactcagggttgggaa gagatcaagcacctgaaggctgagctctggatttacctgcaagatgctgatcagcaactg cagaacatgaagaggaggcactctgagctggagctgaatattgcacagaacatggtttca caagttaaggattttatgaagaaactacagagcaaacaggcatccgtgaacaccataata gaaaaggtgaataagttaacaaagaaggaggaatcgcctgaacacaaggaaataaatcat ttaaatgatcagtggctcgatttgtgccgtcagtctaacaacctgtgcttgcaaagggaa gaggatcttcagagaacaagagattaccatgactgtatgaatgttgttgaagtgttccta gaaaaatttactacagaatgggataacttggccagatctgatgcagagagtacagctgtc cacctggaagctctgaaaaagttagcattggcattgcaggagagaaagtatgctattgaa gatctgaaagatcaaaagcagaaaatgatagagcatctgaatttagatgacaaggagtta gtcaaagaacagacgagtcatttagagcaacgttggtttcagcttgaggacctcattaaa aggaaaatccaagtgtcagtcaccaacttggaggagttaaatgtggtgcagtccagattt caggagctaatggagtgggcagaagagcaacaacccaacatcgccgaggcccttaagcag 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accctgacttctcccgaagttggacgcctcagtctcaaggagcagctctctcatcggcag catctgttgtctgagatggagtcactgaagccgaaggtgcaagcagtgcagctctgccag agtgccctccggatccccgaggatgtggttgccagcttacctctctgtcatgctgctctg cggctgcaggaagaggccagccggctgcagcacaccgccatccagcagtgcaacatcatg caggaggctgtggtgcagtatgaacaatatgagcaagaaatgaaacatctccagcaactg atagaaggagctcacagagagattgaggataaacctgttgccaccagtaacatacaggag ctgcaggctcagatttctcggcatgaggagctggcgcagaaaattaagggctaccaggag cagatcgcttctttgaattccaagtgcaagatgctgacgatgaaagccaagcacgccacc atgctgctgacggtgaccgaggtcgaggggctggcggaagggacagaggacctggatggg gagctcctccccacgccttcggcccacccctctgtggtcatgatgactgcaggtcgctgt cacactttgctgtcaccggtcactgaggagtctggggaggagggaaccaacagtgagatt tcctctccacctgcccgtcgctccccttcacctgtggctaatacagatgcttctgttaac caggacattgcatattaccaagccttgtctgctgagaggttgcagacagatgctgcaaaa attcaccccagcacatccacatcccaggagttctatgaaccgggattggagccatccgct actgccaaactgggtgatttgcagcgttcttgggaaaccttaaagaatgtgatcagtgag aagcagcgcacactctatgaagctttggaacgccagcagaagtaccaggactccctccag tccatctctacgaagatggaggccattgagctgaaactcagtgagagcccagagcctggc aggagtccagaaagccagatggctgaacatcaggcattgatggatgagattctcatgctc caggatgaaatcaatgagctccagtcctctctggcagaggagctggtatccgagtcttgt gaggccgaccccgcggagcagctggccttgcagtccacgctcactgtcttagccgagcga atgtccaccatcaggatgaaagcctcagggaaacggcagcttttggaggagaagttgaat gatcagctggaggaacaaaggcaggaacaggccctgcagaggtatcgctgtgaagccgaa gagctggacagctggctcttgagtaccaaggccactctggacactgcgctgagtccaccc aaggagcccatggacatggaggcccagcttgtggactgccagaatatgctggtggaaata gagcagaaggtggtggctttatcagaactgtcagtccacaatgagaacctgctgctggag ggcaaagctcacaccaaggacgaggccgagcagctggctggaaagctgagaaggctcaag gggagcctgctggagctgcagagagcgctgcacgataagcagctcaacatgcagggaaca gcacaggagaaggaggagagcgatgttgacctaacagccacgcagagccccggcgtccag gaatggctggcccaagctcgcaccacgtggacccagcagcggcagagcagtctccagcaa caaaaagagttagaacaggaattagctgagcagaagagtctccttcgctcagtagccagt cgtggagaggagattctaattcaacattcggcggcagagacttctggtgacgctggcgaa aaacctgatgtgttatcccaggagttggggatggaaggggagaaatcatccgctgaagac cagatgagaatgaaatgggaaagcctacatcaagaatttagtaccaaacagaaactacta cagaatgttctggaacaggaacaagagcaagtgctttatagcagaccaaatcgactgttg tctggtgtgccactgtacaaaggggatgtgccgacccaagataaatctgcagttacatct ttgctggatggactgaaccaagcctttgaggaggtttcatcccagagtggaggggcaaag aggcagagtatacacttggagcagaagttgtatgatggggtctcagccacctctacttgg ttggatgacgttgaagaacgtttatttgttgccacagcacttttaccagaagaaacagag acttgtctcttcaaccaagagaatcttgccaaagacattaaggaaatgtctgaagaaatg gataagaacaaaaacttgttttcccaagcttttccagagaatggtgataatcgagatgtt attgaagatactttgggttgtcttttgggcaggttatccttgctagactcagtagtgaat caacgatgtcatcagatgaaagaaaggcttcagcaaatactaaatttccagaatgatctg aaagtgctgtttacatcactggctgacaacaaatacatcattctgcagaaactggcaaat gtgtttgaacagcccgtagcagaacaaatagaggcaatacaacaggctgaagatggactc aaagaattggatgcaggaatcattgaattaaagaggcgtggtgacaagttacaggtcgag cagccgtccatgcaagaactctccaagctccaggacatgtatgatgagctgatgatgacc attggctcccggaggagtggtctgaaccagaaccttacactcaagagccagtatgagagg gccctacaagatctggctgacctgctagaaactggtcaggagaagatggcaggagaccag aaaatcatcgtgtcttccaaagaggaaattcagcaactacttgacaaacataaggaatac tttcagggcctggaatctcatatgatcttgactgaaacactcttcagaaagataatcagc tttgcagtccaaaaggaaacccagttccatacagagctgatggctcaggcttctgctgta ctgaaacgggctcacaagaggggtgtggagctggagtacattctagagacgtggtcccat ctggatgaggaccagcaggagctcggcagacagctggaggtggtggaaagcagcatccca agcgtgggtctggtggaggagaacgaggacaggcttattgaccgcataacactctaccag catttaaaatctagccttaatgaataccagcccaaattatatcaagtattagatgatggg aaacgacttctgatatccatcagctgctcagatctagaaagccaactaaatcaacttgga gagcgctggctaagtaacaccaataaagtgtctaaggaacttcacagattggaaacaata ttgaaacactggaccagatatcaaagtgaatctgcagatctaattcagtggttacaatct gcaaaagacaggctagaattttggactcagcaatctgtgacagtcccacaagagctggaa atggtccgtgatcatctaaatgctttcctggagttttctaaagaagtggatgcccaatct tccctgaaatcatctgttctgagtactggaaatcagctccttcgactaaaaaaggtggac acagccacgctgcgctctgagctttcgcacattgatagccagtggactgacctgctaacc aatatcccagccatccaggagaagctccaccagctccagatggataaactgccttcccgc catgccatttctgaagtcatgagttggatttctctaatggaaaatgttattcagaaggat gaagataatattaaaaattccataggttacaaggcaattcatgaataccttcagaaatat aagggttttaagatagacattaactgtaaacagctgacggtggattttgtgaaccagtcc gtgctacaaatcagcagtcaggatgtggaaagtaaacgtagtgataagactgattttgct gagcagcttggagcaatgaataaaagttggcaaattctgcaaggtctagtaactgagaag atccagctgttggaaggcttattggaatcttggtcagaatatgaaaataatgtacaatgt ctgaaaacatggtttgaaacccaggaaaagagactaaaacaacagcatcgaattggagat caggcttctgttcaaaatgcactgaaagactgtcaggatctggaagatttgattaaagca aaagaaaaagaagtagagaaaattgagcagaatggacttgctttgattcagaacaagaaa gaagacgtctctggcattgtcatgagcacactgcgagagctcggccaaacctgggcgaat ttagatcacatggttggacaattaaagatactgctaaaatcagtgcttgaccaatggagt aatcacaaagcggcctttgacaagataaacagttacctcatggaggccagatactctctt tcccgattccgtctgctgactggctctttagaagctgtgcaagttcaggtggacaatctt cagaatctccaagatgatctggaaaaacatgaaaggagcttacagaaatttggctctatc accaaccaattattaaaagagtgtcacccacctgtgacagaaactcttaccaatactctg aaagaagtcaacatgagatggaataacttgctggaagagattgctgagcagctacactcc agcaaggccctacttcagctttggcaaagatacaaggactactccaaacagtgtgcttca acagttcagcagcaggaggatcgaaccaatgagctgttgaaggcagctacaaacaaggac atcgccgatgatgaggttgctacatggattcaagattgcaatgacctcctcaaaggactg ggcacagttaaagattccctctttgttctccatgagctgggagagcaactgaagcaacaa gtggatgcttcagcagcatcagctattcaatcggatcaactctctttgagtcaacacttg tgtgccctggagcaggctctctgcaaacagcagacttcgttacaggctggagttcttgat tatgaaacctttgccaagagtttagaagctttggaggcctggatagtggaagctgaagaa atactacaagggcaggaccctagccactcatctgacctctccacaatccaggaaaggatg gaagaacttaagggacagatgttaaaattcagcagcatggctccagatttagaccgtcta aatgagcttggatataggttacccttgaatgataaggaaatcaaaaggatgcagaatctg aaccgccattggtctctgatctcctctcagactacagaaagattcagcaagttgcagtca tttttgctacaacatcagactttcttggaaaaatgtgaaacatggatggaattcctagtt cagacagaacaaaagttagcagtagagatttcaggaaattatcagcaccttttggaacag cagagagcgcacgagttgtttcaagccgagatgttcagtcgtcagcagattttgcactca atcattattgatgggcaacgtcttctagaacaaggtcaagttgatgacagggatgaattc aacctgaaattgacactcctcagtaatcaatggcagggagtgattcgcagggcccagcag aggcgggggatcattgacagccagattcgccagtggcagcgctatagggagatggcagaa aagcttcgtaaatggttggttgaagtgtcctacctccccgtgagtggtctcggaagtgtt cctataccactgcaacaagcaaggaccctctttgatgaagtgcagttcaaagaaaaggtg ttcctgcggcaacaaggcagctacatcctgactgtggaggctggcaagcaactccttctc tcggcggacagtggcgctgaggctgccttgcaggcagaactcactgaaatccaagacaaa tggaaatcagccagcatgcggctggaagaacagaagaaaaaactagccttcttgttgaaa gactgggaaaaatgtgagaaaggaatagcagattccctggagaaactacgaactttcaaa aagaagctttcccagtctctcccggatcaccatgaagagctccatgcagaacaaatgcgt tgcaaggaattagaaaatgcagttgggagctggacagatgacttgacccagttgagcctg ctgaaggacaccctctctgcctatatcagtgctgatgatatctccattcttaatgaacgc atagagcttctgcaaaggcagtgggaagaactatgccaccagctctccttaaggcggcag caaataggtgaaagattgaatgaatgggcagtcttcagtgaaaagaacaaggaactctgt gaatggttgactcaaatggaaagcaaggtttctcagaatggagacattctcattgaagaa atgatagagaagctcaagaaggattatcaagaggaaattgctattgctcaagagaacaag atacagctccaacaaatgggagaacgacttgctaaagccagccatgaaagcaaagcatct gagattgaatacaagctgggaaaggtcaacgaccggtggcagcatctcctggacctcatt gcagccagggtgaagaagctgaaggagaccctggtagccgtgcagcagcttgataagaac atgagcagcctgaggacctggctcgctcacatcgagtcagagctggccaagccaatagtc tacgattcctgtaactcggaagaaatacagagaaagcttaatgagcagcaggagcttcag agagacatagagaagcatagtacaggtgttgcatctgtcctcaacctgtgtgaagtcctg ctgcacgactgtgatgcctgtgccactgatgccgagtgtgactctatacagcaggctacg agaaacctggaccggcggtggagaaacatttgtgctatgtccatggaaaggaggctcaaa atcgaagagacgtggagattgtggcagaaatttctggatgactattcacgttttgaagat tggctgaagtcttcagaaaggacagctgcttttcctagctcttctggggtgatctataca gttgccaaggaagaactaaagaaatttgaggctttccagcgacaggtccacgagtgcctg acgcagctggaactgatcaacaagcagtaccgccgcctggccagggagaaccgcactgat tcagcgtgtagcctcaaacagatggttcacgaaggcaaccagagatgggacaacctgcaa aagcgcgtcacctccatcttgcgcagactcaagcattttattggccagcgtgaggagttt gagactgcgcgggacagcattctggtctggctcacagagatggatctgcagctcactaat attgaacatttttctgagtgtgatgttcaagctaaaattaagcaactcaaggccttccag caggaaatttcactgaaccacaataagattgagcagataattgcccaaggagaacagctg atagaaaagagtgagcccttggatgcggcgatcatcgaggaggaactagatgagctccga cggtactgccaggaggtctttgggcgtgtggaaagataccataagaaactgatccgcctg cctctcccagacgatgagcacgacctctcagatagggagctggagctggaagactctgca gctctgtcggacctgcactggcatgaccgctctgcagacagcctgctttctccacagcct tcctccaacccctccctctcgctcgctcagcccctccggagcgagcggtcaggacgagac accccggctagtgtggactccatccccctggagtgggatcacgactatgatctcagtcgg gacctggagtctgcaatgtccagagctctgccctctgaggatgaagagggtcaggacgat aaagatttctacctccggggagctgttggcttatcagatgtaatgatccctgaaagccct gaggcctatgtaaaactcacagaaagtgcaatcaaaaatacctccggggaccacagtgcc ctagagtcacagatccgacaactgggcaaagccctggatgatagccgctttcagatacag caaactgaaaatatcattcgcagcaaaactcccacggggccggagctagacaccagctac aaaggctacatgaaactgctgggcgaatgcagtggcagtatagactccgtgaagagactg gagcacaaactgaaggaggaagaggagagccttcccggctttgttaacctgcatagtact gaaacccaaacggctggtgtgattgaccgatgggagcttctccaggcccaggcattgagc aaggagttgaggatgaagcagaacctccagaagtggcagcagtttaactcagacttgaac agcatctgggcctggctgggggacacggaggaggagctggaacagctccagcgtctggaa ctcagcactgacatccagaccatcgagctccagatcaaaaagctcaaggagctccagaaa gctgtggaccaccgcaaagccatcatcctctccatcaatctctgcagccccgagttcacc caggctgacagcaaggagagccgggacctgcaggatcgcttgtcgcagatgaatgggcgc tgggaccgagtgtgctctctgctggaggagtggcggggcctgctgcaggatgccctgatg cagtgccaggatttccatgaaatgagccatggtttgcttcttatgctggagaacattgac agaaggaaaaatgaaattgtccctattgattctaaccttgatgcagagatacttcaggac catcacaaacagcttatgcaaataaggcatgagctgttggaatcccaactcagagtagcc tctttgcaagacatgtcttgccaactactggtgaatgctgaaggaacagactgtttagaa gccaaagaaaaagtccatgttattggaaatcggctcagacttctcttgaaggaggtcagt cgtcatatcaaggaactggagaagttattagacgtgtcaagtagtcagcaggatttgtct tcctggtcttctgctgatgaactggacacctcagggtctgtgagtcccacatcaggaagg agcaccccaaacagacagaaaacgccacgaggcaagtgtagtctctcacagcctggaccc tctgtcagcagtccacatagcaggtccacaaaaggtggctccgattcctccctttctgag cctgggccaggtcggtccggccgcgccttcctgttcagagtcctccgaacagctcttccc cttcagcttctcctgctcctcctcattgggctcgcctgccttgtaccaatgtcagaggaa gactacagctgtgccctctccaacaactttgcccggtcattccaccccatgctcagatac acgaatggccctcctccactctga

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