Pongo abelii (Sumatran orangutan): 100447953
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Entry
100447953 CDS
T01416
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase 3 isoform X1
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon00220
Arginine biosynthesis
pon00330
Arginine and proline metabolism
pon01100
Metabolic pathways
pon04020
Calcium signaling pathway
pon04022
cGMP-PKG signaling pathway
pon04066
HIF-1 signaling pathway
pon04071
Sphingolipid signaling pathway
pon04151
PI3K-Akt signaling pathway
pon04370
VEGF signaling pathway
pon04371
Apelin signaling pathway
pon04611
Platelet activation
pon04915
Estrogen signaling pathway
pon04921
Oxytocin signaling pathway
pon04926
Relaxin signaling pathway
pon04931
Insulin resistance
pon04933
AGE-RAGE signaling pathway in diabetic complications
pon05415
Diabetic cardiomyopathy
pon05417
Lipid and atherosclerosis
pon05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
100447953 (NOS3)
00330 Arginine and proline metabolism
100447953 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
100447953 (NOS3)
04371 Apelin signaling pathway
100447953 (NOS3)
04066 HIF-1 signaling pathway
100447953 (NOS3)
04020 Calcium signaling pathway
100447953 (NOS3)
04071 Sphingolipid signaling pathway
100447953 (NOS3)
04022 cGMP-PKG signaling pathway
100447953 (NOS3)
04151 PI3K-Akt signaling pathway
100447953 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100447953 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
100447953 (NOS3)
04921 Oxytocin signaling pathway
100447953 (NOS3)
04926 Relaxin signaling pathway
100447953 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
100447953 (NOS3)
05418 Fluid shear stress and atherosclerosis
100447953 (NOS3)
05415 Diabetic cardiomyopathy
100447953 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
100447953 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
100447953 (NOS3)
Enzymes [BR:
pon01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
100447953 (NOS3)
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Gene cluster
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
100447953
NCBI-ProteinID:
XP_024106112
Ensembl:
ENSPPYG00000018178
LinkDB
All DBs
Position
6:148454422..148475606
Genome browser
AA seq
1203 aa
AA seq
DB search
MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPGHSPPSSPLT
QPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAP
EQLLSQAQDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPP
ELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW
KGSATKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAA
RDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRATIL
VRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGP
PPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRY
EEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDLSLPCILVGPGTGIAP
FRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSRE
PDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDT
NSP
NT seq
3612 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagcgtggcccaggagcctgggccaccctgcggcctggggctgggg
ctgggcctcgggctgtgcggcaagcagggcccagccaccccagcccctgagcccagccgg
gccccagcatccctactcccgccagcgccaggacacagccccccgagctccccgctaacc
cagcccccggaggggcccaagttccctcgtgtgaagaactgggaggtggggagcatcacc
tatgacaccctcagcgcccaggcgcagcaggatgggccctgcaccccaagacgctgcctg
ggctccctggtatttccacggaaactacagggccggccctcccccggccccccggcccct
gagcagctgctgagtcaggcccaggacttcatcaaccagtactacagctccattaagagg
agcggctcccaagcccacgaacagcggcttcaagaggtggaagccgaggtggcagccaca
ggcacctaccagcttagggaaagcgagctggtgttcggggccaagcaggcctggcgcaat
gctccccgctgtgtgggccggatccagtgggggaagctgcaggtgttcgatgcccgggac
tgcaggtctgcacaggaaatgttcacctacatctgcaaccacatcaagtatgccaccaac
cggggcaaccttcgctcggccatcacagtgttcccgcagcgctgccctggccgaggagac
ttccgaatctggaacagccagctggtgcgctatgcgggctaccggcagcaggatggctct
gtgcggggggacccagccaacgtggagatcaccgagctctgcattcagcacggctggacc
ccaggaaacggtcgcttcgacgtgctgcccctgctgctgcaggccccagatgagccccca
gaactcttccttctgccccccgagctggtccttgaggtgcccctggagcaccccacgctg
gagtggtttgcagccctgggcctgcgctggtacgccctcccggcagtgtccaacatgctg
ctggaaattgggggcctggagttccccgcagcccccttcagtggctggtacatgagcact
gagatcggcacgaggaacctgtgtgaccctcaccgctacaacatcctggaggatgtggct
gtctgcatggacctggatacccggacaacctcgtccctgtggaaagacaaggcagcagtg
gaaatcaacgtggccgtgctgcacagttaccagctggccaaagtcaccatcgtggaccac
cacgccgccacggcctccttcatgaagcacctggagaatgagcagaaggccagggggggc
tgccctgcggactgggcctggatcgtgccccccatctcgggcagcctcactcctgtcttc
catcaggagatggtcaactatttcctgtccccggccttccgctaccagccagacccctgg
aaggggagtgccaccaagggcactggcatcaccaggaagaagaccttcaaagaagtggcc
aacgccgtgaagatctccgcctcgctgatgggcacggtgatggcaaagcgagtgaaggcc
acaattctgtatggctccgagaccggccgggcccagagctacgcacagcagctggggaga
ctcttccggaaagcttttgacccccgggtcctgtgtatggatgagtatgacgtggtgtcc
ctcgaacacgagacgctggtgctggtggtaaccagcacatttgggaatggggatcccccg
gagaatggagagagctttgcggctgccctgatggagatgtccggcccctacaacagctcc
cctcggccggaacagcacaagagttataagatccgcttcaacagcatctcctgctcagac
ccactggtgtcctcttggcggcggaagaggaaggagtccagtaacacagacagtgcaggg
gccctgggcaccctcaggttctgtgtgttcgggctgggctcccgggcatacccccacttc
tgcgcctttgctcgtgcggtggacacacggctggaggaactgggcggggagcggctgctg
cagctgggccagggcgacgagctgtgcggccaggaggaggccttccgcggctgggcccag
gccgccttccaggccgcctgtgagaccttctgtgtgggagaggatgccaaggccgccgcc
cgagacatcttcagccccaaacggagctggaagcgccagaggtaccggctgagcgcccag
gccgagggcctgcagttgctgccaggtctgatccacgtgcacaggcggaagatgttccag
gctacagtcctctcagtggaaaacctgcaaagcagcaagtccacgagggccaccatcctg
gtgcgcctggacaccggaggccaggaggggctgcagtatcagccgggggaccacataggt
gtctgcccacccaaccggcccggccttgtggaggcgctgctgagccgcgtggaggacccg
ccggcgcccactgagcccgtggcagtagagcagctggagaagggcagccctggtggccct
ccccccggctgggtgcgggacccccggctgcccccgtgcacgctgcgccaggctctcacc
ttcttcctggacatcacctccccacccagccctcagctcttgcggctgctcagcaccttg
gcagaagagcccagagaacagcaggagctggaggccctcagccaggatccccgacgctac
gaggagtggaagtggttccgctgccccacgctgctggaggtgctggagcagttcccgtcg
gtggcactgcctgccccactgctcctcacccagctgcctctgctccagccccggtactac
tcagtcagctcagcacccagcacccacccaggagagatccacctcactgtagctgtgctg
gcatacaggacccaggatgggctgggccccctgcactatggagtctgctccacgtggcta
agccaacttaagcctggagaccctgtgccctgcttcatccggggggctccctccttccgg
ctgccacccgatctcagcttgccctgcatcctggtgggcccaggcactggcattgccccc
ttccggggattctggcaggagcggctgcatgacattgagagcaaagggctgcagcccact
cccatgactttggtgttcggctgccgatgctcccaactcgaccatctctaccgcgacgag
gtgcagaacgcccagcagcgcggggtgtttggccgagtcctcaccgccttctcccgggaa
cctgacaaccccaagacctacgtgcaggacatcctgaggacagagctggctgcggaggtg
caccgcgtgctgtgcctcgagcggggccacatgtttgtctgcggcgatgtcaccatggca
accaacgtcctgcagaccgtgcagcgcatcttggcgacggagggcgacatggagctggac
gaggccggcgacgtcatcggcgtgctgcgggatcagcaacgctaccacgaagacattttc
gggctcacgctgcgcacccaggaggtgacaagccgcatacgcacccagagcttttccttg
caggagcggcagttgcggggcgcagtgccctgggcgttcgacccgcccggctcagacacc
aacagcccatga
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