KEGG   Pongo abelii (Sumatran orangutan): 100449269
Entry
100449269         CDS       T01416                                 
Symbol
MAPK14
Name
(RefSeq) mitogen-activated protein kinase 14 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon01522  Endocrine resistance
pon04010  MAPK signaling pathway
pon04015  Rap1 signaling pathway
pon04068  FoxO signaling pathway
pon04071  Sphingolipid signaling pathway
pon04114  Oocyte meiosis
pon04148  Efferocytosis
pon04218  Cellular senescence
pon04261  Adrenergic signaling in cardiomyocytes
pon04370  VEGF signaling pathway
pon04380  Osteoclast differentiation
pon04517  IgSF CAM signaling
pon04519  Cadherin signaling
pon04550  Signaling pathways regulating pluripotency of stem cells
pon04611  Platelet activation
pon04613  Neutrophil extracellular trap formation
pon04620  Toll-like receptor signaling pathway
pon04621  NOD-like receptor signaling pathway
pon04622  RIG-I-like receptor signaling pathway
pon04625  C-type lectin receptor signaling pathway
pon04657  IL-17 signaling pathway
pon04658  Th1 and Th2 cell differentiation
pon04659  Th17 cell differentiation
pon04660  T cell receptor signaling pathway
pon04664  Fc epsilon RI signaling pathway
pon04668  TNF signaling pathway
pon04670  Leukocyte transendothelial migration
pon04714  Thermogenesis
pon04722  Neurotrophin signaling pathway
pon04723  Retrograde endocannabinoid signaling
pon04728  Dopaminergic synapse
pon04750  Inflammatory mediator regulation of TRP channels
pon04912  GnRH signaling pathway
pon04914  Progesterone-mediated oocyte maturation
pon04917  Prolactin signaling pathway
pon04926  Relaxin signaling pathway
pon04932  Non-alcoholic fatty liver disease
pon04933  AGE-RAGE signaling pathway in diabetic complications
pon04935  Growth hormone synthesis, secretion and action
pon04936  Alcoholic liver disease
pon05014  Amyotrophic lateral sclerosis
pon05020  Prion disease
pon05022  Pathways of neurodegeneration - multiple diseases
pon05132  Salmonella infection
pon05133  Pertussis
pon05135  Yersinia infection
pon05140  Leishmaniasis
pon05142  Chagas disease
pon05145  Toxoplasmosis
pon05152  Tuberculosis
pon05161  Hepatitis B
pon05163  Human cytomegalovirus infection
pon05167  Kaposi sarcoma-associated herpesvirus infection
pon05169  Epstein-Barr virus infection
pon05170  Human immunodeficiency virus 1 infection
pon05171  Coronavirus disease
pon05205  Proteoglycans in cancer
pon05208  Chemical carcinogenesis - reactive oxygen species
pon05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pon05415  Diabetic cardiomyopathy
pon05417  Lipid and atherosclerosis
pon05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100449269 (MAPK14)
   04015 Rap1 signaling pathway
    100449269 (MAPK14)
   04370 VEGF signaling pathway
    100449269 (MAPK14)
   04668 TNF signaling pathway
    100449269 (MAPK14)
   04068 FoxO signaling pathway
    100449269 (MAPK14)
   04071 Sphingolipid signaling pathway
    100449269 (MAPK14)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    100449269 (MAPK14)
   04519 Cadherin signaling
    100449269 (MAPK14)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    100449269 (MAPK14)
  09143 Cell growth and death
   04114 Oocyte meiosis
    100449269 (MAPK14)
   04218 Cellular senescence
    100449269 (MAPK14)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100449269 (MAPK14)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100449269 (MAPK14)
   04613 Neutrophil extracellular trap formation
    100449269 (MAPK14)
   04620 Toll-like receptor signaling pathway
    100449269 (MAPK14)
   04621 NOD-like receptor signaling pathway
    100449269 (MAPK14)
   04622 RIG-I-like receptor signaling pathway
    100449269 (MAPK14)
   04625 C-type lectin receptor signaling pathway
    100449269 (MAPK14)
   04660 T cell receptor signaling pathway
    100449269 (MAPK14)
   04658 Th1 and Th2 cell differentiation
    100449269 (MAPK14)
   04659 Th17 cell differentiation
    100449269 (MAPK14)
   04657 IL-17 signaling pathway
    100449269 (MAPK14)
   04664 Fc epsilon RI signaling pathway
    100449269 (MAPK14)
   04670 Leukocyte transendothelial migration
    100449269 (MAPK14)
  09152 Endocrine system
   04912 GnRH signaling pathway
    100449269 (MAPK14)
   04914 Progesterone-mediated oocyte maturation
    100449269 (MAPK14)
   04917 Prolactin signaling pathway
    100449269 (MAPK14)
   04926 Relaxin signaling pathway
    100449269 (MAPK14)
   04935 Growth hormone synthesis, secretion and action
    100449269 (MAPK14)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100449269 (MAPK14)
  09156 Nervous system
   04728 Dopaminergic synapse
    100449269 (MAPK14)
   04723 Retrograde endocannabinoid signaling
    100449269 (MAPK14)
   04722 Neurotrophin signaling pathway
    100449269 (MAPK14)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100449269 (MAPK14)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100449269 (MAPK14)
  09159 Environmental adaptation
   04714 Thermogenesis
    100449269 (MAPK14)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    100449269 (MAPK14)
   05208 Chemical carcinogenesis - reactive oxygen species
    100449269 (MAPK14)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100449269 (MAPK14)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100449269 (MAPK14)
   05161 Hepatitis B
    100449269 (MAPK14)
   05171 Coronavirus disease
    100449269 (MAPK14)
   05163 Human cytomegalovirus infection
    100449269 (MAPK14)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100449269 (MAPK14)
   05169 Epstein-Barr virus infection
    100449269 (MAPK14)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100449269 (MAPK14)
   05135 Yersinia infection
    100449269 (MAPK14)
   05133 Pertussis
    100449269 (MAPK14)
   05152 Tuberculosis
    100449269 (MAPK14)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100449269 (MAPK14)
   05140 Leishmaniasis
    100449269 (MAPK14)
   05142 Chagas disease
    100449269 (MAPK14)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    100449269 (MAPK14)
   05020 Prion disease
    100449269 (MAPK14)
   05022 Pathways of neurodegeneration - multiple diseases
    100449269 (MAPK14)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100449269 (MAPK14)
   05418 Fluid shear stress and atherosclerosis
    100449269 (MAPK14)
   05415 Diabetic cardiomyopathy
    100449269 (MAPK14)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100449269 (MAPK14)
   04932 Non-alcoholic fatty liver disease
    100449269 (MAPK14)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100449269 (MAPK14)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100449269 (MAPK14)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100449269 (MAPK14)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     100449269 (MAPK14)
Protein kinases [BR:pon01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   100449269 (MAPK14)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kdo APH NAD_binding_8
Other DBs
NCBI-GeneID: 100449269
NCBI-ProteinID: XP_002816847
Ensembl: ENSPPYG00000016539
UniProt: A0A2J8Y3G6
LinkDB
Position
5:36287279..36371218
AA seq 360 aa
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFSDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG
TPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
NT seq 1083 nt   +upstreamnt  +downstreamnt
atgtctcaggagaggcccacgttctaccggcaggagctgaacaagacaatctgggaggtg
cccgagcgttaccagaacctgtctccagtgggctccggcgcctatggctctgtgtgtgct
gcttttgacacaaaaacggggttacgtgtggcagtgaagaagctctccagaccatttcag
tccatcattcatgccaaaagaacctacagagaactgcggttacttaaacatatgaaacat
gaaaatgtgattggtctgttggatgtttttacacctgcaaggtctctggaggaattcagt
gatgtgtatttggtgacccatctcatgggggcagatctgaacaacattgtgaaatgtcag
aagctcacagatgaccatgttcagttccttatctaccaaattctccgaggtctaaagtat
atacattcagctgacataattcacagggacctaaaacctagtaatctagctgtgaatgaa
gactgtgagctgaagattctggattttggactggctcggcacacagatgatgaaatgaca
ggctacgtggccactaggtggtacagggctcctgagatcatgctgaactggatgcattac
aaccagacagttgatatttggtcagtgggatgcataatggccgagctgttgactggaaga
acattgtttcctggtacagaccatattaaccagcttcagcagattatgcgtctgacagga
acaccccccgcttatctcattaacaggatgccaagccatgaggcaagaaactatattcag
tctttgactcagatgccgaagatgaactttgcgaatgtatttattggtgccaatcccctg
gctgtcgacttgctggagaagatgcttgtattggactcagataagagaattacggcggcc
caagcccttgcacatgcctactttgctcagtaccacgatcctgatgatgaaccagtggcc
gatccttatgatcagtcctttgaaagcagggacctccttatagatgagtggaaaagcctg
acctatgatgaagtcatcagctttgtgccaccaccccttgaccaagaagagatggagtcc
tga

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