KEGG   Pongo abelii (Sumatran orangutan): 100457650
Entry
100457650         CDS       T01416                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon00562  Inositol phosphate metabolism
pon01100  Metabolic pathways
pon01521  EGFR tyrosine kinase inhibitor resistance
pon04012  ErbB signaling pathway
pon04014  Ras signaling pathway
pon04020  Calcium signaling pathway
pon04062  Chemokine signaling pathway
pon04064  NF-kappa B signaling pathway
pon04066  HIF-1 signaling pathway
pon04070  Phosphatidylinositol signaling system
pon04072  Phospholipase D signaling pathway
pon04360  Axon guidance
pon04370  VEGF signaling pathway
pon04380  Osteoclast differentiation
pon04611  Platelet activation
pon04613  Neutrophil extracellular trap formation
pon04625  C-type lectin receptor signaling pathway
pon04650  Natural killer cell mediated cytotoxicity
pon04662  B cell receptor signaling pathway
pon04664  Fc epsilon RI signaling pathway
pon04666  Fc gamma R-mediated phagocytosis
pon04670  Leukocyte transendothelial migration
pon04722  Neurotrophin signaling pathway
pon04750  Inflammatory mediator regulation of TRP channels
pon04919  Thyroid hormone signaling pathway
pon04933  AGE-RAGE signaling pathway in diabetic complications
pon04935  Growth hormone synthesis, secretion and action
pon05167  Kaposi sarcoma-associated herpesvirus infection
pon05169  Epstein-Barr virus infection
pon05170  Human immunodeficiency virus 1 infection
pon05171  Coronavirus disease - COVID-19
pon05200  Pathways in cancer
pon05205  Proteoglycans in cancer
pon05206  MicroRNAs in cancer
pon05214  Glioma
pon05223  Non-small cell lung cancer
pon05225  Hepatocellular carcinoma
Module
pon_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pon00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100457650 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100457650 (PLCG2)
   04064 NF-kappa B signaling pathway
    100457650 (PLCG2)
   04066 HIF-1 signaling pathway
    100457650 (PLCG2)
   04070 Phosphatidylinositol signaling system
    100457650 (PLCG2)
   04072 Phospholipase D signaling pathway
    100457650 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100457650 (PLCG2)
   04613 Neutrophil extracellular trap formation
    100457650 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    100457650 (PLCG2)
   04662 B cell receptor signaling pathway
    100457650 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    100457650 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    100457650 (PLCG2)
   04670 Leukocyte transendothelial migration
    100457650 (PLCG2)
   04062 Chemokine signaling pathway
    100457650 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    100457650 (PLCG2)
   04919 Thyroid hormone signaling pathway
    100457650 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100457650 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100457650 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    100457650 (PLCG2)
   04380 Osteoclast differentiation
    100457650 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100457650 (PLCG2)
   05206 MicroRNAs in cancer
    100457650 (PLCG2)
   05205 Proteoglycans in cancer
    100457650 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    100457650 (PLCG2)
   05214 Glioma
    100457650 (PLCG2)
   05223 Non-small cell lung cancer
    100457650 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100457650 (PLCG2)
   05171 Coronavirus disease - COVID-19
    100457650 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100457650 (PLCG2)
   05169 Epstein-Barr virus infection
    100457650 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100457650 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100457650 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pon04131]
    100457650 (PLCG2)
Enzymes [BR:pon01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100457650 (PLCG2)
Membrane trafficking [BR:pon04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100457650 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100457650 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 PH PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 100457650
NCBI-ProteinID: XP_024089717
Ensembl: ENSPPYG00000007589
LinkDB
Position
18:81199104..81376464
AA seq 1265 aa
MSTMVSVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVDIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKV
FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKPGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgtccaccatggtcagtgtggattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgagcgagcaaaagcagttcgccagaaagaagactgctgcttcaccatcctatat
ggcactcagtttgtcctcagcacgctcagcttggcagctgactctaaagaagatgcagtt
aattggctctctggcttgaaaatcttacaccaagaagcgatgaatgcgtccacacccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggatataggagcacacaaagatgagctcagctttgaa
cagtttcatctcttctataaaaaacttatgtttgaacagcaaaaatcgattctcgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctctgct
gtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcattgatgacaccatgcgtgaaact
gctgagcctttcttgtttgtggatgagtttctcacgtacctgttttcacgagaaaacagc
atctgggatgagaagtatgacgcggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcgtcgtcacataacacgtacctcacaggtgaccagctgcggagcgagtcg
tccccggaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagccggtcatctaccatggctggacgcggaccaccaagatc
aagtttgatgacgtcgtgcaggccatcaaagaccacgcctttgttacctcgagcttccca
gtgatcctgtccatcgaggagcactgcagcgtggagcagcagcgtcacatggccaaggtc
ttcaaggaagtgtttggcgacctgctgctgacgaagcccacggaggccagcgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcaacatggaggacaagaaggatgagcacaagcaacagggagag
ctgtacatgtgggattccattgaccagaaatggactcgacactactgcgccatcgccgat
gccaagctgtccttcagtgatgacattgaacagactatggaggaggaggtgccccaggat
ataccccccacagagctacattttggggagaaatggttccacaagaaggtggagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggatggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtccagcactgccggatccgctccaccatggagggtgggaccctgaaatactac
ctgactgacaacctcaccttcagcagcatctacgccctcatccagcactaccgcgagacg
cacctgcgctgcgcagagtttgagctgcggctcacggaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgacagcctgagccgcggagaggcagaggacatgctg
atgaggattccccgggatggagccttcctgatccggaagcgagaggggagcgactcctac
gccatcaccttcagggctaggggcaaggtgaagcattgtcgcatcaaccgggacggccgg
cactttgtgctggggacctccgcctattttgagagtctggtggagcttgtcagttactat
gagaagcattcactctaccgaaagatgagactgcgctaccctgtgacccctgagctcctg
gagcgctacaatatggaaagagatataaactccctctacgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgacgagctgagcttctgccgtggtgccctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatctcaactgcagacttcgaggagctagaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtt
gtgaaagcccctcagggaaaaaaccagaagtcctttgtcttcatcctggagcccaagaag
cagggcgatcctccggtggagtttgccacagacagagtggaggaactctttgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acgaaggctgacagcatcatcagacagaagcccgtcgacctcctgaaatacaatcaaaag
ggcctgacccgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacagcagataagtac
atgcagatgaatcacgccttgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgaggacagagaaatatgacccgatgccacccgagtcccagaggaagatcctg
atgacgctgacagtcaaggttctcggtgctcgccatctccccaaacctggacgaagtatt
gcctgtccctttgtagaggtggagatctgtggagctgagtatgacaacaacaagttcaag
acaacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acatttgaaatttatgacccaaacctggcatttctgcgctttgtggtttacgaagaagat
atgttcagtgatcccaactttcttgctcatgccacttaccccattaaagcaatcaaatca
ggattcaggtccgttcctctgaagaatgggtacagcgaggacatagagctggcttccctc
ctggttttctgtgagatgcggccagtcctggaaagtgaggaggaactttactcctcctgt
cgccagctgaggaggcggcaagaagaattgaacaaccagctctttctgtatgacacacac
cagaacttgcgcaatgccaaccgggatgccctggttaaagagttcaatgttaatgagaac
cagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttactcatag

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