KEGG   Pongo abelii (Sumatran orangutan): 100458716
Entry
100458716         CDS       T01416                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon00562  Inositol phosphate metabolism
pon01100  Metabolic pathways
pon04015  Rap1 signaling pathway
pon04020  Calcium signaling pathway
pon04022  cGMP-PKG signaling pathway
pon04062  Chemokine signaling pathway
pon04070  Phosphatidylinositol signaling system
pon04071  Sphingolipid signaling pathway
pon04072  Phospholipase D signaling pathway
pon04081  Hormone signaling
pon04082  Neuroactive ligand signaling
pon04261  Adrenergic signaling in cardiomyocytes
pon04270  Vascular smooth muscle contraction
pon04310  Wnt signaling pathway
pon04371  Apelin signaling pathway
pon04540  Gap junction
pon04611  Platelet activation
pon04613  Neutrophil extracellular trap formation
pon04621  NOD-like receptor signaling pathway
pon04713  Circadian entrainment
pon04720  Long-term potentiation
pon04723  Retrograde endocannabinoid signaling
pon04724  Glutamatergic synapse
pon04725  Cholinergic synapse
pon04726  Serotonergic synapse
pon04728  Dopaminergic synapse
pon04730  Long-term depression
pon04742  Taste transduction
pon04750  Inflammatory mediator regulation of TRP channels
pon04911  Insulin secretion
pon04912  GnRH signaling pathway
pon04915  Estrogen signaling pathway
pon04916  Melanogenesis
pon04918  Thyroid hormone synthesis
pon04919  Thyroid hormone signaling pathway
pon04921  Oxytocin signaling pathway
pon04922  Glucagon signaling pathway
pon04924  Renin secretion
pon04925  Aldosterone synthesis and secretion
pon04926  Relaxin signaling pathway
pon04927  Cortisol synthesis and secretion
pon04928  Parathyroid hormone synthesis, secretion and action
pon04929  GnRH secretion
pon04933  AGE-RAGE signaling pathway in diabetic complications
pon04934  Cushing syndrome
pon04935  Growth hormone synthesis, secretion and action
pon04961  Endocrine and other factor-regulated calcium reabsorption
pon04970  Salivary secretion
pon04971  Gastric acid secretion
pon04972  Pancreatic secretion
pon04973  Carbohydrate digestion and absorption
pon05010  Alzheimer disease
pon05016  Huntington disease
pon05017  Spinocerebellar ataxia
pon05022  Pathways of neurodegeneration - multiple diseases
pon05142  Chagas disease
pon05143  African trypanosomiasis
pon05146  Amoebiasis
pon05163  Human cytomegalovirus infection
pon05200  Pathways in cancer
pon05415  Diabetic cardiomyopathy
pon05417  Lipid and atherosclerosis
Module
pon_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pon00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100458716 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100458716 (PLCB2)
   04310 Wnt signaling pathway
    100458716 (PLCB2)
   04371 Apelin signaling pathway
    100458716 (PLCB2)
   04020 Calcium signaling pathway
    100458716 (PLCB2)
   04070 Phosphatidylinositol signaling system
    100458716 (PLCB2)
   04072 Phospholipase D signaling pathway
    100458716 (PLCB2)
   04071 Sphingolipid signaling pathway
    100458716 (PLCB2)
   04022 cGMP-PKG signaling pathway
    100458716 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    100458716 (PLCB2)
   04081 Hormone signaling
    100458716 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100458716 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100458716 (PLCB2)
   04613 Neutrophil extracellular trap formation
    100458716 (PLCB2)
   04621 NOD-like receptor signaling pathway
    100458716 (PLCB2)
   04062 Chemokine signaling pathway
    100458716 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    100458716 (PLCB2)
   04922 Glucagon signaling pathway
    100458716 (PLCB2)
   04929 GnRH secretion
    100458716 (PLCB2)
   04912 GnRH signaling pathway
    100458716 (PLCB2)
   04915 Estrogen signaling pathway
    100458716 (PLCB2)
   04921 Oxytocin signaling pathway
    100458716 (PLCB2)
   04926 Relaxin signaling pathway
    100458716 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    100458716 (PLCB2)
   04918 Thyroid hormone synthesis
    100458716 (PLCB2)
   04919 Thyroid hormone signaling pathway
    100458716 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    100458716 (PLCB2)
   04916 Melanogenesis
    100458716 (PLCB2)
   04924 Renin secretion
    100458716 (PLCB2)
   04925 Aldosterone synthesis and secretion
    100458716 (PLCB2)
   04927 Cortisol synthesis and secretion
    100458716 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100458716 (PLCB2)
   04270 Vascular smooth muscle contraction
    100458716 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    100458716 (PLCB2)
   04971 Gastric acid secretion
    100458716 (PLCB2)
   04972 Pancreatic secretion
    100458716 (PLCB2)
   04973 Carbohydrate digestion and absorption
    100458716 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100458716 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    100458716 (PLCB2)
   04725 Cholinergic synapse
    100458716 (PLCB2)
   04728 Dopaminergic synapse
    100458716 (PLCB2)
   04726 Serotonergic synapse
    100458716 (PLCB2)
   04720 Long-term potentiation
    100458716 (PLCB2)
   04730 Long-term depression
    100458716 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    100458716 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    100458716 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    100458716 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100458716 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100458716 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100458716 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100458716 (PLCB2)
   05142 Chagas disease
    100458716 (PLCB2)
   05143 African trypanosomiasis
    100458716 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100458716 (PLCB2)
   05016 Huntington disease
    100458716 (PLCB2)
   05017 Spinocerebellar ataxia
    100458716 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    100458716 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100458716 (PLCB2)
   05415 Diabetic cardiomyopathy
    100458716 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100458716 (PLCB2)
   04934 Cushing syndrome
    100458716 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pon04131]
    100458716 (PLCB2)
Enzymes [BR:pon01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100458716 (PLCB2)
Membrane trafficking [BR:pon04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100458716 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100458716 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 100458716
NCBI-ProteinID: XP_024088255
Ensembl: ENSPPYG00000006347
LinkDB
Position
16:complement(43186568..43206760)
AA seq 1185 aa
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVELTFHNFVSYKE
NVGKVWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKM
AEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDPGGE
AEGSSPPSAPAGERTVWAGEDGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEF
MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
KLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CLHSESNMPLTMPALFIFLEMKDYVPGAWADLTVALANPIKFFSAHDKKSVKLKEAMGGL
PEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKAVVK
LQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLP
REESAGAAPGEGPEGVDGRLRELKDRLELELLRQGEEQYECVLKRKEQHAAEQISKMMEL
AREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTADKMAQERLKREINNSHI
QEVVQVIKQMTENLEGHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE
SVRACLRTCFPSEAKDKPERACECPPELCEQDPLVAKADAQESRL
NT seq 3558 nt   +upstreamnt  +downstreamnt
atgtctctgctcaaccctgtcctgctgccccccaaggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggatgatgaaactacagttgcctctccagttatcctccgtgtg
gatcctaagggctactacttatactggacgtatcaaagtaaggagatggagtttctggat
atcaccagcatccgggatactcgctttgggaagtttgccaagatgcccaagagccagaag
ctccgggacgtcttcaacatggactttcctgacaacagcttcctgctgaagacactcacg
gtggtgtccggcccggacatggtggaactcaccttccacaacttcgtctcctacaaggag
aacgtgggcaaggtgtgggctgaggacgtactggccctagtcaagcatccgctgacggcc
aacgcctcccgcagcaccttcctggacaagatccttgtgaagctcaagatgcagctcaac
tctgaagggaagattccggtgaagaactttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgctctcagtgcctgccacctccccaaaggcaaaaatgacgccatcaatcct
gaggacttcccagaacctgtctacaagagtttcctcatgagcctctgtcctcggccagaa
atagatgagatcttcacttcttaccatgctaaggccaaaccctacatgacgaaggagcac
ctgaccaaattcatcaaccagaaacagcgggactcccggcttaactccctgctgttcccg
ccagcacggcctgaccaggtgcagggcctcatcgacaagtatgagcccagtggcatcaat
gtgcagaggggccagctgtcacctgagggcatggtctggtttctctgtgggccagagaac
agtgtgctggctcaggacaagctgctgctccaccacgacatgacgcagccactcaatcat
tacttcatcaactcgtcccacaacacctacctgacagccggccagttctcaggcctctcc
tcggctgagatgtaccgccaggtgctgctctctggctgccgttgcgtggagctagactgc
tggaaggggaaaccccctgacgaggagcccattatcacccacggcttcaccatgaccaca
gacatcttcttcaaagaagcaattgaggctattgcagaaagtgcctttaagacctccccc
tatcccatcatcctgtcgtttgagaaccatgtggactcaccccgccagcaggctaagatg
gctgagtattgccggaccatctttggggatatgctgctcacagagcccctggaaaagttc
ccgctaaaaccaggtgtccccttgcccagccccgaggatctcaggggcaagatcctcatc
aagaacaagaagaaccagttttctggccccacctcctccagtaaggatcctggtggggag
gctgagggcagcagcccacccagtgcccctgcaggtgagcgcacagtgtgggctggcgag
gatgggactgagctggaggaggaggaggtggaagaggaagaggaggaggagtcaggaaac
ctggacgaagaagagattaagaagatgcagtcggatgagggcacagcgggcctggaagtg
acggcttatgaggagatgtccagcctagtcaattacatccagcccaccaagttcatctcc
tttgaattctctgcccaaaagaaccgaagttatgtcatctcatccttcacagagctcaag
gcatatgacctgctctccaaggcctcggtgcagtttgtggactacaacaagcgccagatg
agccgcatttaccccaagggaacccgcatggactcctccaactacatgccccagatgttc
tggaatgctggatgccagatggttgccctcaacttccagacaatggacttgcccatgcag
cagaacatggcagtgtttgagttcaacgggcagagcggctacctcctcaagcacgagttc
atgcgccggccagacaagcagttcaaccccttctcagtggaccgcatcgacgtggtggtg
gccaccaccctttccatcacggtgatctctgggcagttcctgtcagaacgcagcgtgcgt
acctatgtggaagtggagctgtttggccttcctggggaccccaagaggcgctatcgaact
aagctgtcacccagtaccaactccatcaatcctgtctggaaggaggagccctttgtcttt
gagaagatcttgatgcctgagctggcctccctcagggtggctgtgatggaggaaggcaac
aagtttcttggacaccgcatcatccccatcaatgccctaaattctgggtaccaccacctg
tgcctgcacagtgagagcaacatgcccctcaccatgcctgcgctcttcatcttcctggag
atgaaggactacgtacctggtgcttgggcagatctcactgtggccctcgccaaccccatt
aagttcttcagtgcccatgacaagaagtctgtgaagctcaaggaggccatgggaggtctg
cctgagaagcccttcccactggcgagtccagttgccagccaggtcaatggggcgttggcc
ccaacgagcaatgggtcaccagcagccagggccggggccagggaagaggctatgaaagaa
gctgcggagccgcggactgccagcctggaggagctccgggagctaaaggccgtcgtgaag
ctgcagcggcggcacgagaaggagctgcgggagttggagcggcgcggagcgcggcgctgg
gaggagctgctgcagcggggcgcggcgcagctggccgagctcgggccaccgggcgtggga
ggcgttggggcctgcaagctgggtccgggcaagggctctcgcaagaagaggagcctgccc
cgcgaggagagcgccggagctgcgccgggcgagggccctgagggcgtggacgggcgcctg
cgggagctgaaggacaggctggaactagagctgctgcggcagggcgaggagcagtacgag
tgcgttctgaagcgcaaagagcagcacgcggccgagcaaatctccaaaatgatggagctg
gccagagagaaacaggcggcagagctgaaggccctgaaggagacgtcggagaacgacacc
aaagagatgaagaaaaagctggagacgaagagactggagcggatccagggcatgaccaaa
gtcaccgcagacaagatggcccaggagaggttgaagagagagattaacaactcccacatc
caggaagtagtgcaggtgatcaagcagatgacggagaacttggaggggcaccaggagaag
ctggaggagaagcaggcggcttgcctggaacagatacgggagatggaaaagcagttccag
aaggaggcgctggcagagtacgaggccaggatgaagggtctagaggcagaggtgaaggag
tcggtgagggcctgcctcaggacctgctttccctctgaggccaaggacaagcccgaaagg
gcctgcgagtgccccccagagctgtgtgagcaggacccactcgtagcaaaggcagatgcc
caggagagccgcctctga

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