Plecotus auritus (brown big-eared bat): 308238977
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Entry
308238977 CDS
T11911
Symbol
PDE8A, AC0HY7_005810
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
pots Plecotus auritus (brown big-eared bat)
Pathway
pots00230
Purine metabolism
pots01100
Metabolic pathways
pots04927
Cortisol synthesis and secretion
pots04934
Cushing syndrome
pots05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
pots00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
308238977 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
308238977 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
308238977 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
308238977 (PDE8A)
Enzymes [BR:
pots01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
308238977 (PDE8A)
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Ortholog
Paralog
GFIT
Motif
Pfam:
PDEase_I
PDE8A_N
PAS_9
PDE8
PAS
PDE8_3rd
PAS_4
PAS_3
PAS_8
Response_reg
Motif
Other DBs
NCBI-GeneID:
308238977
NCBI-ProteinID:
XP_080507624
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Position
15:12717191..12819163
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AA seq
840 aa
AA seq
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MGCAPSIHISETQTVYPGAREAEDAEGPAVLLPPPGGPGALLRPEPEALAATSGALPAEP
PQPRDSKVSASASQVQFGPMRFHADQLQVLLVFIKEDSQCKGFRKACEKAGFKCTVAQEV
QVVLTCFLAAHHDIIIIDHRNPQQLDAPALCRSIRSSKVSENTVIIGVVRRRDGEESVMP
LISAGFTRRYVENPSLLACYAELLQLEFGEVRSQLKLRACNSVFTALERSQDAIKITSED
NCIQYVNPAFETTMGYESGELIGKELAKMPVNERKADLFTTINSCMKMGKEWQGVYCSKN
GDNVQQNVKIIPVIGQGGKIRHYVSIIRVNNGNSKAEKITESVQSDTPTDNQSGKHKDKR
KSSLDVRSVASRASEVASQRRHSSMARIHSMTIEAPITKVINIINAAQENSSVPVTEALD
RVLEILRTTELYSPQFGVKDEDPHANDLIGGLISDGFRRLSGNEYALSTKNLQQVPSGLF
TPVSLHDVPPRIAQAMENEDDWDFNIFELEAATQKRPLIFLGLKIFARFGVCEFLKCSET
TLRLWLQTIEAHYHSSNPYHNSTHAADVLHATAYFLCQERVKISRFQQTLDSVDEAAALI
AAAVHDLDHPGRTNPFLCNAGSALAVLYNDCAVLESHHAALAFQLTTRDDKSNIFKNMER
NEYRTLRQAIIDMVLATEMTKHFEHVNKFVNSVIKPLAELEESEESDPDPDAIHTMLRAP
ENRTLIKRIMIKCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKKLDLPVVMPAFDRNT
CSIPKSQISFIDYFVTDMYDAWDDFVDLQELLQHLDNNFKYWKGLDERKLRGLRPPPEPK
NT seq
2523 nt
NT seq
+upstream
nt +downstream
nt
atgggctgcgccccgagcatccacatttccgagacccagaccgtgtacccgggcgcccgg
gaggccgaggacgcggagggccccgcggtgctgctgcccccgccgggcgggccgggcgcc
ctgctccgtccggagcccgaagccttggccgcgaccagcggcgccctccccgcggagccc
ccccagcctcgcgactcgaaggtatcagcatcagcatcgcaggtgcagtttggccccatg
aggtttcatgcagatcaactccaggtacttttagtgtttatcaaagaagatagccagtgt
aaaggattccgtaaggcgtgtgaaaaagcagggtttaagtgcacagtggcccaggaggtt
caggttgtcctgacttgtttcctggctgcacatcacgacatcatcatcatcgaccacaga
aacccccaacagctggatgcaccggcgctgtgcaggtctattcgatcatcaaaagtctca
gaaaacacagttattattggtgtggtacgcaggcgggatggagaagagtctgtgatgccc
ctcattagtgctggctttacgaggaggtacgtggagaaccccagcctcctggcctgttac
gccgagctgctccagctggagttcggagaggtgcgctcacagctgaaactcagggcttgt
aactcagtgttcacggcactagagagaagccaggacgccattaagatcacgagtgaggac
aactgcattcagtatgtaaatccagcatttgaaacaacaatgggctatgagtcgggtgaa
ttaatagggaaggagttagcaaaaatgcctgtaaatgaaagaaaggctgacttgttcact
actataaactcatgcatgaagatgggcaaggagtggcaaggcgtctactgctccaaaaac
ggagataacgttcaacagaatgtgaagataatacctgtcattggacagggaggaaaaatt
agacactatgtgtccattatccgagtgaacaacggcaacagtaaggctgagaaaataacg
gaatctgttcagtctgacactcccacagataaccaatcaggtaaacataaagacaagagg
aaaagctccctggacgtcaggagtgtcgcctcgcgagcaagcgaagtggccagccagaga
cgacactcctccatggcccggatccactccatgaccattgaggcgcccatcaccaaggtg
atcaatatcatcaatgctgcccaggagaacagttccgtgcctgtgacggaagccttagac
cgtgtcctggaaattctgagaaccactgagctgtattcaccgcagtttggggtgaaggac
gaggatcctcacgccaacgacctcattgggggcctgatatctgatggctttcgaagactc
tctgggaacgagtatgctctctcaacaaagaacctgcagcaagtcccgagcggcttattc
acccccgtgtcccttcacgacgtcccaccgcggatagctcaggccatggagaacgaggac
gactgggacttcaatatttttgaactggaggctgccactcagaaaaggcctttgattttt
cttggtctcaaaatcttcgctcgcttcggggtctgtgaattcttgaagtgctcggagacg
acgctgcggctgtggctgcagactattgaggcccattaccactcctccaacccctaccac
aactccacccatgctgccgacgtgctccacgccactgcctacttcctctgccaggaaagg
gtcaagatctctcgctttcagcaaacgttagactcagtggacgaggccgccgccctcatc
gcagctgccgtccacgacctggaccacccggggaggaccaacccgttcctgtgcaacgcg
ggcagcgcgctggccgtgctgtacaatgactgcgccgtgctggagagccaccacgcggcc
ctggccttccagctgaccaccagggacgacaagagcaacatcttcaagaacatggagagg
aatgagtaccggacgctgcgccaggccatcatcgacatggtcttggccacggagatgaca
aagcactttgagcacgtcaacaagtttgtcaacagcgtcatcaagcccttggcagagctg
gaggagagcgaggagagcgatccagaccctgacgccatacacacgatgctcagggctcca
gagaaccggactctgatcaagcggataatgatcaagtgcgctgacgtgtccaacccctgc
cggcccttggagcagtgcatcgagtgggctgcacgcatctcggaggagtatttttctcag
accgatgaggaaaagaagctggacttacctgtggtgatgccagcttttgaccgaaacacc
tgcagcatccccaagtcccagatctccttcatcgactacttcgtcaccgacatgtacgat
gcctgggacgactttgtagacctacaggagttactgcagcatctggacaacaattttaaa
tactggaaaggactcgacgagaggaagctgcggggcctccgaccacctccggaaccaaaa
tag
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