KEGG   Plecotus auritus (brown big-eared bat): 308246374
Entry
308246374         CDS       T11911                                 
Symbol
MAP2K1, AC0HY7_013207
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
pots  Plecotus auritus (brown big-eared bat)
Pathway
pots01521  EGFR tyrosine kinase inhibitor resistance
pots01522  Endocrine resistance
pots04010  MAPK signaling pathway
pots04012  ErbB signaling pathway
pots04014  Ras signaling pathway
pots04015  Rap1 signaling pathway
pots04022  cGMP-PKG signaling pathway
pots04024  cAMP signaling pathway
pots04062  Chemokine signaling pathway
pots04066  HIF-1 signaling pathway
pots04068  FoxO signaling pathway
pots04071  Sphingolipid signaling pathway
pots04072  Phospholipase D signaling pathway
pots04114  Oocyte meiosis
pots04140  Autophagy - animal
pots04148  Efferocytosis
pots04150  mTOR signaling pathway
pots04151  PI3K-Akt signaling pathway
pots04210  Apoptosis
pots04218  Cellular senescence
pots04270  Vascular smooth muscle contraction
pots04370  VEGF signaling pathway
pots04371  Apelin signaling pathway
pots04380  Osteoclast differentiation
pots04510  Focal adhesion
pots04517  IgSF CAM signaling
pots04519  Cadherin signaling
pots04540  Gap junction
pots04550  Signaling pathways regulating pluripotency of stem cells
pots04613  Neutrophil extracellular trap formation
pots04620  Toll-like receptor signaling pathway
pots04650  Natural killer cell mediated cytotoxicity
pots04660  T cell receptor signaling pathway
pots04662  B cell receptor signaling pathway
pots04664  Fc epsilon RI signaling pathway
pots04666  Fc gamma R-mediated phagosome formation
pots04668  TNF signaling pathway
pots04720  Long-term potentiation
pots04722  Neurotrophin signaling pathway
pots04725  Cholinergic synapse
pots04726  Serotonergic synapse
pots04730  Long-term depression
pots04810  Regulation of actin cytoskeleton
pots04910  Insulin signaling pathway
pots04912  GnRH signaling pathway
pots04914  Progesterone-mediated oocyte maturation
pots04915  Estrogen signaling pathway
pots04916  Melanogenesis
pots04917  Prolactin signaling pathway
pots04919  Thyroid hormone signaling pathway
pots04921  Oxytocin signaling pathway
pots04926  Relaxin signaling pathway
pots04928  Parathyroid hormone synthesis, secretion and action
pots04929  GnRH secretion
pots04934  Cushing syndrome
pots04935  Growth hormone synthesis, secretion and action
pots05010  Alzheimer disease
pots05022  Pathways of neurodegeneration - multiple diseases
pots05034  Alcoholism
pots05132  Salmonella infection
pots05135  Yersinia infection
pots05160  Hepatitis C
pots05161  Hepatitis B
pots05163  Human cytomegalovirus infection
pots05164  Influenza A
pots05165  Human papillomavirus infection
pots05166  Human T-cell leukemia virus 1 infection
pots05167  Kaposi sarcoma-associated herpesvirus infection
pots05170  Human immunodeficiency virus 1 infection
pots05200  Pathways in cancer
pots05205  Proteoglycans in cancer
pots05206  MicroRNAs in cancer
pots05207  Chemical carcinogenesis - receptor activation
pots05208  Chemical carcinogenesis - reactive oxygen species
pots05210  Colorectal cancer
pots05211  Renal cell carcinoma
pots05212  Pancreatic cancer
pots05213  Endometrial cancer
pots05214  Glioma
pots05215  Prostate cancer
pots05216  Thyroid cancer
pots05218  Melanoma
pots05219  Bladder cancer
pots05220  Chronic myeloid leukemia
pots05221  Acute myeloid leukemia
pots05223  Non-small cell lung cancer
pots05224  Breast cancer
pots05225  Hepatocellular carcinoma
pots05226  Gastric cancer
pots05230  Central carbon metabolism in cancer
pots05231  Choline metabolism in cancer
pots05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pots00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    308246374 (MAP2K1)
   04012 ErbB signaling pathway
    308246374 (MAP2K1)
   04014 Ras signaling pathway
    308246374 (MAP2K1)
   04015 Rap1 signaling pathway
    308246374 (MAP2K1)
   04370 VEGF signaling pathway
    308246374 (MAP2K1)
   04371 Apelin signaling pathway
    308246374 (MAP2K1)
   04668 TNF signaling pathway
    308246374 (MAP2K1)
   04066 HIF-1 signaling pathway
    308246374 (MAP2K1)
   04068 FoxO signaling pathway
    308246374 (MAP2K1)
   04072 Phospholipase D signaling pathway
    308246374 (MAP2K1)
   04071 Sphingolipid signaling pathway
    308246374 (MAP2K1)
   04024 cAMP signaling pathway
    308246374 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    308246374 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    308246374 (MAP2K1)
   04150 mTOR signaling pathway
    308246374 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    308246374 (MAP2K1)
   04519 Cadherin signaling
    308246374 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    308246374 (MAP2K1)
   04148 Efferocytosis
    308246374 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    308246374 (MAP2K1)
   04210 Apoptosis
    308246374 (MAP2K1)
   04218 Cellular senescence
    308246374 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    308246374 (MAP2K1)
   04540 Gap junction
    308246374 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    308246374 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    308246374 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    308246374 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    308246374 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    308246374 (MAP2K1)
   04660 T cell receptor signaling pathway
    308246374 (MAP2K1)
   04662 B cell receptor signaling pathway
    308246374 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    308246374 (MAP2K1)
   04666 Fc gamma R-mediated phagosome formation
    308246374 (MAP2K1)
   04062 Chemokine signaling pathway
    308246374 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    308246374 (MAP2K1)
   04929 GnRH secretion
    308246374 (MAP2K1)
   04912 GnRH signaling pathway
    308246374 (MAP2K1)
   04915 Estrogen signaling pathway
    308246374 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    308246374 (MAP2K1)
   04917 Prolactin signaling pathway
    308246374 (MAP2K1)
   04921 Oxytocin signaling pathway
    308246374 (MAP2K1)
   04926 Relaxin signaling pathway
    308246374 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    308246374 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    308246374 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    308246374 (MAP2K1)
   04916 Melanogenesis
    308246374 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    308246374 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    308246374 (MAP2K1)
   04726 Serotonergic synapse
    308246374 (MAP2K1)
   04720 Long-term potentiation
    308246374 (MAP2K1)
   04730 Long-term depression
    308246374 (MAP2K1)
   04722 Neurotrophin signaling pathway
    308246374 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    308246374 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    308246374 (MAP2K1)
   05206 MicroRNAs in cancer
    308246374 (MAP2K1)
   05205 Proteoglycans in cancer
    308246374 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    308246374 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    308246374 (MAP2K1)
   05230 Central carbon metabolism in cancer
    308246374 (MAP2K1)
   05231 Choline metabolism in cancer
    308246374 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    308246374 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    308246374 (MAP2K1)
   05212 Pancreatic cancer
    308246374 (MAP2K1)
   05225 Hepatocellular carcinoma
    308246374 (MAP2K1)
   05226 Gastric cancer
    308246374 (MAP2K1)
   05214 Glioma
    308246374 (MAP2K1)
   05216 Thyroid cancer
    308246374 (MAP2K1)
   05221 Acute myeloid leukemia
    308246374 (MAP2K1)
   05220 Chronic myeloid leukemia
    308246374 (MAP2K1)
   05218 Melanoma
    308246374 (MAP2K1)
   05211 Renal cell carcinoma
    308246374 (MAP2K1)
   05219 Bladder cancer
    308246374 (MAP2K1)
   05215 Prostate cancer
    308246374 (MAP2K1)
   05213 Endometrial cancer
    308246374 (MAP2K1)
   05224 Breast cancer
    308246374 (MAP2K1)
   05223 Non-small cell lung cancer
    308246374 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    308246374 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    308246374 (MAP2K1)
   05161 Hepatitis B
    308246374 (MAP2K1)
   05160 Hepatitis C
    308246374 (MAP2K1)
   05164 Influenza A
    308246374 (MAP2K1)
   05163 Human cytomegalovirus infection
    308246374 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    308246374 (MAP2K1)
   05165 Human papillomavirus infection
    308246374 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    308246374 (MAP2K1)
   05135 Yersinia infection
    308246374 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    308246374 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    308246374 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    308246374 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    308246374 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    308246374 (MAP2K1)
   01522 Endocrine resistance
    308246374 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pots01001]
    308246374 (MAP2K1)
Enzymes [BR:pots01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     308246374 (MAP2K1)
Protein kinases [BR:pots01001]
 Serine/threonine kinases: STE group
  STE7 family
   308246374 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 308246374
NCBI-ProteinID: XP_080520688
LinkDB
Position
1:complement(49110973..49188295)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHQPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDASETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccagacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggctttgcagaagaagctggaggagctg
gagctcgatgagcagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgctggcaatggtggt
gtggtgttcaaggtctcccaccagccgtccggcctggttatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagataataagggagctgcaggttctacatgag
tgtaactccccatacattgtgggcttctatggtgcattctacagtgatggagagatcagc
atctgcatggagcatatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttagggaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaaacacaagattatgcatagagatgtcaagccttctaacatcctagtgaactcc
cgtggggagatcaagctctgtgacttcggagtcagcgggcagctcatcgactccatggcc
aactcctttgtgggcacaaggtcctacatgtcgccagagagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcgtctgagacaccaccccggccaaggacccctgggaggccccttagctcttat
ggaatggacagccgaccgcccatggcaatttttgagttattggattacatagtcaacgag
ccccctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccctgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacgccaactcatgcggctggtgtctaa

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