KEGG   Plecotus auritus (brown big-eared bat): 308254548
Entry
308254548         CDS       T11911                                 
Symbol
RPS6KB1, AC0HY7_021381
Name
(RefSeq) ribosomal protein S6 kinase beta-1 isoform 1
  KO
K04688  ribosomal protein S6 kinase beta [EC:2.7.11.1]
Organism
pots  Plecotus auritus (brown big-eared bat)
Pathway
pots01521  EGFR tyrosine kinase inhibitor resistance
pots01522  Endocrine resistance
pots04012  ErbB signaling pathway
pots04066  HIF-1 signaling pathway
pots04140  Autophagy - animal
pots04150  mTOR signaling pathway
pots04151  PI3K-Akt signaling pathway
pots04152  AMPK signaling pathway
pots04211  Longevity regulating pathway
pots04213  Longevity regulating pathway - multiple species
pots04350  TGF-beta signaling pathway
pots04371  Apelin signaling pathway
pots04666  Fc gamma R-mediated phagosome formation
pots04714  Thermogenesis
pots04910  Insulin signaling pathway
pots04931  Insulin resistance
pots05163  Human cytomegalovirus infection
pots05165  Human papillomavirus infection
pots05170  Human immunodeficiency virus 1 infection
pots05200  Pathways in cancer
pots05205  Proteoglycans in cancer
pots05207  Chemical carcinogenesis - receptor activation
pots05210  Colorectal cancer
pots05212  Pancreatic cancer
pots05221  Acute myeloid leukemia
pots05224  Breast cancer
pots05225  Hepatocellular carcinoma
pots05226  Gastric cancer
pots05231  Choline metabolism in cancer
pots05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pots00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    308254548 (RPS6KB1)
   04350 TGF-beta signaling pathway
    308254548 (RPS6KB1)
   04371 Apelin signaling pathway
    308254548 (RPS6KB1)
   04066 HIF-1 signaling pathway
    308254548 (RPS6KB1)
   04151 PI3K-Akt signaling pathway
    308254548 (RPS6KB1)
   04152 AMPK signaling pathway
    308254548 (RPS6KB1)
   04150 mTOR signaling pathway
    308254548 (RPS6KB1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    308254548 (RPS6KB1)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagosome formation
    308254548 (RPS6KB1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    308254548 (RPS6KB1)
  09149 Aging
   04211 Longevity regulating pathway
    308254548 (RPS6KB1)
   04213 Longevity regulating pathway - multiple species
    308254548 (RPS6KB1)
  09159 Environmental adaptation
   04714 Thermogenesis
    308254548 (RPS6KB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    308254548 (RPS6KB1)
   05205 Proteoglycans in cancer
    308254548 (RPS6KB1)
   05207 Chemical carcinogenesis - receptor activation
    308254548 (RPS6KB1)
   05231 Choline metabolism in cancer
    308254548 (RPS6KB1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    308254548 (RPS6KB1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    308254548 (RPS6KB1)
   05212 Pancreatic cancer
    308254548 (RPS6KB1)
   05225 Hepatocellular carcinoma
    308254548 (RPS6KB1)
   05226 Gastric cancer
    308254548 (RPS6KB1)
   05221 Acute myeloid leukemia
    308254548 (RPS6KB1)
   05224 Breast cancer
    308254548 (RPS6KB1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    308254548 (RPS6KB1)
   05163 Human cytomegalovirus infection
    308254548 (RPS6KB1)
   05165 Human papillomavirus infection
    308254548 (RPS6KB1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    308254548 (RPS6KB1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    308254548 (RPS6KB1)
   01522 Endocrine resistance
    308254548 (RPS6KB1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pots01001]
    308254548 (RPS6KB1)
Enzymes [BR:pots01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     308254548 (RPS6KB1)
Protein kinases [BR:pots01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   308254548 (RPS6KB1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like Pkinase_fungal ABC1 DUF1015
Other DBs
NCBI-GeneID: 308254548
NCBI-ProteinID: XP_080536852
LinkDB
Position
7:22410339..22453155
AA seq 525 aa
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHTNWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
NT seq 1578 nt   +upstreamnt  +downstreamnt
atgaggcgacgacggaggcgggacggcttctacccagcgccggacttccgagacagggaa
gctgaggacatggcaggagtgtttgacatagacctggaccagccagaggacgcgggctct
gaggatgagctggaggaggggggtcagttaaatgaaagcatggaccatgggggagttgga
ccatatgaacttggcatggaacattgtgagaaatttgaaatctcagaaactagtgtgaac
agagggccagaaaaaatcagaccagaatgttttgagctacttcgggtacttggtaaaggg
ggctatggaaaggtttttcaagtacgaaaagtaacaggagcaaatactggaaaaatattt
gccatgaaggtgcttaaaaaggcaatgatagtaagaaatgctaaagatacagctcataca
aaagcagaacggaatattctggaggaagtaaagcatcccttcattgtggatttaatttat
gcctttcagaccggtggaaaactctacctcatccttgagtatctcagcggaggagaatta
tttatgcagttagaaagagagggaatatttatggaagacacagcctgcttttacttggca
gaaatttccatggctttggggcatttacatcaaaaggggatcatctacagagacctgaag
ccggagaatatcatgcttaatcaccaaggtcatgtgaaactaacagactttggactatgc
aaagaatctattcatgatggaacagtcacacacacattttgtggaacaatagaatacatg
gcccctgaaatcttgatgagaagtggccacaatcgtgctgtggattggtggagtctggga
gcattaatgtatgacatgctgactggagcaccaccattcactggggagaatagaaagaaa
acaattgacaaaatcctcaaatgtaaactcaatttgcctccctacctcacacaagaagcc
agagatctgcttaaaaagctgctgaaaagaaatgctgcttctcgtctgggagctggtcct
ggggatgctggagaagttcaagctcatccattcttcagacatactaactgggaagaattg
ctggctcgcaaggtggagcccccctttaaacctctgttgcaatctgaagaggatgtgagt
cagtttgattcaaagtttacacgtcagacacctgttgacagcccagatgactcgactctc
agtgaaagtgccaaccaggtctttctgggttttacatatgtggctccatctgtacttgaa
agcgtgaaagaaaagttttcctttgaaccaaaaatccgatcaccacgaagatttattggc
agcccacgaacacctgtcagcccagtcaaattttctcctggggatttctggggaagaggt
gcttcagccagcacagcaaatcctcagacaccggtggaatacccaatggaaacaagtgga
atagagcagatggatgtgacgatgagtggggaagcttcagccccacttccaatacgacag
ccgaactccgggccatacaaaaaacaagcttttcccatgatctccaaacgaccagagcac
ctgcgtatgaatctatga

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