Komagataella phaffii: PAS_chr2-1_0391
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Entry
PAS_chr2-1_0391 CDS
T01092
Name
(RefSeq) Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide
KO
K01852
lanosterol synthase [EC:
5.4.99.7
]
Organism
ppa
Komagataella phaffii
Pathway
ppa00100
Steroid biosynthesis
ppa01100
Metabolic pathways
ppa01110
Biosynthesis of secondary metabolites
Module
ppa_M00102
Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
Brite
KEGG Orthology (KO) [BR:
ppa00001
]
09100 Metabolism
09103 Lipid metabolism
00100 Steroid biosynthesis
PAS_chr2-1_0391
Enzymes [BR:
ppa01000
]
5. Isomerases
5.4 Intramolecular transferases
5.4.99 Transferring other groups
5.4.99.7 lanosterol synthase
PAS_chr2-1_0391
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GFIT
Motif
Pfam:
SQHop_cyclase_C
SQHop_cyclase_N
TED_complement
Motif
Other DBs
NCBI-GeneID:
8198859
NCBI-ProteinID:
XP_002491292
UniProt:
C4R0I8
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Position
2:join(721942..723167,723229..724108)
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AA seq
701 aa
AA seq
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MTVYYSEKIGLPKTDPQRWRLRVNELGRQYWDYIEKEDLKNDPQTPYVQYLLKGDEFECP
IPEKPQSAFESARNCADFLALIQDESGVFPCQYKGPMFMSIGYVVACYFTNTPIPDHVRT
EMIRYVVNTAHPVDGGWGLHEWDKSTCFGTCMNYVVLRLLGLPKDNPVCIKARKVLHALG
GALATPYWGKAWLSLLNVYKWEGVNPAPPEMWNLPYSLKIHPCRWWVHTRAIALPLSYIS
SYKSQMPLTPLLKELRNEIFLQDFDTIDFSKHRNNVCGIDLYYPHTSLLDFANSILVGYD
KIRPTWLLKESNDAVYELIKKELANTEHLCIAPVNAAFNTIVAYLEEGPESYNFKRLQER
FKDVIFHGPQGMTTMGTNGTQVWDTSFCLQYFFMAGLADLDEYEELIIRDKRIGCFPFST
KEQGYTVSDCTAEAIKAILMVKNHPKFAYLGDYIDEDLLKKGIDGLLSLQNVGSYHFGSF
STYESTRANPALEKINPAEVFGNIMVEYPYVECTDSSVLGLTYFREHWDYRRHDIDTAIE
RGVKFICDAQQEDGSWYGCWGVCFTYAGMFALEALASVNQYYETNEVVRKGCDFLVSKQM
ADGGWSESIKSCETHTYVRGKRGMVVQTSWVLIGLILAKYPHKEVIDRGVQLIMSRQKTR
GDFDFEAVEGIFNHSCGIEYPNYKFLFPIKALGLYSKEYEQ
NT seq
2106 nt
NT seq
+upstream
nt +downstream
nt
atgacagtgtattattcagagaaaatcggcttgccgaagactgatcctcaaagatggagg
ctgagggtcaatgagctcggacgtcagtattgggattacattgaaaaggaggacttgaag
aacgaccctcaaacaccatacgtccagtatctcttgaaaggagatgaatttgaatgtcca
atacctgaaaaacctcaatctgcttttgaatcggcccgaaattgtgcagattttttagct
ttgattcaagatgaatctggagtgtttccgtgtcaatacaaaggaccaatgttcatgagc
ataggctacgttgtagcatgttatttcactaatacaccaattccagatcatgtaaggacc
gaaatgatcagatatgtagtcaatacagcccatccggtggatggaggctggggactacac
gagtgggataaatcgacatgttttggaacatgtatgaattacgttgtccttcgattgttg
ggacttccaaaagataatccagtgtgtatcaaggctagaaaggtattacatgctctagga
ggagctttggccactccatattggggaaaggcttggctttcacttctaaatgtgtacaaa
tgggaaggagtgaaccctgcacctccagaaatgtggaatcttccatactcgctcaaaatt
catccatgtagatggtgggtacatacaagagccattgctttaccactgagttacatttct
tcctacaaaagtcaaatgcctctgactccactgttgaaagagctgagaaatgaaatattt
ctacaggatttcgataccatagacttttctaagcataggaacaatgtgtgtggtatcgat
ctttattatcctcatacttcactgttggactttgcgaacagtattcttgtcggctacgat
aaaattagacctacatggttgctgaaagaatctaatgatgcagtgtatgagctgattaag
aaagagcttgccaacacagagcatctatgtatcgctcctgtgaatgctgcttttaatacg
attgttgcataccttgaagaaggtccagagtcgtacaatttcaaacgcttgcaagaaaga
ttcaaagatgtcatcttccatgggccccaaggaatgaccactatgggtaccaacggcacg
caggtctgggacaccagtttttgcctacaatactttttcatggcaggattagcagatctt
gatgaatatgaggagttaattatcagagacaaaaggatcggatgctttccatttagtacc
aaggagcaaggttacacagtaagtgattgcactgccgaggcaatcaaggcgatcttgatg
gtgaaaaaccatcccaaatttgcctaccttggagattacattgatgaggatctgcttaag
aaaggtattgatggattattatctctacaaaacgtggggtcatatcattttggttcgttc
tcgacatatgaaagcactagagctaatcctgcgctggaaaagatcaaccccgcagaagta
tttggcaatatcatggtagagtatccttacgtagaatgtacagactcttcggttttgggt
cttacctatttcagagaacattgggactatcgccgacacgatattgacactgctatagag
aggggtgtcaagttcatctgcgacgcccagcaggaagatgggtcatggtatggctgttgg
ggggtctgctttacttacgcaggaatgtttgcgctagaagctttggcttctgtgaatcaa
tattatgaaaccaatgaagtagtgaggaaagggtgtgatttcctggtctccaagcagatg
gctgatggtggctggtctgaaagtatcaaatcctgtgaaactcatacctatgttcgtgga
aaaaggggtatggtagttcaaacttcttgggttctaataggtttgattcttgctaagtac
ccccataaggaagtcatagacaggggggttcaactaatcatgagtcgccaaaagacaaga
ggagactttgactttgaagctgtagaaggtattttcaaccatagctgcggaattgagtat
ccaaactacaaattcctgtttcccatcaaggccttggggttatattccaaagagtatgag
caataa
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