KEGG   Komagataella phaffii: PAS_chr2-2_0230
Entry
PAS_chr2-2_0230   CDS       T01092                                 
Name
(RefSeq) One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate
  KO
K00021  hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
Organism
ppa  Komagataella phaffii
Pathway
ppa00900  Terpenoid backbone biosynthesis
ppa01100  Metabolic pathways
ppa01110  Biosynthesis of secondary metabolites
Module
ppa_M00095  C5 isoprenoid biosynthesis, mevalonate pathway
Brite
KEGG Orthology (KO) [BR:ppa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    PAS_chr2-2_0230
Enzymes [BR:ppa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.34  hydroxymethylglutaryl-CoA reductase (NADPH)
     PAS_chr2-2_0230
SSDB
Motif
Pfam: HMG-CoA_red Sterol-sensing HPIH Patched
Other DBs
NCBI-GeneID: 8198637
NCBI-ProteinID: XP_002491966
UniProt: C4R2G2
LinkDB
Position
2:complement(1957199..1960159)
AA seq 986 aa
MLTGLSKICAHRPIHTIVVTALLVSLAYLTIVEEYTSRSSLSNPFISFYHPPGNSDYQNW
IPVDDSVKLKSKSAQHLSVCALKFKRVNGHQIPDLAGSFQSADPTEIFVVQDFDKSFDYF
DSISTIEGKDGIQWKVRHPNRLGRYSEYFRSVFSKTLRLVQGAEPFDIVLIAFAYVAMWY
TFLQLYYEMKTKANSNFWLTFGSLLSSGCAFVFALAVTVKVYGIKVPLTSLTEGVPFLVA
TIGFKHKVAFTVPILQASRSKKAKEIPDTIISVIEQTTGWPLIKDHLIMISAFLACSFYA
PRMEGLKNFCILSANILTFDLIMIFTFFTAVLSLKAQINKVHETTALQQVLEEDGIAEDV
AERIAASNRNMFSRSTSVVSFKVIMIAGFLGFHLFVLGTSWLYDSDVSSSSIFGKSNVSA
LSKAAAKHIPIGSEGTIVTIMPTRVYMPVDLLLKLEDDFLNIFSKISASITDPLISKLLF
IITGISATINVYLLNAARFHSSREIAVSTIAKPQTPDVVPTVEPLPNENDTSIRPLEEMV
SLLKEGKTRELNNDEVSSLVVQGKLPLYALEKQLVDKTRAVIVRRKAIASLADAPVLRTE
KLPYKDYDYDRVFGACCENVIGFMPLPVGVAGPLIIDGKPYHIPMATTEGCLVASTMRGC
KAINSGGGVETVLTADGMTRGPCVSFPSLSRAGAAKMWLDSEEGQKTIKGAFNSTSRFAR
LQHVKTTLAGTLLFIRFKTTTGDAMGMNMISKGVEYSLKFMSEECDWPDMEVISVSGNYC
TDKKVAAINWIEGRGKSVVAEARIPADVVRSVLKSDVEALVELNVSKNLIGSAMAGSIGG
FNAQAANLVTAVYLATGQDPAQNVESSNCITLMNKLPNGDLQISVSMPSIEVGTIGGGTV
LEPQGSMLELLGVKGPHPTNPGANSRQLAKIVASAVLAAELSLCSALAAGHLVQSHMTHN
RKQAPVKEVNGTAARLAEQSKICIKS
NT seq 2961 nt   +upstreamnt  +downstreamnt
atgcttactgggttgtccaagatatgtgcgcatagaccaatccataccatagtggtgacc
gctctcttagtttccttagcatacctaaccattgtggaggagtacacatcgagatcttca
ttatccaatccttttatatcgttttaccacccaccaggaaacagtgattaccaaaattgg
attccagtggatgactctgtgaagctcaaaagcaagtcagcccagcatctctctgtatgc
gctttgaagtttaaaagggttaatggacatcagattcccgatctggcaggaagttttcag
agcgcagacccaactgaaatatttgtcgttcaggattttgacaaatcatttgactatttt
gattcaatttcaaccattgagggtaaggatggcatccaatggaaagtcagacaccccaat
aggttgggacgttattctgagtacttcagatctgttttttcaaaaactttgagactggtt
cagggtgctgaaccattcgacattgtgcttattgcttttgcttacgttgctatgtggtac
acatttttgcagctctattatgaaatgaaaacaaaggccaactctaacttttggctgact
ttcggctctctgctgtcttcaggttgtgcatttgtgtttgcattggccgtcactgtaaaa
gtatacggtatcaaggttccactcacatctttaactgaaggtgtcccatttttggtagct
accattggtttcaaacacaaagttgcattcactgttcctattctccaagcttcccgttca
aaaaaagccaaagaaattcctgacaccattatttcagtgattgaacaaaccacagggtgg
cctctgattaaggatcatctcattatgatttccgccttcttagcatgttctttttatgcc
ccccgtatggaaggactcaaaaacttttgcattctctccgctaatatcttaacgtttgac
cttataatgattttcacattttttaccgctgtattatctttaaaagctcagattaataag
gttcacgaaacaactgctttgcagcaagttctggaggaagatggaattgctgaagatgtt
gctgaacgcattgctgcttcaaaccgaaatatgttttcccgtagtaccagcgtcgtcagc
ttcaaagtgataatgatcgctgggttccttggattccatttatttgtgttgggaacttca
tggctctatgactctgacgtttcaagctcttctatatttggtaagagcaatgtatctgcc
ttatccaaagctgctgccaaacatattcctattggatccgaaggaactattgtgaccatt
atgcctacgagggtttacatgcctgttgatttacttctaaagttggaagatgattttctg
aacattttttccaagatatcggctagcataactgatcctttgattagcaaacttcttttc
ataattaccggaataagtgccacaatcaacgtttacttgttgaatgctgctcgattccac
tcgtctagagaaattgctgtctctacaattgcaaagcctcaaacgccagacgttgttccc
acagtagaaccgcttccaaatgaaaatgacacaagcattcgaccattggaggagatggtt
tcattgctgaaggaaggtaaaacacgagagctgaacaatgatgaggtatcatctctcgtt
gttcaaggaaaacttcccttgtacgccctagaaaaacaacttgttgataagacccgcgca
gttattgtaagaaggaaggcaattgcttccttagcagatgctccggtcttgagaaccgaa
aagctgccttacaaagattatgattatgaccgtgtatttggcgcttgttgtgagaatgtt
atcggattcatgcccttaccagtcggcgttgctggtcccttgatcattgacggtaaacct
tatcacattcccatggctactactgaaggctgcttagtagcctcaaccatgagaggttgt
aaagctatcaattctggaggcggtgtagaaactgttctgacagccgacggaatgacaaga
ggaccatgcgtttctttcccatctctttctcgtgcaggtgcagctaagatgtggctagat
agtgaagaagggcaaaagaccattaagggtgcgtttaactccacctctagatttgcccgt
ttgcagcatgttaagacaacccttgctggtacattattgttcatccgattcaagactact
actggtgatgcgatgggtatgaacatgatttctaagggtgtggagtattcactaaagttt
atgtcggaagaatgtgactggcctgacatggaagttatttctgtttcaggtaattactgt
acagacaaaaaagttgctgcaatcaactggatcgaaggtcgtggtaagtctgtcgttgct
gaagctcgtattccagccgatgttgtcagaagcgttctgaagtccgatgttgaggcattg
gtagaattgaatgttagcaagaacttgattggatccgcaatggcaggatcaattggtggt
ttcaacgcacaagctgccaatctagttacagcagtatacttagctacaggacaggatcca
gcccagaatgtcgaaagttccaactgtattaccttgatgaacaagctcccaaatggagat
ttacaaatttcagtctctatgccatctatcgaagttggaaccattggtggaggaaccgtt
ttggaacctcaaggatcaatgttggaactattaggagttaaaggtcctcacccaactaat
ccaggtgcaaactcaaggcagttggctaagatcgttgcttctgctgtcttggctgcagag
ctgtccttgtgctctgcccttgcagctggtcacttagtccaaagtcatatgacccataac
agaaagcaagctccagtcaaggaggtaaacggcactgccgctaggctagcggaacaatct
aagatttgcattaaatcttga

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