KEGG   Panthera pardus (leopard): 109247332
Entry
109247332         CDS       T06062                                 
Symbol
PPP3CA
Name
(RefSeq) serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1
  KO
K04348  serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad04010  MAPK signaling pathway
ppad04020  Calcium signaling pathway
ppad04022  cGMP-PKG signaling pathway
ppad04114  Oocyte meiosis
ppad04218  Cellular senescence
ppad04310  Wnt signaling pathway
ppad04360  Axon guidance
ppad04370  VEGF signaling pathway
ppad04380  Osteoclast differentiation
ppad04625  C-type lectin receptor signaling pathway
ppad04650  Natural killer cell mediated cytotoxicity
ppad04658  Th1 and Th2 cell differentiation
ppad04659  Th17 cell differentiation
ppad04660  T cell receptor signaling pathway
ppad04662  B cell receptor signaling pathway
ppad04720  Long-term potentiation
ppad04724  Glutamatergic synapse
ppad04728  Dopaminergic synapse
ppad04921  Oxytocin signaling pathway
ppad04922  Glucagon signaling pathway
ppad04924  Renin secretion
ppad05010  Alzheimer disease
ppad05014  Amyotrophic lateral sclerosis
ppad05020  Prion disease
ppad05022  Pathways of neurodegeneration - multiple diseases
ppad05031  Amphetamine addiction
ppad05152  Tuberculosis
ppad05163  Human cytomegalovirus infection
ppad05166  Human T-cell leukemia virus 1 infection
ppad05167  Kaposi sarcoma-associated herpesvirus infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ppad05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109247332 (PPP3CA)
   04310 Wnt signaling pathway
    109247332 (PPP3CA)
   04370 VEGF signaling pathway
    109247332 (PPP3CA)
   04020 Calcium signaling pathway
    109247332 (PPP3CA)
   04022 cGMP-PKG signaling pathway
    109247332 (PPP3CA)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    109247332 (PPP3CA)
   04218 Cellular senescence
    109247332 (PPP3CA)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    109247332 (PPP3CA)
   04650 Natural killer cell mediated cytotoxicity
    109247332 (PPP3CA)
   04660 T cell receptor signaling pathway
    109247332 (PPP3CA)
   04658 Th1 and Th2 cell differentiation
    109247332 (PPP3CA)
   04659 Th17 cell differentiation
    109247332 (PPP3CA)
   04662 B cell receptor signaling pathway
    109247332 (PPP3CA)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    109247332 (PPP3CA)
   04921 Oxytocin signaling pathway
    109247332 (PPP3CA)
   04924 Renin secretion
    109247332 (PPP3CA)
  09156 Nervous system
   04724 Glutamatergic synapse
    109247332 (PPP3CA)
   04728 Dopaminergic synapse
    109247332 (PPP3CA)
   04720 Long-term potentiation
    109247332 (PPP3CA)
  09158 Development and regeneration
   04360 Axon guidance
    109247332 (PPP3CA)
   04380 Osteoclast differentiation
    109247332 (PPP3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109247332 (PPP3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109247332 (PPP3CA)
   05170 Human immunodeficiency virus 1 infection
    109247332 (PPP3CA)
   05163 Human cytomegalovirus infection
    109247332 (PPP3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109247332 (PPP3CA)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    109247332 (PPP3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109247332 (PPP3CA)
   05014 Amyotrophic lateral sclerosis
    109247332 (PPP3CA)
   05020 Prion disease
    109247332 (PPP3CA)
   05022 Pathways of neurodegeneration - multiple diseases
    109247332 (PPP3CA)
  09165 Substance dependence
   05031 Amphetamine addiction
    109247332 (PPP3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109247332 (PPP3CA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:ppad01009]
    109247332 (PPP3CA)
Enzymes [BR:ppad01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     109247332 (PPP3CA)
Protein phosphatases and associated proteins [BR:ppad01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Catalytic subunits
     109247332 (PPP3CA)
SSDB
Motif
Pfam: Metallophos
Other DBs
NCBI-GeneID: 109247332
NCBI-ProteinID: XP_019271409
Ensembl: ENSPPRG00000014654
UniProt: A0A9W2VFQ0
LinkDB
Position
Unknown
AA seq 511 aa
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAM
PSDANLNSINKALATETNGTDSNGSNSSNIQ
NT seq 1536 nt   +upstreamnt  +downstreamnt
atgtccgagcccaaggcaattgatcccaagttgtcgacgaccgacagggtggtgaaagct
gtcccatttcctccaagtcaccgacttacagcaaaagaagtattcgataacgatgggaag
cctcgtgtggatatcttaaaggcacatctcatgaaggagggcagactggaagagagcgtt
gcattgagaataataacagagggggcctcaattcttcgacaggaaaaaaatttgctggat
atcgatgcaccagtcacagtttgtggggacatccatggacaattctttgatttgatgaag
ctttttgaagtggggggatctcctgccaacactcgctacctcttcttaggggactatgtt
gacagagggtacttcagtatcgaatgtgtgctgtatttgtgggccttgaaaattctttac
cccaaaacactgtttttacttcgtggaaatcatgaatgtagacatctaacagagtatttc
acatttaaacaagaatgtaaaataaagtattcagaacgcgtatatgatgcctgtatggat
gcctttgactgcctgcccctggctgccctgatgaaccaacagttcctgtgtgtacacggc
ggtttgtctccagagattaacactttagatgatatcagaaaattagaccgattcaaagaa
ccacctgcttacggacctatgtgtgatatcctgtggtcagaccccctggaggattttgga
aatgagaagactcaggaacatttcactcacaacacagtcagggggtgttcgtacttctac
agctacccggctgtatgtgaattcttacagcacaataacctgttgtctatactccgagcc
catgaagcccaagatgcagggtatcgcatgtacaggaaaagccaaacgacaggcttccct
tctctaattacaattttttcagcaccaaattacttagatgtgtacaataacaaagctgca
gtattgaagtatgagaacaatgtcatgaacatcaggcaattcaactgttctcctcaccca
tactggcttccaaatttcatggatgttttcacttggtccctgccctttgttggggaaaaa
gtgactgaaatgctggtaaatgtcctcaacatctgctcagatgatgaactagggtcagaa
gaagatggatttgatggcgcaacagctgcagcccggaaggaggtgataaggaacaagatc
cgagcaataggcaaaatggcccgagtgttctcagttctcagagaagagagtgagagcgtg
ctaacgctgaaaggcttgactcccacgggcatgctccccagcggagtgctttctggaggg
aagcagaccctgcaaagcgccatcaaaggattttcaccacaacataagatcactagcttc
gaggaggccaagggcttagaccgaattaacgagaggatgccacctcgcagagatgccatg
ccctctgacgccaaccttaactccatcaacaaggctctcgccacagagactaacggcacg
gacagcaatggcagtaatagcagcaatatccagtga

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