Panthera pardus (leopard): 109247423
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Entry
109247423 CDS
T06062
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2 isoform X1
KO
K05083
receptor tyrosine-protein kinase erbB-2 [EC:
2.7.10.1
]
Organism
ppad
Panthera pardus (leopard)
Pathway
ppad01521
EGFR tyrosine kinase inhibitor resistance
ppad01522
Endocrine resistance
ppad01524
Platinum drug resistance
ppad04010
MAPK signaling pathway
ppad04012
ErbB signaling pathway
ppad04020
Calcium signaling pathway
ppad04066
HIF-1 signaling pathway
ppad04151
PI3K-Akt signaling pathway
ppad04510
Focal adhesion
ppad04520
Adherens junction
ppad04530
Tight junction
ppad05200
Pathways in cancer
ppad05205
Proteoglycans in cancer
ppad05206
MicroRNAs in cancer
ppad05212
Pancreatic cancer
ppad05213
Endometrial cancer
ppad05215
Prostate cancer
ppad05219
Bladder cancer
ppad05223
Non-small cell lung cancer
ppad05224
Breast cancer
ppad05226
Gastric cancer
ppad05230
Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:
ppad00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
109247423 (ERBB2)
04012 ErbB signaling pathway
109247423 (ERBB2)
04066 HIF-1 signaling pathway
109247423 (ERBB2)
04020 Calcium signaling pathway
109247423 (ERBB2)
04151 PI3K-Akt signaling pathway
109247423 (ERBB2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
109247423 (ERBB2)
04520 Adherens junction
109247423 (ERBB2)
04530 Tight junction
109247423 (ERBB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
109247423 (ERBB2)
05206 MicroRNAs in cancer
109247423 (ERBB2)
05205 Proteoglycans in cancer
109247423 (ERBB2)
05230 Central carbon metabolism in cancer
109247423 (ERBB2)
09162 Cancer: specific types
05212 Pancreatic cancer
109247423 (ERBB2)
05226 Gastric cancer
109247423 (ERBB2)
05219 Bladder cancer
109247423 (ERBB2)
05215 Prostate cancer
109247423 (ERBB2)
05213 Endometrial cancer
109247423 (ERBB2)
05224 Breast cancer
109247423 (ERBB2)
05223 Non-small cell lung cancer
109247423 (ERBB2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
109247423 (ERBB2)
01524 Platinum drug resistance
109247423 (ERBB2)
01522 Endocrine resistance
109247423 (ERBB2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ppad01001
]
109247423 (ERBB2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
ppad04147
]
109247423 (ERBB2)
04090 CD molecules [BR:
ppad04090
]
109247423 (ERBB2)
Enzymes [BR:
ppad01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
109247423 (ERBB2)
Protein kinases [BR:
ppad01001
]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
109247423 (ERBB2)
Exosome [BR:
ppad04147
]
Exosomal proteins
Exosomal proteins of breast cancer cells
109247423 (ERBB2)
CD molecules [BR:
ppad04090
]
Proteins
109247423 (ERBB2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
GF_recep_IV
Pkinase
Furin-like
TM_ErbB1
ABC1
Haspin_kinase
Kinase-like
Motif
Other DBs
NCBI-GeneID:
109247423
NCBI-ProteinID:
XP_019271567
Ensembl:
ENSPPRG00000004415
UniProt:
A0A9V1E0K9
LinkDB
All DBs
Position
Unknown
AA seq
1327 aa
AA seq
DB search
MSTLAPNHGRRRRWRRRAALRKYKNEVVELKSPLRRAPRAEQSSQAAARPFAARSSPSHG
AGAAVSTMELAAWCRWGLLLALLPSGATGTQVCTGTDMKLRLPASPETHLDMLRHLYQGC
QVVQGNLELTYLHANASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYA
LAVLDNGDPLDSGTPATGAALGGLRELQLRSLTEILKGGVLIQRNPQLCHQDTILWKDIF
HKNNQLALMLIDTNRSRACQPCSPACKDSHCWGASSGDCQSLTRTVCAGGCARCKGPQPT
DCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGA
SCVTACPYNYLSTDVGSCTLVCPLNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREA
RAVTSANIQEFVGCKKIFGSLAFLPESFEGDPASNTAPLQPEQLRVFEALEEITGYLYIS
AWPDSLPNLSVFQNLRVIRGRVLHDGAYSLTLQGLGISWLGLRSLRELGSGLALIHRNSR
LCFVHTVPWDQLFRNPHQALLHSANRPEDECAGEGLACYPLCAHGHCWGPGPTQCVNCSQ
FLRGQECVEECRVLQGLPREYVKDRFCLPCHPECQPQNGSVTCLGSEADQCVACAHYKDP
PFCVARCPSGVKPDLSFMPIWKFADEEGTCQPCPINCTHSCADLDEKGCPAEQRASPVTS
IIAAVVGILLVVVVGLVLGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMR
ILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYV
MAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGM
SYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALES
ILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYM
IMVKCWMIDSECRPRFRELVAEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDED
MGDLVDAEEYLVPQQGFFCPDPAPGAGGTAHRRHRSSSTRSGGGELTLGLEPSEEEPPKS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLSPQDPSPLQRYSEDPTVPLPPETDGYVAPLTC
SPQPEYVNQPEVWPKPPSPLEGPLPPSRPAGATLERPKTLSPKTLSPGKNGVVKDVFAFG
GAVENPEYLAPRGRAAPQPHPPPAFSPAFDNLYYWDQDTSERGSPPSTFEGTPTAENPEY
LGLDVPV
NT seq
3984 nt
NT seq
+upstream
nt +downstream
nt
atgagcacgctcgctcccaatcacgggaggaggaggaggtggaggaggagggctgccttg
aggaagtacaagaatgaagttgtggagctgaagagtcccctgcgtcgtgccccgagagcc
gagcagagctcccaggcagccgcccggcccttcgcagcccggtccagcccgagccatggg
gccggagccgcagtgagcaccatggagctggcggcctggtgccgctgggggctcctcctc
gccctcctgccctccggagccacgggcacccaagtgtgcaccggcacagacatgaagctg
cggctcccagccagtcccgagacccacctggacatgctccgccacctctaccagggctgt
caagtggtacagggtaacctggagctcacctacctgcatgccaatgccagcctctccttc
ctgcaggatatccaggaggtgcaaggctatgtgctcattgcccacaaccaagtgagacag
gtcccactgcagaggctacgaatcgtgcgagggacccagctctttgaggacaactacgcc
ctggccgtgctggacaacggagacccactggacagtggcacccctgctacaggggctgcc
ctaggagggctgcgggagctgcagctccgaagcctcacagagatcctgaagggaggggtc
ctcattcagcggaacccgcagctctgccaccaggacacgattctgtggaaggacatcttc
cacaagaacaaccagctggccctcatgctgatagacaccaaccgctctcgggcctgccaa
ccctgttctccagcttgtaaagactcccactgctggggagcaagttccggggactgtcag
agcttgactcgaactgtctgtgctggtggctgtgcccgctgcaagggcccgcagcccacc
gactgctgccacgagcagtgtgctgctggctgcacgggccccaagcattctgactgcctg
gcctgcctccacttcaaccacagtggcatctgtgagctgcactgcccagccctggtcacc
tacaacacggacaccttcgaatccatgcccaaccctgagggccgttataccttcggtgcc
agctgtgtgactgcctgtccctacaactacctgtctacggacgtgggatcctgcaccctg
gtctgtcccctgaacaaccaagaggtgacagctgaggatggaacacagcggtgtgagaaa
tgcagcaagccctgtgcccgagtgtgctacggcctaggcatggagcacctgcgggaggcg
agggcagtcaccagtgccaacatccaagaatttgtcggctgcaagaagatctttgggagc
ctggcgtttctgccagagagctttgagggggacccagcctccaacactgcccccctgcag
cctgagcagctcagagtgtttgaggctctggaggagattacaggttacctgtacatctca
gcgtggccagacagcttgcctaacctcagtgtcttccagaacctcagagtgatccggggc
cgagttctgcatgacggtgcttactcgctgacccttcaagggctgggcatcagctggctg
gggctgcgttcgctgcgggagctgggcagtgggctggccctcatccaccgcaactctcgc
ctctgcttcgtacacacggtgccctgggaccagctcttccggaacccccaccaggctctg
ctccacagcgccaaccggccagaggacgagtgcgcgggtgagggcctggcctgctacccg
ctgtgtgcccacgggcactgctggggtccgggacccacccagtgtgtcaactgcagccag
ttccttcgaggccaggagtgtgtggaggaatgccgagtactgcaggggcttccccgggag
tatgtgaaggataggttctgtctgccatgccacccagagtgtcagccccagaatggctca
gtgacctgcttgggctcggaagctgaccagtgtgtggcctgtgcccactacaaggaccct
cctttctgtgtggctcgctgccccagtggggtgaaacctgacctctccttcatgcccatc
tggaagtttgcagatgaggagggcacgtgccagccatgccccatcaactgcacccactcc
tgtgcggacctggacgagaagggctgccccgccgagcagagagccagccctgtgacgtcc
atcattgctgctgtggtgggcattctgctggtcgtggttgtggggctggtccttggcatc
ctaatcaagcgaaggcggcagaagatccggaagtacacgatgcggaggctgctgcaggag
acagagctggtggagcccctgacgcctagtggagccatgcccaaccaggctcagatgcga
atcctgaaagaaacagagctgaggaaggtgaaggtgcttggatccggagcttttggcact
gtctataagggcatctggatccctgatggggaaaatgtgaaaatcccagtggccatcaaa
gtgttgagggaaaatacatctcccaaagccaacaaagaaatcttggacgaagcgtatgtg
atggctggcgtgggctccccatatgtgtctcgccttctgggcatctgtctgacatccacc
gtgcagttggtgacacagcttatgccttatggctgcctcttagaccatgtccgagaacac
cgtgggcgcctaggctcccaggacctgctgaactggtgtgtgcagattgccaaggggatg
agctacttggaggatgttcggctcgtgcacagggacctggctgcccggaacgtgctggtc
aagagtcccaaccacgtcaagattacagattttgggctggctcggctgctggacattgac
gagacagagtaccatgccgatgggggcaaggtgcccatcaagtggatggcgctggagtcc
attctccgccggcggttcacccatcagagcgacgtgtggagctacggtgtgactgtatgg
gaactgatgacttttggggccaaaccttatgatgggatcccagcccgggagattcctgac
ctgctggagaagggggaacggctgccccagccccccatctgcaccattgatgtctacatg
atcatggtcaaatgttggatgatagactctgaatgtcggccacgtttccgggagttggtg
gctgaattctcccggatggccagggacccccagcgctttgtggtcatccagaatgaggac
ttgggcccagccagtcccttggacagcactttctaccgttcactgctggaggatgaggac
atgggagacctggtggacgctgaggagtacctggtaccccagcagggtttcttctgccca
gaccctgccccaggcgccgggggcacagcccaccgcagacaccgcagctcatccaccagg
agtggcggtggtgagctgacactggggctggagccctccgaggaagagcctcccaagtct
ccactggcaccctcagaaggggctggctctgatgtgtttgatggcgacctgggaatgggg
gcagccaaggggctgcagagcctttccccacaggaccccagccctctacagcggtacagt
gaggatcctaccgtacccctaccccctgagactgatggctacgttgcccccctgacctgc
agtccccagcctgaatacgtgaaccagccagaggtttggccaaagcccccatcgccctta
gaaggccctctgcctccttctcgacctgccggtgccactctggaaaggcccaagactctg
tcccccaagactctttcccccggcaagaatggggttgtcaaagacgtttttgcctttggg
ggtgctgtggagaaccccgagtacttggcaccccggggcagggctgcccctcagccccac
cctcctccagccttcagcccagcctttgacaacctctattactgggaccaggacacatct
gagcggggctctccacccagcacctttgaagggacccctacagcagagaaccccgaatac
ctgggcctggatgtgccagtgtga
DBGET
integrated database retrieval system
