Panthera pardus (leopard): 109248970 Help Entry 109248970         CDS       T06062                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism ppad  Panthera pardus (leopard) Pathway ppad04020   Calcium signaling pathway ppad04024   cAMP signaling pathway ppad04260   Cardiac muscle contraction ppad04261   Adrenergic signaling in cardiomyocytes ppad04371   Apelin signaling pathway ppad04713   Circadian entrainment ppad04911   Insulin secretion ppad04921   Oxytocin signaling pathway ppad04972   Pancreatic secretion ppad05020   Prion disease ppad05022   Pathways of neurodegeneration - multiple diseases ppad05410   Hypertrophic cardiomyopathy ppad05412   Arrhythmogenic right ventricular cardiomyopathy ppad05414   Dilated cardiomyopathy ppad05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ppad00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     109248970 (RYR2)    04020 Calcium signaling pathway     109248970 (RYR2)    04024 cAMP signaling pathway     109248970 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     109248970 (RYR2)    04921 Oxytocin signaling pathway     109248970 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     109248970 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     109248970 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     109248970 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     109248970 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     109248970 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     109248970 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     109248970 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     109248970 (RYR2)    05414 Dilated cardiomyopathy     109248970 (RYR2)    05415 Diabetic cardiomyopathy     109248970 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ppad04040]     109248970 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:ppad04990]     109248970 (RYR2) Ion channels [BR:ppad04040]  Voltage-gated cation channels   Ryanodine receptor    109248970 (RYR2) Domain-containing proteins not elsewhere classified [BR:ppad04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    109248970 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 PI3_PI4_kinase Motif Other DBs NCBI-GeneID:  109248970 NCBI-ProteinID:  XP_019274628 LinkDB All DBs Position Unknown AA seq 4995 aa AA seqDB search MASSQACVSCSPHVAYTESSIYRPPPCITCPFLFLQDDEVVLQCTATIHKEQQKLCLAAE GFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKF MMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWW TIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSG SEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETL RVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDV GVRKEVDGMGTSEIKYGDSVCYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMD DGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLI GYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGR EGGEAWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLV ESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGR DLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWAST EGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLD LSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYA PCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLER IREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETL KTLLALGCHVGIADEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLA ENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGY GYHLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRP GCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGE ILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFA VNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGAQNSTADIM FYRLSMPIECAEVFSKTVAGGLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVD KDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYL MQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESI KRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLF PAAFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMP NQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRL YSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLM MNSEFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNECYQYSP EFPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNDDLK HILQLIEPSVFKEAATPEEDTEALEKEPSMEDSKPEGAGEEEAKGGKRPKEGLLQMKLPE PVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTAR KTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGN SDLTIRGRLLSLVEKVTYLKKKQAEKPIESGSKKSSTLQQLISETMVRWAQESVIEDPEL VRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEK LMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFL CYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREP DLEKVVRYLAGCGLQSCPMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVV VRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLETEEEEDD TIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAF QMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAA SLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCS LTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKY YCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDY MESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANG WIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRVERTREGDSMAL YNRSRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMEL ESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKR FAYSFLQQLIRYVDEAHQYILEFDGGSRSKAEHFPYEQEIKFFAKVVLPLIDQYFKNHRL YFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTL DARTVMKTGLESVKSALRTFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVA LLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLA AFAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVE LAESGIRYTQMPHVMEVILPMLCSYLSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNI LKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHL KAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVA EVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYS TQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLE DPAIRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQKSTSMHRRYYSLVEHPQ RSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKL IEDLAKPGADPPEEEEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCH DEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTG PMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQN KAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIII STVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQ QSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVN GTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAM ESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPND TRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQF IFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKEKPEEQGPR MGFFSIVTVKSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTMKDMVTAAFSSYWSIFM SLLHFVASVSRGFFRIICSLLLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDGEEGDRR PMEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPI PDVQEKFQEQKVKEEEKEEKEESKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGE PEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKE PPTRSSSGNAKVSSLDSGSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYC LKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRK VMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGV VFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVG LLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIE DPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICG IGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFF PAGDCFRKQYEDQLN NT seq 14988 nt NT seq  +upstreamnt  +downstreamnt atggctagttctcaggcctgtgtttcttgcagtcctcatgttgcctacacggagtcgtcc atttaccgtcctcccccttgtataacttgtccttttctctttttgcaggacgatgaagtg gtcctgcagtgcaccgcgaccatccacaaagaacaacagaaactgtgcttggcagcggaa gggtttggcaacagactttgcttcctggagtctacttcgaattccaagaatgttccccca gacctctccatctgcacttttgtgctggaacagtctctctctgtccgggccctacaggag atgctggctaacacagtggagaaatcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggtcatcgaacactcctgtacggacatgccatattg ctacgccattcctatagtggcatgtatctgtgctgtctgtccacctcccggtcttcaact gataaactggcctttgacgttggcttgcaagaggacacaacaggtgaggcttgttggtgg accattcatcctgcctccaagcagaggtcggaaggagaaaaggtgcgcgttggagatgac ctcatcttagtcagtgtgtcctctgagaggtacctgcatttgtcttacggcaatggcagc ttacacgtggatgccgctttccagcagactctctggagcgtggccccaatcagctcagga agtgaagccgcccaagggtatctaattggtggtgacgtcctcaggttgctgcacggacac atggatgaatgcctcactgtcccttcaggagaacacggtgaagagcaacggagaactgtt cactatgaaggcggtgctgtatctgtccatgcacgttccctgtggagactagagacacta agagttgcgtggagtggaagccacataagatggggccagcccttccgactacgccatgtc acaacaggaaagtacttgagtctcatggaagacaaaaaccttctactcatggacaaagaa aaggctgatgtaaagtcaacagcatttaccttccgatcttccaaggaaaaattggatgta ggggtgagaaaagaagtcgatggcatgggaacatcagaaataaaatatggagactcagta tgctatattcaacacataaatactggcctgtggcttacttaccagtctgtggatgtgaaa tcagtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggtcacatggat gacggcttaaatctctctagatctcagcatgaagaatcacggaccgcacgagtcatccgg agcactgtcttccttttcaacagatttataaggggccttgatgcgctcagcaaaaaagtg aaggcttccaccgtagacctccctatagaatctgtgagtctgagtctgcaggacctgatt ggttacttccatccccccgacgagcacttagagcatgaagacaaacagaacagattacgg gctctaaagaaccgtcagaatctcttccaggaagagggcatgatcaacctcgtgctcgag tgcatcgacaggctgcatgtctatagcagtgcggcgcatttcgcggacgtggcggggaga gaaggaggcgaggcttggaagtcgattctgaattctctctatgagttgctagcggctcta attagaggaaatcgtaaaaactgtgcccaattttctggctccctggactggttgatcagc cgattggaaagactggaagcttcttctggtattcttgaagttttgcactgtgtgttagta gaaagtccagaagccctaaatattatcaaagaaggacacattaaatccataatctccctt ttagacaagcatggaagaaaccacaaggttctggacgtcttgtgctctctctgcgtctgc cacggagtagcggtccgttccaaccagcatctcatctgcgacaatctgctgccgggaaga gatctgcttctgcagacacgtcttgtaaaccacgttagcagcatgagacccaatattttt ctgggcgtcagtgaagggtccgcccagtataagaagtggtactacgagctgatggtggac cacacggagccgttcgtgactgccgaagccactcacctgagggtgggctgggcgtccacc gaagggtactctccctaccctggaggcggtgaggagtggggtggcaatggagtcggagac gatctcttctcctacggatttgatggccttcacctctggtcaggttgtattgcacgtact gtaagctcaccgaatcaacatctcttgagaactgacgatgtcatcagttgctgtttagat ctgagcgccccaagcatctcattccgaattaacgggcaacctgttcaaggaatgtttgag aatttcaacatcgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctgcttggggggagacacggagaatttaaattccttcctccacctgggtatgct ccttgttacgaagctgttctgccaaaagagaagttgaaagtggaacacagcagagaatac aagcaagaaagaacttacacccgagacctgctgggccccacggtttccctgacgcaggcc gccttcacaccaatccctgtggacaccagccagattgtgttacctcctcacctggagaga ataagagaaaaactggcagagaatatccatgaactctgggttatgaataaaattgaactt ggctggcagtatggtccggttagagatgacaataagagacagcatccgtgtctggtggag ttctccaagctaccggagcaggaacgcaattacaatttgcagatgtcgcttgagaccctg aagactttgttggcattaggatgtcatgtgggaatagcagatgaacatgctgaagaaaag gtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgccccg atggacctgagcttcattaaactcacgccctctcaggaagcgatggtggacaagttggcg gagaacgcgcacaacgtgtgggcccgggatcgaatccggcagggctggacttacggcatc cagcaggatgtaaagaacagaagaaaccctcgcctggttccctacacccttctagatgac cgcaccaagaagtccaacaaggacagcctccgcgaggccgtgcgcacgctgctgggatat ggctatcatctggaggcgccagatcaagatcatgctgcccgagccgaagtgtgtagcggc accggggagaggttccgaatcttccgcgctgagaaaacctatgccgtcaaggcaggaagg tggtattttgaatttgaggctgtcactgctggagacatgagagttggatggagcaggcca ggttgtcaacctgaccaagagctgggctcagacgaacgtgcctttgcttttgacggcttc aaggcccagcggtggcaccagggcaacgaacactatgggcgctcttggcaagcgggcgat gtcgtgggatgcatggtggacatgacagagcacaccatgatgttcacactgaatggcgaa atccttctggacgactcgggctcggaactggcgttcaaggacttcgatgttggtgacgga ttcattcctgtctgtagccttggagtggctcaggtgggcaggatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggttacgaaccgtttgct gtgaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccag gtcccttcaaaccatgagcacatcgaggtgaccagaatagatggcaccatcgacagttct ccgtgtttaaaagtcacccagaagtcctttggcgctcagaacagcactgccgacatcatg ttctatcgcctgagcatgccgatcgagtgtgccgaggttttctccaagacggtggcaggc gggctcccaggcgccggcctctttgggcccaagaatgatctggaggattacgatgcggat tctgactttgaggttctaatgaagacagctcatggccatctggtgccagaccgtgttgac aaagacaaggaagccacaaaaccagagtttaataaccacaaagactatgctcaggaaaag ccctctcgtctgaaacaaagatttttgcttagaagaacaaagccagattatagcacgagc cattctgcaaggctcaccgaagatgtccttgcagatgatcgggatgattatgattacttg atgcaaacgtccacgtactattactcagtgagaatctttcccggccaagaacctgctaac gtctgggtgggctggattacatcagatttccatcagtatgatacaggctttgacttggac agagttcgtacagtaaccgttactctaggagatgaaaagggaaaagtacacgaaagcatc aaacgcagcaactgctatatggtgtgcgcgggcgagagcatgagcccagggcaaggacgc aacaataatggcctggagatcgggtgcgtggtggatgctgccagtgggcttctcacattc accgccaacggcaaggagctgagcacctactaccaggtggagccaagtacgaaattattt cctgcagcttttgcccaagctacaagtcccaacgttttccagtttgagctgggaagaatc aagaatgtgatgcctctctccgcgggattattcaagagtgagcacaaaaaccctgtgcca cagtgtcccccgcgtctccacgtgcagtttctgtcccacgtcctgtggagcagaatgccc aaccagttcctgaaggtagatgtgtctcgaataagtgagcgccaaggctggctggtgcag tgtttggatcctctgcagttcatgtctctccatatcccggaggagaacagatctgtggac atactggagctgacagagcaggaagagctgctgaaattccactaccacacgctccggctt tactccgccgtctgcgccctcgggaaccaccgggtggcgcatgcgttgtgcagccacgtg gacgaaccccagctgctctacgccatcgagaacaagtacatgcccggtttgctgcgggcc ggctactatgacctgctgattgacatccacctgagctcctacgccactgccaggctcatg atgaacagtgagttcatcgtgcccatgacggaggagaccaagagcatcaccctcttccct gatgagaacaaaaagcacggcctccccgggattggcctcagcacctccctcaggccacgg atacagttctcctcccccagttttgtgagcatcaataacgaatgctaccaatacagtcca gagttcccgctggacatcctgaaggccaaaaccattcagatgctgacagaagctgttaaa gagggcagcctgcatgcccgggaccccgtggggggcaccactgaatttctctttgtacct ctcatcaagcttttctatactctgctcatcatggggatcttccacaatgacgacttaaaa cacatcttgcagctgatagagcccagtgtgttcaaggaagccgccactccggaagaagac actgaggctctggagaaagagccctccatggaagactccaagccagaaggagctggagaa gaagaagccaaagggggtaagaggcccaaggaaggactgctccaaatgaaactgcctgag ccagttaaattgcagatgtgtctgctgctccagtacctctgtgactgccaggtccgacac cggatagaagccatcgtggccttttcagatgactttgtagccaagctccaagacaatcag cgcttccgttacaacgaagttatgcaagctttaaacatgtcggccgcgctcactgccagg aagacaaaggaatttcgatccccacctcaggaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaagaaatccgagaccagctcttagattttcac gaagatttgatgacacattgtggaattgagctggatgaagatgggtctcttgatggaaac agtgacttaacaattagaggacgcctgctgtccttggtagaaaaggtgacatacctgaag aagaaacaagccgaaaaaccaattgagagtggctccaagaaatcctccactcttcagcag ttgatttctgagaccatggtccgatgggcgcaagagtctgtcattgaagaccctgaactg gtgagggccatgtttgtgttgctccatcgacagtacgatggcattgggggtctggtccgg gctctgccaaagacctacactataaatggtgtctccgtggaggataccatcaacctgctg gcatctctcggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtattttaccagcaccctaat cttatgagggcacttgggatgcacgagacggtgatggaggtcatggtgaatgtccttgga ggtggagagtccaaggaaatcacttttcccaagatggtggccaactgttgccgttttctt tgttacttctgtcgtataagtcggcagaatcaaaaagctatgtttgaccatctcagctat ttattggagaacagcagtgttggtcttgcctcaccagcaatgagaggttcaacaccattg gatgtggcagccgcatcagtgatggataataatgaactggccttagctctgcgtgagcca gatttggaaaaggtagttcgatatttggctggttgtggactgcagagttgcccgatgctg gtatctaagggttacccagatattgggtggaatccagttgaaggagagagataccttgac tttctccgatttgctgtcttctgtaatggggagagtgtggaagagaatgctaatgttgtg gtgaggttgcttatccggaggcccgagtgtttcggtcctgctttgagaggggaaggtggg aacggtcttcttgcagcaatggaagaagccataaaaatagccgaggatccctctcgagat ggtccctcaccgactagcggatccagtaaaacacttgagacagaagaggaggaggatgac actatccacatggggaatgccatcatgacgttttatgcagctttgattgacctcttagga cgctgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccgg tcaattctgagatccctaattccattgggagatttggtgggagtaatcagcattgctttt cagatgccaacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatggcattgaggtt caagatttcctcctccatcttctcgaggttggctttctgcctgatctccgggctgctgct tctttagatacggctgctttgagtgccacagacatggccctggccctcaatcggtacctt tgcacagccgtgttgcctttgttaacaaggtgtgcccctctttttgcgggcacagaacac cacgcttctctcattgactcgttactgcacactgtgtacagactttcgaagggctgctca cttaccaaagctcagcgggattccatagaagtttgtttgctctccatttgtggccaattg agaccttctatgatgcagcacttgctccgaagattagtgtttgatgtcccattattaaat gaacatgcgaagatgcctcttaagttgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaacttcggagctgcctcagaagaagaacttcattta tcaagaaagttgttttggggcatttttgacgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgccgttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaacattacaattcctgagaagttggaatacttc attaacaaatatgctgaacattctcatgacaaatggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcgtctaaagttcagccgttaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaa accatgctggcatggggttggagggttgagagaacacgggagggagacagcatggccctc tacaaccgttctcgtcgtatttctcagacaagccaggtttctgttgatgctgcgcatggt tatagcccccgagccattgatatgagcaatgtcacactgtccagagacctgcacgctatg gcagaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaaaatggagctg gagtccaaaggaggtggaaaccatcccctgctggtaccctatgatacactgacagccaaa gagaaagccaaggatagggaaaaagcacaggacatcctcaagttcttgcagatcaatgga tatgctgtatccaggggattcaaggacctggaattggacacaccttccattgagaaacga tttgcctatagtttccttcagcaactcattcgctatgtggatgaagcccatcagtatatc ctggagtttgatggtggcagcagaagcaaggcggaacattttccttacgagcaagaaatc aagttctttgctaaagttgtgcttcctttaattgatcagtatttcaaaaaccatcgttta tacttcttatctgcagcaagcagacccctctgttctggaggacatgcgtcaaacaaggag aaagaaatggtgacgagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatcaattgtcaactgtcttcatattttgggtcagactttg gatgcaaggaccgtcatgaagactggcctggagagcgttaaaagtgcgctcagaacgttt ctggacaatgcggcggaggatctggagaagacgatggagaatctcaagcagggccagttc acccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggct ctgttgccaatgctgtcatcattatttgagcatattggccagcatcagttcggagaagat ctaatattggaagatgtacaggtgtcatgttatagaattctgactagcttatatgctttg ggaaccagcaaaagtatttatgtggaaaggcaacgctctgcattaggagaatgtcttgct gcttttgctggtgcctttcctgtcgcatttttggaaactcatctcgacaaacataacatc tactctatctacaataccaagtcatcgcgagaaagagcagctctgaatttgccaactaac gtggaagatgtgtgcccaaatataccgtctttggagaaactcatggaagaaattgtggaa ttagcggagtccggcattcgctacacgcagatgccacacgtcatggaagtcatactgccc atgctttgcagctacctgtctcgttggtgggagcacggacctgaaaataatccagaaagg gctgaaatgtgctgtaccgccctgaactccgagcacatgaacacgctcttggggaatata ttgaaaatcatatataataacctgggaattgatgagggagcctggatgaagaggttagca gtattttcacagcccattataaataaagtgaaacctcagctcctgaaaactcatttcttg ccattaatggagaaactcaagaaaaaagcagcgatggtggtgtcggaggaggaccatctg aaagctgaggccaggggggatatgtccgaggcagagcttctcattctcgatgagttcacc actctggccagagacctctatgccttctacccgctcttgattagatttgtggactataac agggcaaagtggctaaaagaacctaacccagaagcagaggaccttttccgcatggtggct gaagtgtttatctactggtcaaaatcccacaatttcaaaagagaagagcagaactttgtg gtacagaatgaaatcaacaatatgtctttccttattacggacaccaagtcaaagatgtca aaggctgctgtctctgatcaggaaaggaagaagatgaagcgcaaaggagatcggtactcc acgcagacctctctcattgtggcagctctgaagcggttgctgcccattgggttgaacatc tgtgcccctggggaccaggagctcatcgctctggccaaaaaccgatttagtatgaaagac actgaggatgaagtacgagatataatccgcagtaatattcatttacaaggcaagttggag gatcctgctatcagatggcaaatggctctttacaaagacttaccgaataggactgaagat acatcagatccagagaagaccgtagagagagtattagatatagcaaatgtgcttttccat cttgagcagaaatctacatctatgcaccggagatattacagtctggtggagcacccacag agatcgaagaaagctgtatggcacaaacttctgtccaagcagaggaagagggcagtggtg gcctgcttccgaatggctcctttatataatctgccaaggcaccgggccgttaacctcttt cttcagggatacgaaaagtcttggattgaaacagaagaacactactttgaagataagctg atagaagatttagcaaaacctggagcagaccctccagaggaagaggaaggcacgaagaga gtcgaccccctccatcagctcatccttctgtttagtcgaacagctttaacagagaaatgc aaactggaggaagattttttatatatggcttatgcagatattatggcaaagagttgtcat gatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagtcacaggatcccaa cgcagcaaggaaaaagaaatggagaagcagaagcttctgtaccagcaagccaggctccat gaccgcggggctgctgagatggtgctacagaccatcagtgccagcaaaggtgatactgga ccaatggtagcggcgactttgaaacttggaattgcaatcttaaatggcgggaactccaca gttcagcagaaaatgcttgactatctcaaggagaagaaggacgtgggtttctttcagagc cttgccggcctgatgcagtcgtgcagcgtcctcgacctaaatgcatttgagcggcagaac aaagctgaaggacttggaatggtcacggaagaaggatcaggagaaaaggttctccaagat gacgagttcacgtgtgacctcttccgtttcctccagctgctttgtgagggacacaactca gattttcaaaattatctgagaactcagactggcaataacacaactgtcaacatcatcatc tctaccgtagactacctactcagagtccaggaatccattagtgatttctattggtattac tctgggaaagatgttattgatgaacaaggacaacggaatttctccaaagcaattcaagta gcaaaacaagtctttaacacgctcacagagtatattcagggtccttgcactgggaatcag cagagcttggcccacagcaggctatgggacgcagttgtgggcttccttcacgtattcgcc cacatgcagatgaagctgtctcaggattccagtcaaatcgagctattaaaagaattaatg gatcttcagaaggatatggtggtcatgttgctgtccatgctagaaggtaatgttgtcaat ggaaccattggcaaacagatggtcgatatgcttgtggagtcttccaacaacgtggagatg attctcaagttttttgacatgttcttaaaactaaaggatttgacctcttctgacacattt aaagaatacgaccctgacggcaagggagtcatttccaagagggacttccataaagcgatg gagagccataaacactacacgcaatcagaaaccgagtttcttctgtcctgtgcagagacg gatgaaaacgaaaccctggactatgaagagtttgtcaaaaggtttcacgagcccgcaaag gacatcggcttcaacgtggccgttcttctgaccaacctttcggagcacatgcccaatgat acgcgactgcagactttcctggagttggcagagagcgtgctgaattacttccagcccttt ctgggccgcatcgagatcatgggaagtgccaaacgcatcgagagggtgtattttgaaatc agtgagtccagccgaacccagtgggagaagccccaggtcaaggagtccaaaaggcagttc atatttgacgtggtcaacgaagggggagaaaaggagaaaatggaactttttgtcaacttc tgtgaggacaccatattcgaaatgcagctggcagcgcagatctcagagtcggatttgaat gagaggtcagcgaataaagaagagagtgagaaggagaagccagaagagcaggggcccaga atgggtttcttttccatcgtgacggtcaagtcggccctgtttgctctcaggtataatatc ttgaccctcatgagaatgctcagcctgaagagcctgaagaaacagatgaaaaaggtgaag aagatgacgatgaaggatatggtcacggccgccttttcgtcctactggagtattttcatg agcctcctgcactttgtggccagcgtttccagaggcttcttccgcatcatttgcagcctg ctgcttggtgggagcctagtagaaggagcaaaaaagatccgagtggcagagctcttagcc aacatgccagaccccactcaggatgaggtgagaggggatggagaagagggggacaggagg cccatggaggccgccctgccctcggaagacctgacagacctgaaggaactgacagaggaa agcgaccttctttcggacatatttggcttggatctgaagagagaaggaggacagtacaaa cttattcctcataatccaaacgctggcctcagcgatctaatgagcaacccggtccctatc cctgacgtgcaagaaaaatttcaggaacagaaggtgaaagaggaagaaaaggaggagaaa gaagaaagcaaatctgaacctgaaaaggccgagggagaagatggagaaaaagaagaaaaa gccaaagaagataagggtaaacagaagttgaggcagctccacacacacagatacggagag ccagaagttcccgagtcggcattctggaagaaaatcatcgcatatcaacagaaacttcta aactattttgctcgcaacttttacaacatgagaatgttagccttattcgtcgcgtttgca atcaatttcatcttgctcttttataaggtctccacttcttctgtggttgaaggaaaggag ccccccactcgcagttcaagtggaaatgccaaagttagcagcctggacagtggctcgcct agaatcatcgcggttcactacgtcctggaggagagcagcggctacatggagcccacgctg cggatcttagccattcttcacacggtcatttctttcttctgcatcatcggctactactgc ttgaaagtcccattggttatttttaagcgagaaaaggaagtagctcgaaaattggaattt gatgggctttatattacagaacagccttcagaagatgatattaaaggccagtgggataga ctcgtaatcaacacacagtcatttcccaacaactactgggacaaatttgttaaaagaaag gttatggataaatatggggagttctatggccgggacagaatcagcgagctccttggtatg gacaaagccgccctagatttcagcgatgcccgggaaaagaagaagccaaagaaagacagc tccctgtcagccgtactgaactctattgatgtgaagtatcagatgtggaaactaggagtc gtcttcacggacaactctttcctctacctggcctggtatatgactatgtccgttctggga cactataacaactttttttttgctgctcatcttcttgacattgccatgggattcaagaca ctgagaaccatcttgtcatcggtaactcacaatggcaagcagcttgtattaactgttggc ttgttagctgttgttgtatacctatatactgttgtggcattcaactttttccgaaaattc tacaataaaagtgaagatggtgatacaccggatatgaaatgtgatgatatgctaacgtgc tacatgttccacatgtacgtcggggtacgtgccggagggggtatcggcgatgaaatcgaa gacccagcaggcgacgaatatgagatctatcgaatcatctttgacatcaccttcttcttc ttcgtgattgtcatcctcttggccataattcaaggtttaattattgatgcttttggagag ctaagagaccaacaggagcaagtcaaagaagacatggagaccaaatgtttcatctgtggg ataggcaacgattacttcgacacagtgccacatggctttgaaacccacactttacaggaa cacaacctggccaattacctgttttttctgatgtatctcataaacaaagatgaaacagag cacacgggacaggaatcttatgtctggaagatgtatcaagaaagatgctgggaattcttc ccagcaggggattgtttccggaaacagtatgaagaccagctaaattaa

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