Panthera pardus (leopard): 109250012 Help Entry 109250012         CDS       T06062                                  Symbol ABL1 Name (RefSeq) tyrosine-protein kinase ABL1   KO K06619   abelson tyrosine-protein kinase 1 [EC:2.7.10.2] Organism ppad  Panthera pardus (leopard) Pathway ppad04012   ErbB signaling pathway ppad04014   Ras signaling pathway ppad04110   Cell cycle ppad04360   Axon guidance ppad04722   Neurotrophin signaling pathway ppad05200   Pathways in cancer ppad05206   MicroRNAs in cancer ppad05208   Chemical carcinogenesis - reactive oxygen species ppad05220   Chronic myeloid leukemia ppad05416   Viral myocarditis Brite KEGG Orthology (KO) [BR:ppad00001]  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     109250012 (ABL1)    04014 Ras signaling pathway     109250012 (ABL1)  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     109250012 (ABL1)  09150 Organismal Systems   09156 Nervous system    04722 Neurotrophin signaling pathway     109250012 (ABL1)   09158 Development and regeneration    04360 Axon guidance     109250012 (ABL1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     109250012 (ABL1)    05206 MicroRNAs in cancer     109250012 (ABL1)    05208 Chemical carcinogenesis - reactive oxygen species     109250012 (ABL1)   09162 Cancer: specific types    05220 Chronic myeloid leukemia     109250012 (ABL1)   09166 Cardiovascular disease    05416 Viral myocarditis     109250012 (ABL1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ppad01001]     109250012 (ABL1) Enzymes [BR:ppad01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      109250012 (ABL1) Protein kinases [BR:ppad01001]  Non-receptor tyrosine kinases   ABL family    109250012 (ABL1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase F_actin_bind SH2 SH3_1 SH3_2 SH3_9 Haspin_kinase Kinase-like SH3_6 Motif Other DBs NCBI-GeneID:  109250012 NCBI-ProteinID:  XP_019276338 Ensembl:  ENSPPRG00000002576 UniProt:  A0A9V1E8S5 LinkDB All DBs Position Unknown AA seq 1150 aa AA seqDB search MGQQPGKVLGDQRRPSLPALHFIKGAGKKESSRHGGPHCNVFVEHEALQRPVASDFEPQG LSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCE AQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQR SISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRN KPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVE EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLL YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKF PIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERP EGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKKGVRGVAST LLQAPELPTKTRTSRRAAEHKDPTDVPETPHSKGPGETDPLDHEPPVSPLLPRKERGPQD GGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERKGAGEEEGRET SNGAPALPPSDAAEPAKSPKPSSGAGVPNGAFRESGGAGFRSPHLWKKSSTLTSSRLAAS EEESGGSSSKRFLRSCSASCVPHGARDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPA LPRKRASENRSDQAARGTVTPPPRLVKKTEEAADEVFRDAGESSPGSSPPSLTPKLLRRQ VTGAPSSGLPHKDETAKSGALGTPVTAEPVPPASRAGPGASGGTGKAPAEEPRARRHKPS SESPGRDKGKLSKLKPAPPPPPPASVGKAGKPAQNPTQEAAGEASTGGKTKAAAVVVDAV NSDAIKPSPLGEGVKKPALPSAPKPQSSSKPAGAPAGAAPAPSTLPSAASALAGDQPAST AFIPLISTRVSLRKTRQPPERIASGTITKSVVLDGTEALCLAISKNSEQMASHSAVLEAG KNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSS VKEISDIVQR NT seq 3453 nt NT seq  +upstreamnt  +downstreamnt atggggcagcagcctggaaaagttcttggggaccagaggaggccaagcttgcctgccctg cactttatcaaaggagcagggaagaaggagtcatcgaggcacgggggtccgcactgcaat gtctttgtggaacacgaagcccttcagaggccagtagcgtctgactttgagccccaaggt ctgagcgaagcagctcgttggaactccaaggaaaaccttcttgctggtcccagtgaaaat gaccccaacctttttgttgcactgtatgattttgtggccagtggggataacaccctaagc atcactaaaggtgaaaagctccgggttctgggctacaaccacaatggggaatggtgtgag gcccagaccaaaaatggccaagggtgggtcccgagcaactacatcacgccggtcaacagt ctggagaaacattcctggtaccacgggcccgtgtcccgcaacgccgccgagtacctgctg agcagcgggatcaacggcagcttcttggtgcgggagagcgagagcagccccggccagagg tccatctcgctgagatacgaagggagggtgtaccactacaggatcaacaccgcttccgat ggcaagctctacgtctcctcagagagccgcttcaacactttggcggagttggttcatcat cactcgactgtggcggacgggctcatcaccactctccattacccagcccccaagcgcaac aagcccaccgtctacggcgtgtcccccaactacgacaagtgggagatggaacgcacagac atcaccatgaagcacaagctgggaggcggccagtacggagaggtgtacgagggcgtgtgg aagaaatacagcctgacggtggccgtgaagaccttgaaggaggacaccatggaggtggaa gagttcttgaaagaagccgcagtgatgaaggagatcaagcaccccaacctcgtgcagttg ctgggggtctgcacccgggagcccccgttctatataatcactgagttcatgacctatggg aacctgctggattacctgcgggagtgtaaccggcaggaggtgaacgctgtggtgctgctg tatatggccacgcagatctcgtcagccatggagtacctggagaagaagaacttcatccac agagatcttgctgcccgaaactgcctggtaggggagaaccacttggtgaaggtggctgat ttcggcctgagcaggttaatgacaggggatacgtacacagcccacgccggggccaagttc cccatcaagtggacagcgccagaaagcctggcctacaacaagttctccatcaagtccgac gtctgggcatttggagtactgctttgggaaattgctacctacggtatgtcaccttaccca ggaattgacctgtcccaggtatacgagctgctagagaaagactatcgcatggaacgcccg gaaggctgcccagagaaggtctacgaactcatgcgagcatgttggcagtggaatccctcc gaccggccctcctttgctgaaatccaccaagcctttgagaccatgttccaagagtccagc atatcagatgaagtggaaaaggaactggggaaaaaaggtgtgcgaggggttgcgagtact ttgctgcaggccccagagctgcccaccaagacaagaacgtccaggagagccgcggagcac aaagaccccactgacgtgcccgagacgccccactccaagggcccaggagagaccgatcct ctggaccatgagccccctgtgtctccactgctccctcgaaaagaacgaggtccccaggat ggcggcctgaatgaggatgagcgcctgcttcccaaagacaaaaagaccaacttgttcagt gccttgatcaagaagaagaagaaaacggccccaacgcccccgaaacgcagcagctccttc cgggagatggacggccagcccgagcgcaagggggccggcgaggaagagggccgagaaacc agcaacggggcaccggctctcccaccctcggacgcagccgagccagccaagtccccaaag cccagcagcggggctggcgtccccaacggagccttccgggagtccgggggtgcaggcttc cggtctccccacctgtggaaaaagtccagtacgctgaccagcagccgcctagcagccagc gaggaggagagtggcggcagctccagcaagcgcttcctgcggtcctgctcggcctcctgc gtgccccacggagccagggacaccgagtggaggtccgtcacactgcctcgggacctgcag tccacgggcaggcagttcgactcgtccacgtttggagggcacaaaagcgagaagccggct ctgcctcggaagcgggcgagtgagaacaggtccgaccaggcggccagaggcacggtgact cccccacccaggctggtgaaaaagaccgaggaagcagccgatgaggtctttcgagacgcg ggggagtccagcccgggctccagccccccaagtctgactccaaaactcctccgcaggcag gtcacgggggctccttcctctggccttccccacaaggacgagaccgccaagtccggtgcc ttggggacacctgtcacagctgagccggtgccccccgccagcagagcagggccaggtgcg tccggagggaccggcaaggcccccgccgaggagcccagagcgaggaggcacaagccttcc tccgagtccccagggagagacaaggggaaactgtccaagctcaaacctgccccaccgccc ccgccgccggcctccgtggggaaagccgggaagcccgctcagaacccgacccaggaagcg gccggggaggccagcactggcgggaaaacgaaagccgcggctgtggtcgtggatgctgtg aacagtgacgccatcaagcccagtccgctgggagagggcgtcaaaaagcccgcgctccca tccgcgccaaagccgcagtcgtccagcaagccagcgggggccccagccggcgcggcgccc gccccctccacgttgccgtcagcagcctccgccctggccggggaccagcccgcgtctact gccttcatccctctcatatcgacccgcgtgtctcttcggaaaacccgccagcctccggag cggatcgccagcggcaccatcaccaagagcgtggtcctggacggcaccgaggccctgtgc ctggccatttccaagaactccgagcagatggccagccatagcgccgtgctggaagccggc aaaaacctgtacacgttctgcgtgagctatgtggattccatccagcagatgaggaacaaa ttcgccttccgcgaggccatcaacaaactggagaataatctccgggagcttcagatctgc ccggcgacagcagggagtggcccagcggccactcaggacttcagcaaactcctcagctcc gtgaaggagatcagtgacatcgtacagaggtag

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