Panthera pardus (leopard): 109252365
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Entry
109252365 CDS
T06062
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial isoform X1
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
ppad
Panthera pardus (leopard)
Pathway
ppad00220
Arginine biosynthesis
ppad00330
Arginine and proline metabolism
ppad01100
Metabolic pathways
ppad04020
Calcium signaling pathway
ppad04022
cGMP-PKG signaling pathway
ppad04066
HIF-1 signaling pathway
ppad04071
Sphingolipid signaling pathway
ppad04151
PI3K-Akt signaling pathway
ppad04370
VEGF signaling pathway
ppad04371
Apelin signaling pathway
ppad04611
Platelet activation
ppad04915
Estrogen signaling pathway
ppad04921
Oxytocin signaling pathway
ppad04926
Relaxin signaling pathway
ppad04931
Insulin resistance
ppad04933
AGE-RAGE signaling pathway in diabetic complications
ppad05415
Diabetic cardiomyopathy
ppad05417
Lipid and atherosclerosis
ppad05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
ppad00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
109252365 (NOS3)
00330 Arginine and proline metabolism
109252365 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
109252365 (NOS3)
04371 Apelin signaling pathway
109252365 (NOS3)
04066 HIF-1 signaling pathway
109252365 (NOS3)
04020 Calcium signaling pathway
109252365 (NOS3)
04071 Sphingolipid signaling pathway
109252365 (NOS3)
04022 cGMP-PKG signaling pathway
109252365 (NOS3)
04151 PI3K-Akt signaling pathway
109252365 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
109252365 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
109252365 (NOS3)
04921 Oxytocin signaling pathway
109252365 (NOS3)
04926 Relaxin signaling pathway
109252365 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
109252365 (NOS3)
05418 Fluid shear stress and atherosclerosis
109252365 (NOS3)
05415 Diabetic cardiomyopathy
109252365 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
109252365 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
109252365 (NOS3)
Enzymes [BR:
ppad01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
109252365 (NOS3)
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Ortholog
Paralog
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
109252365
NCBI-ProteinID:
XP_019280314
Ensembl:
ENSPPRG00000010638
LinkDB
All DBs
Position
Unknown
AA seq
1203 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPTAEPGRAPAPAPPPPPAPDRSSPPLT
KPPEGPKFPRVKNWEVGSITYDTLSAQAQQEGPCTPRRCLGSLVFPRKLQSRPSQDPPPT
EQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEIAAAGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCNSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPP
ELFALPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFHYQPDPW
KGSGSKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHRSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAA
RDIFSAKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQAAILSVENLQSSKSTRATIL
VRLDTGGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPGEPVAVEQLEKGSPGGP
PPSWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEESGEQQELESLSQDPRRY
EEWKWFRCPTLLEALEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP
FRGFWQERLHDIDSKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSRE
PDCPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGPDT
PSP
NT seq
3612 nt
NT seq
+upstream
nt +downstream
nt
atgggcaatttgaagagtgtgggccaggagccggggcctccctgcggcctggggctgggg
ctgggcctgggcctgtgcggcaagcagggcccagcctccccgacagcagagcctggcagg
gcaccggcacccgcacccccacccccacccgcgccagaccgcagcagtccccccctcacc
aagcccccggaggggcccaagttccctcgtgtgaagaactgggaggtggggagcatcact
tacgacaccctgagtgcccaggctcagcaggaggggccctgcacccctagacgctgcctg
ggctccctggtttttccacggaaactgcagagccggccctcccaggacccaccacccact
gagcagctgctgagccaggccagggacttcatcaaccagtactacagctccatcaagagg
agtggctcccaggcccatgagcagaggcttcaggaggtggaagccgagatagcagccgca
ggcacataccagcttcgggagagcgagctggtgttcggggctaagcaggcttggagaaat
gcaccccgctgcgtgggccggatccagtgggggaagctgcaggtgtttgatgcccgggat
tgcaactctgcccaggagatgttcacctacatctgcaaccacatcaagtatgccaccaac
cggggcaacctccgctcggccatcacagtgttcccccagcgcgccccaggccgtggagac
ttccgaatctggaacagccaactggtgcgctacgcggggtacaggcagcaggatggctcc
gtgcggggggacccagccaatgtggagatcactgagctctgcatccagcacggctggacc
ccgggaaacggccgctttgacgtactgcccctactgctccaggccccagatgagcccccg
gaactctttgccctgccccccgagctggtcctcgaggtgcccctggagcaccccacgctg
gagtggtttgcggccctgggcctgcgctggtacgccctcccggcggtgagcaacatgctg
ctggaaattggggggctggagttccccgcggcccctttcagcggctggtacatgagcact
gagatcggcacgcggaacctgtgtgacccgcaccgatacaacatcctggaggatgtggcc
gtctgcatggacttggatacccggaccacctcatccctgtggaaagacaaggcagccgtg
gaaatcaacttggccgtgctgcacagttaccagttggccaaagtgaccattgtggaccac
catgctgccacggcctccttcatgaagcacctggagaatgagcagaaggctagggggggc
tgccctgccgactgggcctggatcgtgccccccatctccggcagcctcacccctgtgttc
catcaggagatggtcaactatgtcctgtcccctgccttccactatcagccagacccgtgg
aagggaagtgggtccaagggtgccggcatcaccaggaagaagacctttaaggaagtggcc
aatgcggtgaagatctctgcctcactcatgggcaccgtgatggcaaagcgagtaaaggca
acaatcctgtatggctccgagaccggccgggcccagagctatgcacagcagctggggaga
ctcttccggaaggctttcgatccccgggtcctgtgcatggatgagtatgatgtcgtgtcc
ctcgagcatgagacgctagtgctggtcgtgaccagcacattcgggaatggtgatccccca
gagaatggagagagttttgcggcagccctgatggaaatgtctggtccctacaacagctcc
cctcggccagaacaacacaggagttacaaaatccgcttcaacagtgtctcctgctcagac
ccgctggtgtcctcctggaggcggaagagaaaggagtccagtaacacagacagtgcaggg
gcactgggtaccctcaggttctgtgtgttcgggctgggctcccgggcgtacccccacttc
tgtgccttcgcccgtgcggtggacacacggctggaggagctgggtggcgagcggctgctg
cagctgggccagggagacgagctgtgtggccaggaggaggccttccgtggctgggcccag
gccgccttccaggcctcctgtgagactttctgcgtgggagaggacgccaaggctgccgcc
cgggacatattcagcgccaaacggagctggaagcgccaaaggtaccggctcagcacccag
gcggagggcctccagctgctgccaggcctgatccatgtgcacaggaggaagatgttccag
gctgccatcctctcagtcgaaaacctgcaaagcagcaagtccacccgggccacgatcttg
gtgcgcctggacactggaggccaggaggggctgcagtaccagccgggggaccacataggc
atctgcccgcccaaccgaccgggcctcgtggaggcgctgctgagccgtgtggaggacccg
cctccgccaggagagcccgtggccgtggagcagctggagaagggcagccctggtggccca
ccccccagctgggttcgggacccccggctgcccccctgcacgctgcgccaggctctcacc
ttcttcctggacatcacctccccgcccagccctcaactccttcgactgctcagcaccctg
gcggaagagtccggtgaacagcaggagctggagagcctcagccaggacccccggcgctac
gaggagtggaagtggttccggtgccccacgctgctggaggcgctggaacagttcccgtcc
gtggcgctgcctgcccccctgctcctcacccagctgcccctgctccagccccggtactac
tccgtcagctcggcgcccagcgcccacccgggagagattcacctcacggtggccgtgctg
gcgtacaggacccaggatggactgggccccctgcactatggagtctgctccacatggctg
agccagctgaaggccggagatcccgtaccttgcttcatcaggggggctccctccttccgg
ctgccgcctgatcccagcttgccctgcatcctagtgggccctggcacaggtattgccccc
ttccggggattttggcaggagcggctgcacgacattgacagcaaagggctgcagccggcc
cccatgaccttggtgttcggctgccgatgctcccagctcgaccacctctaccgcgacgag
gtgcaggatgcccagcagcgcggggtttttggacgcgtcctcaccgccttctcccgggag
cccgactgccctaagacctacgtgcaggacatcctgcggacggagctggcggctgaggtg
caccgcgtgctgtgcctcgagcggggccacatgtttgtgtgcggcgacgtcaccatggca
accagcgtcctgcagacggtgcagcgaatcctagcgacggagggcgacatggagctggac
gaggccggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggacattttc
gggctcacactgcgcacccaggaggtgactagccgcatacgcacccagagtttttccctg
caggagcggcatctgcgcggcgcagtgccctgggcgttcgacccgcccggcccagacacc
cccagtccctga
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integrated database retrieval system
