KEGG   Panthera pardus (leopard): 109256121
Entry
109256121         CDS       T06062                                 
Symbol
RPS6KB1
Name
(RefSeq) ribosomal protein S6 kinase beta-1 isoform X1
  KO
K04688  ribosomal protein S6 kinase beta [EC:2.7.11.1]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad01521  EGFR tyrosine kinase inhibitor resistance
ppad01522  Endocrine resistance
ppad04012  ErbB signaling pathway
ppad04066  HIF-1 signaling pathway
ppad04140  Autophagy - animal
ppad04150  mTOR signaling pathway
ppad04151  PI3K-Akt signaling pathway
ppad04152  AMPK signaling pathway
ppad04211  Longevity regulating pathway
ppad04213  Longevity regulating pathway - multiple species
ppad04350  TGF-beta signaling pathway
ppad04371  Apelin signaling pathway
ppad04666  Fc gamma R-mediated phagosome formation
ppad04714  Thermogenesis
ppad04910  Insulin signaling pathway
ppad04931  Insulin resistance
ppad05163  Human cytomegalovirus infection
ppad05165  Human papillomavirus infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05200  Pathways in cancer
ppad05205  Proteoglycans in cancer
ppad05207  Chemical carcinogenesis - receptor activation
ppad05210  Colorectal cancer
ppad05212  Pancreatic cancer
ppad05221  Acute myeloid leukemia
ppad05224  Breast cancer
ppad05225  Hepatocellular carcinoma
ppad05226  Gastric cancer
ppad05231  Choline metabolism in cancer
ppad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    109256121 (RPS6KB1)
   04350 TGF-beta signaling pathway
    109256121 (RPS6KB1)
   04371 Apelin signaling pathway
    109256121 (RPS6KB1)
   04066 HIF-1 signaling pathway
    109256121 (RPS6KB1)
   04151 PI3K-Akt signaling pathway
    109256121 (RPS6KB1)
   04152 AMPK signaling pathway
    109256121 (RPS6KB1)
   04150 mTOR signaling pathway
    109256121 (RPS6KB1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109256121 (RPS6KB1)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagosome formation
    109256121 (RPS6KB1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109256121 (RPS6KB1)
  09149 Aging
   04211 Longevity regulating pathway
    109256121 (RPS6KB1)
   04213 Longevity regulating pathway - multiple species
    109256121 (RPS6KB1)
  09159 Environmental adaptation
   04714 Thermogenesis
    109256121 (RPS6KB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109256121 (RPS6KB1)
   05205 Proteoglycans in cancer
    109256121 (RPS6KB1)
   05207 Chemical carcinogenesis - receptor activation
    109256121 (RPS6KB1)
   05231 Choline metabolism in cancer
    109256121 (RPS6KB1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109256121 (RPS6KB1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109256121 (RPS6KB1)
   05212 Pancreatic cancer
    109256121 (RPS6KB1)
   05225 Hepatocellular carcinoma
    109256121 (RPS6KB1)
   05226 Gastric cancer
    109256121 (RPS6KB1)
   05221 Acute myeloid leukemia
    109256121 (RPS6KB1)
   05224 Breast cancer
    109256121 (RPS6KB1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    109256121 (RPS6KB1)
   05163 Human cytomegalovirus infection
    109256121 (RPS6KB1)
   05165 Human papillomavirus infection
    109256121 (RPS6KB1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    109256121 (RPS6KB1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109256121 (RPS6KB1)
   01522 Endocrine resistance
    109256121 (RPS6KB1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppad01001]
    109256121 (RPS6KB1)
Enzymes [BR:ppad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     109256121 (RPS6KB1)
Protein kinases [BR:ppad01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   109256121 (RPS6KB1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like Pkinase_fungal ABC1 DUF1015
Other DBs
NCBI-GeneID: 109256121
NCBI-ProteinID: XP_019286631
Ensembl: ENSPPRG00000007317
UniProt: A0A9V1ER12
LinkDB
Position
Unknown
AA seq 525 aa
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
VEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
NT seq 1578 nt   +upstreamnt  +downstreamnt
atgaggcgacgacggaggcgggacggcttttacccagcgccggacttccgagacagggaa
gctgaggacatggcaggagtgtttgacatagacctggaccagccagaggacgcgggctct
gaggatgagctggaggaggggggtcagttaaatgaaagcatggaccatgggggagttgga
ccatatgaacttggcatggaacattgtgagaaatttgaaatatcggaaactagcgtgaac
agagggccagaaaaaatcagaccagaatgtttcgagctacttcgggtacttggtaaaggg
ggctatggaaaggtttttcaagtacggaaagttacaggagcaaatactgggaaaatattt
gccatgaaggtgcttaaaaaggcaatgatagtaagaaatgctaaagatacagctcataca
aaagcagaacggaatattctggaggaagtaaagcatcccttcattgtggatttaatttat
gcctttcagaccggtggaaaactctacctcatccttgagtatctcagcggaggagaatta
tttatgcagttagaaagagaaggaatatttatggaagacacagcctgcttttacttggca
gaaatctccatggctttggggcatttacatcaaaaggggatcatctacagagacctgaag
ccggagaatatcatgctaaatcaccaaggtcatgtgaaactaacagactttggactatgc
aaggaatctattcatgatggaacagtcacacacacattttgtggaacaatagaatacatg
gcccctgaaatcttgatgagaagtggccacaatcgtgctgtggattggtggagtttggga
gcattaatgtatgacatgctgactggagcacccccgttcactggggagaatagaaagaaa
acaattgacaaaatcctcaaatgtaaactcaatttgcctccctacctcacacaagaagcc
agagatctgcttaaaaagctgctgaaaagaaatgctgcttctcgtcttggagctggtcct
ggggatgctggagaagttcaagctcatccattcttcaggcatattaattgggaagaactg
ctggctaggaaggtggaacccccttttaaacctctgttgcaatctgaggaggatgtgagt
cagtttgattcaaagtttacacgtcagacacctgttgacagcccagatgactcaactctc
agtgaaagtgccaaccaggtctttctgggttttacatatgttgctccatctgtacttgaa
agtgtgaaagaaaaattttcctttgaaccaaaaatccgatcacctcgaagatttattggc
agcccgcgaacacctgtcagcccagtcaaattttctcctggggatttctggggaagaggt
gcttcagccagcacggcaaatcctcagacacctgtggaatatccaatggaaacaagtgga
gtagagcagatggatgtgacgatgagtggggaagcttcagcaccacttcccatacgacag
ccgaactctgggccatacaaaaaacaagctttccccatgatctccaaacgaccagagcac
ctacgtatgaatctatga

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