Panthera pardus (leopard): 109257714
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Entry
109257714 CDS
T06062
Symbol
DOT1L
Name
(RefSeq) LOW QUALITY PROTEIN: histone-lysine N-methyltransferase, H3 lysine-79 specific
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
ppad
Panthera pardus (leopard)
Pathway
ppad00310
Lysine degradation
ppad01100
Metabolic pathways
ppad05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
ppad00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
109257714 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
109257714 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
ppad03036
]
109257714 (DOT1L)
Enzymes [BR:
ppad01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
109257714 (DOT1L)
Chromosome and associated proteins [BR:
ppad03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
109257714 (DOT1L)
HMT complexes
Dot1-containing complex
109257714 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
109257714
NCBI-ProteinID:
XP_019289583
Ensembl:
ENSPPRG00000007334
LinkDB
All DBs
Position
Unknown
AA seq
1718 aa
AA seq
DB search
MGAVGEESAEVGVRGGERRVGASTSPWVPPPCPPGRECHRSSSGQGRKLAGRPCLVPTPC
TTGGCKTCPFVFQDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRL
CDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPE
VYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKY
AETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLK
ERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYL
HTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTATPTKVPESKAAVAADTPVDS
GAEEEKAGTTAIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAANPERKPRKSQTALD
LLHAPASSQTAAPSPQDAYRSPHSPFYQLPPCVQRHAPDRPLLAATPPALQKLLESFKIQ
YLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQKEEIKRLFQQKLDEL
GVKALTYNDLIQAQKEISAHNQQLREQTEQLQEDNRELRSQSLQLLKARCEELKLDWSTL
SLENLLKEKQALRSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSAHLR
GKGALGREPEADPGRLHLDLDCSRFSLPHFSSASPELSMNGHAASYELCGALSRPPSKQN
TPQYLASPLDQEVVPCTPSHGSRPRLEKVSGLALPDYTRLSPAKLVLRRHLSQDHAAGGK
TAAGELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPVALQMTGERGGEKGLKERA
YASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRSTPSPVPQTRESLSTL
EKQMGTNAHSAGSKSLAPAPAGFYAGSVAVSPAPLASGADPGTFDEVPSAGGLFASVGSC
GSTPQHPPLLPQPRSSGAASPAHPLCASPRLGGAAQGPLPDANKGDLPPEAGFSDPEGEA
KRRIVFTVSAGGGSTKQSPPSKPSPLPTGGRGDGSQGHGQDSRKRGRRKRAAAGTPGLSS
GVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPESLKSSPVPYQDSDQ
PPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSTRIERKIATISLESRSPPKTLENGG
GLAGRKPPPAGEPANSSKWKSTFSPISDLGLAKCADSPLQAGSALSHNSLFAFRPPLEEP
GSADAKLAAHPRKSFPGALSGAGGLSPSSNPPNGFAFSGGLAADLSLHSFSDGASLSHKV
PEAAGLGAPLSFPAPRGKDSAAEPGPFVNKRQLDGTGGPKGREAGEPGPPACGPPDKASL
AHGKPGKGRDREPDLKNGHNLFIAAANVPPGGLLSGPGLATAASSVVSAAPSAQAHRPFL
GTFAPGPQFALGPMSLQANLGSSVLQSLFGSVPAAGLVHVSSAATRLTNSHAMGSFPSGV
AGGAVGGVFNHAVPSASAHPFGASFGSGAACRSATLSLTPLXPPNAALPPAPALLPANSE
PALLQNLASLPANQAFLPASSAASLQPANASLSIKLASLPHKAPRPSFTVHHQPLPGLAL
AQAAPVIPQASSTGPSAVWVSLGMPPPYAARLAGVKPR
NT seq
5157 nt
NT seq
+upstream
nt +downstream
nt
atgggggctgtgggtgaagagtcagcagaggtgggggtgcgaggtggggagagaagggtt
ggggcatcgacgtcaccctgggtccctcctccctgcccgcctgggagggagtgccacagg
tccagctcgggccaggggcggaaactggctggtaggccctgcctggtccccacaccctgt
accaccggagggtgtaaaacctgtccctttgtctttcaggacaaacaccacgatgctgct
cacgaaatcatcgagaccatccggtgggtctgcgaagagatcccggacctcaagctcgct
atggagaactacgttttaatcgactacgacaccaaaagcttcgagagcatgcagaggctc
tgtgataagtacaaccgcgccatcgacagcatccaccagctgtggaaggggaccactcag
cccatgaaactgaacacccggccgtccaacgggctcctgcggcacatcctgcagcaggtg
tataaccactcggtgacggaccccgagaagctcaacaactacgagcccttctccccggag
gtgtacggggagacctcctttgacctggtcgcgcagatgatcgacgagatcaagatgacc
gaggacgacctgtttgtggacctgggcagcggagtgggccaggtcgtgctccaggtggcc
gcggccaccaactgcaaacatcactatggcgtggagaaagccgacatcccagccaagtac
gcggagaccatggaccgagagttcaggaagtggatgaaatggtatggaaaaaagcatgca
gaatacacactggaaagaggcgacttcctctcggaggagtggagagagcggattgccaac
acaagtgttatatttgtgaataactttgcctttggtcctgaggtggatcaccagctgaag
gagcggtttgcgaacatgaaggaaggtggcagaattgtgtcctcgaagccctttgcgcct
ctgaacttcagaataaacagcagaaacttgagcgacatcggcaccatcatgcgcgtcgtg
gagctctcgcccctgaagggctctgtgtcctggacggggaagccagtctcctactacctg
cacaccatcgaccgcaccatacttgaaaactatttttctagtctgaaaaacccaaaactc
agggaggagcaagaggcggctcggcgccggcagcagcgagagaacaagagcaacacggcc
actcccaccaaggtgcccgagagcaaggctgccgtggccgcggacacccccgtggattcc
ggtgccgaggaagagaaggctgggacgaccgccatcaaaaagccgtccccctccaaagcc
cggaagaagaagctgaacaagaaggggcggaaaatggccggcaggaagcgcgggcgcccc
aagaagatgagcgctgccaaccccgagcgcaagccccggaagagccaaactgcactggac
ctcctgcacgccccggcctcgtcacagacggcggcgccctcgccacaggatgcgtacagg
tcacctcatagccccttctatcagctacctccctgcgtgcagcggcacgcccccgaccgg
ccgctgctggcagccaccccgcccgcactgcagaagctgctagaatccttcaagattcag
tacctgcagttcttggcctacaccaagaccgcccagtacaaggccagccttcagcagctg
ctggaccaggagaaggagaagaacgcccggctgctgggggccgcacagcagctgttcggc
cactgccaggcccagaaagaggagatcaagaggctcttccagcagaaactggatgagctg
ggggtgaaggcgctgacctacaacgacctgattcaggcgcagaaggagatctcggcccat
aaccagcagctgagggagcagacagagcagctgcaggaggacaacagggagctgaggagc
cagagcctgcagctgctcaaggctcggtgtgaggagttgaaactggactggtccacgctg
tcgctggagaacctgctgaaggagaagcaggccctgaggagccagatctccgagaagcag
aggcactgcctggagctgcagatcagcatcgtggagctggagaagagccagcggcagcaa
gagcttctgcagctcaagtcctgcgtgccgcccgacgacgccctgtcggcgcacctgcgc
gggaaaggcgccctgggccgggagccggaggcggaccccggccggctgcacctcgacctg
gactgctctaggttctccctgccacacttcagcagcgccagcccggaactctccatgaac
ggccacgcggccagctacgagctctgcggtgcgctgagccggcccccgtccaagcagaac
accccccagtacctggcctccccgctggaccaggaggtcgtgccctgcacccccagccac
ggcagccggccgaggctcgagaaggtgtccggcctggccttgccggactacaccaggctg
tccccggccaagctggtgctgaggcggcacctcagccaggaccacgcggccggcggcaag
acggcggccggggagctgcacccgcgagccgagcacgccaaggagaacggccttccgtac
cagagcccgggcatcgccaacggcatcaagctgagccctcaggacccccggccctcgtcc
cccgtggccttacagatgacaggggagaggggcggcgagaagggtttgaaggagcgtgcc
tatgccagcagcggggaggccatcaccagcctgcctgtcagcatcccgctcagcaccgtg
cagcccagcaagctgcccgtcagcatccctctggccagcgtggtgctgcccagccgtgct
gagaaagtgagaagcacccccagccccgtgccgcagacccgagagtccttgtccacactt
gaaaagcagatgggcactaatgcacacagcgccggaagcaaaagtctcgccccagcccct
gcaggcttctacgcgggctcggtggccgtcagcccagcccccctcgcttccggagcagat
cccggcacctttgacgaggtccccagcgcaggcggtctgtttgccagcgtggggtcctgt
ggctccaccccgcagcacccacccctgctgccgcagccccgcagctctggcgcagcctcg
cccgcccacccgctctgtgccagcccccgcctgggcggcgccgcccagggcccgctccct
gacgccaacaaaggggaccttcctcccgaggccggcttctcggaccccgagggcgaagcc
aagcggaggatcgtcttcaccgtctcggccggcgggggcagcaccaagcagtcgcctccc
agcaagcccagccctctgcccacgggcggccgtggggacggcagccagggccacgggcag
gacagccgcaagcggggcagaaggaagcgggcggcggcagggacccccggcctgagctca
ggcgtgtcgcccaagcgccgggccctgccgtccgtggccggcctcttcacgcagtcttca
gggtcccccctgaacctgaactccatggttagcaacattaaccagcctttggaaatcacg
gccatttcgtcccctgagagcctgaagagctcccctgtcccctaccaggacagcgaccag
ccgcccgtcctcaagaaggagaagcccctgagccagaccaacggggcccactactcccca
ctgacctcggacgaggagcagggctctgaggacgagccgggcagcaccagaattgagaga
aaaattgcgacaatctccttagaaagcagatctcctccgaaaaccttggaaaacggtggt
ggcctggccgggaggaagccgccccctgccggcgagcccgccaacagcagcaagtggaag
tctaccttttcgcccatctccgacctcggcctggccaagtgcgccgacagcccactgcag
gccggctctgccctgagccacaactccctgtttgctttccggccgcccctggaggagccc
ggctcggccgacgccaagctggccgcccaccccaggaaaagcttccctggtgccctgtcg
ggggcaggcgggctgagcccaagcagcaaccctcccaacggcttcgccttcagcgggggc
ctggccgccgacctcagtttacacagcttcagtgatggtgcttctctctcccacaaggtc
cccgaggcggcaggcctgggcgcccccctgagctttcccgccccccggggcaaggacagc
gctgcagagcctgggccctttgtgaacaagaggcagctggacggcacgggcggccccaag
ggcagggaggcaggcgagccgggccccccggcgtgcgggcccccggacaaggcctcgctg
gcgcacggcaagccgggcaagggccgggaccgtgagcccgacctgaagaacggccacaac
ctcttcattgcggccgccaacgtgccccccggcggcctcctcagtggcccgggcctcgcc
acggcggcgtcctcggtggtcagcgcggccccctccgcccaggcgcaccgccccttcctg
ggcacatttgcccccggcccgcagttcgccctgggccccatgtcgctgcaggccaacctg
ggctcgtctgtgctgcagtccctgtttggctccgtgccggccgccggcctggtgcacgtc
tcgtccgccgcaaccagactgaccaactcgcacgccatgggcagctttccctccggggtg
gcaggcggcgcagttggaggtgtctttaaccacgcggtgccttccgcctccgctcatccg
tttggagccagtttcggcagcggggctgcgtgtcgcagcgccacgctgagcttaaccccg
ctnnctccccctaacgccgccttgcctcccgcccccgcgctgctccctgctaactctgag
cccgcgcttctgcagaacctcgcgtccctcccggctaaccaggctttcttacccgcctcc
tctgccgcctctctgcagcctgctaacgcctctctgtccatcaagctcgcctccctcccg
cacaaggccccccgcccctccttcacggtgcaccaccagcccctgcccgggctggccctg
gcccaggccgcgcccgtgatcccacaggccagctccacggggccgtccgccgtgtgggtt
tcccttggcatgccgcctccgtatgccgcgcgccttgcgggggttaagccaagataa
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