KEGG   Panthera pardus (leopard): 109259699
Entry
109259699         CDS       T06062                                 
Symbol
MAPK1
Name
(RefSeq) mitogen-activated protein kinase 1
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad01521  EGFR tyrosine kinase inhibitor resistance
ppad01522  Endocrine resistance
ppad01524  Platinum drug resistance
ppad04010  MAPK signaling pathway
ppad04012  ErbB signaling pathway
ppad04014  Ras signaling pathway
ppad04015  Rap1 signaling pathway
ppad04022  cGMP-PKG signaling pathway
ppad04024  cAMP signaling pathway
ppad04062  Chemokine signaling pathway
ppad04066  HIF-1 signaling pathway
ppad04068  FoxO signaling pathway
ppad04071  Sphingolipid signaling pathway
ppad04072  Phospholipase D signaling pathway
ppad04114  Oocyte meiosis
ppad04140  Autophagy - animal
ppad04148  Efferocytosis
ppad04150  mTOR signaling pathway
ppad04151  PI3K-Akt signaling pathway
ppad04210  Apoptosis
ppad04218  Cellular senescence
ppad04261  Adrenergic signaling in cardiomyocytes
ppad04270  Vascular smooth muscle contraction
ppad04350  TGF-beta signaling pathway
ppad04360  Axon guidance
ppad04370  VEGF signaling pathway
ppad04371  Apelin signaling pathway
ppad04380  Osteoclast differentiation
ppad04510  Focal adhesion
ppad04517  IgSF CAM signaling
ppad04520  Adherens junction
ppad04540  Gap junction
ppad04550  Signaling pathways regulating pluripotency of stem cells
ppad04611  Platelet activation
ppad04613  Neutrophil extracellular trap formation
ppad04620  Toll-like receptor signaling pathway
ppad04621  NOD-like receptor signaling pathway
ppad04625  C-type lectin receptor signaling pathway
ppad04650  Natural killer cell mediated cytotoxicity
ppad04657  IL-17 signaling pathway
ppad04658  Th1 and Th2 cell differentiation
ppad04659  Th17 cell differentiation
ppad04660  T cell receptor signaling pathway
ppad04662  B cell receptor signaling pathway
ppad04664  Fc epsilon RI signaling pathway
ppad04666  Fc gamma R-mediated phagocytosis
ppad04668  TNF signaling pathway
ppad04713  Circadian entrainment
ppad04720  Long-term potentiation
ppad04722  Neurotrophin signaling pathway
ppad04723  Retrograde endocannabinoid signaling
ppad04724  Glutamatergic synapse
ppad04725  Cholinergic synapse
ppad04726  Serotonergic synapse
ppad04730  Long-term depression
ppad04810  Regulation of actin cytoskeleton
ppad04910  Insulin signaling pathway
ppad04912  GnRH signaling pathway
ppad04914  Progesterone-mediated oocyte maturation
ppad04915  Estrogen signaling pathway
ppad04916  Melanogenesis
ppad04917  Prolactin signaling pathway
ppad04919  Thyroid hormone signaling pathway
ppad04921  Oxytocin signaling pathway
ppad04926  Relaxin signaling pathway
ppad04928  Parathyroid hormone synthesis, secretion and action
ppad04929  GnRH secretion
ppad04930  Type II diabetes mellitus
ppad04933  AGE-RAGE signaling pathway in diabetic complications
ppad04934  Cushing syndrome
ppad04935  Growth hormone synthesis, secretion and action
ppad04960  Aldosterone-regulated sodium reabsorption
ppad05010  Alzheimer disease
ppad05020  Prion disease
ppad05022  Pathways of neurodegeneration - multiple diseases
ppad05034  Alcoholism
ppad05132  Salmonella infection
ppad05133  Pertussis
ppad05135  Yersinia infection
ppad05140  Leishmaniasis
ppad05142  Chagas disease
ppad05145  Toxoplasmosis
ppad05152  Tuberculosis
ppad05160  Hepatitis C
ppad05161  Hepatitis B
ppad05163  Human cytomegalovirus infection
ppad05164  Influenza A
ppad05165  Human papillomavirus infection
ppad05166  Human T-cell leukemia virus 1 infection
ppad05167  Kaposi sarcoma-associated herpesvirus infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05171  Coronavirus disease - COVID-19
ppad05200  Pathways in cancer
ppad05203  Viral carcinogenesis
ppad05205  Proteoglycans in cancer
ppad05206  MicroRNAs in cancer
ppad05207  Chemical carcinogenesis - receptor activation
ppad05208  Chemical carcinogenesis - reactive oxygen species
ppad05210  Colorectal cancer
ppad05211  Renal cell carcinoma
ppad05212  Pancreatic cancer
ppad05213  Endometrial cancer
ppad05214  Glioma
ppad05215  Prostate cancer
ppad05216  Thyroid cancer
ppad05218  Melanoma
ppad05219  Bladder cancer
ppad05220  Chronic myeloid leukemia
ppad05221  Acute myeloid leukemia
ppad05223  Non-small cell lung cancer
ppad05224  Breast cancer
ppad05225  Hepatocellular carcinoma
ppad05226  Gastric cancer
ppad05230  Central carbon metabolism in cancer
ppad05231  Choline metabolism in cancer
ppad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ppad05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109259699 (MAPK1)
   04012 ErbB signaling pathway
    109259699 (MAPK1)
   04014 Ras signaling pathway
    109259699 (MAPK1)
   04015 Rap1 signaling pathway
    109259699 (MAPK1)
   04350 TGF-beta signaling pathway
    109259699 (MAPK1)
   04370 VEGF signaling pathway
    109259699 (MAPK1)
   04371 Apelin signaling pathway
    109259699 (MAPK1)
   04668 TNF signaling pathway
    109259699 (MAPK1)
   04066 HIF-1 signaling pathway
    109259699 (MAPK1)
   04068 FoxO signaling pathway
    109259699 (MAPK1)
   04072 Phospholipase D signaling pathway
    109259699 (MAPK1)
   04071 Sphingolipid signaling pathway
    109259699 (MAPK1)
   04024 cAMP signaling pathway
    109259699 (MAPK1)
   04022 cGMP-PKG signaling pathway
    109259699 (MAPK1)
   04151 PI3K-Akt signaling pathway
    109259699 (MAPK1)
   04150 mTOR signaling pathway
    109259699 (MAPK1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    109259699 (MAPK1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109259699 (MAPK1)
   04148 Efferocytosis
    109259699 (MAPK1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    109259699 (MAPK1)
   04210 Apoptosis
    109259699 (MAPK1)
   04218 Cellular senescence
    109259699 (MAPK1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109259699 (MAPK1)
   04520 Adherens junction
    109259699 (MAPK1)
   04540 Gap junction
    109259699 (MAPK1)
   04550 Signaling pathways regulating pluripotency of stem cells
    109259699 (MAPK1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109259699 (MAPK1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109259699 (MAPK1)
   04613 Neutrophil extracellular trap formation
    109259699 (MAPK1)
   04620 Toll-like receptor signaling pathway
    109259699 (MAPK1)
   04621 NOD-like receptor signaling pathway
    109259699 (MAPK1)
   04625 C-type lectin receptor signaling pathway
    109259699 (MAPK1)
   04650 Natural killer cell mediated cytotoxicity
    109259699 (MAPK1)
   04660 T cell receptor signaling pathway
    109259699 (MAPK1)
   04658 Th1 and Th2 cell differentiation
    109259699 (MAPK1)
   04659 Th17 cell differentiation
    109259699 (MAPK1)
   04657 IL-17 signaling pathway
    109259699 (MAPK1)
   04662 B cell receptor signaling pathway
    109259699 (MAPK1)
   04664 Fc epsilon RI signaling pathway
    109259699 (MAPK1)
   04666 Fc gamma R-mediated phagocytosis
    109259699 (MAPK1)
   04062 Chemokine signaling pathway
    109259699 (MAPK1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109259699 (MAPK1)
   04929 GnRH secretion
    109259699 (MAPK1)
   04912 GnRH signaling pathway
    109259699 (MAPK1)
   04915 Estrogen signaling pathway
    109259699 (MAPK1)
   04914 Progesterone-mediated oocyte maturation
    109259699 (MAPK1)
   04917 Prolactin signaling pathway
    109259699 (MAPK1)
   04921 Oxytocin signaling pathway
    109259699 (MAPK1)
   04926 Relaxin signaling pathway
    109259699 (MAPK1)
   04935 Growth hormone synthesis, secretion and action
    109259699 (MAPK1)
   04919 Thyroid hormone signaling pathway
    109259699 (MAPK1)
   04928 Parathyroid hormone synthesis, secretion and action
    109259699 (MAPK1)
   04916 Melanogenesis
    109259699 (MAPK1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    109259699 (MAPK1)
   04270 Vascular smooth muscle contraction
    109259699 (MAPK1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109259699 (MAPK1)
  09156 Nervous system
   04724 Glutamatergic synapse
    109259699 (MAPK1)
   04725 Cholinergic synapse
    109259699 (MAPK1)
   04726 Serotonergic synapse
    109259699 (MAPK1)
   04720 Long-term potentiation
    109259699 (MAPK1)
   04730 Long-term depression
    109259699 (MAPK1)
   04723 Retrograde endocannabinoid signaling
    109259699 (MAPK1)
   04722 Neurotrophin signaling pathway
    109259699 (MAPK1)
  09158 Development and regeneration
   04360 Axon guidance
    109259699 (MAPK1)
   04380 Osteoclast differentiation
    109259699 (MAPK1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    109259699 (MAPK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109259699 (MAPK1)
   05206 MicroRNAs in cancer
    109259699 (MAPK1)
   05205 Proteoglycans in cancer
    109259699 (MAPK1)
   05207 Chemical carcinogenesis - receptor activation
    109259699 (MAPK1)
   05208 Chemical carcinogenesis - reactive oxygen species
    109259699 (MAPK1)
   05203 Viral carcinogenesis
    109259699 (MAPK1)
   05230 Central carbon metabolism in cancer
    109259699 (MAPK1)
   05231 Choline metabolism in cancer
    109259699 (MAPK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109259699 (MAPK1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109259699 (MAPK1)
   05212 Pancreatic cancer
    109259699 (MAPK1)
   05225 Hepatocellular carcinoma
    109259699 (MAPK1)
   05226 Gastric cancer
    109259699 (MAPK1)
   05214 Glioma
    109259699 (MAPK1)
   05216 Thyroid cancer
    109259699 (MAPK1)
   05221 Acute myeloid leukemia
    109259699 (MAPK1)
   05220 Chronic myeloid leukemia
    109259699 (MAPK1)
   05218 Melanoma
    109259699 (MAPK1)
   05211 Renal cell carcinoma
    109259699 (MAPK1)
   05219 Bladder cancer
    109259699 (MAPK1)
   05215 Prostate cancer
    109259699 (MAPK1)
   05213 Endometrial cancer
    109259699 (MAPK1)
   05224 Breast cancer
    109259699 (MAPK1)
   05223 Non-small cell lung cancer
    109259699 (MAPK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109259699 (MAPK1)
   05170 Human immunodeficiency virus 1 infection
    109259699 (MAPK1)
   05161 Hepatitis B
    109259699 (MAPK1)
   05160 Hepatitis C
    109259699 (MAPK1)
   05171 Coronavirus disease - COVID-19
    109259699 (MAPK1)
   05164 Influenza A
    109259699 (MAPK1)
   05163 Human cytomegalovirus infection
    109259699 (MAPK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109259699 (MAPK1)
   05165 Human papillomavirus infection
    109259699 (MAPK1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109259699 (MAPK1)
   05135 Yersinia infection
    109259699 (MAPK1)
   05133 Pertussis
    109259699 (MAPK1)
   05152 Tuberculosis
    109259699 (MAPK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    109259699 (MAPK1)
   05140 Leishmaniasis
    109259699 (MAPK1)
   05142 Chagas disease
    109259699 (MAPK1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109259699 (MAPK1)
   05020 Prion disease
    109259699 (MAPK1)
   05022 Pathways of neurodegeneration - multiple diseases
    109259699 (MAPK1)
  09165 Substance dependence
   05034 Alcoholism
    109259699 (MAPK1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109259699 (MAPK1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    109259699 (MAPK1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    109259699 (MAPK1)
   04934 Cushing syndrome
    109259699 (MAPK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109259699 (MAPK1)
   01524 Platinum drug resistance
    109259699 (MAPK1)
   01522 Endocrine resistance
    109259699 (MAPK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppad01001]
    109259699 (MAPK1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:ppad03036]
    109259699 (MAPK1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:ppad04147]
    109259699 (MAPK1)
Enzymes [BR:ppad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     109259699 (MAPK1)
Protein kinases [BR:ppad01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   109259699 (MAPK1)
Chromosome and associated proteins [BR:ppad03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     109259699 (MAPK1)
Exosome [BR:ppad04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   109259699 (MAPK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH STATB_N Haspin_kinase FTA2 Kdo
Other DBs
NCBI-GeneID: 109259699
NCBI-ProteinID: XP_019292941
Ensembl: ENSPPRG00000009510
UniProt: A0A9V1F0J1
LinkDB
Position
Unknown
AA seq 360 aa
MAAASAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPVAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 1083 nt   +upstreamnt  +downstreamnt
atggcggcggcgtcggcggcgggcgcgggcccggagatggtccgcgggcaggtgttcgac
gtggggccgcgctacaccaacctctcgtatatcggcgagggcgcctacggcatggtgtgc
tctgcttatgataatgtcaacaaagttcgagtagctatcaagaaaatcagtccttttgag
caccagacctactgccagagaaccctgagggagataaaaatcttactgcgcttcagacat
gagaacatcattggaatcaatgatattattagagcgccaaccatcgagcaaatgaaagat
gtatatatcgtacaggacctcatggaaacagatctctacaagctcttgaagacacaacac
ctcagcaacgaccatatctgctattttctttaccagatcctcagagggttaaaatatatc
cattcagctaatgtactgcaccgtgacctcaaaccttccaacctgctgctcaacaccacc
tgtgatctcaagatctgtgactttggtttggcccgcgttgcagatccagaccatgatcac
acagggttcctgacggagtacgtagccacacgttggtaccgggctccagaaattatgttg
aattccaagggctataccaagtccattgatatttggtctgtaggctgcattctggcagag
atgctgtccaacaggcccatcttcccggggaagcattatctcgaccagctgaaccacatt
ctgggtattcttggatccccatcacaggaagacctgaattgtataataaatttaaaagct
agaaactacttgctttctcttccacacaaaaataaggtgccatggaacaggctgttccca
aatgctgattccaaagctctggatttactggacaaaatgttgacgttcaaccctcacaag
aggattgaagtagaacaggctctggcccatccatatctggagcagtattacgacccaagt
gatgagcccgtcgctgaggcaccgttcaagtttgacatggagctagacgacctgcccaag
gaaaagctcaaagagctcatcttcgaagagacggccaggttccagccgggatacaggtct
taa

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