Panthera pardus (leopard): 109259759 Help Entry 109259759         CDS       T06062                                  Name (RefSeq) GTPase HRas   KO K02833   GTPase HRas Organism ppad  Panthera pardus (leopard) Pathway ppad01521   EGFR tyrosine kinase inhibitor resistance ppad01522   Endocrine resistance ppad04010   MAPK signaling pathway ppad04012   ErbB signaling pathway ppad04014   Ras signaling pathway ppad04015   Rap1 signaling pathway ppad04062   Chemokine signaling pathway ppad04068   FoxO signaling pathway ppad04071   Sphingolipid signaling pathway ppad04072   Phospholipase D signaling pathway ppad04137   Mitophagy - animal ppad04140   Autophagy - animal ppad04144   Endocytosis ppad04150   mTOR signaling pathway ppad04151   PI3K-Akt signaling pathway ppad04210   Apoptosis ppad04211   Longevity regulating pathway ppad04213   Longevity regulating pathway - multiple species ppad04218   Cellular senescence ppad04360   Axon guidance ppad04370   VEGF signaling pathway ppad04371   Apelin signaling pathway ppad04510   Focal adhesion ppad04540   Gap junction ppad04550   Signaling pathways regulating pluripotency of stem cells ppad04625   C-type lectin receptor signaling pathway ppad04630   JAK-STAT signaling pathway ppad04650   Natural killer cell mediated cytotoxicity ppad04660   T cell receptor signaling pathway ppad04662   B cell receptor signaling pathway ppad04664   Fc epsilon RI signaling pathway ppad04714   Thermogenesis ppad04720   Long-term potentiation ppad04722   Neurotrophin signaling pathway ppad04725   Cholinergic synapse ppad04726   Serotonergic synapse ppad04730   Long-term depression ppad04810   Regulation of actin cytoskeleton ppad04910   Insulin signaling pathway ppad04912   GnRH signaling pathway ppad04915   Estrogen signaling pathway ppad04916   Melanogenesis ppad04917   Prolactin signaling pathway ppad04919   Thyroid hormone signaling pathway ppad04921   Oxytocin signaling pathway ppad04926   Relaxin signaling pathway ppad04929   GnRH secretion ppad04933   AGE-RAGE signaling pathway in diabetic complications ppad04935   Growth hormone synthesis, secretion and action ppad05010   Alzheimer disease ppad05022   Pathways of neurodegeneration - multiple diseases ppad05034   Alcoholism ppad05132   Salmonella infection ppad05160   Hepatitis C ppad05161   Hepatitis B ppad05163   Human cytomegalovirus infection ppad05165   Human papillomavirus infection ppad05166   Human T-cell leukemia virus 1 infection ppad05167   Kaposi sarcoma-associated herpesvirus infection ppad05170   Human immunodeficiency virus 1 infection ppad05200   Pathways in cancer ppad05203   Viral carcinogenesis ppad05205   Proteoglycans in cancer ppad05206   MicroRNAs in cancer ppad05207   Chemical carcinogenesis - receptor activation ppad05208   Chemical carcinogenesis - reactive oxygen species ppad05210   Colorectal cancer ppad05211   Renal cell carcinoma ppad05213   Endometrial cancer ppad05214   Glioma ppad05215   Prostate cancer ppad05216   Thyroid cancer ppad05218   Melanoma ppad05219   Bladder cancer ppad05220   Chronic myeloid leukemia ppad05221   Acute myeloid leukemia ppad05223   Non-small cell lung cancer ppad05224   Breast cancer ppad05225   Hepatocellular carcinoma ppad05226   Gastric cancer ppad05230   Central carbon metabolism in cancer ppad05231   Choline metabolism in cancer ppad05235   PD-L1 expression and PD-1 checkpoint pathway in cancer ppad05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:ppad00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     109259759    04012 ErbB signaling pathway     109259759    04014 Ras signaling pathway     109259759    04015 Rap1 signaling pathway     109259759    04370 VEGF signaling pathway     109259759    04371 Apelin signaling pathway     109259759    04630 JAK-STAT signaling pathway     109259759    04068 FoxO signaling pathway     109259759    04072 Phospholipase D signaling pathway     109259759    04071 Sphingolipid signaling pathway     109259759    04151 PI3K-Akt signaling pathway     109259759    04150 mTOR signaling pathway     109259759  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     109259759    04140 Autophagy - animal     109259759    04137 Mitophagy - animal     109259759   09143 Cell growth and death    04210 Apoptosis     109259759    04218 Cellular senescence     109259759   09144 Cellular community - eukaryotes    04510 Focal adhesion     109259759    04540 Gap junction     109259759    04550 Signaling pathways regulating pluripotency of stem cells     109259759   09142 Cell motility    04810 Regulation of actin cytoskeleton     109259759  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     109259759    04650 Natural killer cell mediated cytotoxicity     109259759    04660 T cell receptor signaling pathway     109259759    04662 B cell receptor signaling pathway     109259759    04664 Fc epsilon RI signaling pathway     109259759    04062 Chemokine signaling pathway     109259759   09152 Endocrine system    04910 Insulin signaling pathway     109259759    04929 GnRH secretion     109259759    04912 GnRH signaling pathway     109259759    04915 Estrogen signaling pathway     109259759    04917 Prolactin signaling pathway     109259759    04921 Oxytocin signaling pathway     109259759    04926 Relaxin signaling pathway     109259759    04935 Growth hormone synthesis, secretion and action     109259759    04919 Thyroid hormone signaling pathway     109259759    04916 Melanogenesis     109259759   09156 Nervous system    04725 Cholinergic synapse     109259759    04726 Serotonergic synapse     109259759    04720 Long-term potentiation     109259759    04730 Long-term depression     109259759    04722 Neurotrophin signaling pathway     109259759   09158 Development and regeneration    04360 Axon guidance     109259759   09149 Aging    04211 Longevity regulating pathway     109259759    04213 Longevity regulating pathway - multiple species     109259759   09159 Environmental adaptation    04714 Thermogenesis     109259759  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     109259759    05206 MicroRNAs in cancer     109259759    05205 Proteoglycans in cancer     109259759    05207 Chemical carcinogenesis - receptor activation     109259759    05208 Chemical carcinogenesis - reactive oxygen species     109259759    05203 Viral carcinogenesis     109259759    05230 Central carbon metabolism in cancer     109259759    05231 Choline metabolism in cancer     109259759    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     109259759   09162 Cancer: specific types    05210 Colorectal cancer     109259759    05225 Hepatocellular carcinoma     109259759    05226 Gastric cancer     109259759    05214 Glioma     109259759    05216 Thyroid cancer     109259759    05221 Acute myeloid leukemia     109259759    05220 Chronic myeloid leukemia     109259759    05218 Melanoma     109259759    05211 Renal cell carcinoma     109259759    05219 Bladder cancer     109259759    05215 Prostate cancer     109259759    05213 Endometrial cancer     109259759    05224 Breast cancer     109259759    05223 Non-small cell lung cancer     109259759   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     109259759    05170 Human immunodeficiency virus 1 infection     109259759    05161 Hepatitis B     109259759    05160 Hepatitis C     109259759    05163 Human cytomegalovirus infection     109259759    05167 Kaposi sarcoma-associated herpesvirus infection     109259759    05165 Human papillomavirus infection     109259759   09171 Infectious disease: bacterial    05132 Salmonella infection     109259759   09164 Neurodegenerative disease    05010 Alzheimer disease     109259759    05022 Pathways of neurodegeneration - multiple diseases     109259759   09165 Substance dependence    05034 Alcoholism     109259759   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     109259759   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     109259759   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     109259759    01522 Endocrine resistance     109259759  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:ppad04131]     109259759   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:ppad04147]     109259759    04031 GTP-binding proteins [BR:ppad04031]     109259759 Membrane trafficking [BR:ppad04131]  Exocytosis   Small GTPases and associated proteins    Other small GTPases and associated proteins     109259759  Endocytosis   Macropinocytosis    Ras GTPases     109259759 Exosome [BR:ppad04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    109259759   Exosomal proteins of colorectal cancer cells    109259759 GTP-binding proteins [BR:ppad04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     109259759 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc Arf GTP_EFTU MMR_HSR1 RsgA_GTPase FeoB_N ATP_bind_1 G-alpha Septin Ldh_1_N DUF6974 SatRNA_48 nSTAND3 CbiA AAA_16 Motif Other DBs NCBI-GeneID:  109259759 NCBI-ProteinID:  XP_019293072 LinkDB All DBs Position Unknown AA seq 177 aa AA seqDB search MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL AARTVESRQAQDLARSYGIPYIETSAKTRQAVEDTVSLAASAVSRIRETWENVPWVP NT seq 534 nt NT seq  +upstreamnt  +downstreamnt atgacggaatataagctcgtggtggtgggcgctggaggtgtggggaagagtgccctgacc atccagctcatccagaaccacttcgtggacgagtatgaccccaccatcgaggactcctat cggaagcaagtggttattgatggcgagacgtgcctactggacattttggacacggcgggc caggaggagtatagcgccatgcgggaccagtacatgcgcactggggaaggctttctctgt gtgtttgccatcaacaataccaagtcctttgaggacatccaccagtacagggagcaaatc aagcgagtgaaggactccgatgacgtgcccatggtgctggtggggaacaagtgcgacctg gccgcgcgcaccgtggagtcccggcaggcgcaggacctcgcccgcagctacggcatcccg tacatcgagacgtcggccaagactcgccaggctgtggaggatacagtgtcactggcggct tccgccgtttccaggatcagagaaacttgggaaaatgttccatgggttccctga

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