KEGG   Panthera pardus (leopard): 109259912
Entry
109259912         CDS       T06062                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad00562  Inositol phosphate metabolism
ppad01100  Metabolic pathways
ppad01521  EGFR tyrosine kinase inhibitor resistance
ppad01522  Endocrine resistance
ppad01524  Platinum drug resistance
ppad04012  ErbB signaling pathway
ppad04014  Ras signaling pathway
ppad04015  Rap1 signaling pathway
ppad04024  cAMP signaling pathway
ppad04062  Chemokine signaling pathway
ppad04066  HIF-1 signaling pathway
ppad04068  FoxO signaling pathway
ppad04070  Phosphatidylinositol signaling system
ppad04071  Sphingolipid signaling pathway
ppad04072  Phospholipase D signaling pathway
ppad04081  Hormone signaling
ppad04140  Autophagy - animal
ppad04150  mTOR signaling pathway
ppad04151  PI3K-Akt signaling pathway
ppad04152  AMPK signaling pathway
ppad04210  Apoptosis
ppad04211  Longevity regulating pathway
ppad04213  Longevity regulating pathway - multiple species
ppad04218  Cellular senescence
ppad04360  Axon guidance
ppad04370  VEGF signaling pathway
ppad04380  Osteoclast differentiation
ppad04510  Focal adhesion
ppad04550  Signaling pathways regulating pluripotency of stem cells
ppad04611  Platelet activation
ppad04613  Neutrophil extracellular trap formation
ppad04620  Toll-like receptor signaling pathway
ppad04625  C-type lectin receptor signaling pathway
ppad04630  JAK-STAT signaling pathway
ppad04650  Natural killer cell mediated cytotoxicity
ppad04660  T cell receptor signaling pathway
ppad04662  B cell receptor signaling pathway
ppad04664  Fc epsilon RI signaling pathway
ppad04666  Fc gamma R-mediated phagocytosis
ppad04668  TNF signaling pathway
ppad04670  Leukocyte transendothelial migration
ppad04722  Neurotrophin signaling pathway
ppad04725  Cholinergic synapse
ppad04750  Inflammatory mediator regulation of TRP channels
ppad04810  Regulation of actin cytoskeleton
ppad04910  Insulin signaling pathway
ppad04914  Progesterone-mediated oocyte maturation
ppad04915  Estrogen signaling pathway
ppad04917  Prolactin signaling pathway
ppad04919  Thyroid hormone signaling pathway
ppad04923  Regulation of lipolysis in adipocytes
ppad04926  Relaxin signaling pathway
ppad04929  GnRH secretion
ppad04930  Type II diabetes mellitus
ppad04931  Insulin resistance
ppad04932  Non-alcoholic fatty liver disease
ppad04933  AGE-RAGE signaling pathway in diabetic complications
ppad04935  Growth hormone synthesis, secretion and action
ppad04960  Aldosterone-regulated sodium reabsorption
ppad04973  Carbohydrate digestion and absorption
ppad05010  Alzheimer disease
ppad05017  Spinocerebellar ataxia
ppad05020  Prion disease
ppad05100  Bacterial invasion of epithelial cells
ppad05132  Salmonella infection
ppad05135  Yersinia infection
ppad05142  Chagas disease
ppad05146  Amoebiasis
ppad05160  Hepatitis C
ppad05161  Hepatitis B
ppad05162  Measles
ppad05163  Human cytomegalovirus infection
ppad05164  Influenza A
ppad05165  Human papillomavirus infection
ppad05166  Human T-cell leukemia virus 1 infection
ppad05167  Kaposi sarcoma-associated herpesvirus infection
ppad05168  Herpes simplex virus 1 infection
ppad05169  Epstein-Barr virus infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05171  Coronavirus disease - COVID-19
ppad05200  Pathways in cancer
ppad05203  Viral carcinogenesis
ppad05205  Proteoglycans in cancer
ppad05206  MicroRNAs in cancer
ppad05207  Chemical carcinogenesis - receptor activation
ppad05208  Chemical carcinogenesis - reactive oxygen species
ppad05210  Colorectal cancer
ppad05211  Renal cell carcinoma
ppad05212  Pancreatic cancer
ppad05213  Endometrial cancer
ppad05214  Glioma
ppad05215  Prostate cancer
ppad05218  Melanoma
ppad05220  Chronic myeloid leukemia
ppad05221  Acute myeloid leukemia
ppad05222  Small cell lung cancer
ppad05223  Non-small cell lung cancer
ppad05224  Breast cancer
ppad05225  Hepatocellular carcinoma
ppad05226  Gastric cancer
ppad05230  Central carbon metabolism in cancer
ppad05231  Choline metabolism in cancer
ppad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ppad05415  Diabetic cardiomyopathy
ppad05417  Lipid and atherosclerosis
ppad05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    109259912 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    109259912 (PIK3CB)
   04014 Ras signaling pathway
    109259912 (PIK3CB)
   04015 Rap1 signaling pathway
    109259912 (PIK3CB)
   04370 VEGF signaling pathway
    109259912 (PIK3CB)
   04630 JAK-STAT signaling pathway
    109259912 (PIK3CB)
   04668 TNF signaling pathway
    109259912 (PIK3CB)
   04066 HIF-1 signaling pathway
    109259912 (PIK3CB)
   04068 FoxO signaling pathway
    109259912 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    109259912 (PIK3CB)
   04072 Phospholipase D signaling pathway
    109259912 (PIK3CB)
   04071 Sphingolipid signaling pathway
    109259912 (PIK3CB)
   04024 cAMP signaling pathway
    109259912 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    109259912 (PIK3CB)
   04152 AMPK signaling pathway
    109259912 (PIK3CB)
   04150 mTOR signaling pathway
    109259912 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    109259912 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109259912 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    109259912 (PIK3CB)
   04218 Cellular senescence
    109259912 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109259912 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    109259912 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109259912 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109259912 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    109259912 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    109259912 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    109259912 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    109259912 (PIK3CB)
   04660 T cell receptor signaling pathway
    109259912 (PIK3CB)
   04662 B cell receptor signaling pathway
    109259912 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    109259912 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    109259912 (PIK3CB)
   04670 Leukocyte transendothelial migration
    109259912 (PIK3CB)
   04062 Chemokine signaling pathway
    109259912 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109259912 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    109259912 (PIK3CB)
   04929 GnRH secretion
    109259912 (PIK3CB)
   04915 Estrogen signaling pathway
    109259912 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    109259912 (PIK3CB)
   04917 Prolactin signaling pathway
    109259912 (PIK3CB)
   04926 Relaxin signaling pathway
    109259912 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    109259912 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    109259912 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    109259912 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109259912 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    109259912 (PIK3CB)
   04722 Neurotrophin signaling pathway
    109259912 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    109259912 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    109259912 (PIK3CB)
   04380 Osteoclast differentiation
    109259912 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    109259912 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    109259912 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109259912 (PIK3CB)
   05206 MicroRNAs in cancer
    109259912 (PIK3CB)
   05205 Proteoglycans in cancer
    109259912 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    109259912 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    109259912 (PIK3CB)
   05203 Viral carcinogenesis
    109259912 (PIK3CB)
   05230 Central carbon metabolism in cancer
    109259912 (PIK3CB)
   05231 Choline metabolism in cancer
    109259912 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109259912 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109259912 (PIK3CB)
   05212 Pancreatic cancer
    109259912 (PIK3CB)
   05225 Hepatocellular carcinoma
    109259912 (PIK3CB)
   05226 Gastric cancer
    109259912 (PIK3CB)
   05214 Glioma
    109259912 (PIK3CB)
   05221 Acute myeloid leukemia
    109259912 (PIK3CB)
   05220 Chronic myeloid leukemia
    109259912 (PIK3CB)
   05218 Melanoma
    109259912 (PIK3CB)
   05211 Renal cell carcinoma
    109259912 (PIK3CB)
   05215 Prostate cancer
    109259912 (PIK3CB)
   05213 Endometrial cancer
    109259912 (PIK3CB)
   05224 Breast cancer
    109259912 (PIK3CB)
   05222 Small cell lung cancer
    109259912 (PIK3CB)
   05223 Non-small cell lung cancer
    109259912 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109259912 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    109259912 (PIK3CB)
   05161 Hepatitis B
    109259912 (PIK3CB)
   05160 Hepatitis C
    109259912 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    109259912 (PIK3CB)
   05164 Influenza A
    109259912 (PIK3CB)
   05162 Measles
    109259912 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    109259912 (PIK3CB)
   05163 Human cytomegalovirus infection
    109259912 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109259912 (PIK3CB)
   05169 Epstein-Barr virus infection
    109259912 (PIK3CB)
   05165 Human papillomavirus infection
    109259912 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109259912 (PIK3CB)
   05135 Yersinia infection
    109259912 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    109259912 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109259912 (PIK3CB)
   05142 Chagas disease
    109259912 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109259912 (PIK3CB)
   05017 Spinocerebellar ataxia
    109259912 (PIK3CB)
   05020 Prion disease
    109259912 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109259912 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    109259912 (PIK3CB)
   05415 Diabetic cardiomyopathy
    109259912 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    109259912 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    109259912 (PIK3CB)
   04931 Insulin resistance
    109259912 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    109259912 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109259912 (PIK3CB)
   01524 Platinum drug resistance
    109259912 (PIK3CB)
   01522 Endocrine resistance
    109259912 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppad04131]
    109259912 (PIK3CB)
Enzymes [BR:ppad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     109259912 (PIK3CB)
Membrane trafficking [BR:ppad04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    109259912 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 109259912
NCBI-ProteinID: XP_019293402
Ensembl: ENSPPRG00000001380
UniProt: A0A9V1F171
LinkDB
Position
Unknown
AA seq 1070 aa
MCFNFIMPPAMADILDIWAVDSQLASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSILENLEDKLYGGKLIVAVHFENCQDVFSFQISPNMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFMLVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKMRIISHVWENNNPFQIVLVKGNKLNTEESVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINICDLPRMARLCFAIYAVLDKVKTKKSTKTI
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcaatttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagttagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatattcagttggaggttcctcgggaagctaccatttcctatattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaaggctctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctacatgaatttgatgcactg
aaggatcctgaagtgaatgaattccgaataaaaatgcgcaaattcagtgaagaaaagatt
cagtcacttgtgggattgtcttggatggattggctaaaacagacgtatccaccagaacat
gaaccatccatccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagctttcaaatatctcctaatatgaatcct
atcaaaataaatgaactggcaatccaaaaacgtttgactattcatgggaaagaagatgaa
gttagcccgtatgactatgtgttacaagtcagtgggcgagtagaatatgtgtttggtgat
cacccactaattcagttccagtatatccggaactgtgtaatgaataggaccttgcctcat
tttatgcttgtggaatgttgcaagatcaagaagatgtatgaacaggaaatgattgccata
gaagctgccataaatagaaattcatcaaaccttcctcttcctttaccaccaaagaaaatg
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaagaaagtgtaaaagttcatgtcagggctggcctttttcatggt
accgaactcctgtgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaccactggaatttgatataaatatttgtgacctgccacgaatggctcgatta
tgttttgctatttatgcagttttggataaagtgaaaacgaaaaaatcgactaaaactatt
aatccctctaaatatcagaccatccggaaatctgggaaagtgcattatcctgtagcatgg
gtaaatacaatggtttttgactttaaaggacagttgagatctggagacataatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcag
acaaatccatatacagaaaatgcaacagctttgcatatcaaattcccagagaataaaaaa
caaccttattattatcctccctttgataagataatcgagaaggcagctgagattgcaagc
agtgacagtgctaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactgaaagaa
atcttggacagggatcccttgtctcaactgtgtgagaacgaaatggatcttatttggact
ttgcgacaagattgcagagagaatttcccacagtcactgccaaaattactgctgtcgatc
aagtggaataaacttgaagatgttgctcagcttcaagccctacttcagatttggcctaaa
ctgcccccccgggaggccttggagcttctagatttcaactatccagatcagtacgtgcga
gaatatgctgtgggctgcctgcgacagatgagtgatgaagaactctctcaatatctttta
caactggtgcaagttttgaaatacgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttgctaaccgcaggatagggcagtttctattttggcaccttaggtca
gaagtgcatattcctgctgtctcagtacagtttggtgtcatccttgaagcatactgccgg
ggaagtgtagggcatatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcaatgaagctaaacagagccaaagggaaggag
gccatgcatacttgtttaaaacagaatgcttaccgggaagccctctctgacctgcagtca
cctctgaatccgtgtgtcatcctctcagaactctatgttgaaaaatgtaaatacatggat
tccaaaatgaagcctttgtggctcgtgtacaacaacaaagtttttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaagatatgttgacactccagatgttg
cgcttgatggatttactttggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcaacaggagaccgctctggcctcatcgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgcagcagcggccttcaacaaagacgcc
cttctgaactggcttaaagaatacaactctggggatgacctagaccgagccattgaagag
tttaccttgtcctgtgccggctactgtgtagcttcttatgtccttgggattggtgataga
catagtgacaacatcatggtcaagaaaaccggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggaacgagtgccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaaatttggc
cgtttccgccagtgttgtgaggatgcatatctgattttacgacgtcacgggaatctcttc
atcactctttttgcactgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccttaggaaagagtgaagaagaagcgcttaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

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