KEGG   Panthera pardus (leopard): 109260261
Entry
109260261         CDS       T06062                                 
Symbol
CACNA1B
Name
(RefSeq) voltage-dependent N-type calcium channel subunit alpha-1B isoform X1
  KO
K04849  voltage-dependent calcium channel N type alpha-1B
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad04010  MAPK signaling pathway
ppad04020  Calcium signaling pathway
ppad04721  Synaptic vesicle cycle
ppad04723  Retrograde endocannabinoid signaling
ppad04725  Cholinergic synapse
ppad04726  Serotonergic synapse
ppad04727  GABAergic synapse
ppad04728  Dopaminergic synapse
ppad04930  Type II diabetes mellitus
ppad05016  Huntington disease
ppad05020  Prion disease
ppad05022  Pathways of neurodegeneration - multiple diseases
ppad05032  Morphine addiction
ppad05033  Nicotine addiction
ppad05207  Chemical carcinogenesis - receptor activation
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109260261 (CACNA1B)
   04020 Calcium signaling pathway
    109260261 (CACNA1B)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    109260261 (CACNA1B)
   04725 Cholinergic synapse
    109260261 (CACNA1B)
   04728 Dopaminergic synapse
    109260261 (CACNA1B)
   04726 Serotonergic synapse
    109260261 (CACNA1B)
   04723 Retrograde endocannabinoid signaling
    109260261 (CACNA1B)
   04721 Synaptic vesicle cycle
    109260261 (CACNA1B)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    109260261 (CACNA1B)
  09164 Neurodegenerative disease
   05016 Huntington disease
    109260261 (CACNA1B)
   05020 Prion disease
    109260261 (CACNA1B)
   05022 Pathways of neurodegeneration - multiple diseases
    109260261 (CACNA1B)
  09165 Substance dependence
   05032 Morphine addiction
    109260261 (CACNA1B)
   05033 Nicotine addiction
    109260261 (CACNA1B)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    109260261 (CACNA1B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:ppad04040]
    109260261 (CACNA1B)
Ion channels [BR:ppad04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   109260261 (CACNA1B)
SSDB
Motif
Pfam: Ion_trans GPHH PKD_channel Phage_TAC_15
Other DBs
NCBI-GeneID: 109260261
NCBI-ProteinID: XP_019293941
Ensembl: ENSPPRG00000022620
LinkDB
Position
Unknown
AA seq 1966 aa
MVRFGDELGSRYGGAGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNP
IPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDG
DKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILAT
AGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIG
LEFYMGKFHKACFPNSTDPEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNIL
FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK
ERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRAA
TKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVK
AQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRS
YFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWSSLRNLVV
SLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQIL
TGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK
DEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAAAFVKHTRGAASHSSSVSSINSPRP
QNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRYATTRHLRPDMKTHLDRPLV
VELGRDGPRGPAGGKARPDGAEAGEGTDPPRRHHRHRDKAPAAAPAAAAEQDRADAPKAE
GGESGAREERARPHRSRSKEARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHA
PDQGKEGAAPGTKGERRARHRGGPRAGPREAGSGEEPARRHRARHKAQPTHEDAEKEGEV
EDRDKEKELRNHQPKEPRCDLEASEMMGVGPVHALPSTCLQKVEEQPEDADNQRNVTRMG
SQPSDLSATVHIPVTLTGPPGETTVVPSGNVDLESQAEGKKEAEADDVMRSGPRPIVPYS
SMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSPRNNALKYMDY
IFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDI
NTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILVVYMLFMFIFAVIAVQLF
KGKFFYCTDESKGLERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTG
EGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD
KVMSECSLEKNERACIDFAISAKPLTRYMPQDKQSFQYKTWTFVVSPPFEYFIMAMIALN
TVVLMMKFYNAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVL
GSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCL
LIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSC
LSNQACDEHANANECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPH
HLDEFIRVWAEYDPAACCRIHYKDMYSLLRCIAPPVGLGKNCPRRLAYKVCNFRASIRHT
LPCPKCKHSTHSLPGLGMTTPHLSFLLSCPAPHSNLLDALVPHLISRPLQLAGERQPSEA
AHTKLSGWALRAGVGYWVGAGGQALPVPRKQLSYPALPPGSQVGANGQTGPRPRAPEEGS
RGTSRPGAAAPPSLKSPTAQGFLVPGGGEDRGRGGPKAGPPASPLD
NT seq 5901 nt   +upstreamnt  +downstreamnt
atggtccgcttcggggacgagctgggcagccgctatgggggcgccggtggggagcgggct
cggggcggcggggccggcggggcgggcggcccgggccccggggggctgcagccgggccag
cgggtcctctacaagcagtcgatcgcgcagcgcgcgcggactatggcgctctacaacccc
atcccggtcaagcagaactgcttcaccgtcaaccgctcgctcttcgtcttcagcgaggac
aacgtcgtccgcaaatacgccaagcgcatcaccgagtggcctccatttgaatacatgatc
ctggccaccatcatcgccaactgtattgtgctggcactggagcagcacctgcctgacggg
gacaagacacccatgtctgagcggctggatgacacagagccctacttcattggcatcttc
tgctttgaggcggggatcaagatcatagctctgggcttcgtcttccacaagggctcctac
ttgcggaacggctggaacgtcatggactttgtggtggttctcacagggatcctggccaca
gcgggcactgacttcgacctgcggaccctgcgggctgtgcgtgtgctcaggcccctgaag
ctggtgtctgggattccgagtctgcaggtggtgctcaagtccataatgaaggccatggtc
ccgcttctgcagattgggttgcttctcttctttgccatcctcatgtttgccatcattggc
ctcgagttctacatgggaaaattccacaaggcctgtttccccaacagcacagatccagag
ccggtgggtgactttccctgtggcaaggaggccccggcccggctgtgtgagggcgacacc
gagtgccgggagtactggccgggacccaactttggcatcaccaactttgacaatatcctg
tttgccatcttgacagtgttccagtgcatcaccatggagggatggactgacatcctttat
aacacaaatgatgcagccggcaacacctggaactggctctacttcatccctctcatcatc
atcggctccttcttcatgctcaacctggtgttgggtgtgctctcaggagagtttgccaag
gagcgtgagagggtcgagaaccgccgggccttcctgaagctccgccggcagcagcagatt
gagcgggagctcaatgggtacctggaatggatcttcaaggctgaggaagtcatgctggct
gaggaggacaagaatgcggaggagaagtcccctctggatgcagtgttgaagagagcagcc
accaagaagagccggaatgacctgatccatgccgaggagggggaggaccggtttgcagac
ctctgtgctgttggatcccccttcgcccgcgccagcctcaagagtgggaagacagagagt
tcgtcatacttccgtaggaaggagaagatgttccggttcttcatccgccgcatggtgaag
gcacagagcttctactgggtggtgctgtgtgtggtggccctgaatacgctgtgcgtggcc
atggttcactacaaccagccgcagcggctcaccacggcgctgtactttgcagagtttgtt
ttcctgggtctcttcctcacagagatgtccctgaagatgtatggcctggggcccagaagc
tacttccggtcctcattcaactgcttcgactttggggtcattgtggggagcatctttgaa
gtggtctgggccgccatcaagccaggaacctccttcgggatcagcgtgctgcgggcactc
cggttgctgcggatcttcaaagtcacaaagtactggagctccctgcggaacctggtggtg
tctctgctcaactccatgaagtctatcatcagcctccttttcctgctgttcctgttcatc
gtggtctttgccctgctgggcatgcagctgtttgggggacagttcaactttcaagatgag
accccgacaaccaactttgacaccttccccgcggccatccttaccgtcttccagatccta
acaggagaggactggaatgcagtgatgtatcacgggatcgaatcgcaaggtggagtcagc
aaaggcatgttctcctctttttatttcattgtcttgacgctgtttggaaattacactctg
ctgaacgtcttcctggccatcgctgtggacaacctcgccaacgctcaggagctgaccaag
gatgaagaggagatggaagaagcagccaatcagaagcttgctctgcaaaaggccaaagaa
gtggctgaagtgagccccatgtctgccgcaaacatctctattgctgctgcttttgtaaag
cacacgcgaggtgctgcatctcacagctcatctgtctccagcataaactcacccaggccg
cagaactcggccaaagcacgctcggtctgggagcagcgggccagccagctgcggctgcag
aacctgcgggccagctgcgaggcgctgtacagcgagatggaccccgaggagcggctgcgc
tacgccaccacgcgccacctgcggccggacatgaagacgcacctggaccggccgctcgtg
gtggagctgggccgcgacgggccgcggggccccgcggggggcaaggcccggcccgacggc
gcggaggccggcgagggcacggacccgccccgcaggcaccaccggcaccgcgacaaggcc
ccggcagcggccccggcggcggcggcggagcaggacagggcggacgccccgaaggccgag
ggcggggagtccggggcccgggaggagcgggcgcggccgcaccgcagccgcagcaaggag
gcccggagcgagcgcggacgcggcccgggccccgagggcggccggcgccaccaccggcgc
ggctccccggaggaggcggccgagcgggagccccggcgccaccgcgcccaccggcacgca
cccgaccagggcaaggagggcgccgcgcccgggaccaagggcgagcggcgagcgcgccac
cgcggcggcccccgggccggcccccgggaggccggcagcggcgaggagccggcgcggcgg
caccgggcccggcacaaggcgcagcccacgcacgaggacgcagagaaggagggcgaggtc
gaggacagggacaaggagaaggagctccggaaccatcagcccaaggagccacgctgtgac
ctggaggccagtgagatgatgggtgtgggccctgtacatgcactgcccagcacctgccta
cagaaggtggaggaacagccagaagatgcagacaatcagcggaatgtcacacggatgggc
agtcaaccctcggacctgagtgccactgtgcatatcccggtgacgctgaccggccctcct
ggggagaccacggttgttcccagtggtaatgtggacctggaaagccaagctgaagggaag
aaggaggcagaagccgatgacgtgatgaggagtggcccccgacctatcgtcccgtacagc
tccatgttctgcttaagccccaccaacctgctccgccgcttctgccattacatcgtgacc
atgcggtactttgagatggtcattcttgtggtcatcgccctgagcagcattgccctggca
gccgaggatcctgtgcggacagactcgcccaggaacaacgctctgaagtacatggactac
attttcacaggcgtctttaccttcgagatggtgataaagatgattgatttgggactgctg
ctgcaccctggggcctacttccgggacctgtggaatattctggacttcatcgtggtcagt
ggggccttggtggcatttgccttctcgagcttcatgggaggatccaaagggaaagacatc
aacaccatcaagtccctgagagtcctgcgtgtcctgcggcccctcaagaccataaaacgg
ctgcctaagcttaaggccgtgtttgactgtgtggtgaactccctgaagaacgtccttaac
atcctggttgtctatatgctcttcatgttcatatttgctgtcattgcggtgcagctcttc
aaagggaagtttttctactgcacggatgagtccaaggggctggagagggactgccggggt
cagtatttggattatgagaaggaggaagtggaagctcaaccacggcagtggaagaaatac
gattttcactatgacaacgtgctctgggctctgctgacactgttcacagtgtccacggga
gaagggtggcccatggtcctgaaacactctgtggatgccacctacgaggagcagggccca
agccccgggtaccgcatggagctatccatcttctatgtggtctactttgtggtcttcccc
ttcttctttgtcaatatctttgtggccttgattatcatcaccttccaggagcagggggac
aaggtgatgtctgagtgcagcctggagaagaacgagagggcttgcattgactttgccatc
agcgccaagcccctgacacggtacatgccccaggacaagcagtcgttccagtacaagacg
tggacgtttgtcgtgtctccgccctttgagtacttcatcatggccatgattgccctcaac
acggtggtgctgatgatgaagttctacaatgcaccctatgaatacgagctgatgttgaaa
tgcctgaacattgtgttcacatccatgttctccatggaatgcgtgctgaagatcatcgcc
tttggggtgctgaactatttcagagatgcctggaatgtctttgactttgtcactgtgttg
ggaagtattactgatattttagtaacagagattgcggaaacgaacaacttcatcaacctc
agcttcctacgcctcttccgtgctgcccggctcatcaagctgctccgccaaggctacacc
atccgcatcctgctgtggaccttcgtccagtccttcaaggccctgccttacgtgtgtctg
ctcatcgccatgcttttcttcatctatgccatcattggcatgcaggtatttggaaatatt
gccctggatgatgacaccagcatcaaccggcacaacaactttcgaacatttttacaagcc
ttgatgctgttgttcaggagtgccactggggaggcctggcatgagatcatgctgtcttgt
ctcagcaaccaggcctgtgatgagcacgccaatgccaatgagtgtgggagtgactttgcc
tacttttacttcgtctccttcatcttcctttgctcctttctgatgttgaacctctttgtg
gccgtgatcatggacaattttgagtaccttacacgggactcttccatcttagggcctcac
catctggacgagttcatccgggtctgggctgagtacgacccggccgcgtgttgccggatt
cattataaggatatgtacagtttgttgcgttgtattgcgccacccgttggcttagggaag
aactgccctcgtaggttggcctacaaggtttgcaacttcagagcctccatccgacatact
cttccctgcccgaaatgcaaacacagcacacactccctgcctggtttgggaatgacgaca
cctcacctctctttcctcctgtcctgccctgccccgcactccaacctcctggacgctttg
gtccctcatctaatctcccgacccctccagctggctggggagaggcagccttctgaggca
gcgcacacaaagctttctggctgggccttgagggcaggggtcggctactgggtgggagcc
gggggccaggccctgcctgtgccaaggaagcagctgtcttacccggctctgcctccaggc
tctcaagtgggtgctaatggtcagacaggcccgaggccaagggccccagaggaggggagc
aggggtaccagcagaccaggagcagctgcccctcccagtctgaagagcccaacagcccag
ggatttctggtccctgggggaggagaggacagaggcagaggaggcccaaaggcaggccct
cctgcttcacctctggattga

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