KEGG   Panthera pardus (leopard): 109262816
Entry
109262816         CDS       T06062                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad01521  EGFR tyrosine kinase inhibitor resistance
ppad01522  Endocrine resistance
ppad04010  MAPK signaling pathway
ppad04012  ErbB signaling pathway
ppad04014  Ras signaling pathway
ppad04015  Rap1 signaling pathway
ppad04022  cGMP-PKG signaling pathway
ppad04024  cAMP signaling pathway
ppad04062  Chemokine signaling pathway
ppad04066  HIF-1 signaling pathway
ppad04068  FoxO signaling pathway
ppad04071  Sphingolipid signaling pathway
ppad04072  Phospholipase D signaling pathway
ppad04114  Oocyte meiosis
ppad04140  Autophagy - animal
ppad04148  Efferocytosis
ppad04150  mTOR signaling pathway
ppad04151  PI3K-Akt signaling pathway
ppad04210  Apoptosis
ppad04218  Cellular senescence
ppad04270  Vascular smooth muscle contraction
ppad04370  VEGF signaling pathway
ppad04371  Apelin signaling pathway
ppad04380  Osteoclast differentiation
ppad04510  Focal adhesion
ppad04540  Gap junction
ppad04550  Signaling pathways regulating pluripotency of stem cells
ppad04613  Neutrophil extracellular trap formation
ppad04620  Toll-like receptor signaling pathway
ppad04650  Natural killer cell mediated cytotoxicity
ppad04660  T cell receptor signaling pathway
ppad04662  B cell receptor signaling pathway
ppad04664  Fc epsilon RI signaling pathway
ppad04666  Fc gamma R-mediated phagocytosis
ppad04668  TNF signaling pathway
ppad04720  Long-term potentiation
ppad04722  Neurotrophin signaling pathway
ppad04725  Cholinergic synapse
ppad04726  Serotonergic synapse
ppad04730  Long-term depression
ppad04810  Regulation of actin cytoskeleton
ppad04910  Insulin signaling pathway
ppad04912  GnRH signaling pathway
ppad04914  Progesterone-mediated oocyte maturation
ppad04915  Estrogen signaling pathway
ppad04916  Melanogenesis
ppad04917  Prolactin signaling pathway
ppad04919  Thyroid hormone signaling pathway
ppad04921  Oxytocin signaling pathway
ppad04926  Relaxin signaling pathway
ppad04928  Parathyroid hormone synthesis, secretion and action
ppad04929  GnRH secretion
ppad04934  Cushing syndrome
ppad04935  Growth hormone synthesis, secretion and action
ppad05010  Alzheimer disease
ppad05022  Pathways of neurodegeneration - multiple diseases
ppad05034  Alcoholism
ppad05132  Salmonella infection
ppad05135  Yersinia infection
ppad05160  Hepatitis C
ppad05161  Hepatitis B
ppad05163  Human cytomegalovirus infection
ppad05164  Influenza A
ppad05165  Human papillomavirus infection
ppad05166  Human T-cell leukemia virus 1 infection
ppad05167  Kaposi sarcoma-associated herpesvirus infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05200  Pathways in cancer
ppad05205  Proteoglycans in cancer
ppad05206  MicroRNAs in cancer
ppad05207  Chemical carcinogenesis - receptor activation
ppad05208  Chemical carcinogenesis - reactive oxygen species
ppad05210  Colorectal cancer
ppad05211  Renal cell carcinoma
ppad05212  Pancreatic cancer
ppad05213  Endometrial cancer
ppad05214  Glioma
ppad05215  Prostate cancer
ppad05216  Thyroid cancer
ppad05218  Melanoma
ppad05219  Bladder cancer
ppad05220  Chronic myeloid leukemia
ppad05221  Acute myeloid leukemia
ppad05223  Non-small cell lung cancer
ppad05224  Breast cancer
ppad05225  Hepatocellular carcinoma
ppad05226  Gastric cancer
ppad05230  Central carbon metabolism in cancer
ppad05231  Choline metabolism in cancer
ppad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109262816 (MAP2K1)
   04012 ErbB signaling pathway
    109262816 (MAP2K1)
   04014 Ras signaling pathway
    109262816 (MAP2K1)
   04015 Rap1 signaling pathway
    109262816 (MAP2K1)
   04370 VEGF signaling pathway
    109262816 (MAP2K1)
   04371 Apelin signaling pathway
    109262816 (MAP2K1)
   04668 TNF signaling pathway
    109262816 (MAP2K1)
   04066 HIF-1 signaling pathway
    109262816 (MAP2K1)
   04068 FoxO signaling pathway
    109262816 (MAP2K1)
   04072 Phospholipase D signaling pathway
    109262816 (MAP2K1)
   04071 Sphingolipid signaling pathway
    109262816 (MAP2K1)
   04024 cAMP signaling pathway
    109262816 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    109262816 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    109262816 (MAP2K1)
   04150 mTOR signaling pathway
    109262816 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109262816 (MAP2K1)
   04148 Efferocytosis
    109262816 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    109262816 (MAP2K1)
   04210 Apoptosis
    109262816 (MAP2K1)
   04218 Cellular senescence
    109262816 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109262816 (MAP2K1)
   04540 Gap junction
    109262816 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    109262816 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109262816 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    109262816 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    109262816 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    109262816 (MAP2K1)
   04660 T cell receptor signaling pathway
    109262816 (MAP2K1)
   04662 B cell receptor signaling pathway
    109262816 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    109262816 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    109262816 (MAP2K1)
   04062 Chemokine signaling pathway
    109262816 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109262816 (MAP2K1)
   04929 GnRH secretion
    109262816 (MAP2K1)
   04912 GnRH signaling pathway
    109262816 (MAP2K1)
   04915 Estrogen signaling pathway
    109262816 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    109262816 (MAP2K1)
   04917 Prolactin signaling pathway
    109262816 (MAP2K1)
   04921 Oxytocin signaling pathway
    109262816 (MAP2K1)
   04926 Relaxin signaling pathway
    109262816 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    109262816 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    109262816 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    109262816 (MAP2K1)
   04916 Melanogenesis
    109262816 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    109262816 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    109262816 (MAP2K1)
   04726 Serotonergic synapse
    109262816 (MAP2K1)
   04720 Long-term potentiation
    109262816 (MAP2K1)
   04730 Long-term depression
    109262816 (MAP2K1)
   04722 Neurotrophin signaling pathway
    109262816 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    109262816 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109262816 (MAP2K1)
   05206 MicroRNAs in cancer
    109262816 (MAP2K1)
   05205 Proteoglycans in cancer
    109262816 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    109262816 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    109262816 (MAP2K1)
   05230 Central carbon metabolism in cancer
    109262816 (MAP2K1)
   05231 Choline metabolism in cancer
    109262816 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109262816 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109262816 (MAP2K1)
   05212 Pancreatic cancer
    109262816 (MAP2K1)
   05225 Hepatocellular carcinoma
    109262816 (MAP2K1)
   05226 Gastric cancer
    109262816 (MAP2K1)
   05214 Glioma
    109262816 (MAP2K1)
   05216 Thyroid cancer
    109262816 (MAP2K1)
   05221 Acute myeloid leukemia
    109262816 (MAP2K1)
   05220 Chronic myeloid leukemia
    109262816 (MAP2K1)
   05218 Melanoma
    109262816 (MAP2K1)
   05211 Renal cell carcinoma
    109262816 (MAP2K1)
   05219 Bladder cancer
    109262816 (MAP2K1)
   05215 Prostate cancer
    109262816 (MAP2K1)
   05213 Endometrial cancer
    109262816 (MAP2K1)
   05224 Breast cancer
    109262816 (MAP2K1)
   05223 Non-small cell lung cancer
    109262816 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109262816 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    109262816 (MAP2K1)
   05161 Hepatitis B
    109262816 (MAP2K1)
   05160 Hepatitis C
    109262816 (MAP2K1)
   05164 Influenza A
    109262816 (MAP2K1)
   05163 Human cytomegalovirus infection
    109262816 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109262816 (MAP2K1)
   05165 Human papillomavirus infection
    109262816 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109262816 (MAP2K1)
   05135 Yersinia infection
    109262816 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109262816 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    109262816 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    109262816 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    109262816 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109262816 (MAP2K1)
   01522 Endocrine resistance
    109262816 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppad01001]
    109262816 (MAP2K1)
Enzymes [BR:ppad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     109262816 (MAP2K1)
Protein kinases [BR:ppad01001]
 Serine/threonine kinases: STE group
  STE7 family
   109262816 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 109262816
NCBI-ProteinID: XP_019297259
Ensembl: ENSPPRG00000022608
UniProt: A0A9V1F7G5
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgagcagcaacggaagcgcctggaggcctttcttacccagaagcagaaggtc
ggggaattgaaggatgacgactttgagaagatcagcgagctgggcgccggcaacggtggt
gtggtgttcaaggtctcccataagccgtctggcctggtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctgcaggttctacatgag
tgcaactccccatacatcgtgggcttctatggcgcgttctacagcgacggcgagatcagt
atctgtatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tccgtgcagtcggacatctggagcatggggctatctctggttgagatggcagtcgggagg
tatcccatccctcctcccgatgccaaggagctggagctgatgtttgggtgccaagtggag
ggagatgcggctgagacgccacccaggccgaggacccctggaaggcccctcagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaagctgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcctcataaaaaacccagcagagagagcagatctgaaacaactcatggttcatgccttt
atcaagagatctgatggtgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagtacaccgacccacgcggccggcgtctaa

DBGET integrated database retrieval system