KEGG   Panthera pardus (leopard): 109263166
Entry
109263166         CDS       T06062                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad00562  Inositol phosphate metabolism
ppad01100  Metabolic pathways
ppad04015  Rap1 signaling pathway
ppad04020  Calcium signaling pathway
ppad04022  cGMP-PKG signaling pathway
ppad04062  Chemokine signaling pathway
ppad04070  Phosphatidylinositol signaling system
ppad04071  Sphingolipid signaling pathway
ppad04072  Phospholipase D signaling pathway
ppad04081  Hormone signaling
ppad04082  Neuroactive ligand signaling
ppad04261  Adrenergic signaling in cardiomyocytes
ppad04270  Vascular smooth muscle contraction
ppad04310  Wnt signaling pathway
ppad04371  Apelin signaling pathway
ppad04540  Gap junction
ppad04611  Platelet activation
ppad04613  Neutrophil extracellular trap formation
ppad04621  NOD-like receptor signaling pathway
ppad04713  Circadian entrainment
ppad04720  Long-term potentiation
ppad04723  Retrograde endocannabinoid signaling
ppad04724  Glutamatergic synapse
ppad04725  Cholinergic synapse
ppad04726  Serotonergic synapse
ppad04728  Dopaminergic synapse
ppad04730  Long-term depression
ppad04742  Taste transduction
ppad04750  Inflammatory mediator regulation of TRP channels
ppad04911  Insulin secretion
ppad04912  GnRH signaling pathway
ppad04915  Estrogen signaling pathway
ppad04916  Melanogenesis
ppad04918  Thyroid hormone synthesis
ppad04919  Thyroid hormone signaling pathway
ppad04921  Oxytocin signaling pathway
ppad04922  Glucagon signaling pathway
ppad04924  Renin secretion
ppad04925  Aldosterone synthesis and secretion
ppad04926  Relaxin signaling pathway
ppad04927  Cortisol synthesis and secretion
ppad04928  Parathyroid hormone synthesis, secretion and action
ppad04929  GnRH secretion
ppad04933  AGE-RAGE signaling pathway in diabetic complications
ppad04934  Cushing syndrome
ppad04935  Growth hormone synthesis, secretion and action
ppad04961  Endocrine and other factor-regulated calcium reabsorption
ppad04970  Salivary secretion
ppad04971  Gastric acid secretion
ppad04972  Pancreatic secretion
ppad04973  Carbohydrate digestion and absorption
ppad05010  Alzheimer disease
ppad05016  Huntington disease
ppad05017  Spinocerebellar ataxia
ppad05022  Pathways of neurodegeneration - multiple diseases
ppad05142  Chagas disease
ppad05143  African trypanosomiasis
ppad05146  Amoebiasis
ppad05163  Human cytomegalovirus infection
ppad05200  Pathways in cancer
ppad05415  Diabetic cardiomyopathy
ppad05417  Lipid and atherosclerosis
Module
ppad_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    109263166 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    109263166 (PLCB2)
   04310 Wnt signaling pathway
    109263166 (PLCB2)
   04371 Apelin signaling pathway
    109263166 (PLCB2)
   04020 Calcium signaling pathway
    109263166 (PLCB2)
   04070 Phosphatidylinositol signaling system
    109263166 (PLCB2)
   04072 Phospholipase D signaling pathway
    109263166 (PLCB2)
   04071 Sphingolipid signaling pathway
    109263166 (PLCB2)
   04022 cGMP-PKG signaling pathway
    109263166 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    109263166 (PLCB2)
   04081 Hormone signaling
    109263166 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    109263166 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109263166 (PLCB2)
   04613 Neutrophil extracellular trap formation
    109263166 (PLCB2)
   04621 NOD-like receptor signaling pathway
    109263166 (PLCB2)
   04062 Chemokine signaling pathway
    109263166 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    109263166 (PLCB2)
   04922 Glucagon signaling pathway
    109263166 (PLCB2)
   04929 GnRH secretion
    109263166 (PLCB2)
   04912 GnRH signaling pathway
    109263166 (PLCB2)
   04915 Estrogen signaling pathway
    109263166 (PLCB2)
   04921 Oxytocin signaling pathway
    109263166 (PLCB2)
   04926 Relaxin signaling pathway
    109263166 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    109263166 (PLCB2)
   04918 Thyroid hormone synthesis
    109263166 (PLCB2)
   04919 Thyroid hormone signaling pathway
    109263166 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    109263166 (PLCB2)
   04916 Melanogenesis
    109263166 (PLCB2)
   04924 Renin secretion
    109263166 (PLCB2)
   04925 Aldosterone synthesis and secretion
    109263166 (PLCB2)
   04927 Cortisol synthesis and secretion
    109263166 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    109263166 (PLCB2)
   04270 Vascular smooth muscle contraction
    109263166 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    109263166 (PLCB2)
   04971 Gastric acid secretion
    109263166 (PLCB2)
   04972 Pancreatic secretion
    109263166 (PLCB2)
   04973 Carbohydrate digestion and absorption
    109263166 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    109263166 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    109263166 (PLCB2)
   04725 Cholinergic synapse
    109263166 (PLCB2)
   04728 Dopaminergic synapse
    109263166 (PLCB2)
   04726 Serotonergic synapse
    109263166 (PLCB2)
   04720 Long-term potentiation
    109263166 (PLCB2)
   04730 Long-term depression
    109263166 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    109263166 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    109263166 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    109263166 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    109263166 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109263166 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    109263166 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109263166 (PLCB2)
   05142 Chagas disease
    109263166 (PLCB2)
   05143 African trypanosomiasis
    109263166 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109263166 (PLCB2)
   05016 Huntington disease
    109263166 (PLCB2)
   05017 Spinocerebellar ataxia
    109263166 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    109263166 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109263166 (PLCB2)
   05415 Diabetic cardiomyopathy
    109263166 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    109263166 (PLCB2)
   04934 Cushing syndrome
    109263166 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppad04131]
    109263166 (PLCB2)
Enzymes [BR:ppad01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     109263166 (PLCB2)
Membrane trafficking [BR:ppad04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    109263166 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    109263166 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 Gp58 Sde182_NH-like
Other DBs
NCBI-GeneID: 109263166
NCBI-ProteinID: XP_019298119
Ensembl: ENSPPRG00000009870
UniProt: A0A9V1F941
LinkDB
Position
Unknown
AA seq 1193 aa
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEIEFLD
ITSIRDTRFGKFAKIPKSQKLRDVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGQNWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSSCHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPDQVRGLIDKYEPSAINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLILYQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGRPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKEPGGE
AEGDCPPSASVGEGTAWAGEEGTEPEEEEVEEEEESGSLNEEEIKKMQSDEGTAGLEVTA
YEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSR
IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMR
RPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKL
SPSANSINPVWKEEPFVFEKILMPELASLRVAVMEEGNRFLGHRIIPINALNSGYHHLCL
HSESNMALTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAHDKKSVKLKEAIGVLPE
KPFPPGSPVAGHVNGALAPLSNGSAAHAVALAAAGARAREEAVKEAAEPRTASPEELREL
KGVVKLQRRHEKELRDLERRGARRWEELLQRGAAQLAELGPPGPGGCGGRRLGASKGSRK
KRTPLCEEAAGAAPSEGREGPEGADARAQELKDRLELELLQQGEERYECILKRKEQHVAE
QIAKMMELAREKQAAELKTLKETLETDTKEMKKKLEAKRIERIQAMVKVTSDKMAQERLK
REINNSHIQEVVQTIKQMTENLEKHQEKLEEKQAACLEQIREMEKQFQQEALAEYEARMK
GLEAEVKESVRTCLRDCFPSEAKDKPERSFGAFKELCEQDPLTAKADAQESRL
NT seq 3582 nt   +upstreamnt  +downstreamnt
atgtctctgctcaaccctgtcctgctgccccccaaggtgaaggcttatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaaccacaatagcctccccggttatcctccgcgtg
gatcccaagggctactacttatattggacatatcagagtaaggagatagagtttctggat
atcaccagcatcagggatactcgctttgggaagtttgccaagatacccaagagccagaag
ctccgggatgtcttcaacatggactttcctgacaacaacttcctgctaaagacgctcact
gtggtgtctggccctgacatggtggacctcaccttccacaactttgtctcctacaaggag
aacgtgggccagaactgggctgaagatgtactggctctggtcaagcacccgctgacagcc
aatgcctctcgcagcaccttcctggacaaaatcctggtaaagctcaagatgcagctcaat
cctgaagggaagattcctgtgaagaattttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgccctcagctcctgccacctccccaaaggcaagaatgatgccatcaatcct
gaggacttcccagaatccgtctacaagagtttcctcatgagcctctgtcctcggccagaa
atagatgagatcttcacttcctaccacgccaaggccaagccctacatgaccaaggagcac
ctgaccaaattcatcaaccagaaacagagggactcccgcctcaactctttgctgtttccg
cccgcccggcctgaccaagtgcggggcctcatcgacaagtacgagcccagtgcaatcaac
gtgcagaggggccagctgtcacctgagggcatggtgtggtttctctgtgggccggagaac
agtgtgctggcccaggacaagctgatactctaccaagacatgacacagccactcaaccat
tacttcatcaactcctcacacaacacctacctgacagctggccagttctctggcctttcc
tcggcagagatgtaccgccaggtgctgctggctggctgtcgctgcgtggagctggactgc
tggaagggcaggccccctgacgaggagcccatcatcacccacggctttaccatgaccaca
gacatctatttcaaggaagcaattgaagccattgcagaaagtgcttttaagacctccccc
tatcctgtcatcctgtcatttgaaaaccatgtggactcaccccgccaacaggccaagatg
gctgagtattgccggacgatgtttggggacatgctactcacagagcccctggaaaagttc
ccactgaaaccaggcatccccctgcccagccccgaggatctccgaggcaagatcctcatc
aagaacaaaaagaaccagttttctggcccagcatcccccagcaaggagccgggtggggag
gctgagggcgactgcccacccagtgcctctgtgggtgagggcacagcgtgggctggtgaa
gaaggaacagagccggaggaggaagaggtggaagaggaggaggagtcgggaagcctgaat
gaggaagagatcaagaagatgcagtcagacgagggcacagcgggcctggaggtgacagct
tatgaggagatgtccagcctagtgaattacattcaacccaccaagttcatctcctttgag
ttctctgcccagaagaaccgaagttatgtcatctcctccttcacagagctcaaggcttat
gacctgctctccaaggcctcggtgcagtttgtggactacaacaagcgccagatgagccgc
atttaccctaagggcacccgcatggactcctccaactacatgccccagatgttctggaat
gctggttgccagatggttgccctcaacttccagacgatggacctgcccatgcagcagaac
atggcgctgtttgagttcaatgggcagagtggctacctcctcaagcatgagttcatgcgc
cggccagacaagcagttcaaccccttctcagtggaccgcatcgatgtggtggtagccacc
accctctccattacggtgatctctggccagttcctgtcagaacgcagtgtgcgcacctat
gtcgaagtggagctgtttggccttcctggggaccccaagaggcgctatcgcaccaagctg
tcacccagtgccaactctatcaatcctgtctggaaggaggagccctttgtctttgagaag
atcttgatgcctgagctggcctccctcagggtggctgtaatggaggaaggcaacagattt
cttggacaccgcatcatccccattaatgccctgaattctggctaccaccatctgtgcctg
cacagcgagagcaacatggcccttaccatgcctgcgctttttgtcttcctggagatgaag
gactatgtacctgacacttgggcagatctcaccgtggctcttgccaatcccatcaagttc
ttcagtgcccacgataagaagtctgtgaagctcaaggaagccataggagttctgcctgag
aaacccttcccacccgggagtccagtcgccggccacgtcaatggggcactggccccactg
agcaacgggtctgcagcccacgctgtggctcttgcagcagccggggccagggccagggag
gaggccgtgaaagaagctgcggagccacggaccgccagcccggaggagctgcgggagctg
aagggcgtcgtgaagctgcagcggcggcacgagaaggagctgcgggacctggagcggcgc
ggcgcgcggcgctgggaggagctgctgcagaggggcgcggcgcagctggccgagctgggg
ccaccgggcccggggggctgcgggggccgcaggctcggcgcgagcaagggctcccgcaag
aagaggaccccgctctgcgaggaggccgccggggccgcgccgagcgagggccgcgagggc
cccgagggcgcggacgcgcgcgcgcaggagctgaaggaccgcctggagctggagctgctg
cagcagggcgaggagcggtacgagtgcatcctgaagcgcaaggagcagcacgtggccgag
caaatcgccaagatgatggagctggccagagagaagcaggctgcggaattgaagaccctc
aaggagaccttggagactgataccaaagagatgaagaaaaagctggaggccaagaggata
gagcggatccaggccatggtcaaagtcacctcggacaagatggctcaagaaaggctgaag
agagagattaacaactctcacattcaggaggtggtgcaaaccatcaagcagatgacagag
aacctggagaagcaccaggagaagctggaagagaagcaggcagcttgcctggagcagatc
cgggagatggaaaagcagttccagcaggaggcactggcagagtacgaggccaggatgaag
ggcttggaggccgaggtgaaggagtcagtgaggacctgcctcagggactgcttcccctct
gaggccaaggacaagcctgagagatcctttggggccttcaaggagctgtgtgagcaggac
ccactcacagcaaaggcagatgcccaggagagtcgcctctga

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