KEGG   Panthera pardus (leopard): 109265767
Entry
109265767         CDS       T06062                                 
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad01522  Endocrine resistance
ppad04010  MAPK signaling pathway
ppad04015  Rap1 signaling pathway
ppad04068  FoxO signaling pathway
ppad04071  Sphingolipid signaling pathway
ppad04114  Oocyte meiosis
ppad04148  Efferocytosis
ppad04218  Cellular senescence
ppad04261  Adrenergic signaling in cardiomyocytes
ppad04370  VEGF signaling pathway
ppad04380  Osteoclast differentiation
ppad04517  IgSF CAM signaling
ppad04519  Cadherin signaling
ppad04550  Signaling pathways regulating pluripotency of stem cells
ppad04611  Platelet activation
ppad04613  Neutrophil extracellular trap formation
ppad04620  Toll-like receptor signaling pathway
ppad04621  NOD-like receptor signaling pathway
ppad04622  RIG-I-like receptor signaling pathway
ppad04625  C-type lectin receptor signaling pathway
ppad04657  IL-17 signaling pathway
ppad04658  Th1 and Th2 cell differentiation
ppad04659  Th17 cell differentiation
ppad04660  T cell receptor signaling pathway
ppad04664  Fc epsilon RI signaling pathway
ppad04668  TNF signaling pathway
ppad04670  Leukocyte transendothelial migration
ppad04714  Thermogenesis
ppad04722  Neurotrophin signaling pathway
ppad04723  Retrograde endocannabinoid signaling
ppad04728  Dopaminergic synapse
ppad04750  Inflammatory mediator regulation of TRP channels
ppad04912  GnRH signaling pathway
ppad04914  Progesterone-mediated oocyte maturation
ppad04917  Prolactin signaling pathway
ppad04926  Relaxin signaling pathway
ppad04932  Non-alcoholic fatty liver disease
ppad04933  AGE-RAGE signaling pathway in diabetic complications
ppad04935  Growth hormone synthesis, secretion and action
ppad04936  Alcoholic liver disease
ppad05014  Amyotrophic lateral sclerosis
ppad05020  Prion disease
ppad05022  Pathways of neurodegeneration - multiple diseases
ppad05132  Salmonella infection
ppad05133  Pertussis
ppad05135  Yersinia infection
ppad05140  Leishmaniasis
ppad05142  Chagas disease
ppad05145  Toxoplasmosis
ppad05152  Tuberculosis
ppad05161  Hepatitis B
ppad05163  Human cytomegalovirus infection
ppad05167  Kaposi sarcoma-associated herpesvirus infection
ppad05169  Epstein-Barr virus infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05171  Coronavirus disease
ppad05205  Proteoglycans in cancer
ppad05208  Chemical carcinogenesis - reactive oxygen species
ppad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ppad05415  Diabetic cardiomyopathy
ppad05417  Lipid and atherosclerosis
ppad05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109265767
   04015 Rap1 signaling pathway
    109265767
   04370 VEGF signaling pathway
    109265767
   04668 TNF signaling pathway
    109265767
   04068 FoxO signaling pathway
    109265767
   04071 Sphingolipid signaling pathway
    109265767
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    109265767
   04519 Cadherin signaling
    109265767
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    109265767
  09143 Cell growth and death
   04114 Oocyte meiosis
    109265767
   04218 Cellular senescence
    109265767
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    109265767
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109265767
   04613 Neutrophil extracellular trap formation
    109265767
   04620 Toll-like receptor signaling pathway
    109265767
   04621 NOD-like receptor signaling pathway
    109265767
   04622 RIG-I-like receptor signaling pathway
    109265767
   04625 C-type lectin receptor signaling pathway
    109265767
   04660 T cell receptor signaling pathway
    109265767
   04658 Th1 and Th2 cell differentiation
    109265767
   04659 Th17 cell differentiation
    109265767
   04657 IL-17 signaling pathway
    109265767
   04664 Fc epsilon RI signaling pathway
    109265767
   04670 Leukocyte transendothelial migration
    109265767
  09152 Endocrine system
   04912 GnRH signaling pathway
    109265767
   04914 Progesterone-mediated oocyte maturation
    109265767
   04917 Prolactin signaling pathway
    109265767
   04926 Relaxin signaling pathway
    109265767
   04935 Growth hormone synthesis, secretion and action
    109265767
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    109265767
  09156 Nervous system
   04728 Dopaminergic synapse
    109265767
   04723 Retrograde endocannabinoid signaling
    109265767
   04722 Neurotrophin signaling pathway
    109265767
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    109265767
  09158 Development and regeneration
   04380 Osteoclast differentiation
    109265767
  09159 Environmental adaptation
   04714 Thermogenesis
    109265767
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    109265767
   05208 Chemical carcinogenesis - reactive oxygen species
    109265767
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109265767
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    109265767
   05161 Hepatitis B
    109265767
   05171 Coronavirus disease
    109265767
   05163 Human cytomegalovirus infection
    109265767
   05167 Kaposi sarcoma-associated herpesvirus infection
    109265767
   05169 Epstein-Barr virus infection
    109265767
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109265767
   05135 Yersinia infection
    109265767
   05133 Pertussis
    109265767
   05152 Tuberculosis
    109265767
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    109265767
   05140 Leishmaniasis
    109265767
   05142 Chagas disease
    109265767
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    109265767
   05020 Prion disease
    109265767
   05022 Pathways of neurodegeneration - multiple diseases
    109265767
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109265767
   05418 Fluid shear stress and atherosclerosis
    109265767
   05415 Diabetic cardiomyopathy
    109265767
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    109265767
   04932 Non-alcoholic fatty liver disease
    109265767
   04933 AGE-RAGE signaling pathway in diabetic complications
    109265767
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    109265767
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppad01001]
    109265767
Enzymes [BR:ppad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     109265767
Protein kinases [BR:ppad01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   109265767
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase
Other DBs
NCBI-GeneID: 109265767
NCBI-ProteinID: XP_019302838
Ensembl: ENSPPRG00000024827
UniProt: A0A9V1FH94
LinkDB
Position
Unknown
AA seq 367 aa
MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMHYTQTVDIWSAGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPDEFVQRLQSAEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAERRV
TAAEALTHPYFESLQDTEDEPKAQKYDESFDDVDRTLDEWKRVTYKEVLSFKPPRQLGTK
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctccccgccgcccgcccgcaagggcttttaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtgtaccaggacctgcagcccgtgggctccggcgcgtacggcgcc
gtgtgctcggccgtggacagccgcaccggtgccaaggtggccatcaagaagctgtaccgg
cccttccagtccgagctgttcgccaagcgcgcctaccgcgagcttcgcctcctcaagcac
atgcgtcacgagaacgtcatcgggctgctggacgtgttcactcctgacgaaaccctggat
gatttcacagacttttacctggtgatgccgttcatgggcaccgacctgggcaaactcatg
aagcacgagaagctgagcgaggaccgaatccagttccttgtctaccagatgctgaagggg
ctaaagtacatccatgctgctggcatcatccacagggacctgaagcctggcaatctggca
gtgaatgaggactgtgagctgaagatcctggacttcggcttggccaggcaggccgacagc
gagatgactgggtacgtggtgacccggtggtaccgtgcacctgaggtcatcttgaattgg
atgcactacacccagacggtggacatctggtcagcgggctgcatcatggcagagatgatc
acagggaagacgctgttcaagggcagtgaccacctggaccagctgaaggagatcatgaag
gtgacagggactcctcccgatgaatttgtgcagaggctgcagagtgccgaagcgaagaac
tacatgaagggcctccccgagttggagaagaaggattttgcctccatcctgactaacgca
agtcctctggctgtgaacctcctggagaaaatgctggtactggatgccgaacggcgggtg
actgcggccgaggcgctcacacacccctacttcgagtcactgcaggacacggaggatgaa
cccaaggcccagaagtacgacgagtcctttgacgatgtggatcgcacgctggacgagtgg
aagcgtgtcacatataaggaagtgctcagcttcaagcctccccggcagctggggaccaag
gtgtccaaggagacagcgctgtga

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