Panthera pardus (leopard): 109267979
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Entry
109267979 CDS
T06062
Symbol
EGFR
Name
(RefSeq) epidermal growth factor receptor isoform X1
KO
K04361
epidermal growth factor receptor [EC:
2.7.10.1
]
Organism
ppad
Panthera pardus (leopard)
Pathway
ppad01521
EGFR tyrosine kinase inhibitor resistance
ppad01522
Endocrine resistance
ppad03272
Virion - Hepatitis viruses
ppad04010
MAPK signaling pathway
ppad04012
ErbB signaling pathway
ppad04014
Ras signaling pathway
ppad04015
Rap1 signaling pathway
ppad04020
Calcium signaling pathway
ppad04066
HIF-1 signaling pathway
ppad04068
FoxO signaling pathway
ppad04072
Phospholipase D signaling pathway
ppad04144
Endocytosis
ppad04151
PI3K-Akt signaling pathway
ppad04510
Focal adhesion
ppad04520
Adherens junction
ppad04540
Gap junction
ppad04630
JAK-STAT signaling pathway
ppad04810
Regulation of actin cytoskeleton
ppad04912
GnRH signaling pathway
ppad04915
Estrogen signaling pathway
ppad04921
Oxytocin signaling pathway
ppad04926
Relaxin signaling pathway
ppad04928
Parathyroid hormone synthesis, secretion and action
ppad04934
Cushing syndrome
ppad05160
Hepatitis C
ppad05163
Human cytomegalovirus infection
ppad05165
Human papillomavirus infection
ppad05171
Coronavirus disease - COVID-19
ppad05200
Pathways in cancer
ppad05205
Proteoglycans in cancer
ppad05206
MicroRNAs in cancer
ppad05207
Chemical carcinogenesis - receptor activation
ppad05208
Chemical carcinogenesis - reactive oxygen species
ppad05210
Colorectal cancer
ppad05212
Pancreatic cancer
ppad05213
Endometrial cancer
ppad05214
Glioma
ppad05215
Prostate cancer
ppad05218
Melanoma
ppad05219
Bladder cancer
ppad05223
Non-small cell lung cancer
ppad05224
Breast cancer
ppad05225
Hepatocellular carcinoma
ppad05226
Gastric cancer
ppad05230
Central carbon metabolism in cancer
ppad05231
Choline metabolism in cancer
ppad05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ppad00001
]
09120 Genetic Information Processing
09125 Information processing in viruses
03272 Virion - Hepatitis viruses
109267979 (EGFR)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
109267979 (EGFR)
04012 ErbB signaling pathway
109267979 (EGFR)
04014 Ras signaling pathway
109267979 (EGFR)
04015 Rap1 signaling pathway
109267979 (EGFR)
04630 JAK-STAT signaling pathway
109267979 (EGFR)
04066 HIF-1 signaling pathway
109267979 (EGFR)
04068 FoxO signaling pathway
109267979 (EGFR)
04020 Calcium signaling pathway
109267979 (EGFR)
04072 Phospholipase D signaling pathway
109267979 (EGFR)
04151 PI3K-Akt signaling pathway
109267979 (EGFR)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
109267979 (EGFR)
09144 Cellular community - eukaryotes
04510 Focal adhesion
109267979 (EGFR)
04520 Adherens junction
109267979 (EGFR)
04540 Gap junction
109267979 (EGFR)
09142 Cell motility
04810 Regulation of actin cytoskeleton
109267979 (EGFR)
09150 Organismal Systems
09152 Endocrine system
04912 GnRH signaling pathway
109267979 (EGFR)
04915 Estrogen signaling pathway
109267979 (EGFR)
04921 Oxytocin signaling pathway
109267979 (EGFR)
04926 Relaxin signaling pathway
109267979 (EGFR)
04928 Parathyroid hormone synthesis, secretion and action
109267979 (EGFR)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
109267979 (EGFR)
05206 MicroRNAs in cancer
109267979 (EGFR)
05205 Proteoglycans in cancer
109267979 (EGFR)
05207 Chemical carcinogenesis - receptor activation
109267979 (EGFR)
05208 Chemical carcinogenesis - reactive oxygen species
109267979 (EGFR)
05230 Central carbon metabolism in cancer
109267979 (EGFR)
05231 Choline metabolism in cancer
109267979 (EGFR)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
109267979 (EGFR)
09162 Cancer: specific types
05210 Colorectal cancer
109267979 (EGFR)
05212 Pancreatic cancer
109267979 (EGFR)
05225 Hepatocellular carcinoma
109267979 (EGFR)
05226 Gastric cancer
109267979 (EGFR)
05214 Glioma
109267979 (EGFR)
05218 Melanoma
109267979 (EGFR)
05219 Bladder cancer
109267979 (EGFR)
05215 Prostate cancer
109267979 (EGFR)
05213 Endometrial cancer
109267979 (EGFR)
05224 Breast cancer
109267979 (EGFR)
05223 Non-small cell lung cancer
109267979 (EGFR)
09172 Infectious disease: viral
05160 Hepatitis C
109267979 (EGFR)
05171 Coronavirus disease - COVID-19
109267979 (EGFR)
05163 Human cytomegalovirus infection
109267979 (EGFR)
05165 Human papillomavirus infection
109267979 (EGFR)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
109267979 (EGFR)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
109267979 (EGFR)
01522 Endocrine resistance
109267979 (EGFR)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ppad01001
]
109267979 (EGFR)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
ppad04147
]
109267979 (EGFR)
Enzymes [BR:
ppad01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
109267979 (EGFR)
Protein kinases [BR:
ppad01001
]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
109267979 (EGFR)
Exosome [BR:
ppad04147
]
Exosomal proteins
Exosomal proteins of colorectal cancer cells
109267979 (EGFR)
Exosomal proteins of pancreatic cancer cells
109267979 (EGFR)
Exosomal proteins of bladder cancer cells
109267979 (EGFR)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
GF_recep_IV
Pkinase
Furin-like
TM_ErbB1
Kinase-like
ABC1
Borrelia_P83
Motif
Other DBs
NCBI-GeneID:
109267979
NCBI-ProteinID:
XP_019306584
Ensembl:
ENSPPRG00000000798
UniProt:
A0A9V1FPH4
LinkDB
All DBs
Position
Unknown
AA seq
1207 aa
AA seq
DB search
MRPSGTAGAALLLLLAAHFQASPALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYMQRNYDLSFLKTIQEVAGYVLIALNTVEKIPLENLQIIRGNVLYENTHALS
VLSNYGTNKTGLRELPMRNLHEILQGAVRFSNNPVLCNVETIQWRDIVDNDFISNMSMDF
QNHVGNCQKCDPGCPNGSCWGPGKENCQKLTKIICAQQCSGRCRGRSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACSSDSYEVEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPKELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIVSGNQKLCYANTINWKKL
FGTSSQKTKIINNKDEKGCKAIGHVCHPLCSSEGCWGPEPKDCVSCQNVTRGKECVEKCN
VLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDSCVQCAHYIDGPHCVKTCPAGIM
GENNTLVWKFADANRMCHLCHSNCTYGCSGPGLEGCATDGPKIPSIATGIVGGLLLVVVV
ALGVGLFLRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISTILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQ
QGFFHSPSTSRTPLLSSLSATSNNSTVTCIDRNGSCPLKEDSFLQRYSSDPTGTLTEDNM
DDTFLPAPEYINQAVPKRPAGSVQNPVYHNQPLNPAPGRDPHYQNPHSNAVDNPEYLNTH
PTCVNSVLDSPTLWAQKGNHQISLDNPDYQQDFFPKEAKSNGIFKGPAAENADYLRVAPP
SSEFIGA
NT seq
3624 nt
NT seq
+upstream
nt +downstream
nt
atgcgaccctccgggaccgcgggagccgcgctcctgctgctgctggctgcgcacttccag
gcgagtccggcgctggaggagaagaaagtttgccaaggcacaagtaaccggctcacccag
ttgggcacttttgaggaccactttctcagcctgcagaggatgtttaataactgtgaggtg
gtccttgggaatttggaaatcacctacatgcaaaggaattatgacctttccttcttaaaa
accatccaagaggttgccggctatgtactcattgccctcaacacagtggagaagattcct
ttggaaaacctgcagatcatccgaggaaatgtgctctatgaaaacacccatgccttatcc
gtcttatccaactatggcacaaataaaaccggactgcgggagctgcccatgagaaactta
catgaaatcctgcaaggcgctgtgcggttcagcaacaaccctgtcctctgcaacgtggaa
accatccagtggcgggatatcgttgacaacgatttcataagcaacatgtcgatggacttc
cagaaccacgtgggcaactgccaaaagtgtgatccaggatgtcccaatggaagctgctgg
ggtcctggaaaggagaattgccagaaattgaccaaaatcatctgcgcccagcagtgttcc
gggcgctgccgcggcaggtcccccagcgactgctgccataaccagtgtgctgccggctgc
acggggccccgagagagcgactgcctggtctgccgcaagttccgggatgaagccacgtgc
aaggacacctgcccgccactcatgctctacaaccctaccacctaccagatggacgtcaac
ccagagggaaaatacagctttggtgccacctgtgtgaagaaatgcccccgtaactatgtg
gtgacagaccacggttcgtgtgtccgtgcctgcagttctgacagctacgaagtggaggaa
gatggcgtccgcaagtgtaaaaagtgtgaggggccttgccgtaaagtttgtaatggaata
ggaattggtgaatttaaagacacactttccatcaatgctacaaatattaaacacttcaaa
aattgcacctcgatcagtggagatcttcatatcctgccagtagcatttagaggtgactcc
ttcacgcatactccacctctagatccaaaggaactggatattctaaaaactgtaaaggaa
attacagggtttttgctgattcaggcctggcctgaaaacaggactgacctccatgctttc
gagaacctagaaatcatacgtggaagaacaaagcaacatggtcagttttctcttgcggtt
gtcggcctggacataacgtccttgggattacgctccctcaaggagataagtgatggagat
gtgatcgtttcaggaaaccaaaaattgtgctatgcaaatacaataaactggaaaaaactg
tttgggacttcaagtcagaaaaccaaaattataaacaacaaagatgaaaaaggctgcaag
gccataggccatgtctgtcatccattatgctcgtcagagggatgctggggcccggagccg
aaagactgcgtgtcctgccaaaacgtcacccgtggcaaggagtgtgtggagaagtgcaat
gttctggagggggagccaagggagtttgtggagaattccgagtgcatacagtgccatcca
gaatgcctgccccaggccatgaatatcacctgcacaggacgaggaccagacagctgcgtg
cagtgtgcacactacatcgacggccctcactgcgtcaagacctgcccggctggcatcatg
ggagaaaacaacaccctggtctggaagtttgcggatgccaatcgcatgtgtcacctgtgc
cattcaaactgtacctacggctgttctgggccaggtcttgaaggctgtgcaacagatggg
cccaagatcccatccatcgccactgggattgttgggggcctcctcttggtggtggtggtg
gcccttggggtgggcctctttctgcgccgacgccacatcgtccgcaagcgcacacttcgc
agactgctgcaggaaagagagcttgttgagcctcttacgcccagcggagaagctcccaac
caagctctcttgaggatcttaaaggaaacagaattcaaaaagatcaaggtgctgggctct
ggagcatttggcacagtgtacaagggactctggatcccagaaggtgagaaggttaaaatt
cccgtggccatcaaggagttacgagaagccacatctccaaaagccaacaaggaaatcctt
gatgaagcttacgtgatggccagtgtggacaatccccacgtgtgccgcctcctgggcatc
tgcctgacgtccacggtccagctcatcacacagctcatgcccttcggctgcctcctggac
tatgtccgcgagcacaaggacaacattggctcccagtacctgctcaactggtgtgtgcag
attgcgaagggcatgaactacctggaagaccggcgcttggtgcaccgtgacctggcagcc
aggaatgtcctggtgaagacgccacagcatgtcaagatcacagattttgggctggccaaa
ctgcttggcgccgaggagaaagaataccacgcagaaggaggcaaagtgcctatcaagtgg
atggctttggaatcaattttacaccgaatttacacccaccaaagtgacgtctggagctat
ggagtcaccgtttgggagttgatgacctttgggtctaaaccttacgacggaatccctgca
agtgagatctcgaccatcctggagaaaggagagcgcctcccgcagccacccatatgcacc
atcgatgtctacatgatcatggtcaagtgctggatgatagatgcagacagtcgcccgaaa
ttccgtgagttgatcattgaattctccaaaatggcccgagacccccagcgctaccttgtc
atccagggagatgagagaatgcatctgccaagccctacagactccaatttttaccgcgcc
ctgatggacgaagaagacatggaagacgtcgtagatgccgatgagtacctcatcccccag
caaggcttcttccacagcccctccacatcccggacccccctcctgagttctctgagtgcc
accagcaacaattccaccgtgacttgcatcgatagaaatgggagctgccccctcaaggaa
gacagcttcttgcagcggtacagctcagaccccactggcaccttgactgaggacaacatg
gatgacactttcctcccggcacctgaatacataaaccaggctgttcccaaaaggcctgcg
ggttccgtccagaaccccgtctatcacaatcagcctctaaatccagctcctggcagagac
cctcactaccaaaatccccacagcaatgcagtggacaaccctgagtatctcaacacccac
cccacttgcgtcaacagtgtgctcgacagccccaccctctgggcccagaaaggcaaccac
cagattagcctggacaaccctgactaccagcaggacttctttcccaaggaagccaagtca
aatggcatctttaagggtcctgcagctgaaaatgcagactacctaagggttgcaccgccc
agcagtgaatttattggagcatga
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integrated database retrieval system
