Panthera pardus (leopard): 109268343 Help Entry 109268343         CDS       T06062                                  Symbol SYNE2 Name (RefSeq) nesprin-2   KO K19346   nesprin-2 Organism ppad  Panthera pardus (leopard) Pathway ppad04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:ppad00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     109268343 (SYNE2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:ppad03036]     109268343 (SYNE2) Chromosome and associated proteins [BR:ppad03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     109268343 (SYNE2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  CH Spectrin_SYNE1 KASH Spectrin SYNE1 CAMSAP_CH TetR_C_29 Motif Other DBs NCBI-GeneID:  109268343 NCBI-ProteinID:  XP_019307133 Ensembl:  ENSPPRG00000005719 LinkDB All DBs Position Unknown AA seq 6910 aa AA seqDB search MASSPVLPTEDEQVSLGIDGRHITLQAEQEDTQKKTFTCWINSQLAKRTPPSVVSDLFAD IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLKNRSIKLINIHVTDIIDGN PSIILGLIWTIILHFHIEELARTLSCNYNQPSLDSVSVADSSPTSSPPAKKCSKAQERWQ MSAKKALLLWAQEQCAPCESVSVTDFKSSWRNGMAFLAVIHALRPDLIDMNTVKHRSNKD NLKEAFGIAEREFKIPKLLEPEDVDVVNPDEKSIMTYVAQFLRYSKDASGTGAVAQGKVK DAVVWLTLQEKKLQKLLTDSENETCSKKYDSLLSFLESFNEGKEPFLDILPIERNLDELN EDQLQLREVWDGLNYQINVWKRELNDALPSPLHQIEAWLQEVEELIDEDLPASQDYCEAV ALIQEKMTLIKNLMDKFDCHSHTLLAFENRDEKNLPLVSPKKLEEMKARINNISGEKFIP LLEFHYYKCTVLGLLDEVKSKLDVWNVKYGNKESVELLLEDWHKFIEEKEFLAQLETSLQ KCEEIHKNLDGEYQDISKQYMAVEYDICMYRKSIYNVKSTLQKVLTCWATYLEKLRLLKA CFEETKKEQIKEIPFETISQWSVEHTTLNEVGNFLIQVSNDELGSSISKELRRLNKRWRK FITKTQLEMKLPLRKKQDQPIFDNYENTQLREEEKPTVDFSMDMSIELPESHNQHVKAGE GHEKENEFTGQLKVAEDVEKLIEQVEIWEAETESLLELLRCHEGVDASVEESLQHLIAKG SMYEELVSRIEDTLQMDVQNISSQESLQHVLTVGLQTKIQEAKEKVQISMVKLVSVLKNS ADASPDLDVRLKMEESQRELESYMTRAEQLLGQRESRSGLISKYKEALIILNSKSLVKYL KAVEELKNDVTEGIKLSLEEESRRVCAKWESLHHEMSLYIQQLKIDIEKGKLSDSISKLE KQINKEKKLIRRGRTKGLIKEHEACFSEEGGLYQLHHHMDVLRELCEELTSQKSQQEVRR ALKDYEQKIERLRKCASEIHGALQPAVGGVSKNKEPMSTSENGGRNAHSEVPSANSDNQP SAEQAMGSTKNFSLESELKPQQEESVMEKYEKGHDASVRSLQERYDTHRENLELCLQNNK FRIISDFSSDVVRSSACLQAKLTDLQVLENETDSCWKEFEITSLKLEELESDVKKPFIRE ARDRLKEKEREFQMTLNTRMESLETALKIVLPVEKESLLLCGSDLLLHEMAIQEFHLIDA DGIYQNLRNIQDSIIKQIEICNNLEQWGDFALKELHPLDLHATKNIILKHRTQLDETNHK VQSCKDALKALEDFLASLKTAELPFELVTDLSASDTQVVPENTLTIENKEGETNLMKDKA RHLDERLKMLGISFKDAERGDDTCEKLVDALSKKLFETHGYGVQEEFTEDKLLETCTFKN NELLKNIQDVYNQISKISLKDPTAPAVKQRKKSLMKLDKDLDEYEEEKKCLQEMVNSLPQ FRDGREKSLNQQCQNTALLWENTKASVTECLDQCERVLELLKQYQNFKSVLTTLIQKEEN VISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCRNLQFHLNKMRSFEEPPF EKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKVLRKVELHQLTE EEREKLKEELQVHEQKSSEFSKRVAKIQFLLQSSETPLELQVMESSVLNKIENVKMHLTG ESNCSALSGHTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHS MMLLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFGNIKM NLKECFESSETKKSVEEKLQKLSDFLTLEGRGSKTQQVGTVLSHVKKHLPKAHVKELHSW IINQEIELEKMESICQARTKELNACLQQLLSLQDDHRNLSTWLTSQEEKWKALEKPGEKT ELFCEAVARKREQFESMAQLNNSLKEYGLTEEEEIIMESTHLIDRYQTFLRQLCEIDEED KLPPTEDQSFNDLAHDVIHWIAGIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDAK IQTIMSQAESSKAPLAPKTLTDIKNQWDNTIHLANTYLSHQEKLLLEGEKYLQSKEDLRL MLTELKKKQEVGFALQHGLQEKKAQLKIYKKFLQKAQDLTSLLKELKSQGSYLLECTKNP NFSEEPWLEIKHLHESLLQQLQDSVQKLEGHVQEHHSYQVCVTDLNTTLDNLSKELASFS DKPLDQIATEEKLQKLQELENRLSLQDGTLEKILALAKSIKKNTSSVGQKIIKDDIKSLK CKQKDLENRLESAKQETENCLHSILQSKRSAEQKEKFSLPGREEEVTCDVQESTQDSAVL EKLEQDWEINKNSAVEMVLSKQLSLNVQESMKNTDDEHKVNELQNQPLELDVVLRNEQLK EIEELYAQLDAKKSAIEPLEQTEYLNKAETSALVLHNAGYSVNYLDNLLQALITLKKNKE SQYCFLKDFQERLAAIESSVKALLTEKESLKVGPLDSAAYLDKMKNYLASIEKEKDSLSK MKIEWENLSKCVTDMDKKVLESQIQQLARSWEQVQQLAQKKYSQQVAENDEFILFMRKIQ DLDVSLQQQQQLGLNSPEEQEGSPGTVALATELRAIKQRFLALKGQAEFQMERIWGEKEK NTLEDAMNNLQKRLEASEPLNTEVENQIKMCETRTRMREIILWVKNLLGELAPTISLLPD DILSQIRKCKMTHDGILDKHQAVESLVEEVKDNTPNLPADESNDLNHLLQDLQNQYQMLV LKSTERSQQLEFKLEERSRFFAVIEKVQLSLQENEALINPKMKTASTETELEHERVTLMS SQKELQEAESVILTHLREQTDICKDLNVFERLFLDDQLKNLKARAHRTQRLIQSKCNEVE RKIHFYREFHEKTSVLQKEVDHIRHNELLLNQEINQDVEKELCGLKDRLTGIQSSILQVR KLKEVFECIGLSWDGSQLDQLHTQVVEKEKELEEKIKQLADHVADRGRYQASLSKLRAMD LQIKKRAEAVLEMPQTSPESSLLDAQILNRRIEKAMCLCQEILKTLNESKAFDDTFKEKE MPRIKLYAEENDKLRKVLQNSILKSQPKEVNEQNFQDKLEDSLHVLKQIKSQLEQPLLIN LDIEHIQNEKDNCEAFQEQVQAEMDSVKAVTIIEKQREENSSGANDVEAKLRDIEDLHMQ LATSLDLRTDVLNDAYESLTRYNEAVTRAMGILTAREAIIASRRIDLADPEESLEISHWK QEELQSTIADIQDLTEKLGIVSSPEAKQQLQCTIHGLVLKDSAVREAAKIKEAEIEGCLE NYKCYRKIKEKICTHLSQMETVLGQSMFPLPVSYKEALERLEQSKALGSNLTSTKEELMK LRRVHRHIRPVCTDSDDVCLLRTTSALWDKWLSLLEAAKEWEIWCEELKWEWKFVSEEVS RWFILESDLQEQVYFSSXTKEAATTEELCELLDCLCRYQENVEKQQLLLTLLLQRLRSIQ NAPQSLQAIETGPAFQEITSMQERCNKLFQKAQENKELVENETQERHSFTKEIITLKNLF QQTATSFQNMELHDHPEKAEQFEELQSIFKKEKLTFENIMEKLRIKYSEMYTLVPAEIES QVEECRKALEDIDEKISSEVLKSSPSYTMSRKIDEINKGLHNVEKMLQQKSKNIEKAQEI QKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQ LNKAILKMEAYHDLLKSTEAWTENTSRLLANPADYDSSKMLSQHASTLQMALEDSEQKHN LLHSVFTDLEDLSIIFETDDLAQSVQELSRQVADLQQKIMESLPQIQRMADDVVAIETEV KSMDKKVSKIKAILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQT GMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKIVIKQTNECNEEIENLKQILNNYSAEF SHEHISPDQTANLPQVQGEIEGMEQQILSLNQKKEDLLVDLKAAILNLHQHLQRDQQELE QEMPSTRTSEEEGVAEREGSEWKLNKSSMSFLPALKEEAEESSLKSENGEKTAERSSGSW SLLCKHDQDMEEDRASSSSGTIIQEATEKISTCENAMAQVLAPDSVNAEQGPEFSLSPNQ TEEGATRPLKAAALGFSDKHGDFEATVEKPGLKPADILHACKTQVAELELWLHQANVAFE PETLNADMQQLVEQQLVGCQAMLTEIEHKVASLLESCKDRGPGDSGATHQEAEALSLKLK TVKCNLEKVQIMLQEKYSEDQHSATLKKPSEHQNDLQPDNLSELEPVVSERPQFSRQKDF QQQQVLELKPTEQKDFIKFVEFNAKKIRPQFCQPDKDTTQKSSESIKASSPAKDAPDSVL STQGQSGDKWQYLRHELSSKIGLPLPQLVQPQVATNMSILPSVSVYNFRYPTTEELKTYT TQLEDLRQEANNLQTQENMTEETYINLDKKLFELFLTLSQCLASVEEMLQTPGLFREDVC ARQVHYETLALELKKLYLAMGDKKDDLLKAMTWCGKNADLFHECFNNLQVYLEHTQATAA SRSKSLKAGLDYNRSYQNEIKRLYDQLTKNKTSLQQSLNEISGQSIDEQLQKADAYTVEL QNSESRVAKLRDEGERLRLPYVLLQEVYKLEDVLDSMWGILRARYTELSSPFITESQQDA LLQGMVELVAIGKEKLAHDHLKQPKSKDALQAQIQNHKLFFQKLVADMLLIQTYSNRMPP SLLQKKDTFWAEQIQEIKLLEEKSHQRGIKLQSLLQKWEEFDENYASLEKDLEILVSTLP SVSLVEETEERLVERISFYQQIKRNIDEKHARLYQTLNEGRELVASVSCPELEGQIAKLE EQWLALNKKIDHELHRLQTLLKHLLSYNRDSDQLTKWLESSQQTLNYWKEQSLNVSQDLD TIRSNINSFFEFSKELDDKSSLKTAVISTGNQLLHLKEADTATLRASLAQFEQKWTALIT QLPDIQEKLHQLQMEKLPSRKAITEMISWLNGVEHQTADEDCEHSLSSASQVKNLLQKYK EFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRMHGTLNRKI QHLEQLLESITETENKIQILNNWMEAQEERLKTLQKPGSVISVHRMLLDCQDIENQLASK SKALDELRQCYLTSESGTMPLLEDTASRIDGLFQKRSSVISQVNELKTSTQSVLQEWKIY ESLYDEVATMTIRFWYCMEHSKPGFLSLEALGCQVQNLQSLQDEAESSEASWEKLQEVIR KLKDRCPSVAEIIEEKCQNTHARWTQVNQDIAEQLQKAQSLLQLWKAHNSAHTEAAARLE QQEAKYQQLENINMSGNNLAEILTRALQDVKELQDDVQKTKEAFLQNSALLDRLPQLTES STHVPLSTQLHSLQRVSYLEKMLLVKANEFEFVLSQFKDFGERLESLKGLITHEEEHLDK LYHQEKEENPELFLNHVLALTAQSPDVEHLNEISLKLPLSDIAIKTLQNVNRQWIRATAT ALERCSELQATGLNEKFLYCCEKWVQLLEKTEETLKVTMADSLPALLEQQKTYEMLEAEV SINQTVADSYVTQSLQLLDTTEIEKRPEFVSKFTKLKERWQSAAQSLRQRKSHIDGLVGR WRHFTTAAEDLLRFLANTGPLLSAAKSQDCHSLPQTRRLIRELKSKDIHFQRRHITYALT LEAGEKLLNAASLETKELIDKKISQLQDNWKDTKLQVGEMITQLQNNIETWDQCEKKIKE LKSRLKVLKAQSRDPLPELHEDLHKEKELIKELEKSLANWTQNLKELHTLKTDLTQHILA EDVMVLEEQTEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVL QTADLSIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKTRAAEIDDKLNKIND RWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQK RLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNIC AMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAAYPNSSEVLYTNAKEELKRFEA FQRQIHERLTQLELINKQYRRLARENRTDTASKLKQMVHEGNQRWDNLQKRVTAVLRRLR HFTNQREEFEGTRESVLVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKID QLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSRAPGLEDEKEAS ENETDMEDPREIQADSWRKRRESEEPSSPQSLCHLVPPAPGPERSGCETPVSVDSIPLEW DHTGDVGGSSSHEDDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISEDHSWHV PDSPSCPKHRYKQMGSDRNVQTIPSDSSTPYKPAYVKLLLSPGTDGGKEGARALNGSSQQ EDEGLAALTGQQSGAFDRWELIQAQELHNQLRMKQNLQQLNSKISDITTWLKKTEAELET LKMAEPPSDIHEMELRVKQLKEILKAFDTYKALVVSVNMSSEEFLQTESAESKELQGRVG QLALHWDAAQGAVESWRAGLRRALVQCQDFHQLSQDLLLWLASAESRRQKARVTDPEADP QVLLECQEELMQLKNELVEREPQVNTLQELSNSLLIKGHGEDYIEAEEKVHVIEKKLKQL LEQVSQDLMSLQGSQNPDPSLPSLDEVDSGDEPPAASTPAPQAKFGAERMTKDQNKADSR VPGPGSSRPRRSFLARVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM LRYTNGPPPT NT seq 20733 nt NT seq  +upstreamnt  +downstreamnt atggcgtctagtcctgtgcttcccaccgaggatgaacaggtctccttgggcatcgatggt cgccatattacactgcaagctgagcaggaagacactcagaagaaaaccttcacctgctgg ataaactcacagttggcaaagcgcactcctccctcggtcgtgtcagacctatttgcggac attaaaaaggggcatgtcctcctggacttgctagaagtactctcaggacaacagttgcct cgagacaaaggatctaatacctttcagtgtagaatcaatatagaacatgccctgacattc ctaaaaaaccgatcaatcaagctaataaatattcatgtcaccgatattatagacggaaac ccatccatcattcttggcctaatttggacaattatactgcactttcatatcgaagagctt gcccggactctttcttgcaattacaatcaaccttccttggacagtgtgagtgtggctgac tcatctcctacctcaagtcctccagccaagaaatgctccaaagcccaagaaagatggcag atgtctgcaaagaaggctcttctcttgtgggctcaggagcaatgtgccccgtgtgagtct gtcagtgtgacagattttaagtcaagctggagaaatgggatggcttttttggctgtcatt catgccttgcgaccagacctaattgacatgaatacagtgaagcatagatccaacaaagac aatctgaaagaggcctttggaattgccgaacgggaatttaaaatccccaagttgctagaa ccagaagatgtggacgttgttaatcctgatgaaaagtcaatcatgacttatgtggcacaa tttctacggtattcgaaggatgcatctgggactggagctgtagctcagggaaaggtgaaa gatgctgtggtctggttaactctacaagagaaaaaactacagaaattgctaacggattca gaaaatgagacctgctctaaaaagtatgatagcctgctgtcctttttggagtccttcaat gaaggaaaagagccctttttggacatcctgccaatagaaaggaacttggatgagctgaat gaagatcagttacagttgagagaagtctgggatggcctcaactaccagattaatgtgtgg aaaagggagctgaatgatgccttgccctcaccactgcatcaaatcgaagcctggctccag gaggtagaggagcttatcgatgaagatttgccagcttcccaggattattgtgaagccgtg gctctaatacaagagaaaatgactttaatcaagaatctgatggataaatttgattgtcat tcgcatactcttctggcatttgaaaatagagatgaaaaaaatttgccactggtatcacct aagaaattggaggaaatgaaagcacgaatcaacaacatttcgggcgaaaaattcattcca cttctagaatttcattactataagtgcacagttcttggtttgctagatgaagtaaaatcc aaattggatgtttggaacgtcaaatatgggaacaaagaatctgtggaattgttgctggaa gactggcataaatttattgaagaaaaagagttccttgctcaacttgaaacttccttgcaa aagtgtgaagaaatacataagaatttagatggagaatatcaggatattagcaaacaatat atggcagtggaatatgatatttgtatgtatagaaaaagtatatataatgtcaagtccact cttcagaaagttttgacatgttgggctacttatctggaaaaacttcgcttactaaaggct tgttttgaggagacaaagaaggaacagattaaagagattccctttgagacaatatcccag tggagtgtagaacatactactttaaatgaagtgggaaatttcctaattcaagtcagtaat gatgaacttggatcatctatttctaaagaactgagaaggctgaataaaagatggagaaaa tttattacaaaaactcaacttgaaatgaaacttccacttagaaaaaaacaggatcagccc atttttgacaattatgaaaatactcagctacgtgaagaagaaaaaccaactgttgatttt tcaatggatatgtcaatagaacttcctgaaagtcataatcagcatgtaaaggctggggaa ggacatgaaaaagaaaatgaattcacagggcaactcaaagtggctgaagatgttgaaaaa ctcattgaacaagtggaaatctgggaggcagaaactgaatctcttctggagcttctgaga tgtcatgagggtgtagacgcctcagtggaagaatctttgcagcatcttattgccaaaggc tctatgtatgaagagcttgtgtctagaattgaagataccttacaaatggatgtgcaaaat atttccagccaggagtcccttcaacatgttctcacagttgggcttcagacaaagattcaa gaagctaaagagaaagttcagatcagtatggtgaaattagtttccgtgttgaaaaactca gctgatgcttccccagatctggatgtcaggctgaaaatggaggagtcacagagggaactt gaatcatacatgacaagggctgagcaattacttggacaaagagagagccggagtggacta atttcaaaatacaaggaagcactaataattctaaattctaaaagtctggtcaagtatttg aaagctgttgaggaactgaaaaatgatgtaactgagggtataaagctgtctttggaagaa gagagtagacgtgtctgtgccaagtgggagtctcttcatcatgagatgtctttgtatatt caacaactgaaaatagacattgaaaaaggaaaactcagtgacagtatttcaaaacttgaa aaacaaataaataaagaaaagaaactaattcgcagaggaaggaccaagggtctcatcaag gaacatgaggcctgcttttctgaggaaggcggtctgtaccagctccaccaccacatggac gtcctgcgggagctgtgtgaagagctgacttcacagaagagtcaacaagaagtgaggaga gccctgaaagattatgaacagaagatagaaagacttcggaaatgtgcttccgagattcac ggggcgctgcagcccgcggtgggaggcgtgtcgaaaaacaaggagcccatgagcacatct gagaacggaggaaggaatgcccacagcgaggtgccatctgcaaactcagataatcagcca tcagctgaacaggcaatgggatcaactaagaattttagcctggaatctgagttaaagcct caacaggaagaaagcgttatggagaagtatgagaagggtcacgatgcgtctgtccgtagt ttacaagagaggtatgatacacacagagaaaatcttgagctgtgcctgcaaaacaacaaa ttcagaattatttctgatttctccagtgacgtagtaaggagtagtgcttgtcttcaggct aaactgacagatctacaggtcttagaaaatgaaactgattcctgctggaaggagtttgaa atcacttcactgaagttagaagagcttgagagtgatgtaaagaagccctttatacgcgag gcaagagacagattaaaagaaaaagaaagagagtttcagatgactcttaataccagaatg gaatctttggagactgcgctgaagattgtgttacctgtggagaaggaatcacttctcctc tgtggctcagacctgctcctccatgaaatggccattcaagaatttcatctcattgatgct gatggcatttatcaaaacctgaggaatatccaagattccatcataaaacagattgaaata tgtaataatttggaacagtggggcgactttgcattgaaagaattacacccactggatctc catgcaacaaagaatattatactgaaacacagaacacaacttgatgaaacgaaccacaag gtacagagttgtaaagatgccctcaaagctctggaggactttctggcttctctgaaaaca gctgaactcccttttgagcttgttacagacctgtcagcctcagatacacaggtggtacca gaaaacactttgacaatagaaaataaagaaggagaaaccaatctgatgaaggacaaggcc agacatttggatgaacgtttgaagatgcttggtataagctttaaagatgctgaacggggt gacgacacctgtgaaaaacttgttgatgctttgtccaaaaagttatttgagacacatggc tatggcgtgcaggaggagttcactgaagacaagttactagagacttgtactttcaaaaat aatgaactcctgaaaaatattcaagatgtgtacaatcaaatcagtaaaatcagtcttaag gatcccactgctccagctgtgaaacaacggaaaaaatcactaatgaaactggataaggat ctagatgaatatgaagaagagaagaaatgcttgcaagaaatggtcaattctcttccgcag ttcagagacggccgagaaaaatcgctgaatcaacagtgccaaaatacggcacttttgtgg gagaatacaaaagcttcggtcactgaatgccttgaccaatgtgaaagagttttggagctc ttaaaacagtatcagaattttaaaagtgtcttgacaactttgattcaaaaagaagagaat gtcatctcccttcaggcttcctacatgggaaaagagaacctgaagaaaaggatagcagag attgaaattgtcaaagaagaatttaatgaacatttagaagttgtagacaagattaaccag gtctgtagaaacctacaatttcatctaaataaaatgagaagttttgaagagcctcctttt gagaaagaagctaatattattgtggatagatggcttgatataaatgaaaaaaccgaagac tactatgaaaatcttggtcgagctctagctttgtgggacaagctttttaacttaaaaaat gtcattgatgagtggactgaaaaggtccttcgaaaagtggaattacatcaactgactgaa gaagaaagagaaaagctgaaggaagagttacaagtccacgaacaaaaatcttcagagttt tctaaaagagtggctaaaatacagtttctccttcaaagcagcgaaacgcctcttgaattg caggtcatggagtcctctgttttaaacaagatagaaaatgtaaaaatgcatttaacagga gaatccaactgctctgcgctcagtggccatacagctgagctaagggaggatctcgaccaa gccaagactcagatcggaatgactgagtccctgttaaaagccctgtctccttctgacagc ttagagatctttactaaactagaggagatacaacagcaaatcctacagcaaaagcacagt atgatgttactggagaatcaaataggttgtctgactcctgaactctctgaattaaaaaag caatatgaaagtgtcagtgatttatttaataccaaaaaaagtgttttgcaagatcacttt tctaagttattgaatgatcagtgcaagaactttaatgactggtttggcaacattaaaatg aaccttaaggagtgttttgaatcatcagaaacaaaaaagagtgtggaagaaaagctgcaa aaactttctgatttcttaactcttgaaggaagaggcagtaaaacacagcaggtgggaact gtactaagtcatgtgaagaagcatctgcccaaagcacatgttaaggagcttcacagttgg attataaatcaagaaattgaattagaaaaaatggagtccatttgccaggcacgaacaaag gagctgaatgcctgcttgcagcagctactgagtctccaggatgaccacagaaatctgagc acatggttgaccagtcaagaagagaaatggaaagcactggaaaaaccaggagagaaaact gagctattttgcgaagctgtagctagaaaaagggaacaatttgaatctatggcccagctg aacaattctttgaaggaatatgggcttactgaagaagaagaaataataatggaatcaaca catttgattgatagataccagacatttttgagacaattatgtgaaattgatgaagaggat aagttacctcctacagaggaccagagctttaatgatcttgcacatgatgtaattcattgg atagcagggattaaagagtcccttatggttttgaattcatctgaaggcaaaatgccgctt gaggaaagaatccaaaaaataaaggaaatcattttgctaaagcctgaaggggacgctaaa atacagaccatcatgagtcaggctgagagcagcaaggctccattggctccaaagaccctt actgatatcaagaaccagtgggacaacacaatccatttagccaacacgtatctaagccat caagaaaagcttctactagaaggagagaagtatttgcaaagtaaggaggatctgagatta atgctcacagaactgaaaaagaaacaagaagtgggctttgctctgcaacacggtttgcag gagaagaaagctcagttaaaaatttataagaaattcctccagaaagcgcaagatttgaca tccttgctaaaagagttaaaatctcaaggaagttacctcttagaatgcactaaaaatccc aacttcagtgaagagccttggctggagataaagcatctacacgaaagtcttctacagcaa ctacaggattccgtgcaaaaattggaaggtcacgttcaagaacaccactcataccaggtt tgcgtcacagacctgaatactacattggacaatctctccaaggaacttgccagtttttct gataagcctttggatcaaatagcaactgaggaaaaactgcagaagctgcaggaactagag aatagactcagtttacaagatggcacattggagaagattttagctttagcaaaatccatc aagaaaaacacatcttcagtgggacagaagattattaaagatgatataaaatcacttaag tgtaaacaaaaggatttggaaaaccgacttgaatctgctaagcaggagacagaaaattgt cttcatagcattctccaatcaaaacgctcagcagaacagaaagaaaagtttagtctgcca ggcagagaggaggaggtcacttgtgatgtgcaggagtccactcaggactcagctgtactg gaaaaattggagcaagattgggaaataaacaagaattcagctgtggaaatggttttgtca aaacaactttctctcaatgttcaagaaagcatgaaaaacactgacgatgagcataaagtc aatgagctgcaaaatcaacctttagaattagatgtcgtgttaagaaatgaacaattaaaa gagatagaggaattatatgcccagttggacgcaaagaaatcagccattgaaccactggaa 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caacttccagatattcaagaaaaacttcaccagctccagatggagaaattgccatctcgt aaagcaatcacagaaatgattagctggttgaacggtgtggaacatcagaccgcagatgaa gactgtgagcattctctgagttccgcatctcaagttaaaaaccttcttcagaagtacaag gagttcagaatggagatggactataaacaatggatagtggactttgttaaccagtcctta cttcagttaagcacctgtgatgtagaaagtaagcgctatgagagaacagaatttgcagaa cacctgggagagatgaaccgccaatggcaccggatgcatggaacactgaatagaaagata caacatttagaacaacttttggaaagtatcaccgagactgaaaacaaaatacagattttg aacaactggatggaggcgcaagaggagagactgaaaactttacaaaaacctggaagtgtg atctccgtgcacaggatgcttctggattgtcaggatatagaaaatcaactggcaagtaaa tccaaggcgcttgatgagttgagacaatgttacctgacttcggagagtgggaccatgcca ttgttagaagacacagcatccagaattgatgggttatttcaaaagagaagcagtgttatc agccaggtcaacgagctcaagacctccacgcagtctgttttgcaggagtggaagatttac gaaagcctgtatgatgaggtggcgacgatgacaatccgattctggtactgcatggagcac agcaagcctgggtttttgtcattagaggccttaggatgccaggtgcagaacctccagtct cttcaagatgaagctgagagcagtgaagcaagctgggagaaactgcaggaggtgattcga aaactcaaagatcgctgcccctcggttgctgaaataatcgaagagaaatgccaaaatact catgctaggtggacccaggtaaaccaagacattgcagagcagttgcagaaggcccagagt ctgttgcagctctggaaggcccataacagtgctcacaccgaagctgcagcaaggctggag cagcaggaagcaaagtaccaacagcttgaaaacatcaacatgtctggaaacaacctggca gagatcctgacccgggccctgcaggatgtaaaggaactgcaggatgacgtacagaagacg aaagaagcctttctccagaattctgctctcctggatcgacttccacagctcacagagtcc agtacccacgtgcccctctctacacaactgcactccctccagagggtttcctacttggaa aagatgctgcttgtgaaagctaatgaatttgagtttgtcctgtcgcagttcaaggatttt ggggaacggctggaatctttaaaaggtctcattacgcatgaagaagagcatttggataaa ctctaccatcaagaaaaagaagaaaatcctgagttattcctgaaccatgtgctggcactg acagcccagtcacctgatgtggaacatttgaatgaaataagcctcaaactcccccttagt gacatagccataaagacgttacaaaatgtgaaccgacagtggattcgggccacggcaaca gccctggaacgctgcagtgagcttcaggcaacaggattgaatgaaaagtttctttattgc tgtgaaaaatgggtccagcttctggagaagacagaagagacgctcaaggtgactatggct gacagcctcccagctctcctggaacagcagaaaacatacgagatgttagaagctgaagtg tctataaaccagacagtggctgattcttatgtcacccagtccttacaactcttggacacc acagaaatagagaagagaccggaatttgtttcaaagttcacgaaactgaaggagcggtgg cagagtgcggcccagagcctccggcagaggaagagccacatcgatgggctggtggggcga tggcggcacttcaccacggccgcggaggacttgctccgcttcctcgccaacaccggcccc ctgctgtctgccgccaagagccaggattgccacagcctcccccaaaccaggaggctgatc cgtgagctgaagagcaaagacattcattttcagagacggcacatcacctatgcactcacc ttagaagctggggaaaagttactgaacgcagctagcctggaaacaaaagagttgattgac aagaaaatcagtcaactccaggacaactggaaggacacaaagctccaagtaggagagatg attacccagttgcagaataatatagagacctgggaccagtgtgaaaagaaaatcaaggag ttgaaaagcaggctgaaagttttaaaggcacaaagtagagatcctcttccggaacttcat gaggacctccataaagaaaaagagctgattaaggaactagagaagtctttggccaactgg acccagaacttgaaagaacttcacactctgaagaccgacttaacccagcacattcttgcg gaggacgtgatggttttggaggagcaaacagagcatttgcacagacaatgggaagacctc tgcttgagagtggctatacgcaaacaggagattgaagacagactcaattcatggattgtg ttcaatgaaaaaaataaagagttgtgtgcatggctggtgcagatggaaaacaaagttcta cagacagcagatcttagtattgaagaaatgattgaaaagttacagaaggactgcatggaa gaaataaacttgtttagtgaaaacaagttacagttaaagcaaatgggtgaccagttgatc aaggccagcaacaagacaagagcagctgagatcgatgacaagctcaacaaaatcaatgac 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