Panthera pardus (leopard): 109268830
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Entry
109268830 CDS
T06062
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
ppad
Panthera pardus (leopard)
Pathway
ppad05012
Parkinson disease
ppad05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
ppad00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
109268830 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
109268830 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ppad01001
]
109268830 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ppad04131
]
109268830 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
ppad04147
]
109268830 (LRRK2)
Enzymes [BR:
ppad01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
109268830 (LRRK2)
Protein kinases [BR:
ppad01001
]
Serine/threonine kinases: TKL group
LRRK family
109268830 (LRRK2)
Membrane trafficking [BR:
ppad04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
109268830 (LRRK2)
Exosome [BR:
ppad04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
109268830 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
LRR_8
LRR_4
COR-B
Ras
COR-A
LRR_9
Beta-prop_RSE1_2nd
Arf
WD40_CDC20-Fz
Beta-prop_EML_2
LRR_NXF1-5
LRR_13
Beta-prop_WDR36-Utp21_1st
AAA_22
T2SSE
Beta-prop_THOC3
nSTAND3
Ank_2
ABC_tran
Kdo
PduV-EutP
GTP_EFTU
SRPRB
G-alpha
TsaE
MMR_HSR1
AAA_7
ARM_CUL7_CUL9
TniB
AAA_16
NB-ARC
Beta-prop_HPS5
WD40_Prp19
MobB
WD40_WDHD1_1st
AAA_29
Septin
nSTAND_NTPase5
NACHT
FtsK_SpoIIIE
SRP54
LRR_6
Motif
Other DBs
NCBI-GeneID:
109268830
NCBI-ProteinID:
XP_019308005
Ensembl:
ENSPPRG00000015172
UniProt:
A0A9V1FT91
LinkDB
All DBs
Position
Unknown
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYADHASKLFHGKK
VHVPVLIVLDLYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGRDWEVLGIHQLIL
KMLTVHNASVNLLTVGLKALDLLLTSGKITLLILDEETDIFLLIFDAMRTFSANDEVQKL
GCKALRVLFERVSEEQLTEFVENKDYMILLNALKNFKDEEEIVLHVVHCLHSLAIPCSNV
EVLMSGNVRCYNIVVEAMKAFPDNEKIQEVSCCLLHRLTLGNFFNILVLNDVHEFVVKAV
RRYSENATLQIAALSCLALLTETIFLNQDLEEKNENQENDDEEEEKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNASMDTM
VVVAPKIIAVMKYHEASLSVQLEALRAVLHFIVPGMPEESKEDTEYQHKLHMVKKQYFRN
DIHKLVLAALNRFIGNPGIQKCGLKVISSLAHFPDALQVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLGLIGCLITKKNLCIGTGHLLAKILVSSLQRFKDMAEVQIKGFQTILTILELSV
SFSNLLVHHSFDSVIFHQMSSSIMEQKDQQFLNLCCKCFAKLAMDDELKSVMLEKACDQN
NSIMVECLLLLGADANRTKEATSLICQVCEKASSPKLVELLLNGGSREQDVRKALTISIG
KGDSQIISLLLRRLALDLANNSICLGGFCIGKIEPSWLGPLFPDRTSNLRKETNVGSTLA
RMVLRYQMKSVVEEGAASGSDGNFPEEVLDKFDEWTFIPDSCVDSVFGQSDDLDSEGSEG
SFLVKRKSNSISVGEFYRDRALQRCSPNLQRHSNSLGPIFDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELHQ
NGLTNFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDISRNDINPSVVLDPAV
KCPTLKQFNLSYNQLSSFPENLGDVVEKLEQLILEGNKISGICSHLSLKELKILNLSKNH
ITSLSEDFLEACPKVESFSARMNYLAAVPFLPSSLTSLKLSQNRFTCVPEAILNLPHLRS
LDMSSNDIQYLPSPAHWKSLNLRELLFSFNQISVLDLSEKAHVWSRVEKLHLAHNKLKEI
PPEIGCLENLTSFDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTKSKKSDPGVQSATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVKEN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDHHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPEQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRHISIPKNFIVECMVATNH
NSKSASIWLGCGHTDKGQLSFLDLNMEKHTSEEVTDSRILCLALVHLPAEKESWIVCGTQ
SGMLLVISTEDGKKRHTLKKMTDSVTCLYCNSVPKQSKQKNFLLVGTADGNLAIFEDKTV
KCKGAAPLKILNIGNVSTPLMCLSESMNSTEKNIMWGGCGTKLFSFSDDFTIQKLIETKT
NQLFSYAAFSDSNIIAVVVDTALYVAKKNSPFVEVWDKKTEKLCELIDCVHFLKEEMVKV
NAESKHKISYSGRVKTLCLQKNTALWIGTGGGHVLLLDLSTRRIIRIVHNFCDSVRVMMT
AQLGSLKNVMLVLGYIRKSTEGTQHQKEIQSCLSVWDINLPHEVHNLEKHIEVRNELAEK
MRRISVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggtagctgtcaggggtgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtccaaattctg
gaggatttgctggtgttcacgtacgcggaccacgcctccaagttatttcacggcaaaaaa
gtccacgtgcctgtgttgatcgtcttggacttgtatatgagagtcgctagtgtgcagcag
gtgggttggtcacttctatgcaaattgatagaaatctgtccaaatacaatgcaaagctta
atgggaccgcaggatattggacgtgattgggaagtacttgggatccaccaactgattctt
aaaatgctaacagttcataatgccagtgtaaacctgttaacagttggactaaaggcctta
gatctcctcctaacttcaggtaaaataactttgctgatattggatgaagagactgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgacgaagtccaaaaactt
ggatgcaaagctttacgtgtgctgtttgaaagagtttcagaggagcagctgactgaattt
gttgagaataaagattatatgatcttgctaaatgcattaaaaaattttaaagatgaagag
gaaattgtgcttcatgtagtgcactgtttacactccctagcaattccttgcagtaatgtt
gaagtcctcatgagtggcaacgtgaggtgttacaatattgtggtagaagccatgaaagca
ttccctgacaatgaaaaaattcaagaagtgagttgctgcttgctccataggcttacctta
ggtaatttttttaatattcttgtattaaacgatgtacatgagtttgtggtgaaagctgtg
cggcggtattcagagaacgccacgttacaaattgcagcgctcagctgtttagcactcctc
actgagaccattttcctaaatcaagatttggaggaaaagaatgaaaatcaggagaatgat
gatgaggaagaagaaaaattgttttggttggaagcctgttacaaagcgttgacgtggcat
agaaagaacaagcacgtgcaggaagctgcatgttgggccctaaacaatctcctcatgtac
caaaacagtctccatgagaagatcggagacgaagacggccagttcccagctcatagggaa
gtgatgctctccatgctgatgcattcttcatcgaaagaagtcttccaggcctctgcaaat
gcgttgtccactctgttagaacaaaatgttaatttcagaaaaatcctcttgtcaaaagga
atatacctgaatgtattggagttaatgcagaagcatatacattctcctgaggttgcagaa
agcggctgtaaaatgctaaatcatctttttgaaggaagtaatgcttccatggatacaatg
gtagtagtggcccccaaaataatagcagttatgaaatatcatgaggcatcattatcagtg
cagctggaggcacttcgagctgttttacattttatagttccaggcatgccagaagagtcc
aaggaagatacagaatatcaacataagctacatatggttaaaaaacagtatttcaggaat
gatattcacaaactggtcctagcagcgttgaacaggttcattggaaatcctgggattcag
aaatgtggattgaaagtaatttcttccttagcacattttcctgatgcattacaagtatta
tccctggaaggtgctattgattcggtacttcacacacttcagatgtatccagatgaccaa
gaaattcaatgtctgggtttaggtcttataggatgcttgattacaaagaagaatttatgc
ataggaactgggcatctgctggcaaaaattctggtttccagtttacaacgatttaaggat
atggctgaagtacagattaaaggatttcagacaatcttaacaatactggaattgtcagtg
tctttttccaacctgctggtgcatcattcctttgattcggtgatattccatcagatgtct
tccagtatcatggaacaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattagctatggacgatgagttaaaaagcgtgatgttagagaaagcatgtgatcagaat
aacagtatcatggttgaatgcttgcttctgttgggagcagacgccaatcgaacaaaggag
gcaacttctttaatttgtcaggtatgtgagaaagcaagcagtcccaaattggtggaactg
ttactgaatggtggttcccgtgaacaggatgtccggaaagctctgacaataagcattgga
aaaggtgacagccagatcatcagcttactcttacggagactcgccctggatctggccaat
aatagcatttgccttggaggattttgtataggaaaaatcgaaccttcatggcttggtcct
ttgtttccagataggacatctaatttaagaaaagaaacaaatgtaggatccaccctagca
agaatggtgctcagatatcagatgaaaagtgttgtggaagaaggagcagcctcaggcagc
gatgggaattttcctgaagaagttcttgataaatttgatgaatggaccttcattccagac
tcttgtgtggacagtgtgtttggtcaaagcgacgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaagaaaatccaattcaattagtgtgggagaattttaccgagatcgt
gccttacagcgttgctcaccaaatttgcagagacattccaattcattgggacccattttc
gatcatgaagatttactgaggcgaaaaagaaaaatattgtcttcagatgactcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttccctggcttctgag
agagaatatattacatcattagacctttcagcaaatgaactaagagacattgatgcccta
agccagaaatgctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatggactcacgaactttccacaacaactgtgtgaaaccctgaagtgtttgacacatttg
gacttgcacagtaataaatttacatcatttccctcttacttgttgaaaatgaattgtatt
gccaaccttgatatctctcgaaatgacatcaacccctcagtagttttggatcctgcagtg
aagtgcccaaccttgaagcagtttaacttgtcatataatcagctgtcttcttttcctgag
aaccttggtgatgtggtagagaaattggaacagctcattttagaaggaaataaaatatca
ggaatatgttcccacttaagcctgaaggaactgaaaattttaaaccttagtaaaaaccac
attacatccctatcagaagatttccttgaggcgtgtcctaaagtggagagtttcagtgcc
agaatgaattatcttgctgctgtgccttttttgccttcttctctgacaagcctaaaattg
tcccaaaacagatttacatgtgttcctgaagcaattttaaatcttccacacttacggtcc
ttagatatgagcagcaatgatattcaatatctaccgagtcctgcacactggaaatctttg
aacttaagggaactcttgttcagttttaatcagatcagcgtcttggacttgagcgaaaaa
gcacatgtatggtcaagagtagagaaactgcatcttgctcataataaactgaaagagatt
cctcctgagattggctgtcttgaaaacctgacctcctttgatgtcagttacaatctggaa
ctgagatcctttcctaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactacgtcttaattttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcagcagcggttaaaaaaggctgtgccctataaccgaatgaaacttatgattgtg
ggaaatactgggagtggtaaaaccaccttactgcagcaactaacgaaaagcaagaaatca
gatcctggggtgcaaagcgccacagttggtatagatgtgaaggactggcctatccaaata
agaggcaaagggaagaaagacctcattctaaatgtgtgggattttgcaggtcgtgaggaa
ttctacagcactcatcctcacttcatgacccagcgggccctctacctggctgtctatgac
ctcagcaaagggcaggctgaagtcgatgccatgaagccttggctcttcaatataaaggcc
cgtgcttcttcttcccctgtgattcttgttggcacacatttggatgtttccgatgaaaag
cagcgcaaagcctgcataagtaaaatcaccaaggaactgctgaacaagcgagggtttcct
gcaataagagattaccactttgtgaatgccacagaggaatctgatgctttggcaaagctt
cggaaaaccatcataaatgagagtcttaatttcaagatccgagatcagcctgtcgttggg
cagctgattccagactgctatgtagaacttgagaaaatcattttatcggaacgtaaaaat
gtgccaattgaatttcctgtaatcgaccggaaacgattattacaactcgtaaaagaaaat
cagctacagttggatgaaaatgagcttcctcatgcggttcacttcctaaatgaatcaggg
gtccttcttcattttcaagatccagcgctgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctatccaaaa
catcctaagggaatcatttcacgcagagatgtggaaaaatttctttcaaagaaaaagagg
tttccaaagaactacatgtcacagtactttaaactcctagaaaaattccagattgccctg
ccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgata
gagctccctcattgtgagaactctgaaattatcattcgactatatgaaatgccttatttt
ccaatgggattttggtcaaggttaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagaccatcacccagag
agtttcttaaaaattacagttccttcgtgtagaaaaggctgtattcttttgggccaagtt
gtggaccacatcgattctctcatggaagaatggtttcctggattactggaaattgatatc
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gaacatcaaaaaatcttgcttgatgacttgatgaagaaagcagaagaaggagaccttcta
gtcaatccagagcaaccaaggctcaccattcctatatctcaaattgctcctgacttaatt
ttggctgacctgcctagaaatattatgttgaataatgatgaattggaatttgaacaagct
ccagaattcctcttaggtgatggcagttttggatctgtttatcgagcagcctatgaagga
gaagaagtggctgtgaagattttcaataaacatacatcacttagattgttaagacaagag
ctggtggtcctttgccacctgcaccaccccagcttaatatctttgctggcggctgggatt
cgtcctcgcatgttggtgatggagttagcctccaagggttcactggaccgcttgcttcag
caggacaaagccagtctcaccagaaccctacagcacaggattgcactccatgtggctgat
ggcttgagatacctccactcagccatgatcatataccgtgacttgaagccccacaatgtg
ctgctctttaccctgtaccccaatgctgccatcatcgcaaagattgctgactatgggatt
gctcagtactgctgtagaatggggataaagacatcagagggcacaccagggtttcgtgca
cctgaagttgcaagaggaaatgttatttataaccagcaggctgatgtttattcatttggc
ttactactctatgacatcttgacaactggaggtagaatagcagagggtttgaagtttcca
aatgagtttgatgaactggcaatacaagggaaattacctgatccagttaaagaatatggt
tgtgccccatggcctatggtggagaagttaattaaaaagtgtttgaaagaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgagttaatctgtctg
atgagacatatatcaatacctaaaaactttatagttgaatgcatggttgctacaaatcat
aacagcaagagtgcaagcatctggctgggctgtgggcacactgacaaaggacagctctca
tttcttgacttaaatatggaaaaacacacttctgaggaagttactgacagcagaatactg
tgcctagctttggtgcatcttcctgctgaaaaggaaagctggattgtgtgtgggacacag
tctggcatgctcctggtcatcagtaccgaagatgggaaaaagagacatacccttaaaaag
atgactgattctgtaacttgcttatattgcaattccgttcccaagcaaagcaagcaaaaa
aactttcttctggtgggaactgctgatggcaatttagcaatttttgaagataaaactgtt
aagtgtaaaggagccgctcctttgaagatactaaatataggaaatgtcagtactccactg
atgtgtttgagtgaatccatgaattcaactgaaaaaaacattatgtggggaggatgtggc
acaaaacttttctcattttctgatgatttcaccattcagaagctcattgagacaaagaca
aatcagttgttttcttatgcagctttcagtgattccaacatcatagcagtggtggtggac
acggctctctacgttgctaagaaaaatagcccatttgtggaagtatgggataagaagact
gaaaaactctgtgaacttatagactgtgtgcactttttaaaggaggaaatggtaaaagta
aacgcggaatcaaaacacaaaatatcttattctgggagagtgaaaactctctgcctccag
aagaacactgccctctggataggaactggaggaggccatgttttactccttgatctttca
actcgtcgaattatacgtatagttcacaatttttgtgattctgtcagagtcatgatgaca
gcacagttaggaagccttaaaaatgtcatgctggttttgggatatatccggaaaagtact
gaaggcacacaacaccaaaaagagatacagtcttgtttgtctgtttgggatatcaacctt
ccacatgaagtgcataatttagaaaaacatattgaagtaagaaacgaattagctgaaaaa
atgagaagaatatctgttgaataa
DBGET
integrated database retrieval system
