KEGG   Panthera pardus (leopard): 109274721
Entry
109274721         CDS       T06062                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad00562  Inositol phosphate metabolism
ppad01100  Metabolic pathways
ppad04015  Rap1 signaling pathway
ppad04020  Calcium signaling pathway
ppad04022  cGMP-PKG signaling pathway
ppad04062  Chemokine signaling pathway
ppad04070  Phosphatidylinositol signaling system
ppad04071  Sphingolipid signaling pathway
ppad04072  Phospholipase D signaling pathway
ppad04081  Hormone signaling
ppad04082  Neuroactive ligand signaling
ppad04261  Adrenergic signaling in cardiomyocytes
ppad04270  Vascular smooth muscle contraction
ppad04310  Wnt signaling pathway
ppad04371  Apelin signaling pathway
ppad04540  Gap junction
ppad04611  Platelet activation
ppad04613  Neutrophil extracellular trap formation
ppad04621  NOD-like receptor signaling pathway
ppad04713  Circadian entrainment
ppad04720  Long-term potentiation
ppad04723  Retrograde endocannabinoid signaling
ppad04724  Glutamatergic synapse
ppad04725  Cholinergic synapse
ppad04726  Serotonergic synapse
ppad04728  Dopaminergic synapse
ppad04730  Long-term depression
ppad04742  Taste transduction
ppad04750  Inflammatory mediator regulation of TRP channels
ppad04911  Insulin secretion
ppad04912  GnRH signaling pathway
ppad04915  Estrogen signaling pathway
ppad04916  Melanogenesis
ppad04918  Thyroid hormone synthesis
ppad04919  Thyroid hormone signaling pathway
ppad04921  Oxytocin signaling pathway
ppad04922  Glucagon signaling pathway
ppad04924  Renin secretion
ppad04925  Aldosterone synthesis and secretion
ppad04926  Relaxin signaling pathway
ppad04927  Cortisol synthesis and secretion
ppad04928  Parathyroid hormone synthesis, secretion and action
ppad04929  GnRH secretion
ppad04933  AGE-RAGE signaling pathway in diabetic complications
ppad04934  Cushing syndrome
ppad04935  Growth hormone synthesis, secretion and action
ppad04961  Endocrine and other factor-regulated calcium reabsorption
ppad04970  Salivary secretion
ppad04971  Gastric acid secretion
ppad04972  Pancreatic secretion
ppad04973  Carbohydrate digestion and absorption
ppad05010  Alzheimer disease
ppad05016  Huntington disease
ppad05017  Spinocerebellar ataxia
ppad05022  Pathways of neurodegeneration - multiple diseases
ppad05142  Chagas disease
ppad05143  African trypanosomiasis
ppad05146  Amoebiasis
ppad05163  Human cytomegalovirus infection
ppad05200  Pathways in cancer
ppad05415  Diabetic cardiomyopathy
ppad05417  Lipid and atherosclerosis
Module
ppad_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    109274721 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    109274721 (PLCB4)
   04310 Wnt signaling pathway
    109274721 (PLCB4)
   04371 Apelin signaling pathway
    109274721 (PLCB4)
   04020 Calcium signaling pathway
    109274721 (PLCB4)
   04070 Phosphatidylinositol signaling system
    109274721 (PLCB4)
   04072 Phospholipase D signaling pathway
    109274721 (PLCB4)
   04071 Sphingolipid signaling pathway
    109274721 (PLCB4)
   04022 cGMP-PKG signaling pathway
    109274721 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    109274721 (PLCB4)
   04081 Hormone signaling
    109274721 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    109274721 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109274721 (PLCB4)
   04613 Neutrophil extracellular trap formation
    109274721 (PLCB4)
   04621 NOD-like receptor signaling pathway
    109274721 (PLCB4)
   04062 Chemokine signaling pathway
    109274721 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    109274721 (PLCB4)
   04922 Glucagon signaling pathway
    109274721 (PLCB4)
   04929 GnRH secretion
    109274721 (PLCB4)
   04912 GnRH signaling pathway
    109274721 (PLCB4)
   04915 Estrogen signaling pathway
    109274721 (PLCB4)
   04921 Oxytocin signaling pathway
    109274721 (PLCB4)
   04926 Relaxin signaling pathway
    109274721 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    109274721 (PLCB4)
   04918 Thyroid hormone synthesis
    109274721 (PLCB4)
   04919 Thyroid hormone signaling pathway
    109274721 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    109274721 (PLCB4)
   04916 Melanogenesis
    109274721 (PLCB4)
   04924 Renin secretion
    109274721 (PLCB4)
   04925 Aldosterone synthesis and secretion
    109274721 (PLCB4)
   04927 Cortisol synthesis and secretion
    109274721 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    109274721 (PLCB4)
   04270 Vascular smooth muscle contraction
    109274721 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    109274721 (PLCB4)
   04971 Gastric acid secretion
    109274721 (PLCB4)
   04972 Pancreatic secretion
    109274721 (PLCB4)
   04973 Carbohydrate digestion and absorption
    109274721 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    109274721 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    109274721 (PLCB4)
   04725 Cholinergic synapse
    109274721 (PLCB4)
   04728 Dopaminergic synapse
    109274721 (PLCB4)
   04726 Serotonergic synapse
    109274721 (PLCB4)
   04720 Long-term potentiation
    109274721 (PLCB4)
   04730 Long-term depression
    109274721 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    109274721 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    109274721 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    109274721 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    109274721 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109274721 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    109274721 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109274721 (PLCB4)
   05142 Chagas disease
    109274721 (PLCB4)
   05143 African trypanosomiasis
    109274721 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109274721 (PLCB4)
   05016 Huntington disease
    109274721 (PLCB4)
   05017 Spinocerebellar ataxia
    109274721 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    109274721 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109274721 (PLCB4)
   05415 Diabetic cardiomyopathy
    109274721 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    109274721 (PLCB4)
   04934 Cushing syndrome
    109274721 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppad04131]
    109274721 (PLCB4)
Enzymes [BR:ppad01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     109274721 (PLCB4)
Membrane trafficking [BR:ppad04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    109274721 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    109274721 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 109274721
NCBI-ProteinID: XP_019318079
Ensembl: ENSPPRG00000002992
UniProt: A0A9W2UJD9
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESADQEEEAHPEYKFGSELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEVGSRDGPQTSNSSV
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcaaaaggaagttccttcctttttgcaagaagga
gccgtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggagaagtgaaggcaaggaaggacaagttcta
gaatgttccctcatcaacagtattcgattgggagccaccccaaaggatcccaaaatcctg
gctgctcttgaagctgttggaaagtcagagaatgatctggaagggcgaatagtttgtgtc
tgcagtggcacagatctggtgaacatcagtttcacatacatggtggctgaaaatccggaa
gtaactaagcaatgggtagaaggactgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacctgcctcaaaaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaatcgag
cctgcagcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcgaaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttgttc
ccattttatgatgctaaaagggcaatgcagatcatcgagatgtatgagcctgatgaagat
ttgaagaaaaaaggcctcatatcaagcgatgggttttgcagatatctgatgtcagatgaa
aatgcccctgtcttcctggatcgtttagaactttaccaagaaatggaccatcctctggcc
cactacttcatcagttcttcccataacacctatctcactggccgacagtttggtggaaag
tcttccgtagaaatgtacagacaggttctcctggctggttgcaggtgtgttgaacttgac
tgttgggatggaaaaggtgaagaccaggaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcgtttgtcacatcc
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccactcgaaccaggcaggcccttaccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataagcggctgaaacctgaggtcgaaaaaaaacagcttgaagctttgaaaagcatg
atggaagctggagaatctgctgccccggttaacatcttagaggatgataatgaagaagaa
atagagagtgctgaccaagaggaggaagctcaccctgaatacaaatttggaagtgaactt
tctgctgatgacttgggtcacaaggaggctgttgcaaatagtgtcaagaaggcttcagat
gaccttgaacatgaaatcaacaaaaagggcctggttactgtagaagatgaacaggcatgg
atggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtctacaatg
atcaactatgcacagcccgtaaaatttcaaggtttccatgtggctgaagagcgcaatatt
cattataatatgtcttcttttaatgagtccgttggtctaggctacttgaagacacacgcg
attgaatttgtgaattacaacaaacggcaaatgagccgcatttaccccaagggaggccgg
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctcaactatcagaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgcgggtaccttctcaaaccagatttcatgagacggcccgatcgaacatttgat
cccttctctgaaactcctgtcgacggggttattgcagccacttgctcagtgcaggtcata
tcaggtcagtttttatcagataagaaaattggtacatatgtagaagtggatatgtatggt
ttacccactgacaccatacgtaaggaattccgaactcgcatggtgatgaacaatggactc
aatccagtttacaatgaagaatcatttgtgtttcggaaggtgatcctccctgacctggca
gtcttgagaatagctgtgtatgacgacaacaataggctgataggccagaggattcttccg
ctggatggcctccaagcaggttatcgacacatttctcttcgaaatgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagtgat
acttctaagaatgacaagaaaggaaaggccaacactgccaaagcaaacgtgaccccgcag
agcagctctgagctcagaccaaccaccacggcggccctggggtctggagtggaagccaag
aaaggtatcgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctaaattctttaaagaagaaacatgctaag
gagcacagcaccatgcagaagctgcattgcacacaagttgacaaaattgtggcacagtat
gacaaagagaagtcaacgcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatagtggcccagcacacaaaggaatggtcagaaatgatt
aacacccacagtgctgaggaacaagaaatccgggacctgcacctcagccagcagtgcgag
ctcctgagaaagctactgatcaacgcccacgagcagcaaacccagcagctaaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggagagtcagg
gagttaaatagcagcaacaccaaaaagtttctggaagaaagaaagagactcgccatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctggagttcctagag
aaacagaatgagcagctattgaaatcctgccatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaagttggaagccgagatggaccgcagaccagcaacagtagtgtg
aaactccagaacgcaaactga

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